iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Ath-007211

UUCD1 version

UUC-ArT-01707

Ensembl Protein ID

AT1G04860.1

UniProt Accession

Q8W4N3; Q9MAT4; UBP2_ARATH

Genbank Protein ID

AAG42750.1; AAF40451.1; AEE27752.1; AAL32541.1

Protein Name

Ubiquitin carboxyl-terminal hydrolase 2; Deubiquitinating enzyme 2; Ubiquitin thioesterase 2; Ubiquitin-specific-processing protease 2

Genbank Nucleotide ID

AF302659; AC004809; CP002684; AY062463

Gene Name

UBP2; At1g04860; F13M7.15

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT1G04860	AT1G04860.1	AT1G04860.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Post-translational Modifications (PTMs)
dbPPT	dbPTM
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.60e-80	271.7	232	956

Active Site

Position(s)	Description	Evidence
240	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
907	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw..kskkkavsprellkalkkeaeefsgyeqqDaqEfla 97
           Gl NlgNtC++NS++Q L+++  lr+ +l+++         ++  g+l++sl+klf+e     + k++++pr+++ +++++a++f+gy+q+D++E+l+
   Q: 232  GLVNLGNTCFFNSIMQNLLSLDRLRDHFLKENG--------SGVGGPLASSLRKLFTETKpeAGLKSVINPRAFFGSFCSKAPQFRGYDQHDSHELLR 321
           9*****************************322........456789************99999********************************** PP
   S: 98   flldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke.......... 185
           +lld+l++e +         +       +++   +++++k+++li+ +F+g+++s + c ec+++s+ +epfldlslpvp k++  k+          
   Q: 322  CLLDSLSTEESA--------L-------RKKRGVSDNDEKSTTLIESVFGGETSSIVSCMECGHSSKVYEPFLDLSLPVPFKKSPPKKpqpvsrakka 404
           *********922........1.......2222445678999***************************************999886669********* PP
   S: 186  .................................................................................................. 185
                                                                                                             
   Q: 405  klppkrvpknvskvskvskvlpgmvlselnssgksmavtadsdtscsslapldngpvletpsvltldnnqasesasqsdtgfdgswldfigpetsgde 502
           ************************************************************************************************** PP
   S: 186  .................................................................................................. 185
                                                                                                             
   Q: 503  tnldmqedgidnvitaevnqivpspnivanssvssgdqtlegnterlmqdyeeiakaeanldekdvqamqsdecpatsgisaefsqascigcdpgige 600
           ************************************************************************************************** PP
   S: 186  .................................................................................................. 185
                                                                                                             
   Q: 601  ssssvnpwdeeelplvvadsqilympykeiscndksvegeceasssfvtgdhepqnsdfvdfgglfdepettegpvfgppskaeasgvgfmafssesd 698
           ************************************************************************************************** PP
   S: 186  ...........slqdcLesftkeeelegenkyycekck............................................................ 212
                      s++ cL +ftk e l ++n+++ce+c                                                             
   Q: 699  peeiddsdlpvSVERCLGHFTKHEILSDDNAWNCENCSknlklqrlrekrksnedesrssntsngwvkenedegfgeteilavkqdpndtscvkdhss 796
           **************************************999999999999999999999999999999999999999999999999999999999999 PP
   S: 213  ...............................kkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqkekkkYe 279
                                           k++a+kk+ ++k P+vL++hLkRfs + + ++ +k+n +v f++ +dl++++ s++++++ +  Y+
   Q: 797  dgrkaarihsadeseskgtqdededsekvitVKRDATKKVLINKAPPVLTIHLKRFSQDLR-GRLSKLNGHVAFKEVIDLRQYMDSRCSGED-PPVYR 892
           99999999999999999999888888888887888*********************98887.8889**********************9985.***** PP
   S: 280  LiavvvHsGslssGHYvayvkn.........ekgk..WllfdDskVtevkeeevleetgstaYvlfYkr 337
           L + v HsG++++GHYvayv+          +  +  W++++D +V++v+ e+vl    s+aY+lfY+r
   Q: 893  LAGLVEHSGTMRGGHYVAYVRGgqrvketdsS--StaWYNVSDAYVRQVSLEKVLH---SEAYILFYER 956
           **********************7777655433..166*******************...********98 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Is involved in resistance to the arginine analog canavanine (CAN).

Protein Sequence
(Fasta)

MGKKAKKKAR APTKEIQTME ISKKVSEEPP SQAGEIAEGD VKAVKETQAC VHFDKALNLE 60
KVLDKIKSSR QIKCAECNEG VYGKRGTKAK GSKGKKDFSS SDPKSNNKAI WLCLECGCYV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCGATAGAGT TGTGTTGGGA GAGCCTATGT CACTAACCCC TTTGTCTGCC CCTCTTTCGG 60
AGCGATTCTT TTCTCATTCT TTCGTCGGAC TCTCTGTCTC CTTTTGACGG CGGCACCAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0009507--C:chloroplast
GO:0000502--C:proteasome complex
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ath:AT1G04860

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000997	Aegilops tauschii	27.70	9.00e-57	214.00
IUUC-Atr-003015	Amborella trichopoda	37.47	2.00e-66	246.00
IUUC-Aly-005494	Arabidopsis lyrata	86.50	0.00e+00	1484.00
IUUC-Ame-011659	Astyanax mexicanus	42.07	4.00e-28	119.00
IUUC-Bdi-014465	Brachypodium distachyon	36.84	2.00e-50	193.00
IUUC-Bol-015853	Brassica oleracea	72.90	0.00e+00	1065.00
IUUC-Bra-017226	Brassica rapa	68.15	0.00e+00	1074.00
IUUC-Cme-027348	Cyanidioschyzon merolae	35.82	5.00e-19	89.00
IUUC-Dor-030443	Dipodomys ordii	42.00	2.00e-26	114.00
IUUC-Dme-031870	Drosophila melanogaster	31.70	2.00e-17	84.70
IUUC-Ete-032807	Echinops telfairi	42.00	6.00e-27	115.00
IUUC-Eeu-034835	Erinaceus europaeus	42.00	5.00e-27	115.00
IUUC-Gma-044402	Glycine max	42.51	0.00e+00	652.00
IUUC-Hvu-047146	Hordeum vulgare	32.80	9.00e-49	188.00
IUUC-Meu-056256	Macropus eugenii	41.45	3.00e-23	103.00
IUUC-Mtr-057945	Medicago truncatula	56.23	1.00e-99	357.00
IUUC-Mac-064941	Musa acuminata	30.63	3.00e-70	259.00
IUUC-Oan-073656	Ornithorhynchus anatinus	29.87	1.00e-35	144.00
IUUC-Ppa-095622	Physcomitrella patens	57.34	3.00e-44	173.00
IUUC-Pop-099136	Populus trichocarpa	45.64	0.00e+00	696.00
IUUC-Pca-101069	Procavia capensis	41.61	2.00e-27	117.00
IUUC-Ppe-101794	Prunus persica	44.18	1.00e-122	433.00
IUUC-Pva-103092	Pteropus vampyrus	42.00	5.00e-27	115.00
IUUC-Spo-108149	Schizosaccharomyces pombe	33.56	2.00e-19	90.50
IUUC-Smo-108942	Selaginella moellendorffii	57.48	5.00e-40	157.00
IUUC-Sit-110283	Setaria italica	38.91	5.00e-43	169.00
IUUC-Sly-111487	Solanum lycopersicum	40.37	1.00e-168	586.00
IUUC-Stu-112820	Solanum tuberosum	41.42	1.00e-176	612.00
IUUC-Tca-121701	Theobroma cacao	47.46	1.00e-150	526.00
IUUC-Tae-125305	Triticum aestivum	31.77	3.00e-46	180.00
IUUC-Tur-126788	Triticum urartu	35.59	4.00e-45	176.00
IUUC-Vvi-131230	Vitis vinifera	74.19	6.00e-23	97.80

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence