iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ocu-074623

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAGW02043024

Gene Name

TRIP12

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000016726.3	ENSOCUT00000030148.2	ENSOCUP00000020825.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.20e-96	322.0	1659	2038

Active Site

Position(s)	Description	Evidence
2005	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 6    kkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlq..pnpdsglknp.....................ehlk 69
           ++ le+++++E g++l G+t+ef+al+s+elq++dlgl++ +e   ++ +   + +++                         ++  
   Q: 1659 RAMLEIQYENEVGTGL-GPTLEFYALVSQELQRADLGLWRGEEVTLSNPKgsQEGTKY---IqnlqglfalpfgrtakpahiaKVKM 1741
           56899***********.**********************6665533332200222333...14458888999**********9999* PP
   S: 70   lFeflGrllgkalqdgrlldlplsksfyklllgkklsl..edleevdpelykslkeikena......es.................. 130
            F+flG+l++ka++d rl+dlpl  +fyk +l+++ sl  +dl ++dp +++s+  +++ +      e+                  
   Q: 1742 KFRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLtsHDLFDIDPVVARSVYHLEDIVrqkkrlEQdksqtkeslqyaletltm 1828
           **********************************654444**************999999855555511555666666554444444 PP
   S: 131  ...dieelgldltfsvseei.....lgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviplellslF 209
              ++e+            +     l+   + eLk gG++ipVt+ N+eeY +lv+ + l+eg+ +q+++fr+Gf++v+pl++l++F
   Q: 1829 ngcSVED------------LgldftLPGFPNIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPLSHLQYF 1903
           4444444............25555578999********************************************************* PP
   S: 210  teeelellicGe..eeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk... 291
            +eel++l+cG+  +++d+++l + ++ ++gyt+ds+a+++++e+l++f++e+++ fLqFvTgs+rlP+gGf++l+p l+++rk   
   Q: 1904 YPEELDQLLCGSkaDTWDAKTLMECCRPDHGYTHDSRAVKFLFEILSSFDNEQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKtfe 1990
           ************7778999999999999*********************************************************** PP
   S: 292  ..dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFels 336
             ++ dd lPs++TC+nyLkLP+Yss ei+++kLl+A +e+ ++F+ls
   Q: 1991 stENPDDFLPSVMTCVNYLKLPDYSSIEIMRDKLLTAAREGqQSFHLS 2038
           988888***************************************985 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

MSNRPNNNPG GSLRRSQRNT AGAQPQDDAV GGRSHLGQAK HKGYSPPESR KSNSKAPKVQ 60
SNTTTELSRG HLSKRSCSSS SAVIVPQPED PERANTSERQ KTGQVPKKDN SRGVKRSASP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGGTTGCGG CCGGCGGGGA GCCGCGCTCC GCCGGGACCC CCGACCCCGG CCCGAGGCGC 60
GCCCGGCCCC GGCCCGGCCT CCTCGTGGGG CAGCGGAGGT CGCGGTGGGT GGGGCGGCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR000569--HECT_dom
IPR004170--WWE-dom
IPR018123--WWE-dom_subgr

PROSITE

PS50237--HECT
PS50918--WWE

Pfam

PF00632--HECT
PF02825--WWE

SMART

SM00119--HECTc
SM00678--WWE

Gene Ontology

GO:0016607--C:nuclear speck
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0009790--P:embryo development
GO:2000780--P:negative regulation of double-strand break repair
GO:1901315--P:negative regulation of histone H2A K63-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000750	Aegilops tauschii	38.69	2.00e-126	447.00
IUUC-Aml-001502	Ailuropoda melanoleuca	95.79	0.00e+00	3592.00
IUUC-Atr-002821	Amborella trichopoda	37.45	9.00e-117	416.00
IUUC-Apl-003531	Anas platyrhynchos	89.84	0.00e+00	3305.00
IUUC-Aly-005962	Arabidopsis lyrata	38.94	7.00e-115	409.00
IUUC-Ath-006636	Arabidopsis thaliana	38.66	7.00e-114	405.00
IUUC-Ago-007875	Ashbya gossypii	36.20	5.00e-82	300.00
IUUC-Acl-008242	Aspergillus clavatus	35.55	6.00e-113	402.00
IUUC-Afl-008736	Aspergillus flavus	38.83	2.00e-110	394.00
IUUC-Afu-008812	Aspergillus fumigatus	34.95	1.00e-113	405.00
IUUC-Ani-009407	Aspergillus nidulans	36.67	9.00e-110	392.00
IUUC-Ang-009763	Aspergillus niger	39.82	2.00e-105	378.00
IUUC-Aor-009941	Aspergillus oryzae	30.77	2.00e-112	401.00
IUUC-Ate-010459	Aspergillus terreus	36.42	6.00e-86	313.00
IUUC-Ame-011761	Astyanax mexicanus	87.36	0.00e+00	2942.00
IUUC-Bgr-012265	Blumeria graminis	34.86	2.00e-104	374.00
IUUC-Bta-013070	Bos taurus	94.70	0.00e+00	3453.00
IUUC-Bci-013890	Botrytis cinerea	39.92	3.00e-103	370.00
IUUC-Bdi-014046	Brachypodium distachyon	38.47	8.00e-122	432.00
IUUC-Bol-015942	Brassica oleracea	44.23	3.00e-114	407.00
IUUC-Bra-016849	Brassica rapa	44.23	7.00e-114	405.00
IUUC-Cja-019046	Callithrix jacchus	94.93	0.00e+00	3561.00
IUUC-Cfa-020521	Canis familiaris	97.15	0.00e+00	3558.00
IUUC-Cpo-021639	Cavia porcellus	91.74	0.00e+00	3471.00
IUUC-Cre-022767	Chlamydomonas reinhardtii	39.88	1.00e-89	323.00
IUUC-Csa-023231	Chlorocebus sabaeus	97.39	0.00e+00	3643.00
IUUC-Cho-024380	Choloepus hoffmanni	92.96	0.00e+00	2154.00
IUUC-Cin-025482	Ciona intestinalis	51.02	1.00e-159	556.00
IUUC-Csv-026121	Ciona savignyi	48.44	0.00e+00	1536.00
IUUC-Cgl-026716	Colletotrichum gloeosporioides	35.09	3.00e-111	397.00
IUUC-Cne-026857	Cryptococcus neoformans	39.77	7.00e-95	342.00
IUUC-Cme-027226	Cyanidioschyzon merolae	35.34	5.00e-75	276.00
IUUC-Dre-028174	Danio rerio	86.64	0.00e+00	2966.00
IUUC-Dor-030939	Dipodomys ordii	86.66	0.00e+00	2762.00
IUUC-Dse-031444	Dothistroma septosporum	39.11	6.00e-105	376.00
IUUC-Dme-032162	Drosophila melanogaster	67.73	3.00e-174	607.00
IUUC-Ete-032345	Echinops telfairi	90.27	0.00e+00	2283.00
IUUC-Eca-033229	Equus caballus	95.40	0.00e+00	3507.00
IUUC-Eeu-035205	Erinaceus europaeus	82.44	0.00e+00	2988.00
IUUC-Fca-036444	Felis catus	95.02	0.00e+00	3540.00
IUUC-Fal-037131	Ficedula albicollis	92.89	0.00e+00	3466.00
IUUC-Fox-038035	Fusarium oxysporum	38.50	1.00e-110	394.00
IUUC-Fso-038320	Fusarium solani	37.07	2.00e-110	395.00
IUUC-Gmo-039497	Gadus morhua	85.35	0.00e+00	2917.00
IUUC-Ggr-040057	Gaeumannomyces graminis	35.05	6.00e-109	389.00
IUUC-Gga-041021	Gallus gallus	93.33	0.00e+00	3471.00
IUUC-Gac-042474	Gasterosteus aculeatus	79.58	0.00e+00	2971.00
IUUC-Gma-043060	Glycine max	38.92	1.00e-121	431.00
IUUC-Ggo-044855	Gorilla gorilla	94.97	0.00e+00	3565.00
IUUC-Hsa-046147	Homo sapiens	92.55	0.00e+00	3469.00
IUUC-Hvu-047775	Hordeum vulgare	38.69	1.00e-124	441.00
IUUC-Itr-048131	Ictidomys tridecemlineatus	94.93	0.00e+00	3465.00
IUUC-Kpa-049098	Komagataella pastoris	38.10	4.00e-86	313.00
IUUC-Lch-049818	Latimeria chalumnae	83.70	0.00e+00	3036.00
IUUC-Lpe-051017	Leersia perrieri	38.44	3.00e-118	420.00
IUUC-Loc-051777	Lepisosteus oculatus	86.71	0.00e+00	3305.00
IUUC-Lma-052990	Leptosphaeria maculans	39.74	2.00e-111	398.00
IUUC-Laf-053727	Loxodonta africana	95.31	0.00e+00	3553.00
IUUC-Mcc-055799	Macaca mulatta	98.82	0.00e+00	3644.00
IUUC-Meu-056065	Macropus eugenii	93.96	0.00e+00	2097.00
IUUC-Mor-057054	Magnaporthe oryzae	34.55	6.00e-108	386.00
IUUC-Mpo-057417	Magnaporthe poae	39.74	5.00e-110	393.00
IUUC-Mtr-057849	Medicago truncatula	37.36	1.00e-113	405.00
IUUC-Mla-058870	Melampsora laricipopulina	42.37	6.00e-106	379.00
IUUC-Mga-059580	Meleagris gallopavo	91.54	0.00e+00	2935.00
IUUC-Mvi-060507	Microbotryum violaceum	40.19	3.00e-113	404.00
IUUC-Mmr-060816	Microcebus murinus	97.15	0.00e+00	3622.00
IUUC-Mdo-062866	Monodelphis domestica	95.90	0.00e+00	3465.00
IUUC-Mmu-063906	Mus musculus	94.15	0.00e+00	3525.00
IUUC-Mac-064675	Musa acuminata	38.92	2.00e-111	396.00
IUUC-Mpu-066199	Mustela putorius furo	98.33	0.00e+00	3613.00
IUUC-Mlu-067110	Myotis lucifugus	94.34	0.00e+00	3519.00
IUUC-Nfi-068482	Neosartorya fischeri	35.10	3.00e-113	404.00
IUUC-Ncr-068906	Neurospora crassa	39.32	7.00e-110	392.00
IUUC-Nle-069410	Nomascus leucogenys	95.69	0.00e+00	3556.00
IUUC-Opr-070401	Ochotona princeps	86.75	0.00e+00	1952.00
IUUC-Ont-072100	Oreochromis niloticus	82.53	0.00e+00	3083.00
IUUC-Oan-073121	Ornithorhynchus anatinus	93.28	0.00e+00	3586.00
IUUC-Oba-075380	Oryza barthii	36.36	3.00e-113	403.00
IUUC-Obr-076915	Oryza brachyantha	37.77	2.00e-118	421.00
IUUC-Ogl-077055	Oryza glaberrima	38.70	5.00e-118	419.00
IUUC-Ogu-078892	Oryza glumaepatula	40.77	2.00e-112	400.00
IUUC-Oin-079256	Oryza indica	38.52	6.00e-117	416.00
IUUC-Olo-080343	Oryza longistaminata	38.52	2.00e-117	417.00
IUUC-Ome-081422	Oryza meridionalis	38.24	1.00e-116	415.00
IUUC-Oni-083047	Oryza nivara	40.95	3.00e-114	406.00
IUUC-Opu-083641	Oryza punctata	36.30	9.00e-111	395.00
IUUC-Oru-084439	Oryza rufipogon	40.77	6.00e-113	402.00
IUUC-Osa-085972	Oryza sativa	38.44	3.00e-116	412.00
IUUC-Ola-087173	Oryzias latipes	80.35	0.00e+00	3008.00
IUUC-Olu-087871	Ostreococcus lucimarinus	36.70	1.00e-88	320.00
IUUC-Oga-087908	Otolemur garnettii	94.54	0.00e+00	3553.00
IUUC-Oar-090277	Ovis aries	95.81	0.00e+00	3521.00
IUUC-Ptr-091543	Pan troglodytes	92.65	0.00e+00	3474.00
IUUC-Pan-092243	Papio anubis	98.77	0.00e+00	3643.00
IUUC-Psi-093150	Pelodiscus sinensis	92.27	0.00e+00	3500.00
IUUC-Pno-094891	Phaeosphaeria nodorum	40.90	2.00e-112	401.00
IUUC-Ppa-095181	Physcomitrella patens	42.14	3.00e-107	382.00
IUUC-Pfo-096267	Poecilia formosa	81.71	0.00e+00	3032.00
IUUC-Pab-098072	Pongo abelii	95.98	0.00e+00	3566.00
IUUC-Pop-099190	Populus trichocarpa	41.34	6.00e-116	412.00
IUUC-Pca-100311	Procavia capensis	88.47	0.00e+00	3176.00
IUUC-Ppe-101284	Prunus persica	37.52	6.00e-116	413.00
IUUC-Pva-102215	Pteropus vampyrus	90.94	0.00e+00	1278.00
IUUC-Pgr-103694	Puccinia graminis	40.28	2.00e-103	371.00
IUUC-Ptt-103916	Puccinia triticina	38.61	3.00e-97	351.00
IUUC-Pte-104346	Pyrenophora teres	39.41	2.00e-109	391.00
IUUC-Pyt-104508	Pyrenophora triticirepentis	39.48	8.00e-110	392.00
IUUC-Rno-105315	Rattus norvegicus	97.94	0.00e+00	3580.00
IUUC-Sce-106273	Saccharomyces cerevisiae	35.00	2.00e-71	265.00
IUUC-Sha-106835	Sarcophilus harrisii	94.78	0.00e+00	3615.00
IUUC-Sja-107943	Schizosaccharomyces japonicus	37.58	5.00e-94	339.00
IUUC-Spo-108081	Schizosaccharomyces pombe	38.54	6.00e-95	343.00
IUUC-Ssl-108560	Sclerotinia sclerotiorum	40.12	1.00e-106	382.00
IUUC-Smo-109590	Selaginella moellendorffii	43.10	1.00e-111	398.00
IUUC-Sit-110717	Setaria italica	37.94	7.00e-120	426.00
IUUC-Sly-111469	Solanum lycopersicum	38.97	1.00e-121	431.00
IUUC-Stu-112896	Solanum tuberosum	38.22	1.00e-105	377.00
IUUC-Sar-113224	Sorex araneus	83.36	0.00e+00	1801.00
IUUC-Sbi-114313	Sorghum bicolor	38.02	2.00e-123	437.00
IUUC-Sre-114993	Sporisorium reilianum	34.09	1.00e-100	362.00
IUUC-Ssc-115535	Sus scrofa	90.65	0.00e+00	3393.00
IUUC-Tgu-117493	Taeniopygia guttata	90.89	0.00e+00	2672.00
IUUC-Tru-118669	Takifugu rubripes	80.01	0.00e+00	2992.00
IUUC-Tsy-119373	Tarsius syrichta	94.47	0.00e+00	1865.00
IUUC-Tni-120049	Tetraodon nigroviridis	77.61	0.00e+00	863.00
IUUC-Tca-121779	Theobroma cacao	38.76	3.00e-115	410.00
IUUC-Tre-122195	Trichoderma reesei	35.95	4.00e-106	380.00
IUUC-Tvi-122650	Trichoderma virens	36.08	1.00e-109	391.00
IUUC-Tae-123580	Triticum aestivum	38.58	2.00e-124	439.00
IUUC-Tur-126295	Triticum urartu	38.54	4.00e-125	443.00
IUUC-Tme-126964	Tuber melanosporum	40.28	7.00e-105	376.00
IUUC-Tbe-128149	Tupaia belangeri	81.95	0.00e+00	1470.00
IUUC-Ttr-128165	Tursiops truncatus	94.55	0.00e+00	3039.00
IUUC-Uma-129365	Ustilago maydis	36.07	4.00e-89	324.00
IUUC-Vda-129725	Verticillium dahliae	41.08	1.00e-108	389.00
IUUC-Vpa-130678	Vicugna pacos	96.73	0.00e+00	2667.00
IUUC-Vvi-131147	Vitis vinifera	38.94	5.00e-122	433.00
IUUC-Xtr-132636	Xenopus tropicalis	85.80	0.00e+00	3202.00
IUUC-Xma-133458	Xiphophorus maculatus	82.18	0.00e+00	3073.00
IUUC-Yli-134481	Yarrowia lipolytica	39.56	4.00e-98	353.00
IUUC-Zma-135782	Zea mays	37.87	1.00e-117	418.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence