iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Yli-134377

Ensembl Protein ID

CAG79955

UniProt Accession

Q6C4Q6; ATG5_YARLI

Genbank Protein ID

CAG79955.2

Protein Name

Autophagy protein 5

Genbank Nucleotide ID

CR382131

Gene Name

ATG5; YALI0E24519g

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
YALI0_E24519g	CAG79955	CAG79955

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/Other	22.22	5.00e-06	46.20	IUUC-Sce-106216

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Yarrowia lipolytica

Functional Description
(View)

Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes (By similarity).

Protein Sequence
(Fasta)

MGDKRGLVLD ETATYGTVDR LTGWFRNVCI QLPEGTLLVL CCCAVEQRIG VTTFSIGLSY 60
DLLTGLDPSN PDTVQSPWIL TLQVDQKEEY PKGLLLRIPT KQTLKDYWIH QLKEACVSRD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGAGATA AACGTGGTTT GGTGCTGGAT GAAACAGCGA CATATGGTAC GGTAGATAGA 60
CTGACGGGCT GGTTTCGAAA TGTCTGTATT CAATTACCAG AGGGTACGTT ACTCGTGCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0832--Ubl conjugation

Interpro

IPR007239--Atg5

Pfam

PF04106--APG5

Gene Ontology

GO:0034274--C:Atg12-Atg5-Atg16 complex
GO:0034045--C:pre-autophagosomal structure membrane
GO:0000045--P:autophagosome assembly
GO:0006501--P:C-terminal protein lipidation
GO:0006995--P:cellular response to nitrogen starvation
GO:0000422--P:mitophagy
GO:0044804--P:nucleophagy
GO:0015031--P:protein transport

KEGG

yli:YALI0E24519g

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000583	Aegilops tauschii	23.74	8.00e-07	47.40
IUUC-Aml-002403	Ailuropoda melanoleuca	24.44	5.00e-14	69.30
IUUC-Atr-002645	Amborella trichopoda	26.89	2.00e-05	41.20
IUUC-Apl-003611	Anas platyrhynchos	22.89	3.00e-14	70.10
IUUC-Aca-004411	Anolis carolinensis	23.27	2.00e-13	67.00
IUUC-Aly-005636	Arabidopsis lyrata	26.88	2.00e-05	41.60
IUUC-Ath-006959	Arabidopsis thaliana	21.13	1.00e-05	42.00
IUUC-Ago-007978	Ashbya gossypii	31.86	3.00e-20	90.50
IUUC-Acl-008328	Aspergillus clavatus	31.09	6.00e-23	99.00
IUUC-Afl-008638	Aspergillus flavus	28.81	5.00e-21	92.80
IUUC-Afu-009042	Aspergillus fumigatus	26.69	1.00e-19	88.20
IUUC-Ani-009364	Aspergillus nidulans	26.98	2.00e-20	90.90
IUUC-Aor-009889	Aspergillus oryzae	28.81	4.00e-21	93.20
IUUC-Bgr-012153	Blumeria graminis	33.77	3.00e-16	76.60
IUUC-Bta-012360	Bos taurus	19.35	1.80e+00	23.10
IUUC-Bci-013723	Botrytis cinerea	26.37	1.00e-18	84.70
IUUC-Bdi-014520	Brachypodium distachyon	26.44	3.00e-07	47.40
IUUC-Bol-016053	Brassica oleracea	19.55	1.00e-05	42.00
IUUC-Bra-017072	Brassica rapa	27.96	3.00e-06	43.90
IUUC-Cel-018529	Caenorhabditis elegans	23.27	2.00e-08	50.40
IUUC-Cja-019569	Callithrix jacchus	24.72	1.00e-15	74.70
IUUC-Cfa-020473	Canis familiaris	24.72	1.00e-15	74.70
IUUC-Cpo-021421	Cavia porcellus	24.16	7.00e-15	72.40
IUUC-Csa-024197	Chlorocebus sabaeus	24.72	2.00e-15	74.30
IUUC-Cho-024521	Choloepus hoffmanni	24.24	9.00e-15	71.60
IUUC-Cin-025119	Ciona intestinalis	24.00	4.00e-12	63.20
IUUC-Csv-026192	Ciona savignyi	28.25	2.00e-14	70.50
IUUC-Cgl-026686	Colletotrichum gloeosporioides	30.32	1.00e-19	88.20
IUUC-Dre-028466	Danio rerio	22.89	2.00e-14	70.50
IUUC-Dno-029255	Dasypus novemcinctus	39.29	3.70e+00	24.60
IUUC-Dse-031228	Dothistroma septosporum	30.80	5.00e-27	112.00
IUUC-Dme-031703	Drosophila melanogaster	22.77	6.00e-14	68.90
IUUC-Ete-032482	Echinops telfairi	24.38	2.00e-15	73.90
IUUC-Eca-034036	Equus caballus	24.72	1.00e-15	74.70
IUUC-Eeu-035235	Erinaceus europaeus	44.12	1.00e-02	31.60
IUUC-Fca-036263	Felis catus	24.72	2.00e-15	74.30
IUUC-Fal-037064	Ficedula albicollis	22.89	2.00e-14	70.90
IUUC-Fox-037813	Fusarium oxysporum	28.92	4.00e-20	89.40
IUUC-Fso-038139	Fusarium solani	29.94	3.00e-20	90.10
IUUC-Gmo-039509	Gadus morhua	20.47	1.00e-07	47.80
IUUC-Ggr-040111	Gaeumannomyces graminis	30.54	2.00e-19	87.80
IUUC-Gga-040517	Gallus gallus	23.38	6.00e-15	72.40
IUUC-Gac-042270	Gasterosteus aculeatus	23.39	2.00e-10	57.40
IUUC-Gma-044400	Glycine max	30.11	8.00e-07	45.10
IUUC-Ggo-045048	Gorilla gorilla	24.72	9.00e-16	75.10
IUUC-Hsa-046744	Homo sapiens	24.72	1.00e-15	75.10
IUUC-Kpa-049174	Komagataella pastoris	34.58	4.00e-25	106.00
IUUC-Lch-049475	Latimeria chalumnae	24.88	5.00e-16	75.90
IUUC-Lpe-051283	Leersia perrieri	23.88	8.00e-06	43.90
IUUC-Loc-052446	Lepisosteus oculatus	24.38	8.00e-17	78.60
IUUC-Lma-053278	Leptosphaeria maculans	30.34	1.00e-26	111.00
IUUC-Laf-054020	Loxodonta africana	24.44	4.00e-14	69.70
IUUC-Mcc-055176	Macaca mulatta	24.72	1.00e-15	75.10
IUUC-Mor-057164	Magnaporthe oryzae	30.00	5.00e-19	86.30
IUUC-Mpo-057428	Magnaporthe poae	26.52	1.00e-18	84.70
IUUC-Mtr-058424	Medicago truncatula	29.03	3.00e-06	43.50
IUUC-Mla-058872	Melampsora laricipopulina	28.70	1.00e-18	85.10
IUUC-Mga-059859	Meleagris gallopavo	23.38	6.00e-15	72.40
IUUC-Mmr-061482	Microcebus murinus	24.72	1.00e-15	75.10
IUUC-Mdo-062371	Monodelphis domestica	25.37	2.00e-17	80.50
IUUC-Mmu-063139	Mus musculus	25.28	5.00e-16	75.90
IUUC-Mac-065332	Musa acuminata	27.72	4.00e-06	43.50
IUUC-Mpu-066783	Mustela putorius furo	24.16	5.00e-15	72.80
IUUC-Mlu-068165	Myotis lucifugus	25.00	2.00e-14	70.50
IUUC-Nfi-068578	Neosartorya fischeri	27.12	6.00e-20	89.40
IUUC-Ncr-068636	Neurospora crassa	28.15	2.00e-19	87.80
IUUC-Nle-069740	Nomascus leucogenys	24.72	1.00e-15	74.70
IUUC-Opr-070802	Ochotona princeps	41.18	1.00e-02	31.60
IUUC-Ont-072222	Oreochromis niloticus	24.16	4.00e-15	72.80
IUUC-Oan-072760	Ornithorhynchus anatinus	21.49	4.00e-07	46.20
IUUC-Ocu-074844	Oryctolagus cuniculus	24.85	3.00e-15	72.80
IUUC-Oba-075834	Oryza barthii	24.88	2.00e-06	45.10
IUUC-Obr-076230	Oryza brachyantha	29.57	9.00e-07	45.40
IUUC-Ogl-077554	Oryza glaberrima	24.88	2.00e-06	45.10
IUUC-Ogu-078687	Oryza glumaepatula	29.36	3.00e-06	43.90
IUUC-Oin-079677	Oryza indica	26.34	5.00e-08	49.70
IUUC-Olo-081078	Oryza longistaminata	24.88	1.00e-06	45.80
IUUC-Ome-081548	Oryza meridionalis	30.28	3.00e-06	45.40
IUUC-Oni-082050	Oryza nivara	24.88	6.00e-07	46.20
IUUC-Opu-083609	Oryza punctata	30.28	2.00e-06	44.70
IUUC-Oru-085057	Oryza rufipogon	24.88	6.00e-07	46.20
IUUC-Osa-085917	Oryza sativa	24.88	7.00e-07	46.20
IUUC-Ola-087032	Oryzias latipes	22.47	2.00e-12	64.30
IUUC-Olu-087877	Ostreococcus lucimarinus	24.60	1.00e-03	33.50
IUUC-Oga-088468	Otolemur garnettii	25.12	6.00e-16	75.90
IUUC-Oar-089751	Ovis aries	24.72	1.00e-15	74.70
IUUC-Ptr-091064	Pan troglodytes	24.72	1.00e-15	75.10
IUUC-Pan-092505	Papio anubis	24.44	4.00e-14	69.70
IUUC-Psi-093086	Pelodiscus sinensis	24.75	2.00e-14	70.90
IUUC-Pma-094385	Petromyzon marinus	24.44	9.90e-02	28.10
IUUC-Pno-094825	Phaeosphaeria nodorum	33.04	3.00e-27	113.00
IUUC-Ppa-095419	Physcomitrella patens	26.47	3.00e-03	34.30
IUUC-Pfo-096224	Poecilia formosa	23.15	1.00e-13	68.20
IUUC-Pab-098501	Pongo abelii	24.72	1.00e-15	75.10
IUUC-Pop-099243	Populus trichocarpa	24.02	1.00e-06	45.40
IUUC-Ppe-101255	Prunus persica	26.00	6.00e-05	39.70
IUUC-Pva-102828	Pteropus vampyrus	24.72	3.00e-15	73.60
IUUC-Pgr-103672	Puccinia graminis	28.90	2.00e-17	80.90
IUUC-Ptt-104013	Puccinia triticina	27.27	2.00e-14	71.20
IUUC-Pyt-104615	Pyrenophora triticirepentis	32.97	8.00e-24	102.00
IUUC-Rno-106089	Rattus norvegicus	25.87	4.00e-16	75.90
IUUC-Sce-106216	Saccharomyces cerevisiae	23.95	5.00e-10	56.20
IUUC-Sha-106484	Sarcophilus harrisii	25.37	4.00e-17	79.70
IUUC-Sja-107699	Schizosaccharomyces japonicus	31.68	5.00e-24	102.00
IUUC-Spo-108177	Schizosaccharomyces pombe	31.00	4.00e-23	99.40
IUUC-Ssl-108475	Sclerotinia sclerotiorum	30.77	5.00e-23	99.40
IUUC-Smo-109473	Selaginella moellendorffii	29.89	4.00e-04	37.00
IUUC-Sit-110736	Setaria italica	28.44	5.00e-05	40.00
IUUC-Sly-111657	Solanum lycopersicum	25.00	2.00e-05	41.60
IUUC-Sar-113050	Sorex araneus	19.66	2.00e-06	43.50
IUUC-Sbi-114258	Sorghum bicolor	30.43	5.00e-06	43.10
IUUC-Sre-114902	Sporisorium reilianum	29.27	3.00e-07	47.80
IUUC-Ssc-116166	Sus scrofa	25.84	5.00e-15	72.80
IUUC-Tgu-116814	Taeniopygia guttata	22.39	6.00e-14	68.90
IUUC-Tru-118172	Takifugu rubripes	23.73	2.00e-14	70.50
IUUC-Tsy-119010	Tarsius syrichta	20.10	3.00e-07	46.60
IUUC-Tni-120397	Tetraodon nigroviridis	19.39	2.00e-05	40.40
IUUC-Tca-121283	Theobroma cacao	24.00	9.00e-05	39.30
IUUC-Tvi-122545	Trichoderma virens	30.30	2.00e-20	90.50
IUUC-Tae-122685	Triticum aestivum	24.64	7.00e-07	45.80
IUUC-Tur-126407	Triticum urartu	31.19	7.00e-07	45.80
IUUC-Tme-126913	Tuber melanosporum	37.04	8.00e-39	151.00
IUUC-Tbe-127738	Tupaia belangeri	23.88	5.00e-14	68.90
IUUC-Ttr-128528	Tursiops truncatus	24.72	2.00e-15	73.90
IUUC-Uma-129625	Ustilago maydis	34.38	4.00e-08	50.40
IUUC-Vda-129906	Verticillium dahliae	30.00	1.00e-17	80.90
IUUC-Vpa-130223	Vicugna pacos	23.73	5.00e-12	62.80
IUUC-Vvi-131617	Vitis vinifera	24.00	4.00e-05	40.40
IUUC-Xtr-132288	Xenopus tropicalis	23.38	9.00e-17	78.60
IUUC-Xma-134214	Xiphophorus maculatus	19.39	2.00e-04	37.40
IUUC-Zma-135108	Zea mays	27.72	2.00e-05	41.20

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence