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Tag Content
UUCD2 ID IUUC-Dre-028094
UUCD1 version UUC-DaR-01255
Ensembl Protein ID ENSDARP00000046780.5
UniProt Accession Q6PC78; RN185_DANRE
Genbank Protein ID AAH59445.1
Protein Name E3 ubiquitin-protein ligase RNF185; RING finger protein 185; RING-type E3 ubiquitin transferase RNF185
Genbank Nucleotide ID BC059445
Gene Name rnf185; zgc:73070
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSDARG00000032997.6 ENSDART00000046781.6 ENSDARP00000046780.5
ENSDARG00000032997.6 ENSDART00000163101.1 ENSDARP00000139680.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/RING 2.50e-07 32.0 41 82
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iCl+  kd  ++  CgH+f+  Cl++w        +++ CP+C+
   Q: 41   CNICLDTSKD-AVISLCGHLFCWPCLHQW---LETRPNRQVCPVCK 82
           99********.77788*************...666999999****7 PP
   
Organism Danio rerio
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2.
 E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2.
Protein Sequence
(Fasta)
MASAAASESS SSSSSSSAGA ANGQSAGESG GGGAQDSTFE CNICLDTSKD AVISLCGHLF 60
CWPCLHQWLE TRPNRQVCPV CKAGISRDKV IPLYGRGSTG QQDPREKTPP RPQGQRPEPE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Dre-028094|E3,RING|Danio rerio
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGAGCGATGG CTGTTTGTTG ACGCATCAGC TGAAGTTGAA GAGCAGCGGC TCGTGTTTCT 60
CCTCAGACGC GCAGGTAAGC GTTTATCACT ATTATACACG GTTACAGACG AGCTAGCGTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dre-028094|E3,RING|Danio rerio
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0479--Metal-binding
KW-0496--Mitochondrion
KW-1000--Mitochondrion outer membrane
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2
SMART

SM00184--RING
Gene Ontology

GO:0036513--C:Derlin-1 retrotranslocation complex
GO:0016021--C:integral component of membrane
GO:0005741--C:mitochondrial outer membrane
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:0044390--F:ubiquitin-like protein conjugating enzyme binding
GO:0008270--F:zinc ion binding
GO:0006914--P:autophagy
GO:0071712--P:ER-associated misfolded protein catabolic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
KEGG dre:406310
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001042 Aegilops tauschii 50.57 5.00e-23 101.00
IUUC-Aml-001875 Ailuropoda melanoleuca 96.86 3.00e-59 221.00
IUUC-Atr-002721 Amborella trichopoda 54.65 2.00e-24 105.00
IUUC-Apl-003744 Anas platyrhynchos 98.59 5.00e-40 155.00
IUUC-Aca-004254 Anolis carolinensis 80.56 4.00e-33 133.00
IUUC-Aly-006065 Arabidopsis lyrata 55.81 3.00e-25 108.00
IUUC-Ath-007267 Arabidopsis thaliana 55.81 5.00e-25 107.00
IUUC-Ame-011667 Astyanax mexicanus 98.08 2.00e-53 201.00
IUUC-Bgr-012018 Blumeria graminis 40.98 4.00e-09 55.50
IUUC-Bta-012734 Bos taurus 96.86 6.00e-59 219.00
IUUC-Bci-013671 Botrytis cinerea 48.98 3.00e-09 56.20
IUUC-Bdi-014183 Brachypodium distachyon 51.76 2.00e-22 99.00
IUUC-Bol-016132 Brassica oleracea 55.06 2.00e-25 108.00
IUUC-Bra-017631 Brassica rapa 33.49 1.00e-26 113.00
IUUC-Cel-018228 Caenorhabditis elegans 70.24 1.00e-33 136.00
IUUC-Cja-019136 Callithrix jacchus 96.23 1.00e-58 219.00
IUUC-Cfa-020308 Canis familiaris 96.86 3.00e-59 221.00
IUUC-Cpo-021347 Cavia porcellus 97.48 2.00e-59 221.00
IUUC-Cre-022829 Chlamydomonas reinhardtii 55.17 7.00e-26 108.00
IUUC-Csa-023755 Chlorocebus sabaeus 96.86 3.00e-59 221.00
IUUC-Cme-027164 Cyanidioschyzon merolae 46.15 3.00e-16 79.00
IUUC-Dno-029402 Dasypus novemcinctus 96.86 3.00e-59 221.00
IUUC-Dor-030373 Dipodomys ordii 96.86 3.00e-59 221.00
IUUC-Dme-031966 Drosophila melanogaster 60.38 7.00e-54 203.00
IUUC-Ete-032786 Echinops telfairi 96.23 5.00e-59 220.00
IUUC-Eca-034261 Equus caballus 96.86 3.00e-59 221.00
IUUC-Eeu-034614 Erinaceus europaeus 86.79 2.00e-46 178.00
IUUC-Fca-036049 Felis catus 96.86 3.00e-59 221.00
IUUC-Fal-037085 Ficedula albicollis 96.23 1.00e-58 218.00
IUUC-Fso-038195 Fusarium solani 41.82 1.00e-08 54.30
IUUC-Gmo-039369 Gadus morhua 97.48 2.00e-54 205.00
IUUC-Gga-040514 Gallus gallus 96.23 2.00e-58 218.00
IUUC-Gac-041719 Gasterosteus aculeatus 98.11 1.00e-55 209.00
IUUC-Gma-043248 Glycine max 58.14 4.00e-26 111.00
IUUC-Ggo-044504 Gorilla gorilla 96.86 3.00e-59 221.00
IUUC-Hsa-045707 Homo sapiens 96.86 3.00e-59 221.00
IUUC-Hvu-047487 Hordeum vulgare 50.57 1.00e-22 100.00
IUUC-Itr-048343 Ictidomys tridecemlineatus 96.86 5.00e-59 220.00
IUUC-Lch-050658 Latimeria chalumnae 89.94 3.00e-56 211.00
IUUC-Lpe-051034 Leersia perrieri 54.12 4.00e-24 104.00
IUUC-Loc-052118 Lepisosteus oculatus 96.23 5.00e-54 203.00
IUUC-Laf-054438 Loxodonta africana 96.86 4.00e-59 220.00
IUUC-Mcc-054641 Macaca mulatta 93.08 6.00e-52 196.00
IUUC-Meu-056828 Macropus eugenii 88.41 6.00e-32 128.00
IUUC-Mpo-057431 Magnaporthe poae 35.29 1.00e-08 54.30
IUUC-Mtr-058107 Medicago truncatula 58.14 1.00e-25 110.00
IUUC-Mga-059554 Meleagris gallopavo 96.23 2.00e-58 218.00
IUUC-Mvi-060316 Microbotryum violaceum 50.88 1.00e-11 63.50
IUUC-Mmr-061662 Microcebus murinus 90.74 2.00e-50 191.00
IUUC-Mdo-062774 Monodelphis domestica 96.86 3.00e-59 221.00
IUUC-Mmu-063372 Mus musculus 96.86 8.00e-59 219.00
IUUC-Mac-065053 Musa acuminata 53.57 2.00e-22 99.40
IUUC-Mpu-066033 Mustela putorius furo 96.86 3.00e-59 224.00
IUUC-Mlu-067254 Myotis lucifugus 96.86 3.00e-59 221.00
IUUC-Ncr-068628 Neurospora crassa 43.14 1.00e-09 57.80
IUUC-Nle-069850 Nomascus leucogenys 96.86 3.00e-59 221.00
IUUC-Opr-070197 Ochotona princeps 84.91 8.00e-55 206.00
IUUC-Ont-071950 Oreochromis niloticus 97.45 3.00e-58 217.00
IUUC-Oan-073480 Ornithorhynchus anatinus 96.86 3.00e-59 221.00
IUUC-Ocu-073878 Oryctolagus cuniculus 88.68 4.00e-59 220.00
IUUC-Oba-075248 Oryza barthii 53.42 2.00e-22 98.60
IUUC-Obr-076382 Oryza brachyantha 52.94 8.00e-24 103.00
IUUC-Ogl-077553 Oryza glaberrima 52.27 5.00e-25 107.00
IUUC-Ogu-078463 Oryza glumaepatula 52.27 3.00e-25 108.00
IUUC-Oin-080177 Oryza indica 52.27 5.00e-25 107.00
IUUC-Olo-080378 Oryza longistaminata 51.76 2.00e-22 99.00
IUUC-Ome-081605 Oryza meridionalis 52.27 5.00e-25 107.00
IUUC-Oni-082458 Oryza nivara 52.27 1.00e-24 107.00
IUUC-Opu-083362 Oryza punctata 54.12 4.00e-24 105.00
IUUC-Oru-084757 Oryza rufipogon 52.27 4.00e-25 108.00
IUUC-Osa-086198 Oryza sativa 49.46 6.00e-25 107.00
IUUC-Ola-086800 Oryzias latipes 98.11 2.00e-55 208.00
IUUC-Olu-087623 Ostreococcus lucimarinus 46.67 1.00e-14 72.80
IUUC-Oga-088197 Otolemur garnettii 96.86 2.00e-59 221.00
IUUC-Ptr-091106 Pan troglodytes 96.86 3.00e-59 221.00
IUUC-Pan-092671 Papio anubis 96.86 3.00e-59 221.00
IUUC-Psi-093323 Pelodiscus sinensis 96.86 6.00e-59 220.00
IUUC-Pno-094942 Phaeosphaeria nodorum 42.68 9.00e-10 57.80
IUUC-Ppa-095474 Physcomitrella patens 55.68 5.00e-25 107.00
IUUC-Pfo-096943 Poecilia formosa 96.86 1.00e-54 206.00
IUUC-Pab-097845 Pongo abelii 96.86 3.00e-59 221.00
IUUC-Pop-099595 Populus trichocarpa 54.65 1.00e-25 109.00
IUUC-Ppe-102011 Prunus persica 56.98 1.00e-25 109.00
IUUC-Pva-102298 Pteropus vampyrus 96.86 4.00e-59 220.00
IUUC-Pyt-104640 Pyrenophora triticirepentis 37.50 1.00e-09 57.00
IUUC-Rno-105293 Rattus norvegicus 96.86 2.00e-59 221.00
IUUC-Sha-107361 Sarcophilus harrisii 96.86 3.00e-59 221.00
IUUC-Smo-109663 Selaginella moellendorffii 51.76 1.00e-22 98.20
IUUC-Sit-110376 Setaria italica 54.65 4.00e-24 104.00
IUUC-Sly-111909 Solanum lycopersicum 53.49 4.00e-23 101.00
IUUC-Stu-112801 Solanum tuberosum 53.49 2.00e-23 102.00
IUUC-Sar-113669 Sorex araneus 100.00 1.00e-25 107.00
IUUC-Sbi-114275 Sorghum bicolor 51.76 3.00e-22 98.60
IUUC-Ssc-116228 Sus scrofa 96.86 3.00e-59 221.00
IUUC-Tgu-116886 Taeniopygia guttata 96.23 1.00e-58 218.00
IUUC-Tni-120909 Tetraodon nigroviridis 95.60 6.00e-55 206.00
IUUC-Tca-121830 Theobroma cacao 55.29 3.00e-24 104.00
IUUC-Tre-122215 Trichoderma reesei 44.90 9.00e-09 55.80
IUUC-Tae-123670 Triticum aestivum 51.76 1.00e-22 99.40
IUUC-Tur-126676 Triticum urartu 51.76 1.00e-22 99.40
IUUC-Tbe-127360 Tupaia belangeri 99.21 6.00e-42 163.00
IUUC-Ttr-129044 Tursiops truncatus 96.86 3.00e-59 221.00
IUUC-Vpa-130365 Vicugna pacos 96.23 3.00e-58 218.00
IUUC-Vvi-131449 Vitis vinifera 54.55 1.00e-25 110.00
IUUC-Xtr-131916 Xenopus tropicalis 95.89 2.00e-40 157.00
IUUC-Xma-133333 Xiphophorus maculatus 94.34 4.00e-52 197.00
Created Date 25-Jun-2017

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