iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aml-001612

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ACTA01139149

Gene Name

AIRE

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMEG00000010859.1	ENSAMET00000011903.1	ENSAMEP00000011418.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	1.20e-09	38.3	297	341

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           + C+vC++gge    l++C+ C ++fH aCl+++   e p+ + w C++C 
   Q: 297  DECAVCRDGGE----LICCDGCPRAFHLACLSPP-LHEIPSGT-WRCSSCL 341
           57*********....*******************.*******6.******6 PP

Organism

Ailuropoda melanoleuca

Protein Sequence
(Fasta)

RAAGDAVLRR LLRLHRTEIA MAVDSAFPLL HALADHDVVP EDKFQETLRL KEREGCPQAF 60
HALLSWLLTQ DAAAILDFWR VLFKDYNLER YARLQPILDG FPKDMDLSQP RKGRKPPTGP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGGCAGCTG GGGACGCGGT GCTGCGCCGC CTCCTGAGGC TGCACCGCAC GGAGATCGCC 60
ATGGCTGTGG ACAGCGCCTT CCCGCTGCTG CATGCGCTGG CTGACCATGA CGTGGTCCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR008087--AIRE
IPR004865--HSR_dom
IPR000770--SAND_dom
IPR010919--SAND_dom-like
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51414--HSR
PS50864--SAND
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF03172--HSR
PF00628--PHD
PF01342--SAND

PRINTS

PR01711--AIREGULATOR

SMART

SM00249--PHD
SM00258--SAND

Gene Ontology

GO:0005737--C:cytoplasm
GO:0016604--C:nuclear body
GO:0003682--F:chromatin binding
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0045182--F:translation regulator activity
GO:0008270--F:zinc ion binding
GO:0002509--P:central tolerance induction to self antigen
GO:0032602--P:chemokine production
GO:0006959--P:humoral immune response
GO:0045060--P:negative thymic T cell selection
GO:0002458--P:peripheral T cell tolerance induction
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:2000410--P:regulation of thymocyte migration
GO:0097536--P:thymus epithelium morphogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aca-004543	Anolis carolinensis	68.33	2.00e-23	100.00
IUUC-Bta-012988	Bos taurus	78.25	0.00e+00	730.00
IUUC-Bdi-014663	Brachypodium distachyon	61.70	1.00e-13	72.80
IUUC-Cja-019486	Callithrix jacchus	67.54	7.00e-87	313.00
IUUC-Cfa-021069	Canis familiaris	90.27	0.00e+00	662.00
IUUC-Cpo-021649	Cavia porcellus	69.43	3.00e-164	571.00
IUUC-Csa-023960	Chlorocebus sabaeus	76.99	1.00e-172	599.00
IUUC-Dre-028583	Danio rerio	41.03	1.00e-61	230.00
IUUC-Dno-029869	Dasypus novemcinctus	67.02	5.00e-142	498.00
IUUC-Dor-030263	Dipodomys ordii	82.98	1.00e-45	176.00
IUUC-Dse-031258	Dothistroma septosporum	37.14	5.00e-10	60.10
IUUC-Ete-032778	Echinops telfairi	92.73	3.00e-50	192.00
IUUC-Eca-034328	Equus caballus	80.07	0.00e+00	676.00
IUUC-Fca-035400	Felis catus	78.70	0.00e+00	712.00
IUUC-Fal-036644	Ficedula albicollis	46.19	1.00e-75	277.00
IUUC-Fox-038014	Fusarium oxysporum	35.71	5.00e-09	57.40
IUUC-Fso-038262	Fusarium solani	41.18	7.00e-09	56.60
IUUC-Ggo-045250	Gorilla gorilla	75.56	5.00e-170	590.00
IUUC-Hsa-046603	Homo sapiens	75.64	6.00e-170	590.00
IUUC-Hvu-047073	Hordeum vulgare	58.70	1.00e-13	72.80
IUUC-Itr-048977	Ictidomys tridecemlineatus	71.30	2.00e-164	572.00
IUUC-Lch-050310	Latimeria chalumnae	42.15	2.00e-96	345.00
IUUC-Loc-052508	Lepisosteus oculatus	38.10	5.00e-96	345.00
IUUC-Lma-053053	Leptosphaeria maculans	33.10	2.00e-12	68.20
IUUC-Laf-054028	Loxodonta africana	69.10	2.00e-168	585.00
IUUC-Mcc-054935	Macaca mulatta	75.32	5.00e-179	620.00
IUUC-Mga-059318	Meleagris gallopavo	45.54	5.00e-58	218.00
IUUC-Mmr-061557	Microcebus murinus	61.06	1.00e-134	473.00
IUUC-Mdo-062475	Monodelphis domestica	49.73	2.00e-121	429.00
IUUC-Mmu-063994	Mus musculus	70.20	0.00e+00	686.00
IUUC-Mpu-066347	Mustela putorius furo	81.35	0.00e+00	768.00
IUUC-Mlu-068239	Myotis lucifugus	63.85	4.00e-93	334.00
IUUC-Nle-069544	Nomascus leucogenys	79.41	4.00e-27	114.00
IUUC-Opr-071199	Ochotona princeps	76.83	1.00e-74	274.00
IUUC-Ont-072571	Oreochromis niloticus	32.87	1.00e-38	154.00
IUUC-Oan-073739	Ornithorhynchus anatinus	54.05	7.00e-146	510.00
IUUC-Ogl-077865	Oryza glaberrima	56.52	1.00e-12	69.30
IUUC-Olo-080499	Oryza longistaminata	56.52	9.00e-13	70.10
IUUC-Opu-083209	Oryza punctata	56.52	1.00e-12	69.70
IUUC-Ola-086528	Oryzias latipes	36.70	7.00e-45	175.00
IUUC-Oga-088353	Otolemur garnettii	75.00	0.00e+00	694.00
IUUC-Oar-090065	Ovis aries	82.81	9.00e-169	586.00
IUUC-Ptr-091347	Pan troglodytes	76.31	3.00e-165	574.00
IUUC-Pan-092423	Papio anubis	74.61	3.00e-176	611.00
IUUC-Psi-093798	Pelodiscus sinensis	52.15	1.00e-128	453.00
IUUC-Pfo-096145	Poecilia formosa	67.86	2.00e-20	94.00
IUUC-Pab-098369	Pongo abelii	83.84	3.00e-131	461.00
IUUC-Pca-100537	Procavia capensis	71.53	2.00e-177	615.00
IUUC-Ppe-101215	Prunus persica	60.42	2.00e-14	74.70
IUUC-Pva-102639	Pteropus vampyrus	77.64	0.00e+00	653.00
IUUC-Rno-105285	Rattus norvegicus	72.12	0.00e+00	706.00
IUUC-Sha-107159	Sarcophilus harrisii	48.92	9.00e-120	424.00
IUUC-Sit-110355	Setaria italica	60.42	6.00e-13	70.50
IUUC-Sbi-113930	Sorghum bicolor	60.42	6.00e-13	70.50
IUUC-Ssc-115773	Sus scrofa	77.29	0.00e+00	686.00
IUUC-Tgu-116922	Taeniopygia guttata	49.39	6.00e-73	267.00
IUUC-Tru-118263	Takifugu rubripes	31.77	5.00e-56	211.00
IUUC-Tsy-119270	Tarsius syrichta	71.21	3.00e-95	342.00
IUUC-Tni-120138	Tetraodon nigroviridis	30.96	4.00e-57	215.00
IUUC-Tca-121757	Theobroma cacao	54.72	7.00e-14	73.60
IUUC-Tae-124715	Triticum aestivum	58.70	1.00e-13	72.80
IUUC-Tur-126422	Triticum urartu	53.19	1.00e-11	66.20
IUUC-Tme-127204	Tuber melanosporum	55.32	4.00e-14	73.60
IUUC-Tbe-128077	Tupaia belangeri	69.86	0.00e+00	680.00
IUUC-Ttr-128781	Tursiops truncatus	84.78	2.00e-83	303.00
IUUC-Xma-133054	Xiphophorus maculatus	29.93	5.00e-52	198.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence