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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063690
UUCD1 version UUC-MuM-00423
Ensembl Protein ID ENSMUSP00000075579.6
UniProt Accession Q4U2R1; E9PZT6; O88473; Q3TRJ8; Q3TS47; Q3TST2; Q3UFQ6; Q3URH7; Q5DU32; Q7TPR5; Q80VV7; Q9QYT1; Q9Z168; Q9Z171; HERC2_MOUSE
Genbank Protein ID AAC31431.1; AAD08658.1; BAE24711.1; BAE28504.1; BAE36593.1; BAE36828.1; BAE37031.1; BAD90404.1; AAH44667.1; AAH54829.1
Protein Name E3 ubiquitin-protein ligase HERC2; HECT domain and RCC1-like domain-containing protein 2; HECT-type E3 ubiquitin transferase HERC2
Genbank Nucleotide ID AF061529; AF071173; AC102121; AK148361; AK161826; AK162270; AK162708; AK220338; BC044667; BC054829
Gene Name Herc2; Jdf2; Kiaa0393; Rjs
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000030451.15 ENSMUST00000076226.12 ENSMUSP00000075579.6
ENSMUSG00000030451.15 ENSMUST00000205303.1 ENSMUSP00000145997.1
ENSMUSG00000030451.15 ENSMUST00000205678.1 ENSMUSP00000145560.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitecircBasemiRTarBasemicroRNA
TRANSFACRepTarmiRNAMapRAID2
Protein-protein Interaction
IIDPINAHINTMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 3.30e-86 290.9 4466 4795
Active Site
Position(s) Description Evidence
4764 Glycyl thioester intermediate {ECO:0000255|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 7    krlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.....ehlklFeflGrllgkalqdgrll 88
           ++++v+fvgE++ d+gG  +e +a++++elqn  ++l+  ++n++ +   n+d +l np      h ++F+flG+llg+a+++g +l
   Q: 4466 RVWKVKFVGESVDDCGGGYSESIAEICEELQNGLTPLLIVTPNGRDESGANRDCYLLNPatrapVHCSMFRFLGVLLGIAIRTGSPL 4552
           4566******************************************************99*999*********************** PP
   S: 89   dlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvk 175
            l+l+++++k+l g +l++ dl+evd++++  l++i++n+ ++ e +++ l f+     +++++ +++  +++++++t +N+ eYv+
   Q: 4553 SLNLAEPVWKQLAGMSLTIADLSEVDKDFIPGLMYIRDNEATSEEFEAMSLPFT-----VPSASGQDIQLSSKHTHITLDNRAEYVR 4634
           ***************************************9999999999***99.....788999999******************* PP
   S: 176  lvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
           l ++yrl+e ++eqv+a+reG+ +v+p  llslFt  ele+++cG+++i ++ lk+ ++ykg ++++ + +qwFwev+e+fs++er+
   Q: 4635 LAINYRLHE-FDEQVAAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYKG-IEPSASLVQWFWEVMESFSNTERS 4719
           *********.**************************************************77.************************ PP
   S: 263  afLqFvTgssrlPlgGfaelkprlfvirk....dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
            fL+Fv+g+ rlP + +a+++ r fvi+     +  d+ lP+s TCf++LkLP+Ys k++l+ekL yAi+ +k++++
   Q: 4720 LFLRFVWGRTRLP-RTIADFRGRDFVIQVldkyNPPDHFLPESYTCFFLLKLPRYSCKQVLEEKLKYAIHFCKSIDT 4795
           *************.8*************999988888***********************************99875 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity.
 E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity.
Protein Sequence
(Fasta)
MPSESFCLAA QSRLDSKWLK TDIQLAFTRD GLCGLWNEMV KDGEIVYTGT ELAQNRELPL 60
RKDDGVDAQS GTKKEDLNDK EKKEEEETPA PVYRAKSILE SWVWGRQPDV NELKECLSVL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063690|E3,HECT|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGCTCCTGCA GGGAGTGTTC CCTCAGCCGG CTGGCGGAGC AGGCGGCGCC AGGGCTGGCC 60
GAGCTGGGCC GAAGGAGGGC GGAGGGGCCG AAGACGGGCG GCGCCAGGTC CGGGAGAGCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063690|E3,HECT|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0227--DNA damage
KW-0234--DNA repair
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR004939--APC_su10/DOC_dom
IPR006624--Beta-propeller_rpt_TECPR
IPR016186--C-type_lectin-like/link
IPR021097--CPH_domain
IPR001199--Cyt_B5-like_heme/steroid-bd
IPR008979--Galactose-bd-like
IPR000569--HECT_dom
IPR010606--Mib_Herc2
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR014722--Rib_L2_dom2
IPR000433--Znf_ZZ
PROSITE

PS50255--CYTOCHROME_B5_2
PS51284--DOC
PS50237--HECT
PS51416--MIB_HERC2
PS00626--RCC1_2
PS50012--RCC1_3
PS01357--ZF_ZZ_1
PS50135--ZF_ZZ_2
Pfam

PF03256--ANAPC10
PF11515--Cul7
PF00173--Cyt-b5
PF00632--HECT
PF06701--MIB_HERC2
PF00415--RCC1
PF00569--ZZ
PRINTS

PR00633--RCCNDNSATION
SMART

SM01337--APC10
SM01117--Cyt-b5
SM00119--HECTc
SM00706--TECPR
SM00291--ZnF_ZZ
Gene Ontology

GO:0005814--C:centriole
GO:0005737--C:cytoplasm
GO:0016020--C:membrane
GO:0005743--C:mitochondrial inner membrane
GO:0005634--C:nucleus
GO:0032183--F:SUMO binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0006281--P:DNA repair
GO:0016567--P:protein ubiquitination
GO:0007283--P:spermatogenesis
KEGG mmu:15204
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002112 Ailuropoda melanoleuca 95.11 0.00e+00 7039.00
IUUC-Atr-003065 Amborella trichopoda 35.59 5.00e-51 196.00
IUUC-Apl-003983 Anas platyrhynchos 90.20 0.00e+00 8277.00
IUUC-Aca-004300 Anolis carolinensis 89.36 0.00e+00 8156.00
IUUC-Aly-006441 Arabidopsis lyrata 34.43 9.00e-45 175.00
IUUC-Ame-010621 Astyanax mexicanus 84.49 0.00e+00 6890.00
IUUC-Bta-013067 Bos taurus 94.29 0.00e+00 8494.00
IUUC-Bdi-014093 Brachypodium distachyon 33.51 2.00e-49 191.00
IUUC-Bol-015203 Brassica oleracea 34.83 1.00e-52 202.00
IUUC-Bra-016737 Brassica rapa 34.83 8.00e-48 186.00
IUUC-Cja-019687 Callithrix jacchus 93.45 0.00e+00 8365.00
IUUC-Cfa-020672 Canis familiaris 95.18 0.00e+00 8601.00
IUUC-Cpo-021819 Cavia porcellus 93.19 0.00e+00 8396.00
IUUC-Csa-023817 Chlorocebus sabaeus 95.35 0.00e+00 8586.00
IUUC-Cho-024387 Choloepus hoffmanni 93.50 0.00e+00 1863.00
IUUC-Cin-025709 Ciona intestinalis 58.69 0.00e+00 1449.00
IUUC-Csv-026336 Ciona savignyi 42.09 0.00e+00 3012.00
IUUC-Dre-027717 Danio rerio 81.72 0.00e+00 7222.00
IUUC-Dno-029296 Dasypus novemcinctus 94.20 0.00e+00 8502.00
IUUC-Dor-030979 Dipodomys ordii 90.94 0.00e+00 2877.00
IUUC-Dme-032171 Drosophila melanogaster 60.38 0.00e+00 1544.00
IUUC-Ete-032687 Echinops telfairi 84.47 0.00e+00 2840.00
IUUC-Eca-034046 Equus caballus 94.42 0.00e+00 8531.00
IUUC-Eeu-034859 Erinaceus europaeus 93.20 0.00e+00 1913.00
IUUC-Fca-036262 Felis catus 95.20 0.00e+00 8616.00
IUUC-Fal-037562 Ficedula albicollis 90.04 0.00e+00 8201.00
IUUC-Gmo-039054 Gadus morhua 85.38 0.00e+00 1080.00
IUUC-Gga-040359 Gallus gallus 90.11 0.00e+00 8242.00
IUUC-Gac-041879 Gasterosteus aculeatus 90.75 0.00e+00 1044.00
IUUC-Ggo-044692 Gorilla gorilla 96.65 0.00e+00 4287.00
IUUC-Hsa-045995 Homo sapiens 95.43 0.00e+00 8635.00
IUUC-Hvu-047529 Hordeum vulgare 35.93 4.00e-49 190.00
IUUC-Itr-048553 Ictidomys tridecemlineatus 93.94 0.00e+00 2395.00
IUUC-Lch-049808 Latimeria chalumnae 87.02 0.00e+00 3347.00
IUUC-Lpe-051482 Leersia perrieri 33.94 4.00e-46 180.00
IUUC-Loc-052685 Lepisosteus oculatus 84.36 0.00e+00 7510.00
IUUC-Laf-053372 Loxodonta africana 93.99 0.00e+00 8461.00
IUUC-Mcc-054693 Macaca mulatta 95.35 0.00e+00 8624.00
IUUC-Meu-056660 Macropus eugenii 96.30 0.00e+00 1927.00
IUUC-Mga-059371 Meleagris gallopavo 90.38 0.00e+00 7131.00
IUUC-Mmr-060787 Microcebus murinus 95.78 0.00e+00 8695.00
IUUC-Mdo-062518 Monodelphis domestica 88.63 0.00e+00 7952.00
IUUC-Mpu-066478 Mustela putorius furo 95.00 0.00e+00 8571.00
IUUC-Mlu-067596 Myotis lucifugus 88.49 0.00e+00 4262.00
IUUC-Nle-069445 Nomascus leucogenys 94.65 0.00e+00 2159.00
IUUC-Opr-070990 Ochotona princeps 87.98 0.00e+00 2965.00
IUUC-Ont-072285 Oreochromis niloticus 82.67 0.00e+00 7325.00
IUUC-Oan-072721 Ornithorhynchus anatinus 86.37 0.00e+00 3430.00
IUUC-Ocu-074273 Oryctolagus cuniculus 95.32 0.00e+00 8630.00
IUUC-Oba-075573 Oryza barthii 33.68 8.00e-46 179.00
IUUC-Obr-076107 Oryza brachyantha 34.30 5.00e-51 196.00
IUUC-Ogl-077193 Oryza glaberrima 33.68 9.00e-46 179.00
IUUC-Ogu-078817 Oryza glumaepatula 33.68 8.00e-46 179.00
IUUC-Oin-079609 Oryza indica 32.99 5.00e-49 189.00
IUUC-Olo-080629 Oryza longistaminata 33.68 1.00e-45 179.00
IUUC-Ome-081686 Oryza meridionalis 33.68 3.00e-46 180.00
IUUC-Opu-084137 Oryza punctata 33.94 2.00e-46 181.00
IUUC-Oru-085013 Oryza rufipogon 33.68 8.00e-46 179.00
IUUC-Osa-085597 Oryza sativa 33.68 8.00e-46 179.00
IUUC-Ola-087346 Oryzias latipes 92.45 0.00e+00 1205.00
IUUC-Oga-088742 Otolemur garnettii 94.78 0.00e+00 8489.00
IUUC-Oar-090093 Ovis aries 94.44 0.00e+00 8512.00
IUUC-Ptr-091034 Pan troglodytes 89.93 0.00e+00 5646.00
IUUC-Pan-092783 Papio anubis 92.99 0.00e+00 8380.00
IUUC-Psi-094027 Pelodiscus sinensis 90.40 0.00e+00 7908.00
IUUC-Pfo-096208 Poecilia formosa 80.17 0.00e+00 5954.00
IUUC-Pab-097681 Pongo abelii 91.88 0.00e+00 2550.00
IUUC-Pca-100705 Procavia capensis 95.20 0.00e+00 1165.00
IUUC-Pva-103147 Pteropus vampyrus 85.54 0.00e+00 2477.00
IUUC-Rno-105458 Rattus norvegicus 99.15 0.00e+00 8917.00
IUUC-Sha-106959 Sarcophilus harrisii 80.84 0.00e+00 6918.00
IUUC-Sit-109917 Setaria italica 36.36 8.00e-48 185.00
IUUC-Sly-110961 Solanum lycopersicum 35.60 5.00e-53 203.00
IUUC-Sar-113532 Sorex araneus 85.22 0.00e+00 1794.00
IUUC-Sbi-114352 Sorghum bicolor 32.39 2.00e-49 191.00
IUUC-Ssc-115337 Sus scrofa 90.96 0.00e+00 2951.00
IUUC-Tgu-116789 Taeniopygia guttata 89.92 0.00e+00 8226.00
IUUC-Tru-118129 Takifugu rubripes 82.16 0.00e+00 7353.00
IUUC-Tsy-119302 Tarsius syrichta 84.22 0.00e+00 1235.00
IUUC-Tni-120374 Tetraodon nigroviridis 80.78 0.00e+00 7200.00
IUUC-Tca-121094 Theobroma cacao 35.59 7.00e-54 206.00
IUUC-Tae-124157 Triticum aestivum 33.77 1.00e-49 192.00
IUUC-Tur-126300 Triticum urartu 35.57 1.00e-49 192.00
IUUC-Tbe-128137 Tupaia belangeri 87.58 0.00e+00 2296.00
IUUC-Ttr-128273 Tursiops truncatus 89.58 0.00e+00 6239.00
IUUC-Vpa-130471 Vicugna pacos 82.79 0.00e+00 1442.00
IUUC-Xtr-132185 Xenopus tropicalis 85.35 0.00e+00 7686.00
IUUC-Xma-133233 Xiphophorus maculatus 82.54 0.00e+00 7301.00
Created Date 25-Jun-2017

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