iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Ath-006950

UUCD1 version

UUC-ArT-01353

Ensembl Protein ID

AT4G25230.1

UniProt Accession

Q8VYC8; A6XER5; Q9SB40; RIN2_ARATH

Genbank Protein ID

CAA23064.1; CAB81334.1; AEE85028.1; AEE85029.1; ANM66650.1; AAL60000.1; ABG85249.1

Protein Name

E3 ubiquitin protein ligase RIN2; AMF receptor-like protein 1A; RING-type E3 ubiquitin transferase RIN2; RPM1-interacting protein 2

Genbank Nucleotide ID

AL035396; AL161563; CP002687; CP002687; CP002687; AY072178; DQ677669

Gene Name

RIN2; AMFR-1A; At4g25230; F24A6.70

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT4G25230	AT4G25230.1	AT4G25230.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	HINT	Mentha
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	17056617
UBD/Alpha-Helix/CUE	CUE	16212605

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	1.50e-07	32.7	337	379
UBD/Alpha-Helix/CUE	2.50e-10	41.0	540	578

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           CaiC+e++ +  + l C+H+fh+ Cl  w  l +  +   +CP+Cr
   Q: 337  CAICREPMAK-AKRLHCNHLFHLGCLRSW--LDQGLNEVYSCPTCR 379
           ********99.888***************..777899999*****8 PP

UBD/Alpha-Helix/CUE

   S: 3    etaleqLkeiFPnldysviqvvLeantgsleaavnnLLeg 42
             ++e+++e++P++++++i ++L ++t+s+  +vnnLL++
   Q: 540  LAMAETVREVMPHVPDEIIFQDL-QRTNSVAVTVNNLLQM 578
           579********************.**************98 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

E3 ubiquitin protein ligase that acts as positive regulator of RPM1- and RPS2-dependent hypersensitive response (HR), in association with RIN3. Probably not required for RPM1 degradation during HR.

Protein Sequence
(Fasta)

MGIKYLPVSV ASTALSFVGL QVWTELSLDR LRADGLIAKN ISLGDSEHAL ELLLGSYFTI 60
ALLTNFVLNV YILLVLSLKT LFFGDLYDVE TKKLVERLAN YIIYKGTFLP LVIPPTIFQG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTGTTTTCCA GGAAGGAAGA AGATATCGAA TTTTGCTCTT TCTACTTTTC GATTCTCTCT 60
CGATCGAGAG GAGAAAAAGA CAGAGAGGCA CGGTGACACG CTGCTTTCAC AGAATTTCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0381--Hypersensitive response
KW-0472--Membrane
KW-0479--Metal-binding
KW-0611--Plant defense
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003892--CUE
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51140--CUE
PS50089--ZF_RING_2

Pfam

PF02845--CUE
PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0016021--C:integral component of membrane
GO:0005886--C:plasma membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0009626--P:plant-type hypersensitive response
GO:0034052--P:positive regulation of plant-type hypersensitive response
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

ath:AT4G25230

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000658	Aegilops tauschii	37.62	5.00e-22	96.70
IUUC-Atr-003008	Amborella trichopoda	55.33	0.00e+00	627.00
IUUC-Aly-006193	Arabidopsis lyrata	97.23	0.00e+00	1076.00
IUUC-Bdi-014169	Brachypodium distachyon	51.73	2.00e-124	439.00
IUUC-Bol-015123	Brassica oleracea	94.14	0.00e+00	1087.00
IUUC-Bra-017662	Brassica rapa	91.18	0.00e+00	970.00
IUUC-Csv-026133	Ciona savignyi	24.54	3.00e-35	142.00
IUUC-Gma-043393	Glycine max	66.55	0.00e+00	803.00
IUUC-Lpe-051410	Leersia perrieri	51.74	2.00e-69	254.00
IUUC-Mtr-058643	Medicago truncatula	67.06	0.00e+00	816.00
IUUC-Mac-065495	Musa acuminata	54.30	3.00e-159	554.00
IUUC-Oba-074987	Oryza barthii	41.45	1.00e-90	326.00
IUUC-Obr-076485	Oryza brachyantha	51.59	3.00e-126	444.00
IUUC-Ogu-078481	Oryza glumaepatula	40.79	1.00e-94	339.00
IUUC-Oin-079556	Oryza indica	47.00	2.00e-128	452.00
IUUC-Olo-080588	Oryza longistaminata	55.30	4.00e-39	153.00
IUUC-Ome-081941	Oryza meridionalis	43.29	5.00e-102	364.00
IUUC-Oni-082488	Oryza nivara	40.35	4.00e-94	338.00
IUUC-Opu-083500	Oryza punctata	45.78	9.00e-105	373.00
IUUC-Oru-085082	Oryza rufipogon	41.45	1.00e-90	326.00
IUUC-Osa-085509	Oryza sativa	51.04	4.00e-133	467.00
IUUC-Ppa-095969	Physcomitrella patens	44.23	2.00e-119	422.00
IUUC-Pop-099576	Populus trichocarpa	69.69	0.00e+00	793.00
IUUC-Ppe-102033	Prunus persica	69.85	0.00e+00	814.00
IUUC-Smo-109664	Selaginella moellendorffii	44.29	3.00e-115	408.00
IUUC-Sit-110161	Setaria italica	51.77	8.00e-138	483.00
IUUC-Sly-111850	Solanum lycopersicum	63.44	0.00e+00	703.00
IUUC-Sbi-113957	Sorghum bicolor	51.32	1.00e-141	495.00
IUUC-Tca-121783	Theobroma cacao	71.38	0.00e+00	839.00
IUUC-Tae-125510	Triticum aestivum	47.59	1.00e-101	362.00
IUUC-Vvi-130989	Vitis vinifera	70.02	0.00e+00	827.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence