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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Sce-106323
UUCD1 version UUC-SaC-00241
Ensembl Protein ID YFL044C
UniProt Accession P43558; D6VTI6; OTU1_YEAST
Genbank Protein ID BAA09197.1; DAA12396.1
Protein Name Ubiquitin thioesterase OTU1; OTU domain-containing protein 1
Genbank Nucleotide ID D50617; BK006940
Gene Name OTU1; YFL044C
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YFL044C YFL044C YFL044C
Annotation
mRNA Expression
GEOFFGED
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMdbPAFBioGRID
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/OTU OTU 18270205
ULD/UDP/UFD/UBX UBX 24610782
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Participates in the regulation of the ubiquin conjugation pathway involving CDC48 by hindering multiubiquitination of substrates at the CDC48 chaperone. May be indireclty involved in PIS1 gene expression.
 Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Participates in the regulation of the ubiquin conjugation pathway involving CDC48 by hindering multiubiquitination of substrates at the CDC48 chaperone. May be indireclty involved in PIS1 gene expression.
Protein Sequence
(Fasta)
MKLKVTGAGI NQVVTLKQDA TLNDLIEHIN VDVKTMRFGY PPQRINLQGE DASLGQTQLD 60
ELGINSGEKI TIESSDSNES FSLPPPQPKP KRVLKSTEMS IGGSGENVLS VHPVLDDNSC 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Sce-106323|DUB,OTU;ULD,UBX|Saccharomyces cerevisiae
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGAAACTGA AAGTTACTGG AGCAGGAATC AACCAAGTCG TTACTTTGAA GCAAGATGCA 60
ACACTAAATG ATCTTATTGA GCATATCAAT GTAGATGTTA AGACGATGAG GTTTGGATAT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106323|DUB,OTU;ULD,UBX|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR003323--OTU_dom
IPR013087--Znf_C2H2_type
PROSITE

PS50802--OTU
PS00028--ZINC_FINGER_C2H2_1
Pfam

PF02338--OTU
Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0046872--F:metal ion binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0030968--P:endoplasmic reticulum unfolded protein response
GO:0016579--P:protein deubiquitination
GO:0006355--P:regulation of transcription, DNA-templated
GO:0030433--P:ubiquitin-dependent ERAD pathway
KEGG sce:YFL044C
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000271 Aegilops tauschii 30.69 2.00e-25 107.00
IUUC-Aml-001860 Ailuropoda melanoleuca 31.62 4.00e-37 146.00
IUUC-Atr-002548 Amborella trichopoda 30.77 8.00e-31 124.00
IUUC-Apl-004025 Anas platyrhynchos 32.99 1.00e-32 130.00
IUUC-Aca-004505 Anolis carolinensis 30.74 1.00e-39 154.00
IUUC-Aly-005999 Arabidopsis lyrata 30.54 7.00e-30 121.00
IUUC-Ath-006774 Arabidopsis thaliana 30.05 4.00e-30 122.00
IUUC-Ago-007741 Ashbya gossypii 41.14 7.00e-69 251.00
IUUC-Acl-008278 Aspergillus clavatus 31.75 5.00e-40 155.00
IUUC-Afl-008710 Aspergillus flavus 30.99 6.00e-40 155.00
IUUC-Afu-009009 Aspergillus fumigatus 30.06 1.00e-39 154.00
IUUC-Ani-009430 Aspergillus nidulans 33.23 5.00e-40 155.00
IUUC-Ang-009508 Aspergillus niger 30.57 2.00e-23 100.00
IUUC-Aor-009992 Aspergillus oryzae 30.99 6.00e-40 155.00
IUUC-Ate-010440 Aspergillus terreus 31.44 4.00e-37 146.00
IUUC-Ame-011038 Astyanax mexicanus 29.79 7.00e-36 142.00
IUUC-Bgr-012262 Blumeria graminis 27.40 1.00e-33 135.00
IUUC-Bta-012864 Bos taurus 30.93 6.00e-35 139.00
IUUC-Bci-013986 Botrytis cinerea 32.34 1.00e-33 135.00
IUUC-Bdi-014194 Brachypodium distachyon 33.33 4.00e-31 125.00
IUUC-Bol-016166 Brassica oleracea 30.54 3.00e-30 122.00
IUUC-Bra-017783 Brassica rapa 31.03 1.00e-30 124.00
IUUC-Cja-019488 Callithrix jacchus 32.37 4.00e-37 146.00
IUUC-Cfa-020096 Canis familiaris 25.00 1.10e-01 29.30
IUUC-Cpo-021728 Cavia porcellus 31.29 3.00e-35 140.00
IUUC-Cre-022819 Chlamydomonas reinhardtii 30.00 1.00e-22 97.40
IUUC-Csa-024237 Chlorocebus sabaeus 32.37 1.00e-36 144.00
IUUC-Cho-024544 Choloepus hoffmanni 30.82 3.00e-35 140.00
IUUC-Cin-025549 Ciona intestinalis 29.24 1.00e-29 121.00
IUUC-Cgl-026552 Colletotrichum gloeosporioides 28.18 1.00e-27 115.00
IUUC-Cne-027022 Cryptococcus neoformans 29.72 7.00e-29 119.00
IUUC-Cme-027196 Cyanidioschyzon merolae 31.84 2.00e-26 110.00
IUUC-Dre-027799 Danio rerio 29.49 9.00e-34 135.00
IUUC-Dno-029863 Dasypus novemcinctus 30.51 1.00e-33 135.00
IUUC-Dor-030804 Dipodomys ordii 33.50 2.00e-31 127.00
IUUC-Dse-031494 Dothistroma septosporum 27.01 9.00e-32 128.00
IUUC-Dme-032065 Drosophila melanogaster 30.69 9.00e-33 132.00
IUUC-Ete-033193 Echinops telfairi 33.46 1.00e-37 148.00
IUUC-Eca-033993 Equus caballus 31.62 2.00e-36 144.00
IUUC-Fca-035949 Felis catus 31.62 5.00e-37 146.00
IUUC-Fal-037473 Ficedula albicollis 34.87 6.00e-34 135.00
IUUC-Fox-037779 Fusarium oxysporum 29.47 2.00e-21 94.00
IUUC-Fso-038370 Fusarium solani 29.67 5.00e-19 86.30
IUUC-Gmo-038778 Gadus morhua 30.27 1.00e-26 111.00
IUUC-Ggr-039940 Gaeumannomyces graminis 29.97 6.00e-31 125.00
IUUC-Gga-041102 Gallus gallus 30.85 2.00e-37 146.00
IUUC-Gac-041954 Gasterosteus aculeatus 31.67 7.00e-38 148.00
IUUC-Gma-043608 Glycine max 31.73 9.00e-32 127.00
IUUC-Ggo-044753 Gorilla gorilla 32.37 3.00e-36 143.00
IUUC-Hsa-045714 Homo sapiens 32.62 1.00e-36 144.00
IUUC-Hvu-047600 Hordeum vulgare 33.33 1.00e-30 124.00
IUUC-Itr-048026 Ictidomys tridecemlineatus 32.72 9.00e-37 145.00
IUUC-Kpa-049360 Komagataella pastoris 31.06 4.00e-39 152.00
IUUC-Lch-049900 Latimeria chalumnae 31.69 6.00e-36 142.00
IUUC-Lpe-050984 Leersia perrieri 28.21 2.00e-18 83.20
IUUC-Loc-052567 Lepisosteus oculatus 31.03 8.00e-40 155.00
IUUC-Lma-053247 Leptosphaeria maculans 29.43 8.00e-35 138.00
IUUC-Laf-053361 Loxodonta africana 32.36 8.00e-36 142.00
IUUC-Meu-056137 Macropus eugenii 28.88 5.00e-29 119.00
IUUC-Mor-057191 Magnaporthe oryzae 28.21 3.00e-20 90.50
IUUC-Mpo-057565 Magnaporthe poae 28.89 1.00e-23 101.00
IUUC-Mtr-058196 Medicago truncatula 31.03 1.00e-29 120.00
IUUC-Mla-059096 Melampsora laricipopulina 31.73 9.00e-25 105.00
IUUC-Mga-059489 Meleagris gallopavo 33.00 4.00e-33 132.00
IUUC-Mvi-060300 Microbotryum violaceum 33.33 7.00e-32 129.00
IUUC-Mmr-061618 Microcebus murinus 31.54 1.00e-35 141.00
IUUC-Mdo-061909 Monodelphis domestica 31.65 7.00e-36 142.00
IUUC-Mmu-063434 Mus musculus 33.09 3.00e-38 150.00
IUUC-Mac-064676 Musa acuminata 31.47 9.00e-30 121.00
IUUC-Mpu-066733 Mustela putorius furo 31.62 2.00e-37 147.00
IUUC-Mlu-066990 Myotis lucifugus 31.62 1.00e-36 144.00
IUUC-Nfi-068249 Neosartorya fischeri 30.52 4.00e-40 156.00
IUUC-Ncr-068764 Neurospora crassa 30.67 2.00e-29 120.00
IUUC-Nle-069094 Nomascus leucogenys 32.01 2.00e-36 144.00
IUUC-Ont-072124 Oreochromis niloticus 26.42 1.50e-02 33.10
IUUC-Oan-073585 Ornithorhynchus anatinus 30.88 5.00e-35 139.00
IUUC-Oba-075949 Oryza barthii 31.03 2.00e-31 126.00
IUUC-Obr-076096 Oryza brachyantha 31.53 8.00e-32 127.00
IUUC-Ogl-077106 Oryza glaberrima 31.03 2.00e-31 126.00
IUUC-Ogu-078024 Oryza glumaepatula 31.03 4.00e-31 125.00
IUUC-Oin-079635 Oryza indica 31.03 5.00e-31 125.00
IUUC-Olo-080299 Oryza longistaminata 31.03 2.00e-31 126.00
IUUC-Ome-081359 Oryza meridionalis 31.03 4.00e-31 125.00
IUUC-Oni-082459 Oryza nivara 30.54 6.00e-31 124.00
IUUC-Opu-083167 Oryza punctata 31.92 7.00e-32 128.00
IUUC-Oru-084577 Oryza rufipogon 31.03 5.00e-31 125.00
IUUC-Osa-085746 Oryza sativa 32.65 4.00e-06 40.00
IUUC-Ola-086890 Oryzias latipes 30.74 2.00e-39 153.00
IUUC-Olu-087585 Ostreococcus lucimarinus 31.44 8.00e-28 114.00
IUUC-Oga-088190 Otolemur garnettii 32.73 8.00e-37 145.00
IUUC-Oar-089631 Ovis aries 31.27 2.00e-35 140.00
IUUC-Pan-091892 Papio anubis 32.37 2.00e-36 144.00
IUUC-Psi-093696 Pelodiscus sinensis 27.43 8.00e-07 47.80
IUUC-Pma-094491 Petromyzon marinus 27.27 1.00e-29 121.00
IUUC-Pno-094993 Phaeosphaeria nodorum 37.50 1.00e-36 145.00
IUUC-Ppa-095791 Physcomitrella patens 30.58 8.00e-30 121.00
IUUC-Pfo-096301 Poecilia formosa 30.50 3.00e-38 149.00
IUUC-Pab-097873 Pongo abelii 31.65 4.00e-36 143.00
IUUC-Pop-099482 Populus trichocarpa 30.66 3.00e-32 129.00
IUUC-Pca-100817 Procavia capensis 30.77 7.00e-33 132.00
IUUC-Ppe-101624 Prunus persica 32.37 2.00e-33 133.00
IUUC-Pva-102120 Pteropus vampyrus 31.16 2.00e-35 140.00
IUUC-Pgr-103368 Puccinia graminis 34.09 8.00e-31 125.00
IUUC-Ptt-103923 Puccinia triticina 34.39 8.00e-30 122.00
IUUC-Pte-104199 Pyrenophora teres 36.23 3.00e-36 143.00
IUUC-Pyt-104502 Pyrenophora triticirepentis 36.23 7.00e-36 142.00
IUUC-Rno-105605 Rattus norvegicus 32.37 5.00e-37 146.00
IUUC-Sha-107176 Sarcophilus harrisii 31.90 2.00e-36 143.00
IUUC-Sja-107812 Schizosaccharomyces japonicus 25.93 2.00e-31 127.00
IUUC-Spo-108085 Schizosaccharomyces pombe 30.15 2.00e-33 134.00
IUUC-Smo-109050 Selaginella moellendorffii 32.38 9.00e-31 124.00
IUUC-Sit-110056 Setaria italica 34.18 1.00e-31 127.00
IUUC-Sly-111869 Solanum lycopersicum 33.33 1.00e-27 113.00
IUUC-Stu-112452 Solanum tuberosum 34.36 7.00e-32 127.00
IUUC-Sar-113629 Sorex araneus 27.12 3.00e-08 50.40
IUUC-Sbi-114422 Sorghum bicolor 33.33 7.00e-32 128.00
IUUC-Sre-115105 Sporisorium reilianum 35.50 1.00e-26 111.00
IUUC-Ssc-115553 Sus scrofa 31.62 3.00e-36 143.00
IUUC-Tgu-116921 Taeniopygia guttata 31.64 4.00e-34 135.00
IUUC-Tru-117830 Takifugu rubripes 29.93 1.00e-37 147.00
IUUC-Tsy-119320 Tarsius syrichta 32.37 7.00e-37 145.00
IUUC-Tni-119706 Tetraodon nigroviridis 30.99 1.00e-36 144.00
IUUC-Tca-121238 Theobroma cacao 32.55 7.00e-33 131.00
IUUC-Tre-122220 Trichoderma reesei 27.03 8.90e-02 29.60
IUUC-Tae-124711 Triticum aestivum 32.51 5.00e-32 129.00
IUUC-Tme-126966 Tuber melanosporum 28.53 5.00e-37 146.00
IUUC-Tbe-127712 Tupaia belangeri 32.61 1.00e-24 103.00
IUUC-Ttr-129168 Tursiops truncatus 30.93 2.00e-35 140.00
IUUC-Uma-129461 Ustilago maydis 36.59 2.00e-35 141.00
IUUC-Vda-129890 Verticillium dahliae 32.42 6.00e-23 99.00
IUUC-Vpa-130616 Vicugna pacos 32.01 2.00e-37 147.00
IUUC-Vvi-131250 Vitis vinifera 31.75 5.00e-31 125.00
IUUC-Xtr-132126 Xenopus tropicalis 29.41 8.00e-35 138.00
IUUC-Xma-133596 Xiphophorus maculatus 29.43 2.00e-37 147.00
IUUC-Yli-134562 Yarrowia lipolytica 30.21 1.00e-41 161.00
IUUC-Zma-135205 Zea mays 34.18 3.00e-31 125.00
Created Date 25-Jun-2017

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