iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-053727

UUCD1 version

UUC-LoA-00612

Ensembl Protein ID

ENSLAFP00000014922.4

UniProt Accession

G3TJK8; G3TJK8_LOXAF

Protein Name

Uncharacterized protein

Gene Name

TRIP12

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000017783.4	ENSLAFT00000029918.1	ENSLAFP00000029314.1
ENSLAFG00000017783.4	ENSLAFT00000017793.4	ENSLAFP00000014922.4
ENSLAFG00000017783.4	ENSLAFT00000032543.1	ENSLAFP00000024351.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.40e-96	324.2	1661	2040

Active Site

Position(s)	Description	Evidence
2007	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 6    kkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlq..pnpdsglknp.....................ehlk 69
           ++ le+++++E g++l G+t+ef+al+s+elq++dlgl++ +e   ++ +   + +++                         ++  
   Q: 1661 RAMLEIQYENEVGTGL-GPTLEFYALVSQELQRADLGLWRGEEVTLSNPKgsQEGTKY---IqnlqglfalpfgrtakpahiaKVKM 1743
           56899***********.**********************6665533332200222333...14458888999**********9999* PP
   S: 70   lFeflGrllgkalqdgrlldlplsksfyklllgkklsl..edleevdpelykslkeikena......es.................. 130
            F+flG+l++ka++d rl+dlpl  +fyk +l+++ sl  +dl +vdp +++s+  +++ +      e+                  
   Q: 1744 KFRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLtsHDLFDVDPVVARSVYHLEDIVrqkkrlEQdksqtkeslqyaletltm 1830
           **********************************654444**************999999855555511555666666554444444 PP
   S: 131  ...dieelgldltfsvseei.....lgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviplellslF 209
              ++e+            +     l+   + eLk gG++ipVt+ N+eeY +lv+ + l+eg+ +q+++fr+Gf++v+pl++l++F
   Q: 1831 ngcSVED------------LgldftLPGFPNIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPLSHLQYF 1905
           4444444............25555578999********************************************************* PP
   S: 210  teeelellicGe..eeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk... 291
            +eel++l+cG+  +++d+++l + ++ ++gyt+ds+a+++++e+l++f++e+++ fLqFvTgs+rlP+gGf++l+p l+++rk   
   Q: 1906 YPEELDQLLCGSkaDTWDAKTLMECCRPDHGYTHDSRAVKFLFEILSSFDNEQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKtfe 1992
           ************7778999999999999*********************************************************** PP
   S: 292  ..dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFels 336
             ++ dd lPs++TC+nyLkLP+Yss ei++ekLl+A +e+ ++F+ls
   Q: 1993 stENPDDFLPSVMTCVNYLKLPDYSSIEIMREKLLIAAREGqQSFHLS 2040
           988888***************************************985 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MSNRPNNNPG GSLRRSQRNT AGAQPQDDSI GGRSHLGQAK HKGYSPPESR KSNSKAPRVQ 60
SNTTSELSRG HLSKRSCSSS PAVIVPQPED PDRASTSERQ KTGQVPKKDS SRGVKRSASP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCCAACC GGCCTAATAA CAATCCAGGG GGGTCACTGC GACGTTCACA GAGGAACACT 60
GCCGGGGCCC AACCACAAGA CGACTCGATA GGAGGAAGGT ATGCATTTAA CAGTGATTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR000569--HECT_dom
IPR004170--WWE-dom

PROSITE

PS50237--HECT
PS50918--WWE

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0016607--C:nuclear speck
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006974--P:cellular response to DNA damage stimulus
GO:0009790--P:embryo development
GO:2000780--P:negative regulation of double-strand break repair
GO:1901315--P:negative regulation of histone H2A K63-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000750	Aegilops tauschii	38.69	1.00e-126	448.00
IUUC-Aml-001502	Ailuropoda melanoleuca	98.92	0.00e+00	3727.00
IUUC-Atr-002821	Amborella trichopoda	37.45	3.00e-117	417.00
IUUC-Apl-003531	Anas platyrhynchos	92.39	0.00e+00	3408.00
IUUC-Aly-005962	Arabidopsis lyrata	38.94	4.00e-115	410.00
IUUC-Ath-006636	Arabidopsis thaliana	38.66	4.00e-114	407.00
IUUC-Ago-007875	Ashbya gossypii	35.87	1.00e-81	298.00
IUUC-Acl-008242	Aspergillus clavatus	35.70	9.00e-114	405.00
IUUC-Afl-008736	Aspergillus flavus	39.05	1.00e-110	395.00
IUUC-Afu-008812	Aspergillus fumigatus	35.25	2.00e-114	407.00
IUUC-Ani-009407	Aspergillus nidulans	36.82	2.00e-110	394.00
IUUC-Ang-009763	Aspergillus niger	39.96	5.00e-106	380.00
IUUC-Aor-009941	Aspergillus oryzae	30.83	5.00e-113	402.00
IUUC-Ate-010459	Aspergillus terreus	36.47	7.00e-86	313.00
IUUC-Ame-011761	Astyanax mexicanus	86.75	0.00e+00	2923.00
IUUC-Bgr-012265	Blumeria graminis	35.01	3.00e-104	374.00
IUUC-Bta-013070	Bos taurus	97.95	0.00e+00	3562.00
IUUC-Bci-013890	Botrytis cinerea	39.92	7.00e-103	369.00
IUUC-Bdi-014046	Brachypodium distachyon	38.47	8.00e-122	432.00
IUUC-Bol-015942	Brassica oleracea	44.23	2.00e-114	407.00
IUUC-Bra-016849	Brassica rapa	44.23	5.00e-114	406.00
IUUC-Cja-019046	Callithrix jacchus	97.65	0.00e+00	3673.00
IUUC-Cfa-020521	Canis familiaris	97.06	0.00e+00	3581.00
IUUC-Cpo-021639	Cavia porcellus	94.66	0.00e+00	3593.00
IUUC-Cre-022767	Chlamydomonas reinhardtii	39.88	1.00e-89	323.00
IUUC-Csa-023231	Chlorocebus sabaeus	97.44	0.00e+00	3670.00
IUUC-Cho-024380	Choloepus hoffmanni	90.83	0.00e+00	3364.00
IUUC-Cin-025482	Ciona intestinalis	51.40	7.00e-160	556.00
IUUC-Csv-026121	Ciona savignyi	49.18	0.00e+00	1546.00
IUUC-Cgl-026716	Colletotrichum gloeosporioides	35.29	5.00e-111	396.00
IUUC-Cne-026857	Cryptococcus neoformans	40.08	1.00e-94	342.00
IUUC-Cme-027226	Cyanidioschyzon merolae	35.14	3.00e-74	274.00
IUUC-Dre-028174	Danio rerio	86.48	0.00e+00	2966.00
IUUC-Dor-030939	Dipodomys ordii	88.16	0.00e+00	2784.00
IUUC-Dse-031444	Dothistroma septosporum	39.52	1.00e-105	379.00
IUUC-Dme-032162	Drosophila melanogaster	63.64	2.00e-158	554.00
IUUC-Ete-032345	Echinops telfairi	92.69	0.00e+00	2310.00
IUUC-Eca-033229	Equus caballus	98.48	0.00e+00	3615.00
IUUC-Eeu-035205	Erinaceus europaeus	85.54	0.00e+00	3101.00
IUUC-Fca-036444	Felis catus	98.14	0.00e+00	3670.00
IUUC-Fal-037131	Ficedula albicollis	92.94	0.00e+00	3483.00
IUUC-Fox-038035	Fusarium oxysporum	36.46	3.00e-110	392.00
IUUC-Fso-038320	Fusarium solani	37.07	3.00e-110	394.00
IUUC-Gmo-039497	Gadus morhua	87.70	0.00e+00	3001.00
IUUC-Ggr-040057	Gaeumannomyces graminis	35.05	4.00e-108	387.00
IUUC-Gga-041021	Gallus gallus	93.47	0.00e+00	3493.00
IUUC-Gac-042474	Gasterosteus aculeatus	81.37	0.00e+00	3046.00
IUUC-Gma-043060	Glycine max	38.92	3.00e-122	434.00
IUUC-Ggo-044855	Gorilla gorilla	97.65	0.00e+00	3674.00
IUUC-Hsa-046147	Homo sapiens	96.13	0.00e+00	3560.00
IUUC-Hvu-047775	Hordeum vulgare	38.69	7.00e-125	442.00
IUUC-Itr-048131	Ictidomys tridecemlineatus	95.07	0.00e+00	3470.00
IUUC-Kpa-049098	Komagataella pastoris	37.90	6.00e-86	313.00
IUUC-Lch-049818	Latimeria chalumnae	83.65	0.00e+00	3051.00
IUUC-Lpe-051017	Leersia perrieri	38.18	1.00e-118	422.00
IUUC-Loc-051777	Lepisosteus oculatus	86.67	0.00e+00	3288.00
IUUC-Lma-052990	Leptosphaeria maculans	39.74	2.00e-111	398.00
IUUC-Mcc-055799	Macaca mulatta	95.98	0.00e+00	3578.00
IUUC-Meu-056065	Macropus eugenii	93.79	0.00e+00	2102.00
IUUC-Mor-057054	Magnaporthe oryzae	39.04	2.00e-107	384.00
IUUC-Mpo-057417	Magnaporthe poae	39.74	1.00e-109	392.00
IUUC-Mtr-057849	Medicago truncatula	37.78	5.00e-114	406.00
IUUC-Mla-058870	Melampsora laricipopulina	42.77	5.00e-107	383.00
IUUC-Mga-059580	Meleagris gallopavo	94.39	0.00e+00	3036.00
IUUC-Mvi-060507	Microbotryum violaceum	40.00	2.00e-112	401.00
IUUC-Mmr-060816	Microcebus murinus	97.39	0.00e+00	3661.00
IUUC-Mdo-062866	Monodelphis domestica	92.96	0.00e+00	3372.00
IUUC-Mmu-063906	Mus musculus	94.34	0.00e+00	3532.00
IUUC-Mac-064675	Musa acuminata	39.07	8.00e-112	398.00
IUUC-Mpu-066199	Mustela putorius furo	95.94	0.00e+00	3565.00
IUUC-Mlu-067110	Myotis lucifugus	95.07	0.00e+00	3539.00
IUUC-Nfi-068482	Neosartorya fischeri	35.55	3.00e-114	407.00
IUUC-Ncr-068906	Neurospora crassa	39.32	3.00e-109	390.00
IUUC-Nle-069410	Nomascus leucogenys	98.33	0.00e+00	3663.00
IUUC-Opr-070401	Ochotona princeps	87.05	0.00e+00	3093.00
IUUC-Ont-072100	Oreochromis niloticus	82.00	0.00e+00	3071.00
IUUC-Oan-073121	Ornithorhynchus anatinus	93.57	0.00e+00	3613.00
IUUC-Ocu-074623	Oryctolagus cuniculus	95.31	0.00e+00	3580.00
IUUC-Oba-075380	Oryza barthii	36.51	3.00e-113	403.00
IUUC-Obr-076915	Oryza brachyantha	37.50	4.00e-119	423.00
IUUC-Ogl-077055	Oryza glaberrima	38.44	3.00e-118	420.00
IUUC-Ogu-078892	Oryza glumaepatula	40.36	2.00e-112	400.00
IUUC-Oin-079256	Oryza indica	38.26	4.00e-117	416.00
IUUC-Olo-080343	Oryza longistaminata	38.26	2.00e-117	417.00
IUUC-Ome-081422	Oryza meridionalis	37.97	7.00e-117	416.00
IUUC-Oni-083047	Oryza nivara	36.66	3.00e-114	407.00
IUUC-Opu-083641	Oryza punctata	36.44	5.00e-111	396.00
IUUC-Oru-084439	Oryza rufipogon	40.36	5.00e-113	402.00
IUUC-Osa-085972	Oryza sativa	38.44	2.00e-116	413.00
IUUC-Ola-087173	Oryzias latipes	79.96	0.00e+00	3010.00
IUUC-Olu-087871	Ostreococcus lucimarinus	36.70	9.00e-89	320.00
IUUC-Oga-087908	Otolemur garnettii	97.45	0.00e+00	3674.00
IUUC-Oar-090277	Ovis aries	96.32	0.00e+00	3553.00
IUUC-Ptr-091543	Pan troglodytes	96.13	0.00e+00	3566.00
IUUC-Pan-092243	Papio anubis	95.94	0.00e+00	3576.00
IUUC-Psi-093150	Pelodiscus sinensis	95.30	0.00e+00	3617.00
IUUC-Pno-094891	Phaeosphaeria nodorum	41.28	2.00e-113	404.00
IUUC-Ppa-095181	Physcomitrella patens	37.10	1.00e-107	384.00
IUUC-Pfo-096267	Poecilia formosa	86.62	0.00e+00	2986.00
IUUC-Pab-098072	Pongo abelii	98.63	0.00e+00	3675.00
IUUC-Pop-099190	Populus trichocarpa	40.99	7.00e-116	412.00
IUUC-Pca-100311	Procavia capensis	92.21	0.00e+00	3302.00
IUUC-Ppe-101284	Prunus persica	37.57	1.00e-116	415.00
IUUC-Pva-102215	Pteropus vampyrus	97.55	0.00e+00	1393.00
IUUC-Pgr-103694	Puccinia graminis	40.88	1.00e-104	375.00
IUUC-Ptt-103916	Puccinia triticina	39.19	1.00e-98	355.00
IUUC-Pte-104346	Pyrenophora teres	39.63	3.00e-110	394.00
IUUC-Pyt-104508	Pyrenophora triticirepentis	39.70	2.00e-110	394.00
IUUC-Rno-105315	Rattus norvegicus	95.07	0.00e+00	3512.00
IUUC-Sce-106273	Saccharomyces cerevisiae	35.19	3.00e-71	264.00
IUUC-Sha-106835	Sarcophilus harrisii	95.36	0.00e+00	3650.00
IUUC-Sja-107943	Schizosaccharomyces japonicus	37.78	9.00e-95	342.00
IUUC-Spo-108081	Schizosaccharomyces pombe	38.74	1.00e-94	342.00
IUUC-Ssl-108560	Sclerotinia sclerotiorum	40.12	3.00e-106	380.00
IUUC-Smo-108776	Selaginella moellendorffii	43.10	4.00e-112	400.00
IUUC-Sit-110717	Setaria italica	37.80	5.00e-120	426.00
IUUC-Sly-111469	Solanum lycopersicum	39.22	4.00e-122	433.00
IUUC-Stu-112896	Solanum tuberosum	38.07	3.00e-105	376.00
IUUC-Sar-113224	Sorex araneus	87.80	0.00e+00	1907.00
IUUC-Sbi-114313	Sorghum bicolor	38.14	5.00e-124	439.00
IUUC-Sre-114993	Sporisorium reilianum	34.09	6.00e-100	360.00
IUUC-Ssc-115535	Sus scrofa	91.18	0.00e+00	3412.00
IUUC-Tgu-117493	Taeniopygia guttata	94.09	0.00e+00	2773.00
IUUC-Tru-118669	Takifugu rubripes	82.11	0.00e+00	3056.00
IUUC-Tsy-119373	Tarsius syrichta	94.37	0.00e+00	1863.00
IUUC-Tni-120049	Tetraodon nigroviridis	77.61	0.00e+00	865.00
IUUC-Tca-121779	Theobroma cacao	38.47	1.00e-115	412.00
IUUC-Tre-122195	Trichoderma reesei	36.10	6.00e-106	379.00
IUUC-Tvi-122650	Trichoderma virens	36.23	1.00e-109	391.00
IUUC-Tae-123580	Triticum aestivum	38.58	1.00e-124	441.00
IUUC-Tur-126295	Triticum urartu	38.54	2.00e-125	444.00
IUUC-Tme-126964	Tuber melanosporum	40.67	6.00e-106	379.00
IUUC-Tbe-128149	Tupaia belangeri	81.95	0.00e+00	1466.00
IUUC-Ttr-128165	Tursiops truncatus	96.29	0.00e+00	3068.00
IUUC-Uma-129365	Ustilago maydis	36.07	1.00e-88	322.00
IUUC-Vda-129725	Verticillium dahliae	41.28	3.00e-109	390.00
IUUC-Vpa-130678	Vicugna pacos	98.77	0.00e+00	2689.00
IUUC-Vvi-131147	Vitis vinifera	39.37	1.00e-122	435.00
IUUC-Xtr-132636	Xenopus tropicalis	86.81	0.00e+00	3244.00
IUUC-Xma-133458	Xiphophorus maculatus	81.90	0.00e+00	3070.00
IUUC-Yli-134481	Yarrowia lipolytica	39.36	1.00e-97	351.00
IUUC-Zma-135782	Zea mays	37.87	4.00e-118	420.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence