• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Details
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Sce-106439
UUCD1 version UUC-SaC-00028
Ensembl Protein ID YER116C
UniProt Accession P40072; D3DM22; SLX8_YEAST
Genbank Protein ID AAC03214.1; DAA07776.1
Protein Name E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX8; RING-type E3 ubiquitin transferase SLX8; Synthetic lethal of unknown function protein 8
Genbank Nucleotide ID U18916; BK006939
Gene Name SLX8; YER116C
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YER116C YER116C YER116C
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Post-translational Modifications (PTMs)
dbPAFdbPTMUniProtPHOSIDA
BioGRID
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 19139279; 16325482; 17848550; 20351217
Classification
Family E-value Score Start End
E3 activity/RING/RING 4.10e-05 22.5 206 250
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C+iC+e++++  l + CgHvf+  Cl q++ ++++  +++ +C lCr
   Q: 206  CPICFEPPET-ALMTLCGHVFCCPCLfQMV-NSSRTCRQFGHCALCR 250
           ********99.77799*********96666.88888888889****8 PP
   
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Mediates ubiquitination and subsequent desumoylation/degradation of sumoylated proteins and proteins containing SUMO-like domains. Promotes UBC4-dependent ubiquitination that mediates the proteolytic down-regulation of sumoylated proteins. Involved in the stimulation of ubiquitin conjugating enzymes, including UBC1, UBC4, UBC5 and UBC13-MMS2. Acts as a critical suppressor of gross chromosomal rearrangements (GCRs) during normal cell cycle progression. Has a role in localizing the DNA damage protein DCD2. Involved in stabilizing, restarting or resolving transiently stalled replication forks. Prevents accumulation of DNA damage during cell cycle progression. Inhibits RAD51-independent recombination via modulating the sumoylation of DNA repair proteins.
 Mediates ubiquitination and subsequent desumoylation/degradation of sumoylated proteins and proteins containing SUMO-like domains. Promotes UBC4-dependent ubiquitination that mediates the proteolytic down-regulation of sumoylated proteins. Involved in the stimulation of ubiquitin conjugating enzymes, including UBC1, UBC4, UBC5 and UBC13-MMS2. Acts as a critical suppressor of gross chromosomal rearrangements (GCRs) during normal cell cycle progression. Has a role in localizing the DNA damage protein DCD2. Involved in stabilizing, restarting or resolving transiently stalled replication forks. Prevents accumulation of DNA damage during cell cycle progression. Inhibits RAD51-independent recombination via modulating the sumoylation of DNA repair proteins.
Protein Sequence
(Fasta)
MARRPDNQNP EGENLRIKRV RLESVRQNDE EEENEVSRTQ NIVTDNRHDS PEAVVEIIGE 60
RALENTSEED GDDDLSLFRA LEEDPGSDHN TSNNDSGNHD RETMHTEEPE ASSGNNITLT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Sce-106439|E3,RING|Saccharomyces cerevisiae
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGCAAGAA GACCTGATAA CCAAAATCCA GAAGGTGAAA ATCTACGAAT CAAAAGGGTA 60
AGACTAGAGT CGGTCAGGCA GAACGATGAG GAGGAAGAAA ATGAAGTATC GAGAACACAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106439|E3,RING|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00097--zf-C3HC4
SMART

SM00184--RING
Gene Ontology

GO:0000778--C:condensed nuclear chromosome kinetochore
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0033768--C:SUMO-targeted ubiquitin ligase complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0006281--P:DNA repair
GO:0033234--P:negative regulation of protein sumoylation
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016925--P:protein sumoylation
GO:0016567--P:protein ubiquitination
GO:0000723--P:telomere maintenance
KEGG sce:YER116C
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Atr-002444 Amborella trichopoda 36.36 1.00e-08 51.60
IUUC-Ago-007769 Ashbya gossypii 52.17 8.00e-24 101.00
IUUC-Ani-009314 Aspergillus nidulans 41.18 4.00e-07 45.40
IUUC-Bgr-012018 Blumeria graminis 29.47 2.00e-08 51.20
IUUC-Bol-016143 Brassica oleracea 30.95 1.00e-08 52.40
IUUC-Cel-018593 Caenorhabditis elegans 40.00 2.00e-08 50.40
IUUC-Gma-043172 Glycine max 37.74 2.00e-08 50.10
IUUC-Kpa-049242 Komagataella pastoris 37.10 3.00e-10 56.20
IUUC-Mpo-057316 Magnaporthe poae 37.93 8.00e-06 43.10
IUUC-Obr-076527 Oryza brachyantha 31.52 3.00e-09 54.30
IUUC-Pop-099017 Populus trichocarpa 38.18 2.00e-08 50.40
IUUC-Sha-107188 Sarcophilus harrisii 45.00 6.00e-07 45.80
IUUC-Sja-107944 Schizosaccharomyces japonicus 31.43 2.00e-07 47.80
IUUC-Sly-111255 Solanum lycopersicum 36.51 5.00e-09 52.40
IUUC-Sbi-114164 Sorghum bicolor 32.56 5.00e-10 57.40
IUUC-Ssc-115675 Sus scrofa 36.84 9.00e-10 56.60
IUUC-Tca-121830 Theobroma cacao 37.74 3.00e-09 53.10
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved