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Tag Content
iUUCD ID IUUC-Cfa-020894
Ensembl Protein ID ENSCAFP00000022033.3
UniProt Accession F1PK46; F1PK46_CANLF
Genbank Protein ID ENSCAFP00000022033
Protein Name Histone-lysine N-methyltransferase
Genbank Nucleotide ID AAEX03002459
Gene Name WHSC1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSCAFG00000014951.4 ENSCAFT00000023738.4 ENSCAFP00000022033.3
ENSCAFG00000014951.4 ENSCAFT00000043831.1 ENSCAFP00000036806.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 2.80e-16 59.7 830 870
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           +C vC +gg+    l++Ce C  +fHp+Cl++     +p+ + w+C++Cr
   Q: 830  WCFVCSKGGS----LLCCESCPAAFHPDCLNID----MPDGS-WFCNDCR 870
           8*********....*******************....9***8.******8 PP
   
Organism Canis familiaris
Protein Sequence
(Fasta)
QKNPLSVQKV VECIKMKQAP EILGNTNGKT QNCEVNRECS VFLSKAHLST SLQEGVMQKF 60
NGHDALPFIP SEKLKDLTSR VFNGEPGAHD AKLRFESQEG KGLGTPPNTT PIKNGSPEIK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Cfa-020894|E3,PHD|Canis familiaris
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CAAAAAAATC CTCTTTCTGT TCAGAAAGTT GTAGAGTGCA TAAAGATGAA GCAGGCACCA 60
GAAATCCTTG GCAATACAAA CGGAAAGACT CAGAACTGTG AAGTGAATCG TGAATGTTCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cfa-020894|E3,PHD|Canis familiaris
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR006560--AWS_dom
IPR009071--HMG_box_dom
IPR003616--Post-SET_dom
IPR000313--PWWP_dom
IPR001214--SET_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51215--AWS
PS50118--HMG_BOX_2
PS50868--POST_SET
PS50812--PWWP
PS50280--SET
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
PS50089--ZF_RING_2
Pfam

PF00505--HMG_box
PF00855--PWWP
PF00856--SET
SMART

SM00570--AWS
SM00398--HMG
SM00249--PHD
SM00508--PostSET
SM00293--PWWP
SM00184--RING
SM00317--SET
Gene Ontology

GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0018024--F:histone-lysine N-methyltransferase activity
GO:0043565--F:sequence-specific DNA binding
GO:0008270--F:zinc ion binding
GO:0003289--P:atrial septum primum morphogenesis
GO:0003290--P:atrial septum secundum morphogenesis
GO:0060348--P:bone development
GO:0010452--P:histone H3-K36 methylation
GO:0034770--P:histone H4-K20 methylation
GO:0003149--P:membranous septum morphogenesis
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0048298--P:positive regulation of isotype switching to IgA isotypes
GO:2001032--P:regulation of double-strand break repair via nonhomologous end joining
GO:0070201--P:regulation of establishment of protein localization
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002181 Ailuropoda melanoleuca 97.28 0.00e+00 2571.00
IUUC-Apl-003677 Anas platyrhynchos 80.48 0.00e+00 2125.00
IUUC-Aca-004278 Anolis carolinensis 76.22 0.00e+00 1387.00
IUUC-Ame-011932 Astyanax mexicanus 71.22 0.00e+00 1031.00
IUUC-Bta-012522 Bos taurus 86.57 0.00e+00 2268.00
IUUC-Cja-018908 Callithrix jacchus 90.79 0.00e+00 2363.00
IUUC-Cpo-021982 Cavia porcellus 88.27 0.00e+00 2351.00
IUUC-Csa-023807 Chlorocebus sabaeus 91.09 0.00e+00 2385.00
IUUC-Cho-024405 Choloepus hoffmanni 73.98 0.00e+00 730.00
IUUC-Csv-026298 Ciona savignyi 40.00 8.00e-59 221.00
IUUC-Dre-027492 Danio rerio 70.62 0.00e+00 1064.00
IUUC-Dno-030020 Dasypus novemcinctus 86.47 0.00e+00 2051.00
IUUC-Dor-031103 Dipodomys ordii 83.48 0.00e+00 2153.00
IUUC-Ete-032488 Echinops telfairi 82.40 0.00e+00 2133.00
IUUC-Eca-034066 Equus caballus 93.76 0.00e+00 2539.00
IUUC-Eeu-035199 Erinaceus europaeus 71.92 0.00e+00 765.00
IUUC-Fca-035434 Felis catus 89.08 0.00e+00 2049.00
IUUC-Fal-037113 Ficedula albicollis 78.53 0.00e+00 2130.00
IUUC-Gmo-039686 Gadus morhua 71.23 0.00e+00 1017.00
IUUC-Gga-040273 Gallus gallus 78.55 0.00e+00 2103.00
IUUC-Gac-042123 Gasterosteus aculeatus 50.82 0.00e+00 1244.00
IUUC-Ggo-044643 Gorilla gorilla 91.22 0.00e+00 2415.00
IUUC-Hsa-046380 Homo sapiens 91.07 0.00e+00 2374.00
IUUC-Itr-048658 Ictidomys tridecemlineatus 91.01 0.00e+00 1446.00
IUUC-Lch-050217 Latimeria chalumnae 66.29 0.00e+00 1731.00
IUUC-Loc-052766 Lepisosteus oculatus 58.03 0.00e+00 1275.00
IUUC-Laf-053780 Loxodonta africana 89.52 0.00e+00 2454.00
IUUC-Mcc-054928 Macaca mulatta 91.17 0.00e+00 2416.00
IUUC-Meu-056184 Macropus eugenii 73.91 0.00e+00 785.00
IUUC-Mga-059576 Meleagris gallopavo 78.97 0.00e+00 2094.00
IUUC-Mmr-061045 Microcebus murinus 91.27 0.00e+00 2464.00
IUUC-Mdo-062576 Monodelphis domestica 82.72 0.00e+00 2217.00
IUUC-Mmu-063640 Mus musculus 89.74 0.00e+00 2354.00
IUUC-Mac-065303 Musa acuminata 28.04 4.00e-11 63.50
IUUC-Mpu-066512 Mustela putorius furo 96.59 0.00e+00 2540.00
IUUC-Mlu-067280 Myotis lucifugus 79.51 0.00e+00 1093.00
IUUC-Nle-069896 Nomascus leucogenys 90.97 0.00e+00 2288.00
IUUC-Ont-072197 Oreochromis niloticus 73.00 0.00e+00 1040.00
IUUC-Oan-072724 Ornithorhynchus anatinus 78.55 0.00e+00 1371.00
IUUC-Ocu-074758 Oryctolagus cuniculus 87.54 0.00e+00 2313.00
IUUC-Ogl-077641 Oryza glaberrima 27.33 1.00e-09 57.40
IUUC-Oin-079557 Oryza indica 27.33 1.00e-09 57.40
IUUC-Olo-080702 Oryza longistaminata 41.94 2.00e-45 177.00
IUUC-Opu-083371 Oryza punctata 42.31 8.00e-47 182.00
IUUC-Oga-088702 Otolemur garnettii 90.96 0.00e+00 2113.00
IUUC-Oar-089736 Ovis aries 80.36 0.00e+00 1955.00
IUUC-Ptr-091055 Pan troglodytes 91.00 0.00e+00 2374.00
IUUC-Pan-092752 Papio anubis 94.35 0.00e+00 1430.00
IUUC-Psi-093620 Pelodiscus sinensis 80.27 0.00e+00 2136.00
IUUC-Pfo-097464 Poecilia formosa 50.90 0.00e+00 1210.00
IUUC-Pab-098051 Pongo abelii 90.85 0.00e+00 2401.00
IUUC-Pop-099927 Populus trichocarpa 28.96 1.00e-11 65.50
IUUC-Pca-100273 Procavia capensis 88.85 0.00e+00 2367.00
IUUC-Pva-102473 Pteropus vampyrus 78.59 0.00e+00 1964.00
IUUC-Rno-105056 Rattus norvegicus 89.10 0.00e+00 2365.00
IUUC-Sha-107494 Sarcophilus harrisii 83.94 0.00e+00 2208.00
IUUC-Sar-113310 Sorex araneus 90.52 0.00e+00 1886.00
IUUC-Sbi-114581 Sorghum bicolor 33.33 2.00e-09 56.20
IUUC-Ssc-116344 Sus scrofa 85.18 0.00e+00 2294.00
IUUC-Tgu-116786 Taeniopygia guttata 80.39 0.00e+00 2126.00
IUUC-Tru-117638 Takifugu rubripes 50.22 0.00e+00 1244.00
IUUC-Tsy-118937 Tarsius syrichta 92.98 0.00e+00 1540.00
IUUC-Tni-120452 Tetraodon nigroviridis 70.14 0.00e+00 1041.00
IUUC-Tae-125237 Triticum aestivum 29.45 2.00e-07 49.70
IUUC-Tbe-127291 Tupaia belangeri 87.29 0.00e+00 1538.00
IUUC-Ttr-129017 Tursiops truncatus 83.92 0.00e+00 1779.00
IUUC-Xtr-132673 Xenopus tropicalis 67.00 0.00e+00 1762.00
IUUC-Xma-133695 Xiphophorus maculatus 73.90 0.00e+00 1016.00
Created Date 25-Jun-2017

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