iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Rno-104870

UUCD1 version

UUC-RaN-00871

Ensembl Protein ID

ENSRNOP00000071176.1

UniProt Accession

Q5XIE5; Q33E96; MARH3_RAT

Genbank Protein ID

BAE47142.1; AAH83738.1

Protein Name

E3 ubiquitin-protein ligase MARCH3; Membrane-associated RING finger protein 3; Membrane-associated RING-CH protein III; RING-type E3 ubiquitin transferase MARCH3

Genbank Nucleotide ID

AB048840; BC083738

Gene Name

March3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000023013.6	ENSRNOT00000081020.1	ENSRNOP00000071176.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	98.81	2.00e-147	518.00	IUUC-Hsa-046429

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Rattus norvegicus

Functional Description
(View)

E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

MTTSRCSHLP EVLPDCTSSA APVVKTVEDC GSLVNGQPQY VMQVSAKDGQ LLSTVVRTLA 60
TQSPFNDRPM CRICHEGSSQ EDLLSPCECT GTLGTIHRSC LEHWLSSSNT SYCELCHFRF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTCAGCTGA AATCACTTAT CCTTGTGGAT GTAAGCTTGG AGTTGTATTC TACTTCACTG 60
ATCTCTTCTG CACAGCAACG TTTAACCTCA TGTCTCCCAC GTGGCAGAAA GAATATGTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0254--Endocytosis
KW-0967--Endosome
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR033275--MARCH-like
IPR011016--Znf_RING-CH
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51292--ZF_RING_CH

Pfam

PF12906--RINGv

SMART

SM00744--RINGv

Gene Ontology

GO:0030659--C:cytoplasmic vesicle membrane
GO:0031901--C:early endosome membrane
GO:0005768--C:endosome
GO:0016021--C:integral component of membrane
GO:0005764--C:lysosome
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0006897--P:endocytosis
GO:0016567--P:protein ubiquitination

KEGG

rno:364878

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000798	Aegilops tauschii	38.89	9.00e-09	54.30
IUUC-Aml-001957	Ailuropoda melanoleuca	99.21	3.00e-149	520.00
IUUC-Aca-005012	Anolis carolinensis	97.65	2.00e-145	507.00
IUUC-Aly-006064	Arabidopsis lyrata	38.89	2.00e-08	52.80
IUUC-Ath-007473	Arabidopsis thaliana	44.68	6.00e-09	54.70
IUUC-Bta-012331	Bos taurus	99.21	4.00e-149	520.00
IUUC-Bdi-014827	Brachypodium distachyon	36.07	8.00e-09	54.30
IUUC-Bol-016602	Brassica oleracea	34.67	1.00e-09	56.60
IUUC-Bra-016852	Brassica rapa	36.51	1.00e-09	57.00
IUUC-Cel-018164	Caenorhabditis elegans	37.17	1.00e-18	87.80
IUUC-Cja-019689	Callithrix jacchus	99.60	7.00e-150	522.00
IUUC-Cfa-020911	Canis familiaris	99.21	3.00e-149	520.00
IUUC-Cpo-022306	Cavia porcellus	97.63	3.00e-145	507.00
IUUC-Cre-022957	Chlamydomonas reinhardtii	37.80	4.00e-08	52.40
IUUC-Csa-024010	Chlorocebus sabaeus	98.81	4.00e-149	520.00
IUUC-Cho-024645	Choloepus hoffmanni	99.47	1.00e-111	395.00
IUUC-Dno-029999	Dasypus novemcinctus	99.60	1.00e-149	521.00
IUUC-Dor-030860	Dipodomys ordii	100.00	5.00e-150	523.00
IUUC-Ete-032571	Echinops telfairi	98.02	1.00e-147	514.00
IUUC-Eca-034097	Equus caballus	99.21	2.00e-149	521.00
IUUC-Eeu-034645	Erinaceus europaeus	99.24	1.00e-74	272.00
IUUC-Fca-036126	Felis catus	98.02	1.00e-147	514.00
IUUC-Fal-036875	Ficedula albicollis	82.21	1.00e-120	425.00
IUUC-Gga-041200	Gallus gallus	96.28	1.00e-121	429.00
IUUC-Ggo-044825	Gorilla gorilla	98.81	1.00e-148	518.00
IUUC-Hsa-046429	Homo sapiens	98.81	1.00e-148	518.00
IUUC-Itr-048087	Ictidomys tridecemlineatus	99.60	7.00e-150	522.00
IUUC-Lch-049917	Latimeria chalumnae	92.09	4.00e-138	483.00
IUUC-Loc-052071	Lepisosteus oculatus	89.33	7.00e-134	469.00
IUUC-Laf-054385	Loxodonta africana	98.42	2.00e-148	517.00
IUUC-Mcc-054854	Macaca mulatta	99.21	1.00e-149	521.00
IUUC-Mmr-061764	Microcebus murinus	98.37	2.00e-106	377.00
IUUC-Mmu-063185	Mus musculus	99.60	7.00e-150	522.00
IUUC-Mac-064882	Musa acuminata	38.00	9.00e-09	53.90
IUUC-Mpu-066646	Mustela putorius furo	99.21	3.00e-149	520.00
IUUC-Mlu-067494	Myotis lucifugus	98.81	2.00e-148	518.00
IUUC-Nle-069945	Nomascus leucogenys	99.21	1.00e-149	521.00
IUUC-Opr-070431	Ochotona princeps	98.81	2.00e-148	517.00
IUUC-Ocu-074430	Oryctolagus cuniculus	98.81	2.00e-148	518.00
IUUC-Oba-075948	Oryza barthii	32.14	2.00e-09	55.80
IUUC-Ogl-077439	Oryza glaberrima	32.14	2.00e-09	55.80
IUUC-Ogu-078523	Oryza glumaepatula	31.11	2.00e-09	55.80
IUUC-Olo-080950	Oryza longistaminata	35.29	7.00e-09	54.30
IUUC-Ome-081221	Oryza meridionalis	33.77	2.00e-09	56.20
IUUC-Oni-082096	Oryza nivara	32.14	3.00e-09	55.80
IUUC-Opu-083949	Oryza punctata	33.77	2.00e-09	56.20
IUUC-Oru-085237	Oryza rufipogon	32.14	2.00e-09	55.80
IUUC-Osa-085964	Oryza sativa	32.14	3.00e-09	55.80
IUUC-Oga-088072	Otolemur garnettii	98.81	9.00e-149	518.00
IUUC-Oar-089761	Ovis aries	99.60	1.00e-149	521.00
IUUC-Ptr-090839	Pan troglodytes	98.42	3.00e-148	517.00
IUUC-Pan-092795	Papio anubis	99.21	1.00e-149	521.00
IUUC-Psi-093674	Pelodiscus sinensis	98.02	8.00e-148	515.00
IUUC-Pma-094464	Petromyzon marinus	68.56	5.00e-76	276.00
IUUC-Pab-098050	Pongo abelii	99.21	1.00e-149	521.00
IUUC-Pop-099863	Populus trichocarpa	35.21	1.00e-09	56.60
IUUC-Pca-100548	Procavia capensis	92.89	3.00e-135	473.00
IUUC-Pva-103060	Pteropus vampyrus	99.21	4.00e-149	520.00
IUUC-Sly-110996	Solanum lycopersicum	40.00	1.00e-11	63.50
IUUC-Stu-112782	Solanum tuberosum	40.00	1.00e-11	63.20
IUUC-Sar-113720	Sorex araneus	99.21	6.00e-149	519.00
IUUC-Ssc-116322	Sus scrofa	98.81	8.00e-149	518.00
IUUC-Tsy-119057	Tarsius syrichta	99.60	7.00e-150	522.00
IUUC-Tca-121215	Theobroma cacao	39.68	6.00e-10	57.80
IUUC-Tae-124189	Triticum aestivum	32.93	2.00e-09	56.20
IUUC-Tur-126784	Triticum urartu	39.44	7.00e-09	55.10
IUUC-Tbe-128101	Tupaia belangeri	99.21	4.00e-149	520.00
IUUC-Ttr-128776	Tursiops truncatus	99.21	2.00e-149	521.00
IUUC-Vpa-130717	Vicugna pacos	97.37	1.00e-108	384.00
IUUC-Vvi-131510	Vitis vinifera	42.59	4.00e-09	56.60

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence