iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Itr-048695

Ensembl Protein ID

ENSSTOP00000004441.2

UniProt Accession

I3M562; I3M562_ICTTR

Genbank Protein ID

ENSSTOP00000004441

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AGTP01018089

Gene Name

HCK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000004951.2	ENSSTOT00000004951.2	ENSSTOP00000004441.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.60e-15	56.8	78	135

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           + +v +lydyea + ++L+++kGd++ v+   e+ ++W+++ + ++ k+G +P+n+v++++
   Q: 78   DTVVVALYDYEAIHREDLSFQKGDQMVVL---EEAGEWWRARSLATRKEGYIPSNYVARVN 135
           57899************************...999************************97 PP

Organism

Ictidomys tridecemlineatus

Protein Sequence
(Fasta)

GVSSCPSHST PQPAGTGPAC RMGCVKSKFL RNRGKASKSE SSTNLQSPGY MPDPTTPIKL 60
GPNYNGNPPG FVEAGSEDTV VVALYDYEAI HREDLSFQKG DQMVVLEEAG EWWRARSLAT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTGTGTCTT CCTGTCCTTC CCACCCCCTG CCAGCAGGTT TTATTGTTAT CCCCATTTTG 60
CTGGCGAAGA GCTGAGACTG GCTTGGGTGA CAGGAGAGTG ACAGGTGGGT GTGAGTGAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000140	Aegilops tauschii	31.40	4.00e-22	100.00
IUUC-Aml-001284	Ailuropoda melanoleuca	86.91	0.00e+00	941.00
IUUC-Apl-003285	Anas platyrhynchos	77.76	0.00e+00	803.00
IUUC-Aca-004724	Anolis carolinensis	77.17	0.00e+00	795.00
IUUC-Ame-011954	Astyanax mexicanus	74.11	0.00e+00	759.00
IUUC-Bta-013060	Bos taurus	87.81	0.00e+00	947.00
IUUC-Bdi-014122	Brachypodium distachyon	31.78	2.00e-21	97.80
IUUC-Cja-019817	Callithrix jacchus	89.92	0.00e+00	929.00
IUUC-Cfa-020511	Canis familiaris	86.67	0.00e+00	941.00
IUUC-Cpo-022538	Cavia porcellus	90.30	0.00e+00	962.00
IUUC-Csa-024143	Chlorocebus sabaeus	89.96	0.00e+00	941.00
IUUC-Dre-028157	Danio rerio	74.70	0.00e+00	784.00
IUUC-Dno-029761	Dasypus novemcinctus	89.46	0.00e+00	943.00
IUUC-Eca-034090	Equus caballus	85.14	0.00e+00	915.00
IUUC-Fca-035937	Felis catus	84.92	0.00e+00	897.00
IUUC-Fal-036624	Ficedula albicollis	77.01	0.00e+00	797.00
IUUC-Gmo-039009	Gadus morhua	72.37	0.00e+00	761.00
IUUC-Gga-040296	Gallus gallus	75.15	0.00e+00	786.00
IUUC-Gac-042362	Gasterosteus aculeatus	78.79	0.00e+00	766.00
IUUC-Ggo-044570	Gorilla gorilla	87.26	0.00e+00	939.00
IUUC-Hsa-046378	Homo sapiens	87.64	0.00e+00	949.00
IUUC-Loc-052904	Lepisosteus oculatus	77.01	0.00e+00	817.00
IUUC-Laf-053654	Loxodonta africana	89.68	0.00e+00	941.00
IUUC-Mcc-055317	Macaca mulatta	90.50	0.00e+00	944.00
IUUC-Mga-060194	Meleagris gallopavo	80.89	0.00e+00	767.00
IUUC-Mmr-061510	Microcebus murinus	90.87	0.00e+00	957.00
IUUC-Mdo-062035	Monodelphis domestica	83.60	0.00e+00	885.00
IUUC-Mmu-064037	Mus musculus	89.71	0.00e+00	975.00
IUUC-Mpu-066874	Mustela putorius furo	88.89	0.00e+00	942.00
IUUC-Mlu-068202	Myotis lucifugus	83.65	0.00e+00	897.00
IUUC-Nle-069222	Nomascus leucogenys	89.48	0.00e+00	935.00
IUUC-Opr-070705	Ochotona princeps	84.76	0.00e+00	928.00
IUUC-Ont-072347	Oreochromis niloticus	80.36	0.00e+00	757.00
IUUC-Ocu-074490	Oryctolagus cuniculus	87.30	0.00e+00	921.00
IUUC-Ola-086521	Oryzias latipes	79.46	0.00e+00	767.00
IUUC-Oga-088153	Otolemur garnettii	91.09	0.00e+00	958.00
IUUC-Oar-090184	Ovis aries	89.76	0.00e+00	942.00
IUUC-Ptr-090505	Pan troglodytes	83.65	0.00e+00	887.00
IUUC-Pan-092260	Papio anubis	90.30	0.00e+00	942.00
IUUC-Pma-094311	Petromyzon marinus	74.23	0.00e+00	731.00
IUUC-Pfo-096566	Poecilia formosa	74.36	0.00e+00	787.00
IUUC-Pva-103021	Pteropus vampyrus	90.08	0.00e+00	950.00
IUUC-Rno-105309	Rattus norvegicus	91.47	0.00e+00	962.00
IUUC-Sha-107099	Sarcophilus harrisii	82.71	0.00e+00	882.00
IUUC-Tgu-116912	Taeniopygia guttata	76.94	0.00e+00	790.00
IUUC-Tru-118449	Takifugu rubripes	80.22	0.00e+00	753.00
IUUC-Tae-123192	Triticum aestivum	31.78	1.00e-22	101.00
IUUC-Tur-126022	Triticum urartu	32.31	4.00e-22	99.80
IUUC-Tbe-128144	Tupaia belangeri	86.44	0.00e+00	801.00
IUUC-Xma-133902	Xiphophorus maculatus	74.06	0.00e+00	782.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence