• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Details
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Cel-018659
UUCD1 version UUC-CaE-00015
Ensembl Protein ID R05D3.4b
UniProt Accession P34537; Q65ZS6; BRE1_CAEEL
Genbank Protein ID CCD73190.1; CCD73191.1
Protein Name E3 ubiquitin-protein ligase bre-1; RING finger protein rfp-1; RING-type E3 ubiquitin transferase bre-1
Genbank Nucleotide ID FO081667; FO081667
Gene Name rfp-1; bre-1; R05D3.4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00007008 R05D3.4a R05D3.4a
WBGene00007008 R05D3.4b R05D3.4b
Annotation
mRNA Expression
GEO
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Post-translational Modifications (PTMs)
dbPAFdbPTMPhospho.ELMPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 14732404
Classification
Family E-value Score Start End
E3 activity/RING/RING 0.0039 18.0 785 824
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C+ C++++kd  + l C H+f+++C+  ++        ++ +CP C+
   Q: 785  CPSCKTRPKD-CIMLKCYHLFCETCIkTMY------DTRQRKCPKCN 824
           **********.888************6666......888999***96 PP
   
Organism Caenorhabditis elegans
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-117' of histone H2B. H2B 'Lys-117' ubiquitination gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.
 E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-117' of histone H2B. H2B 'Lys-117' ubiquitination gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.
Protein Sequence
(Fasta)
MMKRSNEGIG GENYASSPSD DGQQKRRKIQ FEPVRMPAVS NVNDIRARAV VYQTSKLKQQ 60
LLYKNKRIAE LEKENERSKR RQQTDESNFL KVYNMFSDIE KYICTQTKNE FGEYIGGDTA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Cel-018659|E3,RING|Caenorhabditis elegans
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTATGATGAA AAGAAGTAAT GAAGGTATAG GAGGAGAAAA TTATGCAAGT AGCCCGAGTG 60
ACGATGGACA ACAAAAACGA CGCAAAATTC AATTCGAACC GGTCCGAATG CCCGCTGTTA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cel-018659|E3,RING|Caenorhabditis elegans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2
SMART

SM00184--RING
Gene Ontology

GO:0005634--C:nucleus
GO:0016740--F:transferase activity
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0008270--F:zinc ion binding
GO:0016569--P:covalent chromatin modification
GO:0006664--P:glycolipid metabolic process
GO:0016567--P:protein ubiquitination
KEGG cel:CELE_R05D3.4
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001976 Ailuropoda melanoleuca 34.41 3.00e-37 149.00
IUUC-Apl-003407 Anas platyrhynchos 37.23 1.00e-40 160.00
IUUC-Aca-004850 Anolis carolinensis 36.92 6.00e-41 161.00
IUUC-Aly-006055 Arabidopsis lyrata 27.27 4.00e-19 89.00
IUUC-Ath-007462 Arabidopsis thaliana 27.27 4.00e-19 89.00
IUUC-Ago-007988 Ashbya gossypii 30.86 9.00e-10 57.40
IUUC-Acl-008319 Aspergillus clavatus 26.28 8.00e-12 64.30
IUUC-Afl-008511 Aspergillus flavus 31.34 1.00e-05 43.90
IUUC-Ang-009601 Aspergillus niger 28.35 1.00e-10 60.50
IUUC-Aor-010142 Aspergillus oryzae 22.81 4.00e-14 72.40
IUUC-Ate-010547 Aspergillus terreus 28.26 1.00e-11 63.50
IUUC-Ame-011745 Astyanax mexicanus 36.26 2.00e-38 152.00
IUUC-Bgr-012245 Blumeria graminis 27.56 9.00e-12 64.30
IUUC-Bta-012357 Bos taurus 36.13 2.00e-38 153.00
IUUC-Bci-013926 Botrytis cinerea 28.68 9.00e-09 54.30
IUUC-Bdi-014799 Brachypodium distachyon 29.41 7.00e-19 88.20
IUUC-Bol-015421 Brassica oleracea 42.67 1.00e-16 80.50
IUUC-Bra-016664 Brassica rapa 42.67 1.00e-16 80.50
IUUC-Cja-019042 Callithrix jacchus 32.98 4.00e-37 149.00
IUUC-Cfa-020320 Canis familiaris 34.41 4.00e-37 149.00
IUUC-Cpo-021617 Cavia porcellus 35.27 7.00e-40 158.00
IUUC-Cre-022940 Chlamydomonas reinhardtii 27.74 5.00e-08 51.60
IUUC-Csa-023509 Chlorocebus sabaeus 36.13 6.00e-37 148.00
IUUC-Cho-024616 Choloepus hoffmanni 36.54 2.00e-35 143.00
IUUC-Cin-025174 Ciona intestinalis 31.98 9.00e-38 150.00
IUUC-Csv-025830 Ciona savignyi 33.70 1.00e-35 144.00
IUUC-Cgl-026569 Colletotrichum gloeosporioides 39.53 3.00e-07 48.90
IUUC-Cne-026878 Cryptococcus neoformans 34.62 9.00e-09 54.30
IUUC-Cme-027134 Cyanidioschyzon merolae 42.37 1.00e-13 70.50
IUUC-Dre-028171 Danio rerio 35.90 6.00e-40 158.00
IUUC-Dno-028892 Dasypus novemcinctus 33.69 4.00e-40 159.00
IUUC-Dor-030250 Dipodomys ordii 36.13 7.00e-37 148.00
IUUC-Dse-031300 Dothistroma septosporum 27.59 4.00e-15 75.50
IUUC-Dme-032034 Drosophila melanogaster 37.84 3.00e-43 169.00
IUUC-Ete-033164 Echinops telfairi 36.86 8.00e-39 154.00
IUUC-Eca-033436 Equus caballus 33.69 5.00e-40 158.00
IUUC-Eeu-034801 Erinaceus europaeus 53.76 2.00e-27 116.00
IUUC-Fca-035720 Felis catus 33.69 3.00e-40 159.00
IUUC-Fal-037622 Ficedula albicollis 37.59 1.00e-38 154.00
IUUC-Fox-038017 Fusarium oxysporum 24.72 9.00e-07 47.40
IUUC-Fso-038414 Fusarium solani 26.09 9.00e-08 50.80
IUUC-Gmo-039446 Gadus morhua 33.92 3.00e-36 145.00
IUUC-Ggr-040117 Gaeumannomyces graminis 26.45 2.00e-08 53.10
IUUC-Gga-040412 Gallus gallus 37.59 5.00e-41 161.00
IUUC-Gac-042205 Gasterosteus aculeatus 33.92 5.00e-36 145.00
IUUC-Gma-042797 Glycine max 28.19 2.00e-21 96.70
IUUC-Ggo-044703 Gorilla gorilla 36.13 6.00e-37 148.00
IUUC-Hsa-046462 Homo sapiens 36.13 6.00e-37 148.00
IUUC-Hvu-047689 Hordeum vulgare 28.79 4.00e-18 85.50
IUUC-Itr-048298 Ictidomys tridecemlineatus 36.50 2.00e-38 153.00
IUUC-Kpa-049345 Komagataella pastoris 26.17 4.00e-07 48.50
IUUC-Lch-049429 Latimeria chalumnae 36.50 6.00e-42 164.00
IUUC-Lpe-051253 Leersia perrieri 39.64 2.00e-17 83.20
IUUC-Loc-052847 Lepisosteus oculatus 46.56 3.00e-29 120.00
IUUC-Lma-053312 Leptosphaeria maculans 24.02 1.00e-11 63.50
IUUC-Laf-054122 Loxodonta africana 36.13 7.00e-37 147.00
IUUC-Mcc-054647 Macaca mulatta 36.13 6.00e-37 148.00
IUUC-Meu-056559 Macropus eugenii 35.40 5.00e-36 145.00
IUUC-Mpo-057568 Magnaporthe poae 22.92 1.00e-09 57.40
IUUC-Mtr-057632 Medicago truncatula 26.50 5.00e-18 85.50
IUUC-Mla-059072 Melampsora laricipopulina 39.39 1.00e-13 70.90
IUUC-Mga-059731 Meleagris gallopavo 37.59 1.00e-40 160.00
IUUC-Mvi-060341 Microbotryum violaceum 23.61 2.00e-13 69.70
IUUC-Mmr-061495 Microcebus murinus 36.13 1.00e-39 157.00
IUUC-Mdo-062415 Monodelphis domestica 35.04 4.00e-40 159.00
IUUC-Mmu-063278 Mus musculus 36.13 7.00e-37 147.00
IUUC-Mac-065103 Musa acuminata 28.52 5.00e-24 105.00
IUUC-Mpu-065910 Mustela putorius furo 34.41 3.00e-37 149.00
IUUC-Mlu-067242 Myotis lucifugus 33.69 5.00e-40 158.00
IUUC-Ncr-068695 Neurospora crassa 24.87 6.00e-11 61.60
IUUC-Nle-069058 Nomascus leucogenys 36.13 7.00e-37 148.00
IUUC-Opr-071149 Ochotona princeps 53.92 7.00e-30 124.00
IUUC-Ont-071299 Oreochromis niloticus 35.90 4.00e-38 152.00
IUUC-Oan-072996 Ornithorhynchus anatinus 36.13 6.00e-40 157.00
IUUC-Ocu-074773 Oryctolagus cuniculus 36.13 7.00e-37 148.00
IUUC-Oba-075000 Oryza barthii 30.99 2.00e-18 87.00
IUUC-Obr-076532 Oryza brachyantha 29.73 1.00e-17 84.00
IUUC-Ogl-077200 Oryza glaberrima 30.95 9.00e-19 87.80
IUUC-Ogu-078279 Oryza glumaepatula 30.99 1.00e-18 87.00
IUUC-Oin-079097 Oryza indica 30.95 9.00e-19 87.80
IUUC-Olo-080612 Oryza longistaminata 41.94 6.00e-13 68.90
IUUC-Ome-081304 Oryza meridionalis 30.71 2.00e-17 83.20
IUUC-Oni-082162 Oryza nivara 30.99 1.00e-18 87.00
IUUC-Opu-083683 Oryza punctata 39.71 7.00e-14 71.60
IUUC-Oru-084382 Oryza rufipogon 30.99 1.00e-18 87.00
IUUC-Osa-085839 Oryza sativa 39.71 7.00e-14 71.60
IUUC-Ola-087287 Oryzias latipes 33.92 2.00e-34 140.00
IUUC-Olu-087683 Ostreococcus lucimarinus 31.13 4.00e-10 55.50
IUUC-Oga-088961 Otolemur garnettii 36.86 1.00e-38 154.00
IUUC-Oar-089755 Ovis aries 36.13 2.00e-38 153.00
IUUC-Ptr-091602 Pan troglodytes 36.13 6.00e-37 148.00
IUUC-Pan-092263 Papio anubis 36.13 6.00e-37 148.00
IUUC-Psi-093554 Pelodiscus sinensis 35.77 9.00e-37 147.00
IUUC-Pno-095079 Phaeosphaeria nodorum 29.17 1.00e-14 73.90
IUUC-Ppa-095651 Physcomitrella patens 26.20 2.00e-18 86.70
IUUC-Pfo-097527 Poecilia formosa 34.28 7.00e-35 141.00
IUUC-Pab-098598 Pongo abelii 36.13 7.00e-37 147.00
IUUC-Pop-099376 Populus trichocarpa 27.95 6.00e-23 101.00
IUUC-Pca-100544 Procavia capensis 33.69 6.00e-40 158.00
IUUC-Ppe-102065 Prunus persica 24.48 6.00e-16 78.60
IUUC-Pva-102479 Pteropus vampyrus 34.04 2.00e-40 159.00
IUUC-Pgr-103536 Puccinia graminis 39.19 6.00e-14 71.60
IUUC-Pte-104415 Pyrenophora teres 27.96 2.00e-11 62.80
IUUC-Pyt-104762 Pyrenophora triticirepentis 28.14 3.00e-11 62.80
IUUC-Rno-105165 Rattus norvegicus 33.69 5.00e-40 158.00
IUUC-Sha-107602 Sarcophilus harrisii 34.31 4.00e-40 159.00
IUUC-Sja-107993 Schizosaccharomyces japonicus 30.77 3.00e-08 52.40
IUUC-Spo-108304 Schizosaccharomyces pombe 44.44 1.00e-08 53.90
IUUC-Ssl-108546 Sclerotinia sclerotiorum 25.97 5.00e-08 51.60
IUUC-Sit-110382 Setaria italica 27.46 2.00e-20 92.80
IUUC-Sly-111490 Solanum lycopersicum 30.00 5.00e-22 98.60
IUUC-Sar-113349 Sorex araneus 38.10 4.00e-30 125.00
IUUC-Sbi-114734 Sorghum bicolor 36.11 9.00e-16 75.50
IUUC-Sre-115087 Sporisorium reilianum 26.62 4.00e-14 72.40
IUUC-Ssc-115723 Sus scrofa 36.13 6.00e-37 148.00
IUUC-Tgu-116549 Taeniopygia guttata 37.59 2.00e-38 153.00
IUUC-Tru-118776 Takifugu rubripes 33.92 1.00e-33 137.00
IUUC-Tsy-118808 Tarsius syrichta 36.13 8.00e-37 147.00
IUUC-Tni-120790 Tetraodon nigroviridis 33.92 3.00e-34 139.00
IUUC-Tca-121060 Theobroma cacao 28.07 3.00e-20 92.80
IUUC-Tre-122150 Trichoderma reesei 28.26 6.00e-09 54.70
IUUC-Tvi-122431 Trichoderma virens 23.19 2.00e-09 57.00
IUUC-Tae-125456 Triticum aestivum 27.30 1.00e-19 90.50
IUUC-Tur-126160 Triticum urartu 43.94 5.00e-15 75.50
IUUC-Tme-127177 Tuber melanosporum 30.00 1.00e-09 57.00
IUUC-Tbe-127597 Tupaia belangeri 33.69 1.00e-39 157.00
IUUC-Ttr-128266 Tursiops truncatus 36.13 6.00e-37 148.00
IUUC-Uma-129488 Ustilago maydis 45.45 2.00e-13 69.70
IUUC-Vda-129815 Verticillium dahliae 40.43 1.00e-08 53.90
IUUC-Vpa-130237 Vicugna pacos 34.41 3.00e-37 149.00
IUUC-Vvi-131316 Vitis vinifera 24.62 2.00e-17 83.20
IUUC-Xtr-132906 Xenopus tropicalis 31.72 4.00e-37 149.00
IUUC-Xma-133365 Xiphophorus maculatus 34.28 2.00e-34 140.00
IUUC-Yli-134445 Yarrowia lipolytica 33.33 2.00e-09 56.20
IUUC-Zma-135598 Zea mays 27.86 3.00e-19 89.40
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved