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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063377
Ensembl Protein ID ENSMUSP00000002198.3
UniProt Accession Q8K4Z5; Q8C0M7; Q8C128; Q8C175; Q921T3; SF3A1_MOUSE
Genbank Protein ID BAC26142.1; BAC26294.1; BAC26853.1; CAI25745.1; AAH10727.1; AAH29753.1
Protein Name Splicing factor 3A subunit 1; SF3a120
Genbank Nucleotide ID AK028829; AK029095; AK030223; AL807825; BC010727; BC029753
Gene Name Sf3a1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000002129.11 ENSMUST00000002198.3 ENSMUSP00000002198.3
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
miRTarBasemicroRNATRANSFACRepTar
miRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Phospho.ELMUniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
ULD/UDP/UBQ/UBQ_Other 4.70e-16 59.6 705 788
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   ULD/UDP/UBQ/UBQ_Other
   S: 1    vqvtvksldgs.eltlk.......vnpsdtVaeLKekiekklgippeqqrLiykGkiLeddktLadyglkdgstihllekksgg 76
           ++v+v++++++ e++l+       ++ +d+V+++K ki++++g+p+ +q+L+y+G+ ++d ++La+y++  g +ihl +k++gg
   Q: 705  IKVQVPNMQDKtEWKLNgqglvftLPLTDQVSVIKVKIHEATGMPAGKQKLQYEGIFIKDSNSLAYYNMASGAVIHLALKERGG 788
           689**************999865458888**************************************************99875 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex (By similarity).
 Subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex (By similarity).
Protein Sequence
(Fasta)
MQAGPVQAVP PPPPVATESK QPIEEEASSK EDPTPSKPVV GIIYPPPEVR NIVDKTASFV 60
ARNGPEFEAR IRQNEINNPK FNFLNPNDPY HAYYRHKVSE FKEGKAQEPS AAIPKVMQQQ 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063377|ULD,UBQ_Other|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GAAGTGCTCC CGCGGCTTCT CTCTCTGGGT CGCCGCCATC TTGTCATTGA GTTGGATACT 60
TCGTGTGGTG ATCTTTAATC TTGTCGTCGC ACCGGTTGTC GCCACCGAGG TGGACTGGCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063377|ULD,UBQ_Other|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-1017--Isopeptide bond
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0747--Spliceosome
KW-0832--Ubl conjugation
Interpro

IPR022030--SF3A1
IPR000061--Surp
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom
PROSITE

PS50128--SURP
PS50053--UBIQUITIN_2
Pfam

PF12230--PRP21_like_P
PF01805--Surp
PF00240--ubiquitin
SMART

SM00648--SWAP
SM00213--UBQ
Gene Ontology

GO:0071013--C:catalytic step 2 spliceosome
GO:0016607--C:nuclear speck
GO:0005681--C:spliceosomal complex
GO:0005686--C:U2 snRNP
GO:0071004--C:U2-type prespliceosome
GO:0005684--C:U2-type spliceosomal complex
GO:0003723--F:RNA binding
GO:0000389--P:mRNA 3'-splice site recognition
GO:0006397--P:mRNA processing
GO:0000398--P:mRNA splicing, via spliceosome
GO:0000381--P:regulation of alternative mRNA splicing, via spliceosome
KEGG mmu:67465
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000319 Aegilops tauschii 35.64 2.00e-48 187.00
IUUC-Aml-002416 Ailuropoda melanoleuca 97.66 0.00e+00 1114.00
IUUC-Atr-003001 Amborella trichopoda 48.57 5.00e-65 243.00
IUUC-Apl-003584 Anas platyrhynchos 91.55 0.00e+00 928.00
IUUC-Aca-004690 Anolis carolinensis 85.41 0.00e+00 1006.00
IUUC-Aly-005487 Arabidopsis lyrata 44.81 1.00e-55 211.00
IUUC-Ath-007275 Arabidopsis thaliana 44.40 3.00e-57 216.00
IUUC-Acl-008320 Aspergillus clavatus 42.33 4.00e-48 186.00
IUUC-Afl-008707 Aspergillus flavus 46.69 1.00e-57 217.00
IUUC-Afu-008786 Aspergillus fumigatus 41.11 2.00e-46 180.00
IUUC-Ani-009307 Aspergillus nidulans 44.25 1.00e-52 201.00
IUUC-Ang-009761 Aspergillus niger 46.15 8.00e-57 214.00
IUUC-Aor-010067 Aspergillus oryzae 46.69 9.00e-58 218.00
IUUC-Ate-010515 Aspergillus terreus 44.70 1.00e-57 217.00
IUUC-Ame-011842 Astyanax mexicanus 80.86 0.00e+00 801.00
IUUC-Bgr-012204 Blumeria graminis 35.06 7.00e-65 241.00
IUUC-Bta-013525 Bos taurus 97.91 0.00e+00 1111.00
IUUC-Bci-013842 Botrytis cinerea 46.07 6.00e-50 191.00
IUUC-Bdi-014436 Brachypodium distachyon 36.54 3.00e-74 273.00
IUUC-Bol-015903 Brassica oleracea 45.49 5.00e-53 202.00
IUUC-Bra-017856 Brassica rapa 37.20 4.00e-56 213.00
IUUC-Cel-018261 Caenorhabditis elegans 50.00 2.00e-79 290.00
IUUC-Cja-018989 Callithrix jacchus 97.67 0.00e+00 1102.00
IUUC-Cfa-020629 Canis familiaris 97.65 0.00e+00 1107.00
IUUC-Cpo-021759 Cavia porcellus 97.27 0.00e+00 1102.00
IUUC-Cre-022603 Chlamydomonas reinhardtii 38.93 1.00e-22 100.00
IUUC-Csa-023750 Chlorocebus sabaeus 97.92 0.00e+00 1102.00
IUUC-Cho-024581 Choloepus hoffmanni 98.15 2.00e-122 432.00
IUUC-Cin-025640 Ciona intestinalis 57.85 1.00e-146 514.00
IUUC-Csv-025855 Ciona savignyi 66.67 4.00e-102 365.00
IUUC-Cgl-026573 Colletotrichum gloeosporioides 41.92 3.00e-45 176.00
IUUC-Cne-026952 Cryptococcus neoformans 41.25 3.00e-49 190.00
IUUC-Dre-028055 Danio rerio 82.59 0.00e+00 771.00
IUUC-Dno-029259 Dasypus novemcinctus 97.40 0.00e+00 1112.00
IUUC-Dor-031081 Dipodomys ordii 97.14 0.00e+00 1103.00
IUUC-Dse-031438 Dothistroma septosporum 39.45 2.00e-47 184.00
IUUC-Dme-031975 Drosophila melanogaster 60.19 3.00e-148 519.00
IUUC-Ete-033177 Echinops telfairi 94.76 0.00e+00 880.00
IUUC-Eca-033670 Equus caballus 97.92 0.00e+00 1115.00
IUUC-Eeu-035100 Erinaceus europaeus 92.20 0.00e+00 694.00
IUUC-Fca-036176 Felis catus 97.78 0.00e+00 1108.00
IUUC-Fal-036776 Ficedula albicollis 90.99 0.00e+00 728.00
IUUC-Fox-037706 Fusarium oxysporum 40.83 8.00e-49 188.00
IUUC-Fso-038313 Fusarium solani 42.39 7.00e-45 174.00
IUUC-Gmo-038887 Gadus morhua 81.09 0.00e+00 795.00
IUUC-Ggr-039932 Gaeumannomyces graminis 38.02 1.00e-34 141.00
IUUC-Gga-041184 Gallus gallus 90.20 0.00e+00 902.00
IUUC-Gac-042118 Gasterosteus aculeatus 83.08 0.00e+00 795.00
IUUC-Gma-042726 Glycine max 46.02 2.00e-18 88.20
IUUC-Ggo-045641 Gorilla gorilla 95.04 0.00e+00 1090.00
IUUC-Hsa-045751 Homo sapiens 97.78 0.00e+00 1096.00
IUUC-Hvu-047702 Hordeum vulgare 32.54 2.00e-30 127.00
IUUC-Itr-047960 Ictidomys tridecemlineatus 97.92 0.00e+00 1114.00
IUUC-Kpa-049400 Komagataella pastoris 29.31 6.00e-31 128.00
IUUC-Lch-050152 Latimeria chalumnae 85.43 0.00e+00 721.00
IUUC-Lpe-051570 Leersia perrieri 45.78 1.00e-32 135.00
IUUC-Loc-051753 Lepisosteus oculatus 83.44 0.00e+00 818.00
IUUC-Lma-053219 Leptosphaeria maculans 36.58 2.00e-34 140.00
IUUC-Laf-053643 Loxodonta africana 97.53 0.00e+00 1070.00
IUUC-Mcc-055091 Macaca mulatta 97.79 0.00e+00 1102.00
IUUC-Meu-056036 Macropus eugenii 84.92 0.00e+00 795.00
IUUC-Mor-057214 Magnaporthe oryzae 37.36 5.00e-35 142.00
IUUC-Mpo-057385 Magnaporthe poae 30.00 1.00e-12 67.00
IUUC-Mtr-057954 Medicago truncatula 45.76 2.00e-63 237.00
IUUC-Mla-059020 Melampsora laricipopulina 36.50 2.00e-49 191.00
IUUC-Mga-060176 Meleagris gallopavo 91.53 0.00e+00 930.00
IUUC-Mvi-060278 Microbotryum violaceum 33.39 5.00e-74 272.00
IUUC-Mmr-061602 Microcebus murinus 97.53 0.00e+00 1125.00
IUUC-Mdo-062047 Monodelphis domestica 95.32 0.00e+00 1054.00
IUUC-Mac-065644 Musa acuminata 46.52 1.00e-60 228.00
IUUC-Mpu-066047 Mustela putorius furo 97.53 0.00e+00 1114.00
IUUC-Mlu-067039 Myotis lucifugus 97.79 0.00e+00 1080.00
IUUC-Nfi-068434 Neosartorya fischeri 45.59 4.00e-53 202.00
IUUC-Ncr-068912 Neurospora crassa 39.41 2.00e-39 156.00
IUUC-Nle-069540 Nomascus leucogenys 97.92 0.00e+00 1102.00
IUUC-Opr-071157 Ochotona princeps 97.40 0.00e+00 1090.00
IUUC-Ont-072229 Oreochromis niloticus 82.79 0.00e+00 962.00
IUUC-Oan-073616 Ornithorhynchus anatinus 98.23 4.00e-33 134.00
IUUC-Ocu-074002 Oryctolagus cuniculus 97.66 0.00e+00 1110.00
IUUC-Oba-075659 Oryza barthii 34.53 2.00e-35 143.00
IUUC-Obr-076465 Oryza brachyantha 36.48 1.00e-51 197.00
IUUC-Ogl-077461 Oryza glaberrima 37.80 7.00e-54 205.00
IUUC-Ogu-078515 Oryza glumaepatula 38.36 4.00e-54 206.00
IUUC-Oin-080201 Oryza indica 46.88 2.00e-33 137.00
IUUC-Olo-080751 Oryza longistaminata 34.53 2.00e-35 144.00
IUUC-Ome-081201 Oryza meridionalis 37.04 3.00e-75 276.00
IUUC-Oni-082951 Oryza nivara 46.88 3.00e-33 137.00
IUUC-Opu-083560 Oryza punctata 35.48 4.00e-65 243.00
IUUC-Oru-084440 Oryza rufipogon 37.80 5.00e-54 206.00
IUUC-Osa-085699 Oryza sativa 37.80 7.00e-54 205.00
IUUC-Ola-086705 Oryzias latipes 80.41 0.00e+00 944.00
IUUC-Olu-087794 Ostreococcus lucimarinus 46.03 1.00e-50 194.00
IUUC-Oga-088896 Otolemur garnettii 97.79 0.00e+00 1103.00
IUUC-Oar-090155 Ovis aries 97.16 0.00e+00 879.00
IUUC-Ptr-090754 Pan troglodytes 97.65 0.00e+00 1093.00
IUUC-Pan-092464 Papio anubis 97.92 0.00e+00 1102.00
IUUC-Psi-093166 Pelodiscus sinensis 91.95 0.00e+00 736.00
IUUC-Pma-094280 Petromyzon marinus 85.04 1.00e-127 450.00
IUUC-Pno-095106 Phaeosphaeria nodorum 37.32 9.00e-31 128.00
IUUC-Ppa-095510 Physcomitrella patens 45.87 2.00e-57 217.00
IUUC-Pfo-096212 Poecilia formosa 75.75 3.00e-176 612.00
IUUC-Pab-098482 Pongo abelii 97.92 0.00e+00 1102.00
IUUC-Pop-099479 Populus trichocarpa 45.77 5.00e-56 213.00
IUUC-Pca-100776 Procavia capensis 97.52 1.00e-73 271.00
IUUC-Ppe-101626 Prunus persica 36.79 5.00e-76 279.00
IUUC-Pva-102981 Pteropus vampyrus 96.78 0.00e+00 1041.00
IUUC-Pgr-103503 Puccinia graminis 34.66 2.00e-69 257.00
IUUC-Ptt-103994 Puccinia triticina 32.28 8.00e-62 232.00
IUUC-Pte-104226 Pyrenophora teres 35.40 4.00e-36 145.00
IUUC-Pyt-104732 Pyrenophora triticirepentis 36.24 7.00e-39 155.00
IUUC-Rno-105225 Rattus norvegicus 99.24 0.00e+00 1116.00
IUUC-Sce-106278 Saccharomyces cerevisiae 23.25 6.00e-11 61.20
IUUC-Sha-107353 Sarcophilus harrisii 93.19 0.00e+00 998.00
IUUC-Sja-107876 Schizosaccharomyces japonicus 41.37 4.00e-51 195.00
IUUC-Spo-108266 Schizosaccharomyces pombe 41.58 4.00e-52 199.00
IUUC-Ssl-108518 Sclerotinia sclerotiorum 45.74 4.00e-54 205.00
IUUC-Smo-109675 Selaginella moellendorffii 43.93 4.00e-51 196.00
IUUC-Sit-110019 Setaria italica 36.78 4.00e-51 196.00
IUUC-Sly-111621 Solanum lycopersicum 45.65 3.00e-63 236.00
IUUC-Stu-112703 Solanum tuberosum 46.35 5.00e-64 239.00
IUUC-Sar-113166 Sorex araneus 94.17 0.00e+00 1023.00
IUUC-Sbi-114746 Sorghum bicolor 36.90 5.00e-52 199.00
IUUC-Sre-115196 Sporisorium reilianum 40.27 1.00e-50 194.00
IUUC-Ssc-115573 Sus scrofa 97.91 0.00e+00 1111.00
IUUC-Tgu-117284 Taeniopygia guttata 91.42 0.00e+00 921.00
IUUC-Tru-118236 Takifugu rubripes 78.65 0.00e+00 908.00
IUUC-Tsy-119219 Tarsius syrichta 94.72 0.00e+00 993.00
IUUC-Tni-119929 Tetraodon nigroviridis 81.78 5.00e-101 362.00
IUUC-Tca-121156 Theobroma cacao 43.93 3.00e-60 226.00
IUUC-Tre-122179 Trichoderma reesei 42.24 1.00e-44 174.00
IUUC-Tvi-122326 Trichoderma virens 40.85 2.00e-47 183.00
IUUC-Tae-124733 Triticum aestivum 36.07 2.00e-71 264.00
IUUC-Tur-126352 Triticum urartu 35.23 1.00e-48 188.00
IUUC-Tme-126996 Tuber melanosporum 42.80 2.00e-51 196.00
IUUC-Tbe-127271 Tupaia belangeri 90.39 0.00e+00 965.00
IUUC-Ttr-128433 Tursiops truncatus 95.70 0.00e+00 1103.00
IUUC-Uma-129357 Ustilago maydis 31.01 8.00e-48 185.00
IUUC-Vda-130010 Verticillium dahliae 40.50 2.00e-42 166.00
IUUC-Vvi-131734 Vitis vinifera 39.41 4.00e-79 289.00
IUUC-Xtr-132013 Xenopus tropicalis 85.30 0.00e+00 986.00
IUUC-Xma-134244 Xiphophorus maculatus 75.44 0.00e+00 892.00
IUUC-Yli-134579 Yarrowia lipolytica 36.29 3.00e-31 129.00
IUUC-Zma-135600 Zea mays 36.78 2.00e-51 197.00
Created Date 25-Jun-2017

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