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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063676
Ensembl Protein ID ENSMUSP00000045667.5
UniProt Accession Q80V62; Q9CWC7; FACD2_MOUSE
Genbank Protein ID BAB31563.1; AAH42619.1
Protein Name Fanconi anemia group D2 protein homolog
Genbank Nucleotide ID AK019136; CK634273
Gene Name Fancd2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000034023.16 ENSMUST00000129462.2 ENSMUSP00000145220.1
ENSMUSG00000034023.16 ENSMUST00000123738.1 ENSMUSP00000122091.1
ENSMUSG00000034023.16 ENSMUST00000036340.11 ENSMUSP00000045667.5
ENSMUSG00000034023.16 ENSMUST00000204827.2 ENSMUSP00000144928.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
miRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTM
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/Alpha-Helix/CUE 6.60e-06 27.2 190 229
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/CUE
   S: 2    letaleqLkeiFP.nldysviqvvLeantgsleaavnnLL 40
           l+   +qL++++P nl+++ i++++e++++s++a v+++L
   Q: 190  LTAQMMQLISVAPvNLQHDFITSLPEILGDSQHANVGKEL 229
           77788********************************998 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress (By similarity). Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching.
 Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress (By similarity). Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching.
Protein Sequence
(Fasta)
MISKRRRLDS EDKENLTEDA SKTMPLSKLA KKSHNSHEVE ENGSVFVKLL KASGLTLKTG 60
ENQNQLGVDQ VIFQRKLFQA LRKHPAYPKV IEEFVNGLES YTEDSESLRN CLLSCERLQD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063676|UBD,CUE|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGCGTCAGAG CGCCGTTCTT CTAGCGGGAA AGTCGAAAAC GAAGGGAAGC AACTGGCGGG 60
TCCCCAGGTT AGTGGCTTTT TAGGCTTTCC TGGGAGCGAG ATGGTATCTC TCCGAAGTCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063676|UBD,CUE|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0227--DNA damage
KW-0234--DNA repair
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0832--Ubl conjugation
Interpro

IPR029448--FANCD2
Pfam

PF14631--FancD2
Gene Ontology

GO:0000793--C:condensed chromosome
GO:0005829--C:cytosol
GO:0016604--C:nuclear body
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0070182--F:DNA polymerase binding
GO:0048854--P:brain morphogenesis
GO:0006974--P:cellular response to DNA damage stimulus
GO:0034599--P:cellular response to oxidative stress
GO:0006281--P:DNA repair
GO:0007276--P:gamete generation
GO:0097150--P:neuronal stem cell population maintenance
GO:2000348--P:regulation of CD40 signaling pathway
GO:0050727--P:regulation of inflammatory response
GO:0045589--P:regulation of regulatory T cell differentiation
GO:0051090--P:regulation of sequence-specific DNA binding transcription factor activity
GO:0010332--P:response to gamma radiation
GO:0007129--P:synapsis
KEGG mmu:211651
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000432 Aegilops tauschii 28.48 5.00e-67 250.00
IUUC-Aml-001335 Ailuropoda melanoleuca 75.42 0.00e+00 2087.00
IUUC-Apl-004194 Anas platyrhynchos 50.88 0.00e+00 1343.00
IUUC-Aca-004342 Anolis carolinensis 53.54 0.00e+00 1447.00
IUUC-Aly-005786 Arabidopsis lyrata 28.01 5.00e-70 260.00
IUUC-Ath-007464 Arabidopsis thaliana 29.13 4.00e-84 306.00
IUUC-Ame-011928 Astyanax mexicanus 51.45 0.00e+00 659.00
IUUC-Bta-012694 Bos taurus 72.09 0.00e+00 1984.00
IUUC-Bdi-014978 Brachypodium distachyon 27.62 3.00e-73 271.00
IUUC-Cel-018414 Caenorhabditis elegans 23.71 2.00e-08 55.80
IUUC-Cja-018718 Callithrix jacchus 72.58 0.00e+00 2083.00
IUUC-Cfa-020099 Canis familiaris 75.28 0.00e+00 2100.00
IUUC-Cpo-022409 Cavia porcellus 72.19 0.00e+00 1949.00
IUUC-Csa-023529 Chlorocebus sabaeus 73.07 0.00e+00 2068.00
IUUC-Cho-024646 Choloepus hoffmanni 71.89 0.00e+00 805.00
IUUC-Cin-025320 Ciona intestinalis 25.69 4.00e-59 223.00
IUUC-Csv-025936 Ciona savignyi 35.19 2.00e-03 35.40
IUUC-Cme-027121 Cyanidioschyzon merolae 34.62 2.00e-14 75.50
IUUC-Dre-027518 Danio rerio 50.70 0.00e+00 1290.00
IUUC-Dno-029719 Dasypus novemcinctus 72.89 0.00e+00 2036.00
IUUC-Dme-032205 Drosophila melanogaster 23.51 9.00e-56 213.00
IUUC-Ete-032735 Echinops telfairi 55.19 0.00e+00 963.00
IUUC-Eca-033657 Equus caballus 75.72 0.00e+00 2083.00
IUUC-Eeu-035133 Erinaceus europaeus 57.97 0.00e+00 1503.00
IUUC-Fca-035880 Felis catus 70.60 0.00e+00 1954.00
IUUC-Fal-037013 Ficedula albicollis 51.00 0.00e+00 1207.00
IUUC-Gmo-039371 Gadus morhua 46.71 0.00e+00 702.00
IUUC-Gga-040720 Gallus gallus 51.77 0.00e+00 1357.00
IUUC-Gac-042331 Gasterosteus aculeatus 49.74 0.00e+00 1221.00
IUUC-Ggo-045657 Gorilla gorilla 69.20 0.00e+00 1959.00
IUUC-Hsa-046759 Homo sapiens 74.41 0.00e+00 2145.00
IUUC-Hvu-047390 Hordeum vulgare 28.26 7.00e-72 266.00
IUUC-Itr-048885 Ictidomys tridecemlineatus 74.65 0.00e+00 2156.00
IUUC-Lch-049711 Latimeria chalumnae 54.20 0.00e+00 1389.00
IUUC-Lpe-050891 Leersia perrieri 28.61 5.00e-73 270.00
IUUC-Loc-051888 Lepisosteus oculatus 50.62 0.00e+00 1299.00
IUUC-Laf-053492 Loxodonta africana 75.07 0.00e+00 2085.00
IUUC-Mcc-055632 Macaca mulatta 72.38 0.00e+00 2058.00
IUUC-Mga-059769 Meleagris gallopavo 51.42 0.00e+00 1336.00
IUUC-Mmr-061234 Microcebus murinus 75.09 0.00e+00 2134.00
IUUC-Mdo-062903 Monodelphis domestica 64.37 0.00e+00 1765.00
IUUC-Mpu-066421 Mustela putorius furo 74.80 0.00e+00 1807.00
IUUC-Mlu-067851 Myotis lucifugus 72.07 0.00e+00 2022.00
IUUC-Nle-069694 Nomascus leucogenys 71.60 0.00e+00 952.00
IUUC-Opr-071174 Ochotona princeps 64.60 0.00e+00 1103.00
IUUC-Ont-071414 Oreochromis niloticus 49.18 0.00e+00 1244.00
IUUC-Oan-072704 Ornithorhynchus anatinus 48.22 2.00e-70 259.00
IUUC-Ocu-073877 Oryctolagus cuniculus 73.20 0.00e+00 2024.00
IUUC-Obr-076418 Oryza brachyantha 27.87 1.00e-71 265.00
IUUC-Ogl-077563 Oryza glaberrima 28.57 4.00e-61 229.00
IUUC-Ogu-077998 Oryza glumaepatula 28.77 2.00e-70 261.00
IUUC-Olo-080953 Oryza longistaminata 28.41 1.00e-60 229.00
IUUC-Ome-081590 Oryza meridionalis 28.48 3.00e-67 251.00
IUUC-Opu-083761 Oryza punctata 28.62 4.00e-70 260.00
IUUC-Oru-084791 Oryza rufipogon 28.46 3.00e-69 257.00
IUUC-Osa-085771 Oryza sativa 28.46 3.00e-69 256.00
IUUC-Ola-086402 Oryzias latipes 48.68 0.00e+00 1271.00
IUUC-Oga-088325 Otolemur garnettii 72.04 0.00e+00 1982.00
IUUC-Oar-089492 Ovis aries 71.70 0.00e+00 1999.00
IUUC-Ptr-091257 Pan troglodytes 74.62 0.00e+00 2136.00
IUUC-Pan-091710 Papio anubis 73.99 0.00e+00 632.00
IUUC-Psi-093960 Pelodiscus sinensis 51.82 0.00e+00 1131.00
IUUC-Pma-094600 Petromyzon marinus 46.16 0.00e+00 1153.00
IUUC-Ppa-095666 Physcomitrella patens 27.51 7.00e-84 306.00
IUUC-Pfo-096345 Poecilia formosa 47.68 0.00e+00 1216.00
IUUC-Pab-098684 Pongo abelii 72.64 0.00e+00 2069.00
IUUC-Pca-100659 Procavia capensis 61.00 0.00e+00 1080.00
IUUC-Pva-102653 Pteropus vampyrus 72.45 0.00e+00 2030.00
IUUC-Pgr-103320 Puccinia graminis 31.37 5.00e-01 28.50
IUUC-Rno-105830 Rattus norvegicus 90.41 0.00e+00 2550.00
IUUC-Sha-106852 Sarcophilus harrisii 64.48 0.00e+00 1697.00
IUUC-Sit-110198 Setaria italica 28.23 9.00e-75 276.00
IUUC-Sar-113565 Sorex araneus 54.65 0.00e+00 850.00
IUUC-Ssc-116311 Sus scrofa 73.52 0.00e+00 2044.00
IUUC-Tgu-116706 Taeniopygia guttata 52.17 0.00e+00 1351.00
IUUC-Tru-118512 Takifugu rubripes 46.25 0.00e+00 1173.00
IUUC-Tni-120565 Tetraodon nigroviridis 48.64 0.00e+00 1241.00
IUUC-Tca-121195 Theobroma cacao 29.02 5.00e-85 310.00
IUUC-Tbe-127657 Tupaia belangeri 68.98 0.00e+00 1070.00
IUUC-Ttr-128431 Tursiops truncatus 71.65 0.00e+00 1968.00
IUUC-Vpa-130299 Vicugna pacos 67.36 0.00e+00 1017.00
IUUC-Vvi-131258 Vitis vinifera 28.87 1.00e-38 155.00
IUUC-Xtr-132684 Xenopus tropicalis 55.35 0.00e+00 1442.00
IUUC-Xma-133655 Xiphophorus maculatus 48.36 0.00e+00 1179.00
Created Date 25-Jun-2017

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