iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	COSMIC	CGAP	IntOGen
mRNA Expression
ArrayExpress	TCGA	ICGC	COSMIC
THPA	HPM
DNA & RNA Element
UTRdb	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	PINA	Mentha
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	mUbiSiDa
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	19285439; 19625452; 21148293; 19269966; 20483786

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	0.00013	23.6	24	79
E3 activity/RING/RING	8.20e-07	31.1	27	68

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 5    eflCpIslelMrdPvvlpsGitydrssIekwlasggk..tcPvtrqplteedlvPn 58
            f C I le  r+ vv+ +G+ y   ++++wl++  +  +cPv+++ ++ e++vP 
   Q: 24   TFECNICLETAREAVVSVCGHLYCWPCLHQWLETRPErqECPVCKAGISREKVVPL 79
           699*****************************7776667***********999996 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iCle  ++  +v  CgH+++  Cl++w         ++ CP+C+
   Q: 27   CNICLETARE-AVVSVCGHLYCWPCLHQW---LETRPERQECPVCK 68
           99******88.888***************...555888889****7 PP

Organism

Homo sapiens

Functional Description
(View)

Has E2-dependent E3 ubiquitin-protein ligase activity. May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4. Mediates ubiquitination of PXN/paxillin and Salmonella type III secreted protein sopA. May be involved in regulation of cell motility and localization of PXN/paxillin. Mediates the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N. Mediates the 'Lys-48'-linked polyubiquitination of TMEM173 at 'Lys-150' leading to its proteasomal degradation; the ubiquitination occurrs in mitochondria after viral transfection and regulates antiviral responses.

Protein Sequence
(Fasta)

MAAAEEEDGG PEGPNRERGG AGATFECNIC LETAREAVVS VCGHLYCWPC LHQWLETRPE 60
RQECPVCKAG ISREKVVPLY GRGSQKPQDP RLKTPPRPQG QRPAPESRGG FQPFGDTGGF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTGTGACTG GCAGGCATTC AGACCAATAG TGATTAGGAA ACCTTGAAGC CTGCCCAACG 60
ATCGTGGGCA GGAGGTGGTT TCTGGTTTGT TGGGGCGTGT GTATGTGTAT TTGGGGGGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0479--Metal-binding
KW-0496--Mitochondrion
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0044322--C:endoplasmic reticulum quality control compartment
GO:0016021--C:integral component of membrane
GO:0031966--C:mitochondrial membrane
GO:0042802--F:identical protein binding
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:0044390--F:ubiquitin-like protein conjugating enzyme binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0044257--P:cellular protein catabolic process
GO:1904380--P:endoplasmic reticulum mannose trimming
GO:0071712--P:ER-associated misfolded protein catabolic process
GO:0036503--P:ERAD pathway
GO:0010507--P:negative regulation of autophagy
GO:0031648--P:protein destabilization
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000785--P:regulation of autophagosome assembly
GO:0009617--P:response to bacterium
GO:0055085--P:transmembrane transport

KEGG

hsa:6048

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001155	Aegilops tauschii	48.54	1.00e-23	103.00
IUUC-Aml-001417	Ailuropoda melanoleuca	98.43	5.00e-71	259.00
IUUC-Aca-004254	Anolis carolinensis	75.86	5.00e-36	143.00
IUUC-Ame-011316	Astyanax mexicanus	70.13	5.00e-57	213.00
IUUC-Bta-013109	Bos taurus	98.58	1.00e-79	288.00
IUUC-Bdi-014313	Brachypodium distachyon	54.65	1.00e-23	103.00
IUUC-Bol-016132	Brassica oleracea	43.57	5.00e-27	114.00
IUUC-Bra-017631	Brassica rapa	42.96	1.00e-26	113.00
IUUC-Cja-019902	Callithrix jacchus	97.87	6.00e-79	286.00
IUUC-Cfa-020079	Canis familiaris	97.87	6.00e-79	286.00
IUUC-Cpo-021320	Cavia porcellus	93.41	2.00e-87	314.00
IUUC-Csa-023595	Chlorocebus sabaeus	99.29	4.00e-80	290.00
IUUC-Cme-027164	Cyanidioschyzon merolae	32.24	9.00e-17	80.90
IUUC-Dre-027716	Danio rerio	74.29	2.00e-42	165.00
IUUC-Dno-029843	Dasypus novemcinctus	85.82	2.00e-56	211.00
IUUC-Dor-030170	Dipodomys ordii	97.58	5.00e-69	253.00
IUUC-Eca-033642	Equus caballus	98.78	2.00e-92	330.00
IUUC-Eeu-034778	Erinaceus europaeus	98.29	5.00e-64	235.00
IUUC-Fca-036326	Felis catus	96.45	2.00e-78	284.00
IUUC-Fso-038195	Fusarium solani	40.91	4.00e-10	59.70
IUUC-Gac-042258	Gasterosteus aculeatus	80.80	2.00e-56	211.00
IUUC-Ggo-045474	Gorilla gorilla	100.00	2.00e-80	291.00
IUUC-Hvu-047124	Hordeum vulgare	54.65	2.00e-23	102.00
IUUC-Itr-048037	Ictidomys tridecemlineatus	98.67	9.00e-85	305.00
IUUC-Lch-050367	Latimeria chalumnae	70.83	8.00e-46	175.00
IUUC-Lpe-051034	Leersia perrieri	45.26	1.00e-25	109.00
IUUC-Laf-053395	Loxodonta africana	96.45	6.00e-78	283.00
IUUC-Mcc-054833	Macaca mulatta	99.29	4.00e-80	290.00
IUUC-Meu-055984	Macropus eugenii	86.08	6.00e-36	143.00
IUUC-Mdo-062437	Monodelphis domestica	88.41	5.00e-83	299.00
IUUC-Mmu-064159	Mus musculus	97.89	6.00e-80	289.00
IUUC-Mac-065053	Musa acuminata	57.65	9.00e-24	103.00
IUUC-Mlu-067689	Myotis lucifugus	92.59	7.00e-84	302.00
IUUC-Nle-069705	Nomascus leucogenys	100.00	1.00e-80	291.00
IUUC-Opr-070392	Ochotona princeps	43.97	3.00e-20	90.50
IUUC-Ont-072482	Oreochromis niloticus	74.83	8.00e-59	219.00
IUUC-Ocu-074208	Oryctolagus cuniculus	97.16	2.00e-78	284.00
IUUC-Oba-075461	Oryza barthii	52.75	3.00e-24	105.00
IUUC-Obr-076382	Oryza brachyantha	56.98	8.00e-25	107.00
IUUC-Ogl-077553	Oryza glaberrima	56.25	3.00e-26	111.00
IUUC-Ogu-078463	Oryza glumaepatula	51.38	2.00e-26	112.00
IUUC-Oin-080177	Oryza indica	56.25	3.00e-26	111.00
IUUC-Olo-080378	Oryza longistaminata	54.65	2.00e-23	102.00
IUUC-Ome-081605	Oryza meridionalis	51.38	2.00e-26	112.00
IUUC-Oni-082458	Oryza nivara	56.25	6.00e-26	111.00
IUUC-Opu-083362	Oryza punctata	58.14	1.00e-25	110.00
IUUC-Oru-084757	Oryza rufipogon	55.00	9.00e-27	113.00
IUUC-Osa-086198	Oryza sativa	50.44	1.00e-26	114.00
IUUC-Ola-086507	Oryzias latipes	69.09	3.00e-61	227.00
IUUC-Olu-087623	Ostreococcus lucimarinus	49.25	2.00e-16	79.00
IUUC-Oga-088912	Otolemur garnettii	99.29	5.00e-80	290.00
IUUC-Oar-090284	Ovis aries	95.30	2.00e-71	261.00
IUUC-Ptr-090919	Pan troglodytes	100.00	3.00e-71	260.00
IUUC-Pan-092843	Papio anubis	99.29	4.00e-80	290.00
IUUC-Pfo-096818	Poecilia formosa	80.16	5.00e-57	214.00
IUUC-Pab-098244	Pongo abelii	99.29	5.00e-80	290.00
IUUC-Pop-099595	Populus trichocarpa	43.54	2.00e-27	115.00
IUUC-Pca-100319	Procavia capensis	96.95	3.00e-82	297.00
IUUC-Pva-102249	Pteropus vampyrus	94.33	2.00e-73	267.00
IUUC-Rno-106042	Rattus norvegicus	97.89	6.00e-80	289.00
IUUC-Smo-109079	Selaginella moellendorffii	48.19	2.00e-22	100.00
IUUC-Sit-110690	Setaria italica	53.57	4.00e-22	98.20
IUUC-Sly-110917	Solanum lycopersicum	52.94	5.00e-25	107.00
IUUC-Stu-112117	Solanum tuberosum	49.59	2.00e-24	105.00
IUUC-Sbi-114275	Sorghum bicolor	54.65	3.00e-23	102.00
IUUC-Ssc-115934	Sus scrofa	99.29	5.00e-80	290.00
IUUC-Tru-118679	Takifugu rubripes	61.73	3.00e-23	100.00
IUUC-Tsy-119615	Tarsius syrichta	95.07	4.00e-75	273.00
IUUC-Tca-121830	Theobroma cacao	48.78	2.00e-25	108.00
IUUC-Tae-124655	Triticum aestivum	54.65	1.00e-23	102.00
IUUC-Tur-126198	Triticum urartu	54.65	2.00e-23	102.00
IUUC-Tbe-127773	Tupaia belangeri	96.45	2.00e-76	277.00
IUUC-Ttr-128690	Tursiops truncatus	97.44	9.00e-64	235.00
IUUC-Vvi-131225	Vitis vinifera	60.00	7.00e-26	110.00
IUUC-Xtr-132608	Xenopus tropicalis	80.00	2.00e-45	174.00
IUUC-Xma-134225	Xiphophorus maculatus	80.16	3.00e-57	214.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence