iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Mmu-063891

UUCD1 version

UUC-MuM-00023

Ensembl Protein ID

ENSMUSP00000103528.3

UniProt Accession

Q61510; Q5SU70; TRI25_MOUSE

Genbank Protein ID

BAA09941.1; BAE41230.1; CAI24266.1

Protein Name

E3 ubiquitin/ISG15 ligase TRIM25; Estrogen-responsive finger protein; RING-type E3 ubiquitin transferase; RING-type E3 ubiquitin transferase TRIM25; Tripartite motif-containing protein 25; Ubiquitin/ISG15-conjugating enzyme TRIM25; Zinc finger protein 147

Genbank Nucleotide ID

D63902; AK169562; AL646096

Gene Name

Trim25; Efp; Zfp147; Znf147

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000000275.16	ENSMUST00000100627.8	ENSMUSP00000098192.2
ENSMUSG00000000275.16	ENSMUST00000107896.9	ENSMUSP00000103528.3
ENSMUSG00000000275.16	ENSMUST00000000284.6	ENSMUSP00000000284.6

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
PHOSIDA	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18248090

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	0.0001	23.4	8	81
E3 activity/RING/RING	5.30e-08	34.4	13	54

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 3    peeflCpIslelMrdPvvlpsGitydrssI.ekwlasggk.tcPvtrqpl.teedlvPnltlrrliqawceens 73
            ee+ C++ lel+++Pv++p+G+ +  s++ e w+ +g    cP +r+      +l  n+++ +++++++++++
   Q: 8    AEELSCSVCLELFKEPVTTPCGHNFCMSCLdETWVVQGPPyRCPQCRKVYqVRPQLQKNTVMCAVVEQFLQAEQ 81
           5899**************************66799999989*******99455577999999999999998876 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C++Cle fk+ p+++pCgH f+ +Cl + w     ++ +  rCP Cr
   Q: 13   CSVCLELFKE-PVTTPCGHNFCMSCLdETW----VVQGPPYRCPQCR 54
           ********99.*******************....99999*******8 PP

Organism

Mus musculus

Functional Description
(View)

Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs. Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3.

Protein Sequence
(Fasta)

MAELNPLAEE LSCSVCLELF KEPVTTPCGH NFCMSCLDET WVVQGPPYRC PQCRKVYQVR 60
PQLQKNTVMC AVVEQFLQAE QARTPVDDWT PPARFSASSA ATQVACDHCL TEIAVKTCLV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGGCGCCGC CCCTCCTGTT CAGTTTCGAT TCCTTCCTCG CTGCTTCTTA AGTACCGCGC 60
GGTAGGGTGC GCAGCTGTCC CTGCGCGTCA CGTCGGGTGA GCCCACGAGC GCGATGGCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0051--Antiviral defense
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0391--Immunity
KW-0399--Innate immunity
KW-1017--Isopeptide bond
KW-0436--Ligase
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005913--C:cell-cell adherens junction
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0016604--C:nuclear body
GO:0005654--C:nucleoplasm
GO:0098641--F:cadherin binding involved in cell-cell adhesion
GO:0016874--F:ligase activity
GO:0003723--F:RNA binding
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0051607--P:defense response to virus
GO:0036503--P:ERAD pathway
GO:0045087--P:innate immune response
GO:0046597--P:negative regulation of viral entry into host cell
GO:1902187--P:negative regulation of viral release from host cell
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0006513--P:protein monoubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0046596--P:regulation of viral entry into host cell
GO:1902186--P:regulation of viral release from host cell
GO:0043627--P:response to estrogen
GO:0033280--P:response to vitamin D

KEGG

mmu:217069

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000755	Aegilops tauschii	38.96	2.00e-11	63.90
IUUC-Aml-002424	Ailuropoda melanoleuca	69.34	0.00e+00	888.00
IUUC-Atr-002992	Amborella trichopoda	45.45	3.00e-11	62.80
IUUC-Apl-004101	Anas platyrhynchos	48.49	1.00e-168	586.00
IUUC-Aca-005025	Anolis carolinensis	46.64	5.00e-168	584.00
IUUC-Bta-012735	Bos taurus	69.34	0.00e+00	896.00
IUUC-Cja-019996	Callithrix jacchus	63.01	4.00e-162	564.00
IUUC-Cfa-020466	Canis familiaris	69.03	0.00e+00	887.00
IUUC-Cpo-021737	Cavia porcellus	68.29	0.00e+00	889.00
IUUC-Csa-023217	Chlorocebus sabaeus	71.92	0.00e+00	929.00
IUUC-Cho-024346	Choloepus hoffmanni	46.98	5.00e-66	244.00
IUUC-Dno-030082	Dasypus novemcinctus	68.77	0.00e+00	880.00
IUUC-Dor-030335	Dipodomys ordii	53.32	2.00e-130	459.00
IUUC-Ete-032923	Echinops telfairi	63.39	0.00e+00	732.00
IUUC-Eca-033411	Equus caballus	69.52	0.00e+00	912.00
IUUC-Eeu-034656	Erinaceus europaeus	69.09	8.00e-151	527.00
IUUC-Fca-035371	Felis catus	68.97	0.00e+00	884.00
IUUC-Fal-037008	Ficedula albicollis	46.07	4.00e-158	551.00
IUUC-Gmo-038668	Gadus morhua	33.65	1.00e-100	360.00
IUUC-Gga-040608	Gallus gallus	45.69	6.00e-161	560.00
IUUC-Gac-041409	Gasterosteus aculeatus	35.58	4.00e-111	395.00
IUUC-Ggo-044518	Gorilla gorilla	71.56	0.00e+00	898.00
IUUC-Hsa-045828	Homo sapiens	72.08	0.00e+00	917.00
IUUC-Itr-049070	Ictidomys tridecemlineatus	62.48	0.00e+00	784.00
IUUC-Lch-050478	Latimeria chalumnae	36.90	8.00e-127	447.00
IUUC-Loc-052864	Lepisosteus oculatus	37.64	7.00e-115	407.00
IUUC-Laf-054325	Loxodonta africana	70.92	1.00e-159	555.00
IUUC-Mcc-054920	Macaca mulatta	72.24	0.00e+00	929.00
IUUC-Meu-056367	Macropus eugenii	70.00	1.00e-70	261.00
IUUC-Mga-059975	Meleagris gallopavo	48.33	2.00e-163	569.00
IUUC-Mmr-060748	Microcebus murinus	71.00	0.00e+00	899.00
IUUC-Mdo-062904	Monodelphis domestica	56.72	0.00e+00	691.00
IUUC-Mpu-066473	Mustela putorius furo	69.47	0.00e+00	905.00
IUUC-Mlu-068185	Myotis lucifugus	68.35	0.00e+00	884.00
IUUC-Nle-070177	Nomascus leucogenys	71.29	0.00e+00	917.00
IUUC-Opr-070558	Ochotona princeps	58.94	4.00e-148	517.00
IUUC-Ont-071368	Oreochromis niloticus	34.81	1.00e-107	384.00
IUUC-Ocu-074461	Oryctolagus cuniculus	56.65	0.00e+00	650.00
IUUC-Obr-076219	Oryza brachyantha	41.56	2.00e-12	66.60
IUUC-Ogl-077658	Oryza glaberrima	41.56	3.00e-12	66.20
IUUC-Ogu-078203	Oryza glumaepatula	42.25	2.00e-11	63.90
IUUC-Oin-079383	Oryza indica	41.56	3.00e-12	65.90
IUUC-Ome-081482	Oryza meridionalis	41.56	3.00e-12	66.20
IUUC-Oni-083025	Oryza nivara	41.56	3.00e-12	66.20
IUUC-Opu-083547	Oryza punctata	41.56	3.00e-12	65.90
IUUC-Oru-084946	Oryza rufipogon	34.07	2.00e-08	53.50
IUUC-Osa-085978	Oryza sativa	41.56	3.00e-12	66.20
IUUC-Ola-086503	Oryzias latipes	27.09	6.00e-64	238.00
IUUC-Oga-088937	Otolemur garnettii	66.72	0.00e+00	860.00
IUUC-Oar-089781	Ovis aries	64.86	4.00e-166	577.00
IUUC-Ptr-090771	Pan troglodytes	71.61	0.00e+00	902.00
IUUC-Pan-092830	Papio anubis	72.08	0.00e+00	927.00
IUUC-Psi-093664	Pelodiscus sinensis	51.03	1.00e-177	616.00
IUUC-Pma-094147	Petromyzon marinus	31.06	6.00e-80	291.00
IUUC-Pab-097588	Pongo abelii	71.45	0.00e+00	907.00
IUUC-Pca-100890	Procavia capensis	68.21	1.00e-149	523.00
IUUC-Pva-102314	Pteropus vampyrus	71.18	0.00e+00	881.00
IUUC-Rno-105234	Rattus norvegicus	79.01	0.00e+00	1041.00
IUUC-Sce-106362	Saccharomyces cerevisiae	40.00	5.00e-08	52.40
IUUC-Sha-106807	Sarcophilus harrisii	52.97	0.00e+00	661.00
IUUC-Sar-113283	Sorex araneus	51.09	4.00e-120	424.00
IUUC-Sbi-113834	Sorghum bicolor	41.56	2.00e-12	67.00
IUUC-Ssc-115878	Sus scrofa	78.72	4.00e-103	367.00
IUUC-Tgu-117026	Taeniopygia guttata	46.67	1.00e-133	469.00
IUUC-Tru-117794	Takifugu rubripes	32.46	7.00e-97	348.00
IUUC-Tae-123092	Triticum aestivum	38.96	2.00e-11	63.90
IUUC-Tur-126688	Triticum urartu	38.96	2.00e-11	63.20
IUUC-Tbe-127580	Tupaia belangeri	65.76	6.00e-135	473.00
IUUC-Ttr-128648	Tursiops truncatus	64.44	2.00e-169	588.00
IUUC-Vpa-130254	Vicugna pacos	84.97	6.00e-91	327.00
IUUC-Xtr-132399	Xenopus tropicalis	30.03	1.00e-63	237.00
IUUC-Xma-133960	Xiphophorus maculatus	33.18	5.00e-109	388.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence