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Tag Content
UUCD2 ID IUUC-Gga-040514
UUCD1 version UUC-GaG-00753
Ensembl Protein ID ENSGALP00000011262.2
UniProt Accession Q5ZIR9; RN185_CHICK
Genbank Protein ID CAG32374.1
Protein Name E3 ubiquitin-protein ligase RNF185; RING finger protein 185; RING-type E3 ubiquitin transferase RNF185
Genbank Nucleotide ID AJ720715
Gene Name RNF185; RCJMB04_23p11
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSGALG00000006960.4 ENSGALT00000011276.3 ENSGALP00000011262.2
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/RING 2.30e-07 31.6 41 82
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iCl+  kd  ++  CgH+f+  Cl++w        +++ CP+C+
   Q: 41   CNICLDTAKD-AVISLCGHLFCWPCLHQW---LETRPNRQVCPVCK 82
           99********.77788*************...666999999****7 PP
   
Organism Gallus gallus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2.
 E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2.
Protein Sequence
(Fasta)
MASKGPTTSA STKSSSTGGT SGSSSSNGAG DNTNQDNTFE CNICLDTAKD AVISLCGHLF 60
CWPCLHQWLE TRPNRQVCPV CKAGISRDKV IPLYGRGSTG QQDPREKTPP RPQGQRPEPE 120
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Protein Fasta Sequence


>IUUC-Gga-040514|E3,RING|Gallus gallus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTTCCGGGGC GATCAGGTGA CGGCGGCCGC GGGCAGGGAG CGGCTCCGCG GGTCTCCGGG 60
AGCGCCGGTG AGCACAGCCG AGCGAGTCCG GGTCCGGATC CGAGTCCGGG TCCGGCTGGG 120
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Nucleotide Fasta Sequence


>IUUC-Gga-040514|E3,RING|Gallus gallus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0479--Metal-binding
KW-0496--Mitochondrion
KW-1000--Mitochondrion outer membrane
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2
SMART

SM00184--RING
Gene Ontology

GO:0036513--C:Derlin-1 retrotranslocation complex
GO:0016021--C:integral component of membrane
GO:0005741--C:mitochondrial outer membrane
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:0044390--F:ubiquitin-like protein conjugating enzyme binding
GO:0008270--F:zinc ion binding
GO:0006914--P:autophagy
GO:0071712--P:ER-associated misfolded protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
KEGG gga:416965
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001042 Aegilops tauschii 50.00 2.00e-24 105.00
IUUC-Aml-001875 Ailuropoda melanoleuca 99.38 8.00e-62 229.00
IUUC-Atr-002721 Amborella trichopoda 54.65 1.00e-24 105.00
IUUC-Apl-003744 Anas platyrhynchos 100.00 3.00e-40 156.00
IUUC-Aca-004254 Anolis carolinensis 73.49 1.00e-34 138.00
IUUC-Aly-005785 Arabidopsis lyrata 55.95 4.00e-24 103.00
IUUC-Ath-007401 Arabidopsis thaliana 54.55 2.00e-24 105.00
IUUC-Ame-011667 Astyanax mexicanus 96.79 1.00e-52 198.00
IUUC-Bgr-012018 Blumeria graminis 40.68 4.00e-09 55.10
IUUC-Bta-012734 Bos taurus 99.38 2.00e-61 228.00
IUUC-Bci-013671 Botrytis cinerea 48.98 2.00e-09 57.00
IUUC-Bdi-014313 Brachypodium distachyon 51.76 1.00e-22 99.80
IUUC-Bol-016132 Brassica oleracea 56.18 2.00e-26 111.00
IUUC-Bra-017631 Brassica rapa 33.49 2.00e-26 111.00
IUUC-Cel-018228 Caenorhabditis elegans 67.03 4.00e-35 140.00
IUUC-Cja-019136 Callithrix jacchus 98.75 3.00e-61 227.00
IUUC-Cfa-020308 Canis familiaris 99.38 8.00e-62 229.00
IUUC-Cpo-021347 Cavia porcellus 98.12 6.00e-61 226.00
IUUC-Cre-022829 Chlamydomonas reinhardtii 55.17 6.00e-26 108.00
IUUC-Csa-023755 Chlorocebus sabaeus 99.38 6.00e-62 229.00
IUUC-Cme-027164 Cyanidioschyzon merolae 46.15 1.00e-16 80.10
IUUC-Dre-028094 Danio rerio 96.23 8.00e-59 219.00
IUUC-Dno-029402 Dasypus novemcinctus 99.38 8.00e-62 229.00
IUUC-Dor-030373 Dipodomys ordii 99.38 8.00e-62 229.00
IUUC-Dme-031966 Drosophila melanogaster 60.37 1.00e-55 209.00
IUUC-Ete-032786 Echinops telfairi 98.75 9.00e-62 228.00
IUUC-Eca-034261 Equus caballus 99.38 8.00e-62 229.00
IUUC-Eeu-034614 Erinaceus europaeus 89.38 6.00e-49 186.00
IUUC-Fca-036049 Felis catus 99.38 8.00e-62 229.00
IUUC-Fal-037085 Ficedula albicollis 100.00 1.00e-62 231.00
IUUC-Fso-038195 Fusarium solani 45.28 3.00e-09 56.20
IUUC-Gmo-039369 Gadus morhua 91.67 5.00e-55 206.00
IUUC-Gac-041719 Gasterosteus aculeatus 95.15 2.00e-56 211.00
IUUC-Gma-043248 Glycine max 59.30 6.00e-27 114.00
IUUC-Ggo-044504 Gorilla gorilla 99.38 8.00e-62 229.00
IUUC-Hsa-045707 Homo sapiens 99.38 8.00e-62 229.00
IUUC-Hvu-047487 Hordeum vulgare 51.04 2.00e-24 105.00
IUUC-Itr-048343 Ictidomys tridecemlineatus 99.38 1.00e-61 228.00
IUUC-Lch-050658 Latimeria chalumnae 92.50 9.00e-59 219.00
IUUC-Lpe-051034 Leersia perrieri 55.29 8.00e-25 106.00
IUUC-Loc-052118 Lepisosteus oculatus 96.34 3.00e-57 213.00
IUUC-Laf-054438 Loxodonta africana 99.38 9.00e-62 229.00
IUUC-Mcc-054641 Macaca mulatta 95.62 1.00e-54 204.00
IUUC-Meu-056828 Macropus eugenii 88.57 1.00e-32 130.00
IUUC-Mpo-057431 Magnaporthe poae 35.82 8.00e-09 54.70
IUUC-Mtr-058107 Medicago truncatula 59.30 2.00e-26 112.00
IUUC-Mga-059554 Meleagris gallopavo 100.00 6.00e-62 229.00
IUUC-Mvi-060316 Microbotryum violaceum 50.88 4.00e-12 64.30
IUUC-Mmr-061662 Microcebus murinus 93.25 7.00e-53 199.00
IUUC-Mdo-062774 Monodelphis domestica 99.38 8.00e-62 229.00
IUUC-Mmu-063372 Mus musculus 99.38 2.00e-61 228.00
IUUC-Mac-065053 Musa acuminata 54.76 6.00e-23 100.00
IUUC-Mpu-066033 Mustela putorius furo 99.38 4.00e-62 233.00
IUUC-Mlu-067254 Myotis lucifugus 99.38 8.00e-62 229.00
IUUC-Ncr-068628 Neurospora crassa 41.18 1.00e-09 57.80
IUUC-Nle-069850 Nomascus leucogenys 99.38 8.00e-62 229.00
IUUC-Opr-070197 Ochotona princeps 87.50 2.00e-57 214.00
IUUC-Ont-071950 Oreochromis niloticus 97.45 3.00e-58 217.00
IUUC-Oan-073480 Ornithorhynchus anatinus 99.38 8.00e-62 229.00
IUUC-Ocu-073878 Oryctolagus cuniculus 91.25 1.00e-61 228.00
IUUC-Oba-075248 Oryza barthii 51.25 6.00e-24 103.00
IUUC-Obr-076382 Oryza brachyantha 54.12 2.00e-24 105.00
IUUC-Ogl-077553 Oryza glaberrima 50.53 2.00e-26 112.00
IUUC-Ogu-078463 Oryza glumaepatula 50.53 1.00e-26 112.00
IUUC-Oin-080177 Oryza indica 50.53 2.00e-26 112.00
IUUC-Olo-080378 Oryza longistaminata 51.76 1.00e-22 99.40
IUUC-Ome-081605 Oryza meridionalis 51.06 3.00e-26 111.00
IUUC-Oni-082458 Oryza nivara 50.53 4.00e-26 111.00
IUUC-Opu-083362 Oryza punctata 55.29 8.00e-25 107.00
IUUC-Oru-084757 Oryza rufipogon 50.53 2.00e-26 112.00
IUUC-Osa-086198 Oryza sativa 48.00 2.00e-26 112.00
IUUC-Ola-086800 Oryzias latipes 96.88 5.00e-55 206.00
IUUC-Olu-087623 Ostreococcus lucimarinus 43.66 4.00e-15 74.30
IUUC-Oga-088197 Otolemur garnettii 97.02 2.00e-64 237.00
IUUC-Oar-090284 Ovis aries 70.83 4.00e-45 173.00
IUUC-Ptr-091106 Pan troglodytes 99.38 8.00e-62 229.00
IUUC-Pan-092671 Papio anubis 99.38 6.00e-62 229.00
IUUC-Psi-093323 Pelodiscus sinensis 99.38 1.00e-61 228.00
IUUC-Pno-094942 Phaeosphaeria nodorum 43.90 1.00e-10 60.50
IUUC-Ppa-095474 Physcomitrella patens 54.17 6.00e-27 114.00
IUUC-Pfo-096943 Poecilia formosa 95.62 3.00e-54 204.00
IUUC-Pab-097845 Pongo abelii 99.38 8.00e-62 229.00
IUUC-Pop-098988 Populus trichocarpa 52.08 2.00e-26 112.00
IUUC-Pca-100319 Procavia capensis 71.67 8.00e-46 176.00
IUUC-Ppe-102011 Prunus persica 55.21 5.00e-28 117.00
IUUC-Pva-102298 Pteropus vampyrus 99.38 1.00e-61 228.00
IUUC-Pte-104163 Pyrenophora teres 42.53 6.00e-10 57.40
IUUC-Pyt-104640 Pyrenophora triticirepentis 38.46 2.00e-10 59.70
IUUC-Rno-105293 Rattus norvegicus 99.38 4.00e-62 230.00
IUUC-Sha-107361 Sarcophilus harrisii 99.38 8.00e-62 229.00
IUUC-Smo-109663 Selaginella moellendorffii 52.94 3.00e-23 99.80
IUUC-Sit-110376 Setaria italica 55.81 9.00e-25 106.00
IUUC-Sly-111909 Solanum lycopersicum 54.65 7.00e-24 103.00
IUUC-Stu-112801 Solanum tuberosum 54.65 3.00e-24 104.00
IUUC-Sar-113669 Sorex araneus 100.00 1.00e-25 107.00
IUUC-Sbi-114275 Sorghum bicolor 51.76 1.00e-22 99.40
IUUC-Ssc-116228 Sus scrofa 99.38 8.00e-62 229.00
IUUC-Tgu-116886 Taeniopygia guttata 100.00 1.00e-62 231.00
IUUC-Tru-118679 Takifugu rubripes 65.75 2.00e-22 97.80
IUUC-Tsy-119615 Tarsius syrichta 71.67 4.00e-46 176.00
IUUC-Tni-120909 Tetraodon nigroviridis 91.62 1.00e-56 211.00
IUUC-Tca-121830 Theobroma cacao 53.76 4.00e-26 110.00
IUUC-Tre-122215 Trichoderma reesei 42.86 5.00e-09 56.20
IUUC-Tae-123670 Triticum aestivum 52.94 3.00e-23 101.00
IUUC-Tur-126676 Triticum urartu 52.94 2.00e-23 101.00
IUUC-Tbe-127360 Tupaia belangeri 99.22 1.00e-42 165.00
IUUC-Ttr-129044 Tursiops truncatus 99.38 8.00e-62 229.00
IUUC-Vda-129983 Verticillium dahliae 43.75 1.00e-08 52.80
IUUC-Vpa-130365 Vicugna pacos 98.75 7.00e-61 226.00
IUUC-Vvi-131449 Vitis vinifera 56.98 2.00e-26 111.00
IUUC-Xtr-131916 Xenopus tropicalis 91.14 4.00e-42 163.00
IUUC-Xma-133333 Xiphophorus maculatus 93.90 6.00e-55 206.00
Created Date 25-Jun-2017

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