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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064424
UUCD1 version UUC-MuM-01229
Ensembl Protein ID ENSMUSP00000064515.3
UniProt Accession Q3TIX9; Q3TI55; Q8BLI5; Q8BZZ5; Q9CQR1; SNUT2_MOUSE
Genbank Protein ID BAB26944.1; BAB31299.1; BAC28153.1; BAC32203.1; BAE39717.1; BAE38302.1; BAE39991.1; BAC40299.1; AAH26983.1
Protein Name U4/U6.U5 tri-snRNP-associated protein 2; Inactive ubiquitin-specific peptidase 39
Genbank Nucleotide ID AK010443; AK018595; AK033105; AK045062; AK167668; AK165625; AK168003; AK088354; BC026983
Gene Name Usp39
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000056305.4 ENSMUST00000070345.4 ENSMUSP00000064515.3
ENSMUSG00000056305.4 ENSMUST00000206262.1 ENSMUSP00000145792.1
Annotation
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarmiRNAMap
RAID2
Protein-protein Interaction
IIDMentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 2.10e-51 176.3 224 554
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw..kskkkavsprellkalkkeaee.fsg 86
           +Gl+N+ +  Y N+vLQ+Lsn+p+lr+++le+++ k  ++ p +    l++ + +l+++lw   + k +vsp+e+l+a+  ++++ f+ 
   Q: 224  VGLNNIKANDYANAVLQALSNVPPLRNYFLEEDNYKNIKRPPGDIMFLLVQRFGELMRKLWnpRNFKAHVSPHEMLQAVVLCSKKtFQI 312
           6*********************************9999***********************999999**************99999*** PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlk................sqikclec 159
           ++q D  +fl+++l++l+++l                          +kkk+k++++d+Fqg+++                +q+  ++ 
   Q: 313  TKQGDGVDFLSWFLNALHSAL------------------------GGTKKKKKTIVNDVFQGSMRiftkklphpdlpaeekEQLLHNDE 377
           *********************........................457888888888888888888888888888888888******** PP
   S: 160  dnvssreepfldlslpvpgkeetkke.........slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsf 239
            +++  e++f++l+l++p     k e          l ++L++f    e e    y++ k     +  k+++l+klP++Li+ +kRf  
   Q: 378  YQETMVESTFMYLTLDLPTAPLYKDEkeqliipqvPLFNILAKFNGITEKE----YKTYK----ENFLKRFQLTKLPPYLIFCIKRF-- 456
           ******************877776664455566666666666666666655....44333....3489*******************.. PP
   S: 240  seeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtevkeeevleet 326
           ++++ + ek+ + v+fp++ +dl+++++++ ++++++++Y+Lia +vH G++s+G Y  +v +  +gkW+++ D +Vt +  + +    
   Q: 457  TKNNFFVEKNPTIVNFPITnVDLREYLSEEVQAVHKNTTYDLIANIVHDGKPSEGSYRIHVLHhGTGKWYELQDLQVTDILPQMITL-- 543
           88889********************************************************9935666******************9.. PP
   S: 327  gstaYvlfYkrr 338
            s+aY+ ++krr
   Q: 544  -SEAYIQIWKRR 554
           .********985 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. Regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint. Does not have ubiquitin-specific peptidase activity, but could be a competitor of ubiquitin C-terminal hydrolases (UCHs) (By similarity).
 Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. Regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint. Does not have ubiquitin-specific peptidase activity, but could be a competitor of ubiquitin C-terminal hydrolases (UCHs) (By similarity).
Protein Sequence
(Fasta)
MSSRSKRQSH GSTRGKRESE SRGSSGRIKK ERDREKEPEA ASSRGSPVRV KREAEPAARE 60
VPAPALPVVR VKREREADED SEPEREVRAK NGRVDSEDRR SRHCPYLDTI NRSVLDFDFE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064424|DUB,USP|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGCGCCGGCG CGGAAGCTCC TAACTGGTGG TGGCGATGTC TAGCCGGTCC AAGCGGCAGT 60
CCCATGGTTC CACCCGCGGG AAGCGTGAGT CCGAGTCTCG TGGCAGCTCG GGTCGCATCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064424|DUB,USP|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0747--Spliceosome
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001394--Peptidase_C19_UCH
IPR033809--USP39
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP
PROSITE

PS50235--USP_3
PS50271--ZF_UBP
Pfam

PF00443--UCH
PF02148--zf-UBP
SMART

SM00290--ZnF_UBP
Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005681--C:spliceosomal complex
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0007049--P:cell cycle
GO:0051301--P:cell division
GO:0016579--P:protein deubiquitination
GO:0000245--P:spliceosomal complex assembly
KEGG mmu:28035
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000483 Aegilops tauschii 52.93 1.00e-127 449.00
IUUC-Aml-001846 Ailuropoda melanoleuca 97.00 0.00e+00 1059.00
IUUC-Atr-002758 Amborella trichopoda 51.28 3.00e-128 452.00
IUUC-Apl-003336 Anas platyrhynchos 91.32 2.00e-175 608.00
IUUC-Aca-004846 Anolis carolinensis 96.93 0.00e+00 904.00
IUUC-Aly-005683 Arabidopsis lyrata 50.98 7.00e-117 414.00
IUUC-Ath-007661 Arabidopsis thaliana 50.33 3.00e-116 412.00
IUUC-Ago-007802 Ashbya gossypii 30.85 4.00e-60 225.00
IUUC-Acl-008304 Aspergillus clavatus 41.43 1.00e-91 330.00
IUUC-Afl-008735 Aspergillus flavus 58.12 1.00e-40 161.00
IUUC-Afu-009100 Aspergillus fumigatus 40.48 4.00e-89 322.00
IUUC-Ani-009138 Aspergillus nidulans 48.89 3.00e-94 339.00
IUUC-Ang-009661 Aspergillus niger 44.61 9.00e-95 340.00
IUUC-Aor-010235 Aspergillus oryzae 38.57 5.00e-79 288.00
IUUC-Ate-010346 Aspergillus terreus 36.33 2.00e-71 263.00
IUUC-Ame-011688 Astyanax mexicanus 89.03 0.00e+00 844.00
IUUC-Bgr-011998 Blumeria graminis 47.82 5.00e-115 407.00
IUUC-Bta-013407 Bos taurus 94.51 0.00e+00 1019.00
IUUC-Bci-013977 Botrytis cinerea 49.13 4.00e-115 408.00
IUUC-Bdi-014361 Brachypodium distachyon 53.13 2.00e-134 472.00
IUUC-Bol-016317 Brassica oleracea 50.44 3.00e-115 409.00
IUUC-Bra-017952 Brassica rapa 50.88 4.00e-116 411.00
IUUC-Cel-018491 Caenorhabditis elegans 62.39 2.00e-177 615.00
IUUC-Cja-019134 Callithrix jacchus 97.92 0.00e+00 1058.00
IUUC-Cfa-020098 Canis familiaris 97.91 0.00e+00 1058.00
IUUC-Cpo-021595 Cavia porcellus 99.38 0.00e+00 994.00
IUUC-Cre-022886 Chlamydomonas reinhardtii 50.81 2.00e-31 127.00
IUUC-Csa-024121 Chlorocebus sabaeus 97.88 0.00e+00 1038.00
IUUC-Cho-025057 Choloepus hoffmanni 77.34 5.00e-86 311.00
IUUC-Cin-025473 Ciona intestinalis 62.96 2.00e-64 238.00
IUUC-Csv-025815 Ciona savignyi 81.62 2.00e-117 416.00
IUUC-Cgl-026416 Colletotrichum gloeosporioides 44.71 9.00e-109 387.00
IUUC-Cne-026802 Cryptococcus neoformans 43.17 1.00e-99 357.00
IUUC-Dre-027870 Danio rerio 88.65 0.00e+00 837.00
IUUC-Dno-029655 Dasypus novemcinctus 93.36 0.00e+00 1041.00
IUUC-Dor-030762 Dipodomys ordii 95.44 0.00e+00 1009.00
IUUC-Dse-031441 Dothistroma septosporum 45.59 1.00e-107 383.00
IUUC-Dme-032101 Drosophila melanogaster 64.71 1.00e-179 622.00
IUUC-Ete-032841 Echinops telfairi 93.18 0.00e+00 985.00
IUUC-Eca-033463 Equus caballus 99.80 0.00e+00 1014.00
IUUC-Eeu-034438 Erinaceus europaeus 71.53 0.00e+00 736.00
IUUC-Fca-035774 Felis catus 97.75 0.00e+00 1066.00
IUUC-Fal-036988 Ficedula albicollis 92.65 0.00e+00 912.00
IUUC-Fox-037895 Fusarium oxysporum 45.57 7.00e-105 374.00
IUUC-Fso-038450 Fusarium solani 46.87 3.00e-106 379.00
IUUC-Gmo-038874 Gadus morhua 87.47 0.00e+00 822.00
IUUC-Ggr-040115 Gaeumannomyces graminis 44.82 2.00e-103 369.00
IUUC-Gac-041650 Gasterosteus aculeatus 85.71 0.00e+00 850.00
IUUC-Gma-043697 Glycine max 50.64 8.00e-128 451.00
IUUC-Ggo-044707 Gorilla gorilla 90.97 0.00e+00 1017.00
IUUC-Hsa-046041 Homo sapiens 98.27 0.00e+00 1041.00
IUUC-Hvu-047816 Hordeum vulgare 50.00 1.00e-121 429.00
IUUC-Itr-048945 Ictidomys tridecemlineatus 99.41 0.00e+00 686.00
IUUC-Lch-050419 Latimeria chalumnae 91.88 0.00e+00 896.00
IUUC-Lpe-051593 Leersia perrieri 53.70 2.00e-134 472.00
IUUC-Loc-052930 Lepisosteus oculatus 86.03 0.00e+00 858.00
IUUC-Lma-053256 Leptosphaeria maculans 48.05 1.00e-112 400.00
IUUC-Laf-053555 Loxodonta africana 99.40 0.00e+00 1014.00
IUUC-Mcc-055630 Macaca mulatta 97.88 0.00e+00 1038.00
IUUC-Meu-056579 Macropus eugenii 94.75 1.00e-180 625.00
IUUC-Mor-057078 Magnaporthe oryzae 42.44 1.00e-103 370.00
IUUC-Mpo-057607 Magnaporthe poae 37.86 8.00e-85 307.00
IUUC-Mtr-058644 Medicago truncatula 49.36 2.00e-127 449.00
IUUC-Mla-059120 Melampsora laricipopulina 40.88 4.00e-101 362.00
IUUC-Mvi-060429 Microbotryum violaceum 46.33 3.00e-68 253.00
IUUC-Mmr-061313 Microcebus murinus 96.06 0.00e+00 1029.00
IUUC-Mdo-062801 Monodelphis domestica 91.49 0.00e+00 1038.00
IUUC-Mac-064694 Musa acuminata 52.75 5.00e-130 457.00
IUUC-Mpu-065980 Mustela putorius furo 99.76 0.00e+00 857.00
IUUC-Mlu-067007 Myotis lucifugus 93.49 0.00e+00 1037.00
IUUC-Nfi-068274 Neosartorya fischeri 39.04 3.00e-89 322.00
IUUC-Ncr-068829 Neurospora crassa 47.53 3.00e-106 379.00
IUUC-Nle-069171 Nomascus leucogenys 99.79 0.00e+00 973.00
IUUC-Opr-070494 Ochotona princeps 89.70 0.00e+00 909.00
IUUC-Ont-072290 Oreochromis niloticus 85.63 0.00e+00 870.00
IUUC-Oan-073099 Ornithorhynchus anatinus 97.07 0.00e+00 955.00
IUUC-Ocu-074642 Oryctolagus cuniculus 99.39 0.00e+00 1009.00
IUUC-Oba-075886 Oryza barthii 53.04 1.00e-133 469.00
IUUC-Obr-076220 Oryza brachyantha 53.04 5.00e-134 471.00
IUUC-Ogl-077682 Oryza glaberrima 53.04 6.00e-134 471.00
IUUC-Ogu-078492 Oryza glumaepatula 52.83 1.00e-133 470.00
IUUC-Oin-079956 Oryza indica 53.04 5.00e-134 471.00
IUUC-Olo-080239 Oryza longistaminata 46.82 2.00e-105 377.00
IUUC-Ome-081573 Oryza meridionalis 53.04 3.00e-134 472.00
IUUC-Oni-082975 Oryza nivara 53.04 5.00e-134 471.00
IUUC-Opu-083724 Oryza punctata 53.26 4.00e-134 471.00
IUUC-Oru-084566 Oryza rufipogon 53.04 6.00e-134 471.00
IUUC-Osa-086008 Oryza sativa 53.04 5.00e-134 471.00
IUUC-Ola-086967 Oryzias latipes 89.18 0.00e+00 848.00
IUUC-Olu-087614 Ostreococcus lucimarinus 43.91 1.00e-96 346.00
IUUC-Oga-088047 Otolemur garnettii 80.33 0.00e+00 664.00
IUUC-Oar-089393 Ovis aries 98.46 0.00e+00 1043.00
IUUC-Ptr-090561 Pan troglodytes 98.27 0.00e+00 1043.00
IUUC-Pan-091812 Papio anubis 97.69 0.00e+00 1036.00
IUUC-Psi-093507 Pelodiscus sinensis 98.99 2.00e-171 594.00
IUUC-Pno-095104 Phaeosphaeria nodorum 46.82 2.00e-110 392.00
IUUC-Ppa-095995 Physcomitrella patens 51.53 5.00e-134 471.00
IUUC-Pfo-096754 Poecilia formosa 88.79 0.00e+00 862.00
IUUC-Pab-098053 Pongo abelii 98.27 0.00e+00 1043.00
IUUC-Pop-099230 Populus trichocarpa 48.15 7.00e-135 474.00
IUUC-Pca-100407 Procavia capensis 91.13 0.00e+00 910.00
IUUC-Ppe-101699 Prunus persica 52.39 2.00e-128 452.00
IUUC-Pva-103159 Pteropus vampyrus 94.34 0.00e+00 1065.00
IUUC-Pgr-103433 Puccinia graminis 42.62 8.00e-104 371.00
IUUC-Ptt-103701 Puccinia triticina 39.44 2.00e-91 330.00
IUUC-Pte-104281 Pyrenophora teres 47.61 2.00e-112 399.00
IUUC-Pyt-104714 Pyrenophora triticirepentis 47.61 4.00e-112 398.00
IUUC-Rno-105531 Rattus norvegicus 99.29 0.00e+00 1107.00
IUUC-Sce-106368 Saccharomyces cerevisiae 29.54 7.00e-47 181.00
IUUC-Sha-107093 Sarcophilus harrisii 97.22 0.00e+00 1003.00
IUUC-Sja-108004 Schizosaccharomyces japonicus 42.44 2.00e-114 406.00
IUUC-Spo-108018 Schizosaccharomyces pombe 47.38 3.00e-113 402.00
IUUC-Ssl-108460 Sclerotinia sclerotiorum 46.65 8.00e-107 380.00
IUUC-Smo-108892 Selaginella moellendorffii 52.37 2.00e-131 462.00
IUUC-Sit-110782 Setaria italica 54.19 1.00e-136 479.00
IUUC-Sly-111308 Solanum lycopersicum 51.96 9.00e-138 483.00
IUUC-Stu-112447 Solanum tuberosum 52.83 4.00e-137 481.00
IUUC-Sar-113352 Sorex araneus 78.58 0.00e+00 803.00
IUUC-Sbi-114806 Sorghum bicolor 54.74 1.00e-135 476.00
IUUC-Sre-115059 Sporisorium reilianum 53.57 4.00e-72 265.00
IUUC-Ssc-115677 Sus scrofa 95.45 0.00e+00 750.00
IUUC-Tru-118478 Takifugu rubripes 86.37 0.00e+00 861.00
IUUC-Tsy-119082 Tarsius syrichta 86.43 0.00e+00 734.00
IUUC-Tni-120419 Tetraodon nigroviridis 85.80 0.00e+00 840.00
IUUC-Tca-121294 Theobroma cacao 51.17 2.00e-134 473.00
IUUC-Tre-121962 Trichoderma reesei 46.02 7.00e-102 364.00
IUUC-Tvi-122280 Trichoderma virens 45.69 4.00e-109 388.00
IUUC-Tae-124442 Triticum aestivum 54.00 1.00e-134 473.00
IUUC-Tur-126551 Triticum urartu 54.00 7.00e-134 470.00
IUUC-Tme-126959 Tuber melanosporum 47.40 6.00e-113 401.00
IUUC-Tbe-127737 Tupaia belangeri 90.72 0.00e+00 949.00
IUUC-Ttr-129211 Tursiops truncatus 97.24 2.00e-170 592.00
IUUC-Uma-129591 Ustilago maydis 39.16 2.00e-95 343.00
IUUC-Vda-129674 Verticillium dahliae 44.30 2.00e-95 343.00
IUUC-Vpa-130793 Vicugna pacos 83.70 0.00e+00 892.00
IUUC-Xtr-132430 Xenopus tropicalis 89.90 0.00e+00 892.00
IUUC-Xma-133515 Xiphophorus maculatus 88.65 0.00e+00 850.00
IUUC-Yli-134488 Yarrowia lipolytica 38.63 2.00e-79 289.00
IUUC-Zma-134748 Zea mays 54.51 4.00e-136 478.00
Created Date 25-Jun-2017

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