iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Rno-105111

Ensembl Protein ID

ENSRNOP00000040067.3

UniProt Accession

P60522; O08765; Q9DCP8; Q9UQF7; GBRL2_RAT

Genbank Protein ID

BAA19975.1; AAH58145.1; AAH88139.1

Protein Name

Gamma-aminobutyric acid receptor-associated protein-like 2; GABA(A) receptor-associated protein-like 2; Ganglioside expression factor 2; Golgi-associated ATPase enhancer of 16 kDa

Genbank Nucleotide ID

AB003515; BC058145; BC088139

Gene Name

Gabarapl2; Gef2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000019425.5	ENSRNOT00000048998.3	ENSRNOP00000040067.3

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
ULD/UBL/ATG8	56.03	1.00e-35	142.00	IUUC-Sce-106150

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Rattus norvegicus

Functional Description
(View)

Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1. Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity).

Protein Sequence
(Fasta)

MKWMFKEDHS LEHRCVESAK IRAKYPDRVP VIVEKVSGSQ IVDIDKRKYL VPSDITVAQF 60
MWIIRKRIQL PSEKAIFLFV DKTVPQSSLT MGQLYEKEKD EDGFLYVAYS GENTFGF 117

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Nucleotide Sequence
(Fasta)

CGTTGTTGTT GTGGTCGCTT CGCCGAAGTC TGCGGCTCAA AGAGCCGGCT CCGTCGCTTC 60
CCGCCGCCAT GAAGTGGATG TTTAAGGAGG ACCACTCGCT GGGTAAGCGA GGCAGGTCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0333--Golgi apparatus
KW-0449--Lipoprotein
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport

Interpro

IPR004241--Atg8-like
IPR029071--Ubiquitin-rel_dom

Pfam

PF02991--Atg8

Gene Ontology

GO:0005776--C:autophagosome
GO:0031410--C:cytoplasmic vesicle
GO:0005794--C:Golgi apparatus
GO:0006914--P:autophagy
GO:0015031--P:protein transport

KEGG

rno:100359937; rno:64670

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000059	Aegilops tauschii	60.00	5.00e-39	152.00
IUUC-Aml-001629	Ailuropoda melanoleuca	100.00	1.00e-65	241.00
IUUC-Atr-002842	Amborella trichopoda	62.50	6.00e-35	139.00
IUUC-Aca-005288	Anolis carolinensis	99.14	3.00e-65	239.00
IUUC-Aly-005554	Arabidopsis lyrata	62.07	3.00e-35	139.00
IUUC-Ath-006958	Arabidopsis thaliana	62.07	3.00e-35	139.00
IUUC-Ani-009196	Aspergillus nidulans	59.48	5.00e-39	152.00
IUUC-Ame-010751	Astyanax mexicanus	98.29	5.00e-65	238.00
IUUC-Bta-012520	Bos taurus	99.15	1.00e-65	240.00
IUUC-Bdi-014390	Brachypodium distachyon	61.06	9.00e-40	154.00
IUUC-Bol-016488	Brassica oleracea	62.93	6.00e-41	159.00
IUUC-Bra-017452	Brassica rapa	61.21	1.00e-40	157.00
IUUC-Cja-019273	Callithrix jacchus	99.15	8.00e-66	241.00
IUUC-Cfa-020373	Canis familiaris	100.00	3.00e-66	242.00
IUUC-Cpo-021831	Cavia porcellus	100.00	3.00e-66	242.00
IUUC-Cre-022866	Chlamydomonas reinhardtii	62.50	3.00e-35	140.00
IUUC-Csa-024201	Chlorocebus sabaeus	100.00	3.00e-66	242.00
IUUC-Dre-028371	Danio rerio	96.58	5.00e-64	235.00
IUUC-Dno-029331	Dasypus novemcinctus	100.00	1.00e-65	240.00
IUUC-Dor-030453	Dipodomys ordii	100.00	3.00e-66	242.00
IUUC-Eca-034113	Equus caballus	100.00	5.00e-66	242.00
IUUC-Fca-036385	Felis catus	100.00	3.00e-66	242.00
IUUC-Fal-036896	Ficedula albicollis	99.15	7.00e-66	241.00
IUUC-Gmo-039289	Gadus morhua	98.29	4.00e-65	239.00
IUUC-Ggr-039770	Gaeumannomyces graminis	58.62	9.00e-38	148.00
IUUC-Gac-041604	Gasterosteus aculeatus	98.29	7.00e-65	238.00
IUUC-Gma-043572	Glycine max	62.50	2.00e-34	137.00
IUUC-Ggo-044429	Gorilla gorilla	100.00	3.00e-66	242.00
IUUC-Hsa-046764	Homo sapiens	100.00	3.00e-66	242.00
IUUC-Hvu-047062	Hordeum vulgare	60.00	5.00e-39	152.00
IUUC-Kpa-049124	Komagataella pastoris	58.62	1.00e-38	151.00
IUUC-Lch-049542	Latimeria chalumnae	97.44	3.00e-64	236.00
IUUC-Lpe-051450	Leersia perrieri	60.34	3.00e-39	153.00
IUUC-Meu-056515	Macropus eugenii	100.00	3.00e-66	242.00
IUUC-Mor-057276	Magnaporthe oryzae	58.62	1.00e-37	148.00
IUUC-Mpo-057469	Magnaporthe poae	58.62	9.00e-38	148.00
IUUC-Mtr-058417	Medicago truncatula	61.74	1.00e-34	137.00
IUUC-Mdo-061915	Monodelphis domestica	100.00	2.00e-66	244.00
IUUC-Mmu-064152	Mus musculus	100.00	3.00e-66	242.00
IUUC-Mac-065529	Musa acuminata	61.74	1.00e-35	140.00
IUUC-Mpu-066760	Mustela putorius furo	100.00	2.00e-66	243.00
IUUC-Mlu-068211	Myotis lucifugus	100.00	3.00e-66	242.00
IUUC-Nle-069755	Nomascus leucogenys	100.00	3.00e-66	242.00
IUUC-Ont-072343	Oreochromis niloticus	97.44	4.00e-65	239.00
IUUC-Oan-073485	Ornithorhynchus anatinus	99.06	4.00e-58	215.00
IUUC-Ocu-073861	Oryctolagus cuniculus	100.00	3.00e-66	242.00
IUUC-Oba-075722	Oryza barthii	60.34	8.00e-40	155.00
IUUC-Obr-076374	Oryza brachyantha	61.06	2.00e-39	154.00
IUUC-Ogl-077551	Oryza glaberrima	60.34	8.00e-40	155.00
IUUC-Ogu-078499	Oryza glumaepatula	60.34	8.00e-40	155.00
IUUC-Oin-079771	Oryza indica	61.06	2.00e-39	154.00
IUUC-Olo-080412	Oryza longistaminata	61.06	2.00e-39	154.00
IUUC-Ome-081791	Oryza meridionalis	61.06	2.00e-39	154.00
IUUC-Oni-082774	Oryza nivara	61.06	2.00e-39	154.00
IUUC-Opu-083486	Oryza punctata	61.06	7.00e-39	154.00
IUUC-Oru-084425	Oryza rufipogon	60.34	3.00e-39	152.00
IUUC-Osa-085439	Oryza sativa	61.06	2.00e-39	154.00
IUUC-Ola-086310	Oryzias latipes	94.02	3.00e-63	232.00
IUUC-Oga-088483	Otolemur garnettii	100.00	3.00e-66	242.00
IUUC-Ptr-091560	Pan troglodytes	100.00	3.00e-66	242.00
IUUC-Pan-092269	Papio anubis	100.00	3.00e-66	242.00
IUUC-Pma-094337	Petromyzon marinus	85.34	8.00e-57	211.00
IUUC-Pfo-096380	Poecilia formosa	98.28	2.00e-64	236.00
IUUC-Pab-098563	Pongo abelii	100.00	3.00e-66	242.00
IUUC-Pop-099701	Populus trichocarpa	62.61	2.00e-35	140.00
IUUC-Ppe-101863	Prunus persica	62.07	1.00e-35	140.00
IUUC-Sce-106150	Saccharomyces cerevisiae	56.03	4.00e-36	142.00
IUUC-Sja-107857	Schizosaccharomyces japonicus	57.76	3.00e-38	150.00
IUUC-Spo-108156	Schizosaccharomyces pombe	60.34	2.00e-33	134.00
IUUC-Smo-109082	Selaginella moellendorffii	59.48	3.00e-39	153.00
IUUC-Sly-110959	Solanum lycopersicum	60.34	6.00e-35	139.00
IUUC-Stu-112323	Solanum tuberosum	60.34	6.00e-35	139.00
IUUC-Sbi-114346	Sorghum bicolor	61.06	2.00e-39	153.00
IUUC-Sre-114964	Sporisorium reilianum	59.83	1.00e-39	154.00
IUUC-Ssc-115828	Sus scrofa	100.00	3.00e-66	242.00
IUUC-Tgu-117195	Taeniopygia guttata	99.15	6.00e-66	241.00
IUUC-Tni-120706	Tetraodon nigroviridis	96.58	6.00e-64	235.00
IUUC-Tca-121217	Theobroma cacao	61.74	5.00e-35	139.00
IUUC-Tae-122697	Triticum aestivum	60.00	2.00e-38	152.00
IUUC-Tur-126158	Triticum urartu	59.13	4.00e-38	149.00
IUUC-Tme-126955	Tuber melanosporum	58.97	5.00e-39	153.00
IUUC-Tbe-127765	Tupaia belangeri	100.00	9.00e-47	177.00
IUUC-Ttr-128205	Tursiops truncatus	100.00	3.00e-66	242.00
IUUC-Uma-129435	Ustilago maydis	60.34	1.00e-39	154.00
IUUC-Vpa-130804	Vicugna pacos	97.44	3.00e-64	236.00
IUUC-Vvi-131085	Vitis vinifera	61.95	7.00e-40	155.00
IUUC-Xtr-132685	Xenopus tropicalis	100.00	9.00e-66	241.00
IUUC-Xma-133675	Xiphophorus maculatus	98.28	2.00e-64	236.00
IUUC-Yli-134327	Yarrowia lipolytica	60.34	3.00e-33	133.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence