iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-004068

Ensembl Protein ID

ENSAPLP00000014762.1

UniProt Accession

U3J5I5; U3J5I5_ANAPL

Genbank Protein ID

ENSAPLP00000014762

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADON01081940

Gene Name

USP4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000014796.1	ENSAPLT00000015545.1	ENSAPLP00000014762.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	9.00e-98	327.3	285	904
ULD/UDP/UBQ/UBQ_Other	2.30e-15	55.9	125	201

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellka..lkkeaeefsg 86
           +Gl+NlgNtC+mNS+LQcLsn+p+l++++le k++ ++n++np ++ ge+++++++l++++w++++++v+pr+++k+  ++  a  f g
   Q: 285  CGLSNLGNTCFMNSALQCLSNTPPLTDYFLEdKYEAEINQNNPLGMRGEIAEAYAELIKQIWSGRQSHVAPRMFKKVkyISLSATLFIG 373
           7******************************9******************************************875448999999997 PP
   S: 87   yeq..qDaqEflaflldqleeelkk...eknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfl 170
           ++      +E+l+ +  +l++++ k    + ++++e+++ +++   +ea+e++  +n+s+i+d+F+g +ks+++c++c +vs++++pf+
   Q: 374  SMFliFHYKELLSECHAALHDDVMKaskVHYSRIKELRSRTSQVVAKEAWENHRLRNDSIIVDIFHGLFKSTLVCPKCSKVSVTFDPFC 462
           775226789**************7744455566666677777777788***************************************** PP
   S: 171  dlslpvpgkeetkke.......................................................................... 185
           +l+lp+p ++++ +e                                                                          
   Q: 463  YLTLPLPLRRDRLMEvtlvyadpqrrpvqyrvvvpmmgaisdlceslsklsgvpaenmvvtdvynhrfhkifqmdeglnhimpkddifv 551
           *******999998889************************************************************************* PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 552  yevckpsedgseyvtlsvyfrektmrqssntsgtvlfgqpllisvpkhkltvdhlyvvvleqisryvklplaeeystpcsdkgtcngss 640
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 641  gvaegdieemdhqdggqegkeklseiechsdgcmqvestrdlqpckkqhftfslvnsygtseinsivegkilklnafstlaidwdsdtr 729
           ***************************************************************************************** PP
   S: 186  ............................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksr 246
                                        l+dc+e ft+ e+l +++ +yc++ckk+q+a+kk++l++lP++L++hLkRfs+s++   r
   Q: 730  rllfdeqeaqafekhssllqpqkkkavvALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYSRY--WR 816
           ********************************************************************************99885..55 PP
   S: 247  ekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvl 333
            k+++ vefp++ L++s+f+++p ++   +++Y+Liav +H+G ++ GHY+ay+kn+ ++ W++fdDs+V++ +e+++++   + aYvl
   Q: 817  DKLDTVVEFPIRgLNMSEFVCDPRRG---SYIYDLIAVSNHYGAMGVGHYTAYAKNKVNDkWYYFDDSSVSAASEDQIVT---KAAYVL 899
           6*********************9998...6**************************65555*******************...****** PP
   S: 334  fYkrr 338
           fY+rr
   Q: 900  FYQRR 904
           ***96 PP

ULD/UDP/UBQ/UBQ_Other

   S: 5    vksldgs.eltlkvnpsdtVaeLKekiekklgip.peqqrLiyk......GkiLeddktLadyglkdgstihllekk 73
           ++s+d   + +++++++dtVa++ ++++k+++ip + + rL+++       ++ ++d t++d gl++g+++++++k+
   Q: 125  CESSDPDnVISCHFSKADTVATIEKEMRKLFNIPaEKETRLWNRymsntfEQLSKPDSTVQDAGLYHGQVVLIEVKN 201
           6777888899************************777*****887776656566*****************999886 PP

Organism

Anas platyrhynchos

Protein Sequence
(Fasta)

LVPLWQLNSR LAFSWRYLVD ISWFKQWKKF VGFDSWDMFG VGDPSLFPGP VDNSGLFSDA 60
ETQSLKEHLI DELDYVLVPT EAWNKLVAWY GCIDGQQPIV RKVVEYGLFV KHCKVEVYLL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTGGTACCTC TCTGGCAGCT GAACAGCCGT TTAGCTTTCA GCTGGAGGCA AGTAAGGACA 60
GGAAGCTACA TGGATGAAAA GACAGCGCTC AAAAGAGACA AGAGAAGACA TTGCCCCCGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR028135--Ub_USP-typ
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF06337--DUSP
PF14836--Ubiquitin_3
PF00443--UCH

SMART

SM00695--DUSP

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0031397--P:negative regulation of protein ubiquitination
GO:0016579--P:protein deubiquitination
GO:0034394--P:protein localization to cell surface
GO:0031647--P:regulation of protein stability
GO:0000244--P:spliceosomal tri-snRNP complex assembly
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001597	Ailuropoda melanoleuca	71.60	0.00e+00	1224.00
IUUC-Atr-002991	Amborella trichopoda	33.26	5.00e-117	415.00
IUUC-Aca-004459	Anolis carolinensis	73.32	0.00e+00	1297.00
IUUC-Ath-007343	Arabidopsis thaliana	35.17	2.00e-135	476.00
IUUC-Ame-011064	Astyanax mexicanus	59.68	0.00e+00	822.00
IUUC-Bta-012929	Bos taurus	71.96	0.00e+00	1235.00
IUUC-Bra-016885	Brassica rapa	33.15	1.00e-129	457.00
IUUC-Cja-018798	Callithrix jacchus	68.59	0.00e+00	1204.00
IUUC-Cfa-020599	Canis familiaris	72.63	0.00e+00	1241.00
IUUC-Cpo-022144	Cavia porcellus	70.48	0.00e+00	1229.00
IUUC-Csa-023770	Chlorocebus sabaeus	71.54	0.00e+00	1177.00
IUUC-Cho-024595	Choloepus hoffmanni	63.26	0.00e+00	758.00
IUUC-Dno-029316	Dasypus novemcinctus	72.30	0.00e+00	1233.00
IUUC-Ete-032970	Echinops telfairi	62.99	0.00e+00	743.00
IUUC-Eca-034012	Equus caballus	71.93	0.00e+00	1208.00
IUUC-Fca-035373	Felis catus	68.47	0.00e+00	1204.00
IUUC-Fal-037634	Ficedula albicollis	87.07	0.00e+00	1533.00
IUUC-Gmo-038866	Gadus morhua	60.19	0.00e+00	1022.00
IUUC-Gga-040729	Gallus gallus	81.10	0.00e+00	1448.00
IUUC-Gac-042631	Gasterosteus aculeatus	63.31	0.00e+00	1109.00
IUUC-Ggo-045337	Gorilla gorilla	68.81	0.00e+00	1082.00
IUUC-Hsa-045669	Homo sapiens	69.42	0.00e+00	1223.00
IUUC-Itr-048610	Ictidomys tridecemlineatus	70.83	0.00e+00	1221.00
IUUC-Lch-050533	Latimeria chalumnae	64.10	0.00e+00	1058.00
IUUC-Loc-051800	Lepisosteus oculatus	60.77	0.00e+00	1175.00
IUUC-Laf-053803	Loxodonta africana	72.25	0.00e+00	1254.00
IUUC-Mcc-055556	Macaca mulatta	67.55	0.00e+00	1128.00
IUUC-Meu-056742	Macropus eugenii	63.82	0.00e+00	1051.00
IUUC-Mga-059300	Meleagris gallopavo	81.89	0.00e+00	1427.00
IUUC-Mdo-061848	Monodelphis domestica	72.94	0.00e+00	1244.00
IUUC-Mmu-063960	Mus musculus	69.32	0.00e+00	1210.00
IUUC-Mac-064956	Musa acuminata	34.97	3.00e-129	456.00
IUUC-Mpu-066920	Mustela putorius furo	72.35	0.00e+00	1241.00
IUUC-Mlu-068088	Myotis lucifugus	71.02	0.00e+00	1226.00
IUUC-Nle-070010	Nomascus leucogenys	69.99	0.00e+00	1213.00
IUUC-Opr-070740	Ochotona princeps	69.50	0.00e+00	872.00
IUUC-Ont-072573	Oreochromis niloticus	61.66	0.00e+00	1132.00
IUUC-Oan-073363	Ornithorhynchus anatinus	66.85	0.00e+00	1172.00
IUUC-Ocu-074242	Oryctolagus cuniculus	66.15	0.00e+00	1125.00
IUUC-Ola-086553	Oryzias latipes	62.41	0.00e+00	1149.00
IUUC-Olu-087717	Ostreococcus lucimarinus	36.18	6.00e-104	371.00
IUUC-Oga-088562	Otolemur garnettii	64.72	0.00e+00	1078.00
IUUC-Oar-090439	Ovis aries	71.74	0.00e+00	1229.00
IUUC-Ptr-090801	Pan troglodytes	70.69	0.00e+00	1222.00
IUUC-Pan-092717	Papio anubis	69.46	0.00e+00	1107.00
IUUC-Psi-093942	Pelodiscus sinensis	74.25	0.00e+00	1288.00
IUUC-Pfo-097060	Poecilia formosa	60.77	0.00e+00	1112.00
IUUC-Pca-100161	Procavia capensis	65.22	0.00e+00	1047.00
IUUC-Rno-106081	Rattus norvegicus	72.09	0.00e+00	1253.00
IUUC-Sha-106937	Sarcophilus harrisii	71.24	0.00e+00	1238.00
IUUC-Sly-111746	Solanum lycopersicum	35.28	3.00e-129	456.00
IUUC-Sar-113542	Sorex araneus	69.15	0.00e+00	1177.00
IUUC-Ssc-115637	Sus scrofa	71.02	0.00e+00	1225.00
IUUC-Tgu-117267	Taeniopygia guttata	82.71	0.00e+00	1460.00
IUUC-Tru-118634	Takifugu rubripes	62.24	0.00e+00	1067.00
IUUC-Tni-120107	Tetraodon nigroviridis	60.24	0.00e+00	771.00
IUUC-Tca-121001	Theobroma cacao	33.48	3.00e-128	452.00
IUUC-Tur-126392	Triticum urartu	33.08	1.00e-83	304.00
IUUC-Tme-127062	Tuber melanosporum	31.96	6.00e-105	375.00
IUUC-Tbe-127669	Tupaia belangeri	59.87	0.00e+00	689.00
IUUC-Ttr-128778	Tursiops truncatus	70.49	0.00e+00	1213.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence