iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tru-118781

UUCD1 version

UUC-TaR-00500

Ensembl Protein ID

ENSTRUP00000024546.1

UniProt Accession

H2TIP4; H2TIP4_TAKRU

Protein Name

Nitric oxide synthase-interacting protein

Gene Name

nosip

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000009769.1	ENSTRUT00000024645.1	ENSTRUP00000024546.1
ENSTRUG00000009769.1	ENSTRUT00000024646.1	ENSTRUP00000024547.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	5.40e-13	50.0	40	88

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 2    vpeeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqpl 50
           + ++ +C +sl++ +dPvv+p+G+ yd+++I +++ +++k+  + ++  
   Q: 40   IKDFDCCCLSLQPCQDPVVTPDGYLYDKQAILEFILHQKKEIAKQMKAY 88
           567789*****************************99998444444444 PP

Organism

Takifugu rubripes

Functional Description
(View)

Negatively regulates nitric oxide production by inducing nitric oxide synthase translocation to actin cytoskeleton and inhibiting its enzymatic activity.

Protein Sequence
(Fasta)

MTRHGKNCTA GAVYTYHEKK KDTAASGYGT QSIRLGKDAI KDFDCCCLSL QPCQDPVVTP 60
DGYLYDKQAI LEFILHQKKE IAKQMKAYEK QKQTRKSTTQ LQSKSGEREK VEKFKTTENS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGACGCGTC ACGGAAAAAA TTGTACGGCT GGAGCTGTAT ATACATACCA CGAAAAGAAA 60
AAAGATACAG GTACGTGATG TGATCAGAAG AACCCCTCTA TCGAAAGGTC CATTCATGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-1185--Reference proteome

Interpro

IPR016818--Nitric_oxide_synth-interacting
IPR031790--Znf-NOSIP
IPR013083--Znf_RING/FYVE/PHD

Pfam

PF15906--zf-NOSIP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0061630--F:ubiquitin protein ligase activity
GO:0016567--P:protein ubiquitination
GO:0050999--P:regulation of nitric-oxide synthase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000769	Aegilops tauschii	48.84	2.00e-17	83.60
IUUC-Aml-002069	Ailuropoda melanoleuca	62.50	7.00e-116	409.00
IUUC-Atr-002661	Amborella trichopoda	28.86	1.00e-26	113.00
IUUC-Aca-004630	Anolis carolinensis	66.99	3.00e-119	421.00
IUUC-Aly-006316	Arabidopsis lyrata	28.99	7.00e-28	117.00
IUUC-Ath-007000	Arabidopsis thaliana	28.01	1.00e-26	114.00
IUUC-Acl-008175	Aspergillus clavatus	30.70	1.00e-05	44.70
IUUC-Afl-008440	Aspergillus flavus	23.10	2.00e-08	53.10
IUUC-Afu-009012	Aspergillus fumigatus	30.40	7.00e-07	48.50
IUUC-Ani-009153	Aspergillus nidulans	42.59	6.00e-03	35.40
IUUC-Ang-009556	Aspergillus niger	22.64	4.00e-09	55.50
IUUC-Aor-009892	Aspergillus oryzae	29.31	1.00e-05	43.90
IUUC-Ame-011874	Astyanax mexicanus	75.90	2.00e-122	431.00
IUUC-Bgr-012090	Blumeria graminis	25.78	2.00e-07	50.10
IUUC-Bta-012956	Bos taurus	66.12	4.00e-121	427.00
IUUC-Bci-013897	Botrytis cinerea	37.50	2.00e-08	53.50
IUUC-Bdi-014968	Brachypodium distachyon	29.97	4.00e-31	128.00
IUUC-Bol-015578	Brassica oleracea	28.99	2.00e-30	125.00
IUUC-Bra-017234	Brassica rapa	28.99	2.00e-30	125.00
IUUC-Cel-018637	Caenorhabditis elegans	40.74	6.00e-57	214.00
IUUC-Cja-019632	Callithrix jacchus	66.12	3.00e-120	424.00
IUUC-Cfa-020192	Canis familiaris	64.82	1.00e-118	419.00
IUUC-Cpo-021939	Cavia porcellus	65.47	3.00e-117	414.00
IUUC-Cre-023005	Chlamydomonas reinhardtii	32.32	3.00e-37	148.00
IUUC-Csa-023802	Chlorocebus sabaeus	66.12	6.00e-120	423.00
IUUC-Cho-024637	Choloepus hoffmanni	47.53	3.00e-39	154.00
IUUC-Cin-025180	Ciona intestinalis	52.61	3.00e-87	314.00
IUUC-Csv-026206	Ciona savignyi	56.46	6.00e-44	169.00
IUUC-Cgl-026696	Colletotrichum gloeosporioides	23.57	9.00e-13	67.80
IUUC-Cne-026827	Cryptococcus neoformans	26.16	5.00e-09	55.10
IUUC-Dre-028092	Danio rerio	76.22	1.00e-128	452.00
IUUC-Dno-029501	Dasypus novemcinctus	60.65	2.00e-103	369.00
IUUC-Dor-030542	Dipodomys ordii	65.47	5.00e-121	426.00
IUUC-Dse-031188	Dothistroma septosporum	22.22	1.00e-12	67.40
IUUC-Dme-031734	Drosophila melanogaster	45.60	9.00e-81	293.00
IUUC-Eca-033577	Equus caballus	66.12	6.00e-121	426.00
IUUC-Fca-035761	Felis catus	65.15	3.00e-119	421.00
IUUC-Fox-037703	Fusarium oxysporum	24.16	7.00e-13	68.20
IUUC-Fso-038208	Fusarium solani	24.83	4.00e-13	68.60
IUUC-Gmo-038523	Gadus morhua	68.23	4.00e-70	256.00
IUUC-Ggr-040087	Gaeumannomyces graminis	28.47	4.00e-10	58.90
IUUC-Gac-042621	Gasterosteus aculeatus	73.58	2.00e-123	434.00
IUUC-Gma-042698	Glycine max	29.68	2.00e-28	119.00
IUUC-Ggo-045357	Gorilla gorilla	66.12	4.00e-120	424.00
IUUC-Hsa-046195	Homo sapiens	66.12	4.00e-120	424.00
IUUC-Hvu-047174	Hordeum vulgare	30.64	5.00e-33	134.00
IUUC-Itr-048487	Ictidomys tridecemlineatus	65.03	6.00e-117	413.00
IUUC-Lch-050569	Latimeria chalumnae	66.77	4.00e-110	390.00
IUUC-Lpe-050992	Leersia perrieri	32.37	1.00e-21	97.40
IUUC-Loc-052522	Lepisosteus oculatus	71.66	3.00e-117	414.00
IUUC-Lma-053254	Leptosphaeria maculans	22.97	2.00e-09	56.60
IUUC-Laf-053397	Loxodonta africana	64.50	5.00e-118	417.00
IUUC-Mcc-054681	Macaca mulatta	66.45	2.00e-120	425.00
IUUC-Meu-056723	Macropus eugenii	63.52	1.00e-117	415.00
IUUC-Mor-056961	Magnaporthe oryzae	22.64	7.00e-10	58.20
IUUC-Mpo-057359	Magnaporthe poae	26.56	4.00e-05	42.00
IUUC-Mtr-058063	Medicago truncatula	30.07	9.00e-30	124.00
IUUC-Mla-059004	Melampsora laricipopulina	26.98	1.00e-20	93.60
IUUC-Mvi-060460	Microbotryum violaceum	28.44	3.00e-25	108.00
IUUC-Mmr-060847	Microcebus murinus	66.12	1.00e-119	422.00
IUUC-Mdo-062480	Monodelphis domestica	63.19	2.00e-114	405.00
IUUC-Mmu-063809	Mus musculus	65.15	1.00e-120	425.00
IUUC-Mac-064870	Musa acuminata	29.87	2.00e-33	135.00
IUUC-Mpu-066322	Mustela putorius furo	65.26	4.00e-120	424.00
IUUC-Mlu-067556	Myotis lucifugus	65.15	3.00e-116	411.00
IUUC-Nfi-068440	Neosartorya fischeri	30.40	7.00e-07	48.10
IUUC-Ncr-068898	Neurospora crassa	34.62	1.00e-06	47.40
IUUC-Nle-070049	Nomascus leucogenys	66.45	3.00e-120	424.00
IUUC-Opr-070972	Ochotona princeps	63.75	7.00e-117	413.00
IUUC-Ont-071682	Oreochromis niloticus	78.36	8.00e-134	469.00
IUUC-Oan-073296	Ornithorhynchus anatinus	89.83	5.00e-30	123.00
IUUC-Ocu-074218	Oryctolagus cuniculus	63.64	3.00e-103	367.00
IUUC-Oba-075284	Oryza barthii	30.54	1.00e-30	126.00
IUUC-Obr-076651	Oryza brachyantha	29.87	2.00e-33	136.00
IUUC-Ogl-077899	Oryza glaberrima	30.54	1.00e-30	126.00
IUUC-Ogu-078477	Oryza glumaepatula	29.87	6.00e-31	127.00
IUUC-Oin-080011	Oryza indica	30.54	1.00e-30	126.00
IUUC-Olo-080545	Oryza longistaminata	29.77	6.00e-24	105.00
IUUC-Ome-081543	Oryza meridionalis	30.54	1.00e-30	126.00
IUUC-Oni-082955	Oryza nivara	30.54	1.00e-30	126.00
IUUC-Opu-083565	Oryza punctata	30.54	5.00e-31	127.00
IUUC-Oru-084474	Oryza rufipogon	30.54	1.00e-30	126.00
IUUC-Osa-085913	Oryza sativa	30.54	1.00e-30	126.00
IUUC-Ola-086851	Oryzias latipes	74.27	1.00e-134	472.00
IUUC-Olu-087724	Ostreococcus lucimarinus	39.47	3.00e-10	58.90
IUUC-Oga-087970	Otolemur garnettii	65.26	2.00e-117	414.00
IUUC-Oar-089756	Ovis aries	63.84	2.00e-113	401.00
IUUC-Ptr-091485	Pan troglodytes	65.05	9.00e-117	412.00
IUUC-Pan-091832	Papio anubis	66.45	3.00e-120	424.00
IUUC-Pma-094551	Petromyzon marinus	60.66	3.00e-103	367.00
IUUC-Ppa-095255	Physcomitrella patens	28.81	1.00e-29	123.00
IUUC-Pfo-096373	Poecilia formosa	76.87	2.00e-137	481.00
IUUC-Pab-098247	Pongo abelii	66.12	3.00e-120	424.00
IUUC-Pop-099186	Populus trichocarpa	30.56	7.00e-30	124.00
IUUC-Pca-100677	Procavia capensis	58.72	1.00e-91	328.00
IUUC-Ppe-101403	Prunus persica	29.33	4.00e-29	121.00
IUUC-Pva-103000	Pteropus vampyrus	66.12	1.00e-120	426.00
IUUC-Pgr-103663	Puccinia graminis	30.00	1.00e-27	117.00
IUUC-Ptt-103712	Puccinia triticina	36.92	6.00e-08	51.20
IUUC-Pte-104287	Pyrenophora teres	24.20	9.00e-15	74.30
IUUC-Pyt-104579	Pyrenophora triticirepentis	23.69	2.00e-12	66.60
IUUC-Rno-106069	Rattus norvegicus	65.80	9.00e-122	429.00
IUUC-Sha-106553	Sarcophilus harrisii	62.87	1.00e-115	409.00
IUUC-Smo-108874	Selaginella moellendorffii	32.24	2.00e-36	145.00
IUUC-Sit-110307	Setaria italica	31.54	3.00e-31	128.00
IUUC-Sly-111094	Solanum lycopersicum	30.54	2.00e-30	125.00
IUUC-Stu-112363	Solanum tuberosum	30.54	2.00e-30	125.00
IUUC-Sar-113480	Sorex araneus	63.52	2.00e-112	398.00
IUUC-Sbi-113939	Sorghum bicolor	31.54	7.00e-32	130.00
IUUC-Ssc-115644	Sus scrofa	65.15	9.00e-120	422.00
IUUC-Tni-119672	Tetraodon nigroviridis	89.66	5.00e-43	164.00
IUUC-Tca-121795	Theobroma cacao	30.74	3.00e-32	132.00
IUUC-Tre-122037	Trichoderma reesei	32.47	2.00e-07	49.70
IUUC-Tvi-122524	Trichoderma virens	22.22	4.00e-13	68.60
IUUC-Tae-122828	Triticum aestivum	30.98	4.00e-33	135.00
IUUC-Tur-126387	Triticum urartu	30.53	8.00e-27	114.00
IUUC-Tme-127111	Tuber melanosporum	36.90	2.00e-08	53.50
IUUC-Ttr-128227	Tursiops truncatus	65.80	2.00e-120	424.00
IUUC-Vda-129924	Verticillium dahliae	24.65	3.00e-18	85.90
IUUC-Vpa-130802	Vicugna pacos	73.56	1.00e-33	136.00
IUUC-Vvi-131105	Vitis vinifera	29.19	2.00e-29	122.00
IUUC-Xtr-132830	Xenopus tropicalis	64.31	1.00e-119	422.00
IUUC-Xma-133618	Xiphophorus maculatus	75.90	1.00e-128	452.00
IUUC-Zma-135389	Zea mays	30.20	4.00e-31	128.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence