iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	dbPTM	UniProt
PHOSIDA	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	10527495

Classification

Family	E-value	Score	Start	End
DUB/USP	1.70e-71	239.6	102	736

Active Site

Position(s)	Description	Evidence
110	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
697	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrellle...kkkeklneenp...............................................kepkgellksl 53
           Gl N gNtC+mNSvLQ+L++ +el+e+l +   ++ e+++++++                                               +ep+ +++ +l
   Q: 102  GLVNDGNTCFMNSVLQSLASSRELMEFLDNnviRTYEEIEQNEHneegngqesaqdeathkkntrkggkvygkhkkklnrkssskedeeksQEPDITFSVAL 203
           9*****************************999666666666556777888889999999999999999999999999999999999999999999****** PP
   S: 54   qklfeelw...kskkkavsprellkalkkeaee..fsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde..................... 129
           ++l+++l    +++k ++++++llka++k  ++  + gy+q+DaqEf++ +l +le+++ k+ n++k +++  +ksel+d+                     
   Q: 204  RDLLSALNakyYRDKPYFKTNSLLKAMSKSPRKniLLGYDQEDAQEFFQNILAELESNV-KSLNTEKLDTTPVAKSELPDDalvgqlnlgevgtvyipteqi 304
           *******888899999*************99885556**********************.66999999999******************************* PP
   S: 130  ......aeekkkkknkslisdlFqgqlksqikclecdnvs.sreepfldlslpvpgkeetkkeslqdcLesftkeeelegenkyycekck............ 212
                 ++++ ++ ++  + + ++g + ++i cl+c+++   r++ f  lsl++p+++  ++++l+++L++++k+e +eg   ++c++c             
   Q: 305  dpnsilHDKSIQNFTPFKLMTPLDGITAERIGCLQCGENGgIRYSVFSGLSLNLPNENIGSTLKLSQLLSDWSKPEIIEG---VECNRCAltaahshlfgql 403
           ***************************************99**************************************9...99***************** PP
   S: 213  .................................................kkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfc 265
                                                            +k+  +k++ +++ P+ L++h++R  f+ ++++ +k+n+kv f+ +L+l+p+c
   Q: 404  kefekkpegsipeklinavkdrvhqieevlakpviddedykklhtanmvRKCSKSKQILISRPPPLLSIHINRSVFDPRTYMIRKNNSKVLFKSRLNLAPWC 505
           *****************************************999999999999************************************************* PP
   S: 266  ts.................................................................................peekqke............ 274
           ++                                                                                 +                  
   Q: 506  CDineinldarlpmskkekaaqqdssedeniggeyytklherfeqefedseeekeyddaegnyashynhtkdisnydplngevD-----Gvtsddedeyiee 602
           **9999999999998888888777777777777777777777777776666666555555555555555555555555555550.....0555555555555 PP
   S: 275  ...........................................................................kkkYeLiavvvHsGslssGHYvayvkn 301
                                                                                      + +Y+L +v+vH+G+++ GHY+a+ k 
   Q: 603  tdalgntikkriiehsdvenenvkdneelqeidnvsldepkinvedqletssdeedvipappinyarsfstvpatPLTYSLRSVIVHYGTHNYGHYIAFRKY 704
           5555556666666666666666666777777888888888888888888889999999999999**********9*************************** PP
   S: 302  ekgkWllfdDskVtevkeeevleetgstaYvlfYk 336
            +g+W++++D++V +v+e+evl++     ++lfY+
   Q: 705  -RGCWWRISDETVYVVDEAEVLST--PGVFMLFYE 736
           .999*******************4..89******8 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Present with 8970 molecules/cell in log phase SD medium.

Protein Sequence
(Fasta)

MDLFIESKIN SLLQFLFGSR QDFLRNFKTW SNNNNNLSIY LLIFGIVVFF YKKPDHLNYI 60
VESVSEMTTN FRNNNSLSRW LPRSKFTHLD EEILKRGGFI AGLVNDGNTC FMNSVLQSLA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGATTTGT TTATTGAAAG CAAGATAAAC AGTTTATTAC AATTTTTATT TGGTTCCCGA 60
CAGGATTTTT TGAGAAATTT TAAAACTTGG AGTAACAACA ATAACAATCT ATCGATTTAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005783--C:endoplasmic reticulum
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

sce:YDL122W

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ago-007761	Ashbya gossypii	54.57	0.00e+00	682.00
IUUC-Acl-008136	Aspergillus clavatus	26.13	7.00e-28	117.00
IUUC-Afl-008729	Aspergillus flavus	35.79	5.00e-23	100.00
IUUC-Afu-009119	Aspergillus fumigatus	28.34	6.00e-23	100.00
IUUC-Ani-009286	Aspergillus nidulans	24.82	1.00e-25	109.00
IUUC-Ang-009521	Aspergillus niger	26.99	6.00e-29	120.00
IUUC-Aor-009965	Aspergillus oryzae	29.84	8.00e-25	106.00
IUUC-Ate-010591	Aspergillus terreus	27.39	8.00e-35	139.00
IUUC-Bgr-012133	Blumeria graminis	29.58	5.00e-31	127.00
IUUC-Bci-013590	Botrytis cinerea	26.46	4.00e-22	97.80
IUUC-Cgl-026621	Colletotrichum gloeosporioides	28.27	2.00e-22	99.00
IUUC-Cne-027061	Cryptococcus neoformans	21.40	5.00e-09	54.30
IUUC-Dor-030166	Dipodomys ordii	44.19	4.00e-07	47.40
IUUC-Dse-031252	Dothistroma septosporum	29.21	2.00e-23	102.00
IUUC-Fox-037820	Fusarium oxysporum	36.05	7.00e-17	80.10
IUUC-Fso-038309	Fusarium solani	28.88	3.00e-24	104.00
IUUC-Ggr-040099	Gaeumannomyces graminis	31.69	8.00e-19	87.00
IUUC-Kpa-049268	Komagataella pastoris	44.00	1.00e-80	291.00
IUUC-Lma-053048	Leptosphaeria maculans	26.07	7.00e-19	87.00
IUUC-Mor-057143	Magnaporthe oryzae	28.35	1.00e-29	123.00
IUUC-Mpo-057548	Magnaporthe poae	26.42	5.00e-24	104.00
IUUC-Mla-058970	Melampsora laricipopulina	25.46	3.00e-25	108.00
IUUC-Nfi-068306	Neosartorya fischeri	26.81	2.00e-23	101.00
IUUC-Ncr-068741	Neurospora crassa	35.26	2.00e-19	89.40
IUUC-Pno-094855	Phaeosphaeria nodorum	36.71	1.00e-11	61.60
IUUC-Pte-104330	Pyrenophora teres	26.67	1.00e-18	86.30
IUUC-Pyt-104518	Pyrenophora triticirepentis	27.30	1.00e-19	89.70
IUUC-Ssl-108648	Sclerotinia sclerotiorum	25.78	1.00e-20	93.20
IUUC-Sre-114910	Sporisorium reilianum	26.84	2.00e-13	68.90
IUUC-Tre-122225	Trichoderma reesei	26.99	5.00e-29	120.00
IUUC-Tvi-122277	Trichoderma virens	28.61	2.00e-32	132.00
IUUC-Tme-126935	Tuber melanosporum	26.37	2.00e-13	68.90
IUUC-Uma-129375	Ustilago maydis	25.61	5.00e-14	71.20
IUUC-Vda-129789	Verticillium dahliae	27.36	3.00e-21	95.10
IUUC-Yli-134571	Yarrowia lipolytica	30.79	1.00e-30	125.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence