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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Dme-031703
Ensembl Protein ID FBpp0071023
UniProt Accession Q9W3R7; ATG5_DROME
Genbank Protein ID AAF46252.2; AAL39741.1
Protein Name Autophagy protein 5; APG5-like
Genbank Nucleotide ID AE014298; AY069596
Gene Name Atg5; CG1643
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0029943 FBtr0071065 FBpp0071023
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 adaptor/Cullin RING/Other 20.25 2.00e-07 50.80 IUUC-Sce-106216
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Drosophila melanogaster
Functional Description
(View)

Functional Description


     Involved in autophagic vesicle formation. Conjugation with Atg12, through a ubiquitin-like conjugating system involving Atg7 as an E1-like activating enzyme and Atg10 as an E2-like conjugating enzyme, is essential for its function. The Atg12-Atg5 conjugate acts as an E3-like enzyme which is required for lipidation of Atg8 and its association to the vesicle membranes (By similarity).
 Involved in autophagic vesicle formation. Conjugation with Atg12, through a ubiquitin-like conjugating system involving Atg7 as an E1-like activating enzyme and Atg10 as an E2-like conjugating enzyme, is essential for its function. The Atg12-Atg5 conjugate acts as an E3-like enzyme which is required for lipidation of Atg8 and its association to the vesicle membranes (By similarity).
Protein Sequence
(Fasta)
MAHDREVLRM IWEGQIGICF QADRDEIVGI KPEPFYLMIS RLSYLPLVTD KVRKYFSRYI 60
SAEHQDGAVW FDFNGTPLRL HYPIGVLYDL LHPEEDSTPW CLTIHFSKFP EDMLVKLNSK 120
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Protein Fasta Sequence


>IUUC-Dme-031703|E3,Cullin RING/Other|Drosophila melanogaster
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TTATCAAATA GCATTGTTTC ACCCATCTGG TAACATCGCA AATCGTATTG TGCAAAAAGG 60
AAATATAATT TAGCCAAAAC AAAAGCCAAA TAAGGAACAT GGCCCACGAC CGCGAGGTGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dme-031703|E3,Cullin RING/Other|Drosophila melanogaster
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0832--Ubl conjugation
Interpro

IPR007239--Atg5
Pfam

PF04106--APG5
Gene Ontology

GO:0034274--C:Atg12-Atg5-Atg16 complex
GO:0005776--C:autophagosome
GO:0005737--C:cytoplasm
GO:0034045--C:pre-autophagosomal structure membrane
GO:0048102--P:autophagic cell death
GO:0000045--P:autophagosome assembly
GO:0006914--P:autophagy
GO:0006501--P:C-terminal protein lipidation
GO:0006995--P:cellular response to nitrogen starvation
GO:0009267--P:cellular response to starvation
GO:0061723--P:glycophagy
GO:0035096--P:larval midgut cell programmed cell death
GO:0016236--P:macroautophagy
GO:0000422--P:mitophagy
GO:0044804--P:nucleophagy
GO:0015031--P:protein transport
GO:0035071--P:salivary gland cell autophagic cell death
KEGG dme:Dmel_CG1643
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000583 Aegilops tauschii 28.02 8.00e-16 78.60
IUUC-Aml-002403 Ailuropoda melanoleuca 48.35 1.00e-71 262.00
IUUC-Atr-002645 Amborella trichopoda 28.57 2.00e-15 75.90
IUUC-Apl-003611 Anas platyrhynchos 47.97 3.00e-73 267.00
IUUC-Aca-004411 Anolis carolinensis 46.72 2.00e-72 265.00
IUUC-Aly-005636 Arabidopsis lyrata 28.38 6.00e-18 84.00
IUUC-Ath-006959 Arabidopsis thaliana 23.49 1.00e-16 79.70
IUUC-Ago-007978 Ashbya gossypii 23.61 1.00e-06 46.60
IUUC-Acl-008328 Aspergillus clavatus 29.56 5.00e-16 77.40
IUUC-Afl-008638 Aspergillus flavus 27.23 6.00e-23 100.00
IUUC-Afu-009042 Aspergillus fumigatus 28.10 5.00e-22 97.40
IUUC-Ani-009364 Aspergillus nidulans 27.05 9.00e-21 93.20
IUUC-Aor-009889 Aspergillus oryzae 27.23 6.00e-23 100.00
IUUC-Ate-010511 Aspergillus terreus 31.58 1.00e-09 53.90
IUUC-Ame-011644 Astyanax mexicanus 48.10 3.00e-18 81.60
IUUC-Bgr-012153 Blumeria graminis 31.93 2.00e-12 65.10
IUUC-Bta-012360 Bos taurus 50.93 2.00e-44 170.00
IUUC-Bci-013723 Botrytis cinerea 25.81 4.00e-09 54.30
IUUC-Bdi-014520 Brachypodium distachyon 29.13 6.00e-13 67.40
IUUC-Bol-016053 Brassica oleracea 27.78 2.00e-21 95.50
IUUC-Bra-017072 Brassica rapa 27.47 4.00e-21 94.70
IUUC-Cel-018529 Caenorhabditis elegans 30.74 6.00e-35 140.00
IUUC-Cja-019569 Callithrix jacchus 48.34 9.00e-72 262.00
IUUC-Cfa-020473 Canis familiaris 48.34 1.00e-71 261.00
IUUC-Cpo-021421 Cavia porcellus 48.71 1.00e-71 261.00
IUUC-Cre-022862 Chlamydomonas reinhardtii 28.32 1.00e-12 65.90
IUUC-Csa-024197 Chlorocebus sabaeus 48.34 9.00e-72 262.00
IUUC-Cho-024521 Choloepus hoffmanni 47.66 2.00e-59 221.00
IUUC-Cin-025119 Ciona intestinalis 40.23 3.00e-53 201.00
IUUC-Csv-026192 Ciona savignyi 39.92 2.00e-52 197.00
IUUC-Cgl-026686 Colletotrichum gloeosporioides 23.12 5.00e-05 40.80
IUUC-Dre-028466 Danio rerio 49.44 9.00e-73 265.00
IUUC-Dor-030649 Dipodomys ordii 28.95 3.40e+00 25.40
IUUC-Dse-031228 Dothistroma septosporum 26.56 6.00e-23 100.00
IUUC-Ete-032482 Echinops telfairi 48.09 2.00e-59 221.00
IUUC-Eca-034036 Equus caballus 48.34 2.00e-71 261.00
IUUC-Eeu-035235 Erinaceus europaeus 50.93 1.00e-43 169.00
IUUC-Fca-036263 Felis catus 47.97 3.00e-71 260.00
IUUC-Fal-037064 Ficedula albicollis 47.97 9.00e-74 269.00
IUUC-Fox-037813 Fusarium oxysporum 23.81 1.00e-09 55.80
IUUC-Fso-038139 Fusarium solani 24.41 7.00e-11 60.10
IUUC-Gmo-039509 Gadus morhua 50.45 5.00e-62 229.00
IUUC-Ggr-040111 Gaeumannomyces graminis 23.62 6.00e-07 47.40
IUUC-Gga-040517 Gallus gallus 48.34 6.00e-74 269.00
IUUC-Gac-042270 Gasterosteus aculeatus 48.66 3.00e-60 224.00
IUUC-Gma-044400 Glycine max 30.37 2.00e-15 75.10
IUUC-Ggo-045048 Gorilla gorilla 47.97 3.00e-71 260.00
IUUC-Hsa-046744 Homo sapiens 48.34 1.00e-71 261.00
IUUC-Kpa-049174 Komagataella pastoris 24.49 8.00e-14 70.10
IUUC-Lch-049475 Latimeria chalumnae 48.34 5.00e-73 266.00
IUUC-Lpe-051283 Leersia perrieri 31.85 9.00e-18 85.10
IUUC-Loc-052446 Lepisosteus oculatus 49.08 2.00e-73 267.00
IUUC-Lma-053278 Leptosphaeria maculans 24.51 2.00e-20 92.40
IUUC-Laf-054020 Loxodonta africana 48.35 1.00e-71 261.00
IUUC-Mcc-055176 Macaca mulatta 48.34 1.00e-71 261.00
IUUC-Mor-057164 Magnaporthe oryzae 25.90 3.00e-11 61.60
IUUC-Mpo-057428 Magnaporthe poae 25.51 1.00e-07 49.30
IUUC-Mtr-058424 Medicago truncatula 28.89 2.00e-15 75.10
IUUC-Mla-058872 Melampsora laricipopulina 24.68 6.00e-20 90.90
IUUC-Mga-059859 Meleagris gallopavo 48.34 6.00e-74 269.00
IUUC-Mmr-061482 Microcebus murinus 48.34 5.00e-72 263.00
IUUC-Mdo-062371 Monodelphis domestica 48.71 4.00e-73 266.00
IUUC-Mmu-063139 Mus musculus 48.34 2.00e-71 261.00
IUUC-Mac-065332 Musa acuminata 34.27 2.00e-23 102.00
IUUC-Mpu-066783 Mustela putorius furo 47.97 5.00e-71 259.00
IUUC-Mlu-068165 Myotis lucifugus 48.35 7.00e-71 259.00
IUUC-Nfi-068578 Neosartorya fischeri 28.57 1.00e-22 99.40
IUUC-Nle-069740 Nomascus leucogenys 48.34 1.00e-71 262.00
IUUC-Opr-070802 Ochotona princeps 50.93 3.00e-44 171.00
IUUC-Ont-072222 Oreochromis niloticus 46.86 5.00e-69 253.00
IUUC-Oan-072760 Ornithorhynchus anatinus 52.08 2.00e-57 214.00
IUUC-Ocu-074844 Oryctolagus cuniculus 49.40 2.00e-42 164.00
IUUC-Oba-075834 Oryza barthii 30.41 4.00e-18 84.70
IUUC-Obr-076230 Oryza brachyantha 31.58 5.00e-11 60.80
IUUC-Ogl-077554 Oryza glaberrima 30.41 4.00e-18 84.70
IUUC-Ogu-078687 Oryza glumaepatula 29.82 6.00e-18 84.30
IUUC-Oin-079677 Oryza indica 30.41 3.00e-18 85.10
IUUC-Olo-081078 Oryza longistaminata 29.94 9.00e-18 84.30
IUUC-Ome-081548 Oryza meridionalis 30.41 1.00e-18 88.20
IUUC-Oni-082050 Oryza nivara 30.41 2.00e-18 85.90
IUUC-Opu-083609 Oryza punctata 30.41 4.00e-18 84.70
IUUC-Oru-085057 Oryza rufipogon 30.41 3.00e-18 85.10
IUUC-Osa-085917 Oryza sativa 30.41 6.00e-18 84.30
IUUC-Ola-087032 Oryzias latipes 46.86 1.00e-69 255.00
IUUC-Olu-087877 Ostreococcus lucimarinus 24.37 3.00e-03 33.50
IUUC-Oga-088468 Otolemur garnettii 48.35 3.00e-73 267.00
IUUC-Oar-089751 Ovis aries 48.71 4.00e-72 263.00
IUUC-Ptr-091064 Pan troglodytes 48.34 1.00e-71 261.00
IUUC-Pan-092505 Papio anubis 48.35 1.00e-71 261.00
IUUC-Psi-093086 Pelodiscus sinensis 47.43 4.00e-72 263.00
IUUC-Pno-094825 Phaeosphaeria nodorum 25.56 6.00e-19 87.00
IUUC-Ppa-095419 Physcomitrella patens 29.52 2.00e-21 95.90
IUUC-Pfo-096224 Poecilia formosa 47.23 5.00e-69 253.00
IUUC-Pab-098501 Pongo abelii 48.34 1.00e-71 262.00
IUUC-Pop-099243 Populus trichocarpa 28.64 1.00e-16 79.70
IUUC-Ppe-101255 Prunus persica 27.27 3.00e-17 81.60
IUUC-Pva-102828 Pteropus vampyrus 48.34 3.00e-71 260.00
IUUC-Pgr-103672 Puccinia graminis 25.32 2.00e-19 89.00
IUUC-Ptt-104013 Puccinia triticina 23.03 3.00e-16 78.60
IUUC-Pyt-104615 Pyrenophora triticirepentis 24.42 6.00e-20 90.50
IUUC-Rno-106089 Rattus norvegicus 47.28 2.00e-60 224.00
IUUC-Sce-106216 Saccharomyces cerevisiae 20.25 5.00e-08 50.80
IUUC-Sha-106484 Sarcophilus harrisii 49.08 5.00e-74 269.00
IUUC-Sja-107699 Schizosaccharomyces japonicus 26.14 1.00e-22 99.40
IUUC-Spo-108177 Schizosaccharomyces pombe 23.40 2.00e-17 81.60
IUUC-Smo-109473 Selaginella moellendorffii 35.62 4.00e-22 97.80
IUUC-Sit-110736 Setaria italica 27.98 2.00e-17 82.40
IUUC-Sly-111657 Solanum lycopersicum 27.34 4.00e-22 98.20
IUUC-Sar-113050 Sorex araneus 44.26 1.00e-52 198.00
IUUC-Sbi-114258 Sorghum bicolor 29.05 5.00e-16 77.80
IUUC-Sre-114902 Sporisorium reilianum 25.00 3.00e-18 85.90
IUUC-Ssc-116166 Sus scrofa 44.65 3.00e-64 237.00
IUUC-Tgu-116814 Taeniopygia guttata 47.97 2.00e-73 268.00
IUUC-Tru-118172 Takifugu rubripes 48.34 3.00e-71 260.00
IUUC-Tsy-119010 Tarsius syrichta 43.91 1.00e-63 235.00
IUUC-Tni-120397 Tetraodon nigroviridis 51.04 2.00e-56 210.00
IUUC-Tca-121283 Theobroma cacao 26.90 7.00e-16 77.00
IUUC-Tvi-122545 Trichoderma virens 24.03 8.00e-08 49.70
IUUC-Tae-122685 Triticum aestivum 29.73 2.00e-16 78.60
IUUC-Tur-126407 Triticum urartu 28.67 6.00e-16 77.40
IUUC-Tme-126913 Tuber melanosporum 29.54 1.00e-31 129.00
IUUC-Tbe-127738 Tupaia belangeri 46.07 1.00e-45 174.00
IUUC-Ttr-128528 Tursiops truncatus 49.08 9.00e-72 262.00
IUUC-Uma-129625 Ustilago maydis 23.87 7.00e-16 77.80
IUUC-Vpa-130223 Vicugna pacos 47.78 6.00e-69 253.00
IUUC-Vvi-131617 Vitis vinifera 28.57 5.00e-18 84.30
IUUC-Xtr-132288 Xenopus tropicalis 46.86 4.00e-70 257.00
IUUC-Xma-134214 Xiphophorus maculatus 47.17 3.00e-55 207.00
IUUC-Yli-134377 Yarrowia lipolytica 22.77 6.00e-10 57.00
IUUC-Zma-135108 Zea mays 30.99 2.00e-16 79.00
Created Date 25-Jun-2017

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