iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-028519

UUCD1 version

UUC-DaR-00426

Ensembl Protein ID

ENSDARP00000130549.1

UniProt Accession

A0A0R4I9U0; A0A0R4I9U0_DANRE

Genbank Protein ID

ENSDARP00000130549

Protein Name

E3 ubiquitin-protein ligase RNF168; RING finger protein 168; RING-type E3 ubiquitin transferase RNF168

Genbank Nucleotide ID

CR626884

Gene Name

rnf168; RNF168

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000105172.1	ENSDART00000157583.1	ENSDARP00000130549.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	5.20e-06	27.8	26	65

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C++Cle f + p++lpC H+f++ C+ + +       + +  CPlCr
   Q: 26   CPVCLEIFLE-PVTLPCMHTFCKPCFlETV------DKSNMCCPLCR 65
           ********99.9*************97777......9999******8 PP

Organism

Danio rerio

Functional Description
(View)

E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively).

Protein Sequence
(Fasta)

MPPVSEVDRG PVEESSGGLK RSDCVCPVCL EIFLEPVTLP CMHTFCKPCF LETVDKSNMC 60
CPLCRKRVST WARLNSRNKT LVNMELWRRI QDAFPSQCER RVQGIDDDEE AVMIPKPRVC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGTCTTGTCG TTGCCGCCCA TGGTTTCACA CGCGCGGGCA GTAGGGCGCA AAATATTCCC 60
GGGATTTTGT GGCCTTGTGA GCAAGAAAGC GCGTAAGTGT GTAAGATGTA AAATTTCTAA 120

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Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034725--RNF168
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000755	Aegilops tauschii	40.74	1.00e-11	64.30
IUUC-Aml-001573	Ailuropoda melanoleuca	52.14	1.00e-33	137.00
IUUC-Apl-003963	Anas platyrhynchos	45.61	3.00e-40	159.00
IUUC-Aca-004420	Anolis carolinensis	56.52	9.00e-38	151.00
IUUC-Ath-007019	Arabidopsis thaliana	41.77	2.00e-10	61.60
IUUC-Ame-011521	Astyanax mexicanus	55.51	2.00e-102	365.00
IUUC-Bta-013002	Bos taurus	41.70	6.00e-36	145.00
IUUC-Cja-019945	Callithrix jacchus	41.36	8.00e-37	148.00
IUUC-Cfa-020533	Canis familiaris	37.89	5.00e-32	132.00
IUUC-Cpo-021643	Cavia porcellus	40.18	7.00e-36	145.00
IUUC-Csa-023638	Chlorocebus sabaeus	45.78	3.00e-37	150.00
IUUC-Cho-024319	Choloepus hoffmanni	50.43	1.00e-33	138.00
IUUC-Cin-025679	Ciona intestinalis	35.20	6.00e-24	104.00
IUUC-Csv-026052	Ciona savignyi	33.89	3.00e-22	99.00
IUUC-Dno-029294	Dasypus novemcinctus	51.28	5.00e-34	139.00
IUUC-Ete-032714	Echinops telfairi	48.57	7.00e-29	122.00
IUUC-Eca-033343	Equus caballus	50.83	1.00e-38	154.00
IUUC-Fca-036251	Felis catus	44.64	4.00e-36	146.00
IUUC-Fal-037048	Ficedula albicollis	50.45	1.00e-46	181.00
IUUC-Gmo-039400	Gadus morhua	66.15	6.00e-49	186.00
IUUC-Gga-040444	Gallus gallus	47.21	2.00e-45	177.00
IUUC-Gac-041735	Gasterosteus aculeatus	56.49	2.00e-51	195.00
IUUC-Gma-044332	Glycine max	43.21	6.00e-13	68.60
IUUC-Hsa-046424	Homo sapiens	41.96	4.00e-36	146.00
IUUC-Itr-048965	Ictidomys tridecemlineatus	50.00	6.00e-30	125.00
IUUC-Lch-050649	Latimeria chalumnae	54.79	1.00e-38	154.00
IUUC-Loc-051847	Lepisosteus oculatus	60.74	6.00e-53	201.00
IUUC-Laf-053938	Loxodonta africana	50.43	1.00e-33	138.00
IUUC-Mcc-055360	Macaca mulatta	40.27	9.00e-34	138.00
IUUC-Meu-056684	Macropus eugenii	47.57	4.00e-36	146.00
IUUC-Mtr-058007	Medicago truncatula	43.21	1.00e-12	67.40
IUUC-Mga-059699	Meleagris gallopavo	49.10	5.00e-44	172.00
IUUC-Mmr-060779	Microcebus murinus	40.91	4.00e-35	142.00
IUUC-Mdo-062225	Monodelphis domestica	52.27	7.00e-38	152.00
IUUC-Mmu-064239	Mus musculus	51.14	1.00e-27	118.00
IUUC-Mpu-066141	Mustela putorius furo	45.09	1.00e-38	154.00
IUUC-Mlu-067945	Myotis lucifugus	44.89	5.00e-35	142.00
IUUC-Nle-069769	Nomascus leucogenys	40.18	2.00e-33	137.00
IUUC-Opr-070905	Ochotona princeps	61.36	3.00e-32	133.00
IUUC-Ont-071477	Oreochromis niloticus	46.14	4.00e-50	192.00
IUUC-Oan-073587	Ornithorhynchus anatinus	52.85	4.00e-35	139.00
IUUC-Ocu-073832	Oryctolagus cuniculus	46.67	7.00e-37	148.00
IUUC-Ogl-077658	Oryza glaberrima	42.22	4.00e-12	66.20
IUUC-Oin-079383	Oryza indica	42.22	3.00e-12	66.20
IUUC-Ome-081482	Oryza meridionalis	42.22	5.00e-12	65.90
IUUC-Oni-083025	Oryza nivara	42.22	3.00e-12	66.20
IUUC-Oru-084946	Oryza rufipogon	35.58	3.00e-08	53.10
IUUC-Osa-085978	Oryza sativa	42.22	3.00e-12	66.20
IUUC-Ola-086478	Oryzias latipes	66.67	2.00e-47	180.00
IUUC-Oga-088318	Otolemur garnettii	51.40	5.00e-30	125.00
IUUC-Oar-089647	Ovis aries	45.56	4.00e-35	142.00
IUUC-Ptr-090516	Pan troglodytes	41.96	2.00e-36	147.00
IUUC-Pan-092302	Papio anubis	40.54	1.00e-34	141.00
IUUC-Psi-093604	Pelodiscus sinensis	52.80	4.00e-38	152.00
IUUC-Pfo-096441	Poecilia formosa	61.81	9.00e-51	194.00
IUUC-Pab-097729	Pongo abelii	40.62	1.00e-34	141.00
IUUC-Pop-099737	Populus trichocarpa	43.04	7.00e-11	63.20
IUUC-Pca-100552	Procavia capensis	54.55	1.00e-29	124.00
IUUC-Pva-102780	Pteropus vampyrus	50.43	2.00e-32	134.00
IUUC-Rno-105461	Rattus norvegicus	38.16	7.00e-33	135.00
IUUC-Sha-106809	Sarcophilus harrisii	45.74	9.00e-36	145.00
IUUC-Sly-110934	Solanum lycopersicum	43.18	1.00e-13	70.90
IUUC-Stu-112446	Solanum tuberosum	43.02	2.00e-13	70.50
IUUC-Sar-113579	Sorex araneus	44.24	1.00e-32	134.00
IUUC-Sbi-113834	Sorghum bicolor	43.21	2.00e-12	66.60
IUUC-Tgu-117187	Taeniopygia guttata	55.38	3.00e-41	161.00
IUUC-Tru-118182	Takifugu rubripes	48.11	4.00e-57	215.00
IUUC-Tni-120205	Tetraodon nigroviridis	69.50	8.00e-50	191.00
IUUC-Tca-121416	Theobroma cacao	44.44	7.00e-13	68.20
IUUC-Tre-121992	Trichoderma reesei	32.50	2.00e-08	53.50
IUUC-Tvi-122557	Trichoderma virens	44.68	2.00e-06	47.40
IUUC-Tae-123092	Triticum aestivum	40.74	2.00e-11	64.30
IUUC-Tbe-127622	Tupaia belangeri	43.17	5.00e-37	149.00
IUUC-Ttr-128988	Tursiops truncatus	50.42	3.00e-33	136.00
IUUC-Vpa-130302	Vicugna pacos	51.26	2.00e-33	137.00
IUUC-Vvi-131424	Vitis vinifera	41.30	1.00e-11	63.90
IUUC-Xtr-132196	Xenopus tropicalis	35.55	6.00e-52	198.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence