iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
FBgn0030674	FBtr0339688	FBpp0308745
FBgn0030674	FBtr0339687	FBpp0308744
FBgn0030674	FBtr0339686	FBpp0308743
FBgn0030674	FBtr0340304	FBpp0309265
FBgn0030674	FBtr0339690	FBpp0308747
FBgn0030674	FBtr0074082	FBpp0073898
FBgn0030674	FBtr0339689	FBpp0308746

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PHOSIDA
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	7.10e-114	380.7	4817	5150

Active Site

Position(s)	Description	Evidence
5118	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfyk 98
           +++k+r+++ f++Eeg+d+gG+ re++  +s+e++np++ lf  s++d+ t+ +np+s   np+hl++F+f+Gr+++ka+ d++ll++ +++sfyk
   Q: 4817 EEWKNRFYIVFEDEEGQDAGGLLREWYVIISREIFNPMYALFCVSPGDRVTYMINPSSHA-NPNHLSYFKFVGRVIAKAVHDNKLLECYFTRSFYK 4911
           689*******************************************************86.89********************************* PP
   S: 99   lllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafr 194
           ++lgk+++  d+e+ d e+yk l ++ +n   di++lg +ltfs++ +++g t+ ++Lkp+G+++ Vt+eNk eYv+lv+++++  +i++q++af 
   Q: 4912 HILGKQVKHTDMESQDYEFYKGLDYLMKN---DISTLGYELTFSTEVQEFGVTQIRDLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIRQQLDAFL 5004
           ***************************99...**************************************************************** PP
   S: 195  eGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelk....prl 286
           eGf+++ip++l+s+F+e+elelli+G ++id+edlk++t+y++ yt++s +iqwFw++l++f++ +r++fLqFvTg+s++Pl+Gf +l+     ++
   Q: 5005 EGFYDIIPKHLISIFNEQELELLISGLPDIDIEDLKANTEYHK-YTSKSAQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFGSLEgmngIQK 5099
           *****************************************66.*********************************************9999899 PP
   S: 287  fvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFel 335
           f+i++ d+s+drlP ++TCfn+L+LP Y+s+++l++ Ll Ai+e+ +gF++
   Q: 5100 FQIHRdDRSTDRLPCAHTCFNQLDLPMYKSYDKLRSCLLKAIHECsEGFGF 5150
           9999988899***************************************86 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MKVDTVKLKK GSSELTAECR ELIDELTKRR TRAELLEFLD TVHVWIYGKC ELYHWIEILD 60
RFDKILEEAS RHVNGNEFVL QCDTNFQETD VTLLLHVLNF TTLLIEHSFS RHLYNSIEHL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGCGTTTGC AGTGTTTGGT CACACTATTT ATGCTTGCAT TTCGTCTGTG TAAATTTCAT 60
TTCACAAAAA CCGACATTGT TAAATTAAGC AAATAAGAGT GTTTAAGATC GAAGTGAGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR025527--DUF4414
IPR010309--E3_Ub_ligase_DUF908
IPR010314--E3_Ub_ligase_DUF913
IPR000569--HECT_dom
IPR015940--UBA
IPR009060--UBA-like
IPR004170--WWE-dom

PROSITE

PS50237--HECT
PS50030--UBA
PS50918--WWE

Pfam

PF14377--DUF4414
PF06012--DUF908
PF06025--DUF913
PF00632--HECT
PF00627--UBA
PF02825--WWE

SMART

SM00119--HECTc

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0033227--P:dsRNA transport
GO:0016567--P:protein ubiquitination

KEGG

dme:Dmel_CG8184

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000627	Aegilops tauschii	44.16	1.00e-100	362.00
IUUC-Aml-001684	Ailuropoda melanoleuca	80.42	0.00e+00	748.00
IUUC-Atr-003044	Amborella trichopoda	50.11	2.00e-122	434.00
IUUC-Apl-003729	Anas platyrhynchos	76.35	2.00e-161	560.00
IUUC-Aca-005263	Anolis carolinensis	80.42	0.00e+00	749.00
IUUC-Aly-006083	Arabidopsis lyrata	50.35	2.00e-120	427.00
IUUC-Ath-007472	Arabidopsis thaliana	48.99	2.00e-120	427.00
IUUC-Ago-008005	Ashbya gossypii	48.32	2.00e-126	447.00
IUUC-Acl-008254	Aspergillus clavatus	52.24	2.00e-128	455.00
IUUC-Afl-008712	Aspergillus flavus	52.47	5.00e-130	458.00
IUUC-Afu-009022	Aspergillus fumigatus	52.94	2.00e-130	461.00
IUUC-Ani-009412	Aspergillus nidulans	53.18	2.00e-131	464.00
IUUC-Ang-009771	Aspergillus niger	52.24	3.00e-130	461.00
IUUC-Aor-010186	Aspergillus oryzae	52.03	4.00e-120	425.00
IUUC-Ate-010253	Aspergillus terreus	50.22	6.00e-130	459.00
IUUC-Ame-011067	Astyanax mexicanus	68.21	0.00e+00	771.00
IUUC-Bgr-012043	Blumeria graminis	52.96	3.00e-134	474.00
IUUC-Bta-012813	Bos taurus	80.42	0.00e+00	748.00
IUUC-Bci-013995	Botrytis cinerea	49.57	3.00e-134	474.00
IUUC-Bdi-014884	Brachypodium distachyon	49.42	1.00e-121	432.00
IUUC-Bol-016533	Brassica oleracea	56.16	4.00e-88	316.00
IUUC-Bra-016637	Brassica rapa	49.18	4.00e-117	417.00
IUUC-Cel-018179	Caenorhabditis elegans	66.36	7.00e-177	615.00
IUUC-Cja-018741	Callithrix jacchus	79.76	0.00e+00	738.00
IUUC-Cfa-020083	Canis familiaris	80.42	0.00e+00	747.00
IUUC-Cpo-021923	Cavia porcellus	67.90	6.00e-171	596.00
IUUC-Cre-022900	Chlamydomonas reinhardtii	48.59	5.00e-118	416.00
IUUC-Csa-023853	Chlorocebus sabaeus	80.42	0.00e+00	748.00
IUUC-Cho-024718	Choloepus hoffmanni	80.00	0.00e+00	660.00
IUUC-Cin-025627	Ciona intestinalis	71.69	0.00e+00	679.00
IUUC-Csv-025872	Ciona savignyi	71.00	0.00e+00	656.00
IUUC-Cgl-026647	Colletotrichum gloeosporioides	51.50	3.00e-138	487.00
IUUC-Cne-027095	Cryptococcus neoformans	45.26	1.00e-96	348.00
IUUC-Cme-027267	Cyanidioschyzon merolae	47.52	2.00e-109	390.00
IUUC-Dre-028525	Danio rerio	68.14	0.00e+00	722.00
IUUC-Dno-029680	Dasypus novemcinctus	80.42	0.00e+00	747.00
IUUC-Dor-030902	Dipodomys ordii	72.88	0.00e+00	652.00
IUUC-Dse-031197	Dothistroma septosporum	52.96	4.00e-133	470.00
IUUC-Ete-032690	Echinops telfairi	67.69	1.00e-158	555.00
IUUC-Eca-033915	Equus caballus	78.54	0.00e+00	721.00
IUUC-Eeu-034963	Erinaceus europaeus	79.76	0.00e+00	736.00
IUUC-Fca-035824	Felis catus	80.42	0.00e+00	748.00
IUUC-Fox-037756	Fusarium oxysporum	55.29	1.00e-136	482.00
IUUC-Fso-038464	Fusarium solani	55.19	1.00e-137	485.00
IUUC-Gmo-039073	Gadus morhua	68.83	0.00e+00	780.00
IUUC-Ggr-039946	Gaeumannomyces graminis	49.57	4.00e-131	463.00
IUUC-Gga-040309	Gallus gallus	81.82	3.00e-158	550.00
IUUC-Gac-042430	Gasterosteus aculeatus	68.83	0.00e+00	781.00
IUUC-Gma-042956	Glycine max	46.41	2.00e-120	428.00
IUUC-Ggo-044785	Gorilla gorilla	44.20	5.00e-106	379.00
IUUC-Hsa-046879	Homo sapiens	80.42	0.00e+00	748.00
IUUC-Hvu-047697	Hordeum vulgare	48.63	4.00e-121	430.00
IUUC-Itr-048430	Ictidomys tridecemlineatus	80.42	0.00e+00	748.00
IUUC-Kpa-049228	Komagataella pastoris	53.08	5.00e-132	466.00
IUUC-Lch-050252	Latimeria chalumnae	67.99	0.00e+00	765.00
IUUC-Lpe-051550	Leersia perrieri	48.18	4.00e-121	430.00
IUUC-Loc-052472	Lepisosteus oculatus	69.19	0.00e+00	783.00
IUUC-Lma-053159	Leptosphaeria maculans	52.59	8.00e-135	476.00
IUUC-Laf-054154	Loxodonta africana	80.42	0.00e+00	748.00
IUUC-Mcc-055085	Macaca mulatta	80.42	0.00e+00	748.00
IUUC-Meu-056727	Macropus eugenii	45.79	4.00e-102	367.00
IUUC-Mor-057201	Magnaporthe oryzae	53.77	6.00e-132	466.00
IUUC-Mpo-057597	Magnaporthe poae	49.14	4.00e-130	460.00
IUUC-Mtr-058273	Medicago truncatula	48.28	3.00e-123	437.00
IUUC-Mla-058888	Melampsora laricipopulina	49.02	5.00e-114	403.00
IUUC-Mvi-060320	Microbotryum violaceum	50.00	4.00e-123	437.00
IUUC-Mmr-060820	Microcebus murinus	80.42	0.00e+00	748.00
IUUC-Mdo-062930	Monodelphis domestica	80.66	0.00e+00	749.00
IUUC-Mmu-063601	Mus musculus	80.42	0.00e+00	747.00
IUUC-Mac-065229	Musa acuminata	46.54	3.00e-119	424.00
IUUC-Mpu-066653	Mustela putorius furo	80.42	0.00e+00	748.00
IUUC-Mlu-067418	Myotis lucifugus	80.42	0.00e+00	749.00
IUUC-Nfi-068278	Neosartorya fischeri	52.71	7.00e-130	459.00
IUUC-Ncr-068813	Neurospora crassa	51.97	9.00e-133	469.00
IUUC-Nle-069418	Nomascus leucogenys	80.42	0.00e+00	748.00
IUUC-Opr-070187	Ochotona princeps	65.09	5.00e-158	553.00
IUUC-Ont-071300	Oreochromis niloticus	68.83	0.00e+00	780.00
IUUC-Oan-073046	Ornithorhynchus anatinus	80.28	0.00e+00	744.00
IUUC-Ocu-074178	Oryctolagus cuniculus	80.42	0.00e+00	749.00
IUUC-Oba-075757	Oryza barthii	48.41	5.00e-121	429.00
IUUC-Obr-076553	Oryza brachyantha	48.41	1.00e-120	429.00
IUUC-Ogl-077520	Oryza glaberrima	48.41	5.00e-121	430.00
IUUC-Ogu-078278	Oryza glumaepatula	48.41	3.00e-121	430.00
IUUC-Oin-079767	Oryza indica	48.41	4.00e-121	430.00
IUUC-Olo-080380	Oryza longistaminata	47.97	2.00e-119	424.00
IUUC-Ome-081925	Oryza meridionalis	47.97	2.00e-119	424.00
IUUC-Oni-082619	Oryza nivara	48.41	5.00e-121	430.00
IUUC-Opu-083684	Oryza punctata	47.97	1.00e-119	425.00
IUUC-Oru-084501	Oryza rufipogon	48.41	4.00e-121	430.00
IUUC-Osa-086251	Oryza sativa	48.41	6.00e-120	424.00
IUUC-Ola-087437	Oryzias latipes	39.69	3.00e-92	333.00
IUUC-Olu-087813	Ostreococcus lucimarinus	49.75	3.00e-114	404.00
IUUC-Oga-088903	Otolemur garnettii	80.42	0.00e+00	748.00
IUUC-Oar-090210	Ovis aries	80.42	0.00e+00	747.00
IUUC-Ptr-090502	Pan troglodytes	39.46	3.00e-95	344.00
IUUC-Pan-092368	Papio anubis	81.03	0.00e+00	693.00
IUUC-Pno-094871	Phaeosphaeria nodorum	52.83	8.00e-135	476.00
IUUC-Ppa-095657	Physcomitrella patens	47.18	1.00e-121	432.00
IUUC-Pfo-096232	Poecilia formosa	68.83	0.00e+00	783.00
IUUC-Pab-098583	Pongo abelii	80.42	0.00e+00	748.00
IUUC-Pop-099613	Populus trichocarpa	50.82	2.00e-123	437.00
IUUC-Pca-100310	Procavia capensis	81.05	6.00e-125	443.00
IUUC-Ppe-102109	Prunus persica	48.44	3.00e-123	437.00
IUUC-Pva-102116	Pteropus vampyrus	74.06	0.00e+00	673.00
IUUC-Pgr-103465	Puccinia graminis	48.93	1.00e-122	435.00
IUUC-Ptt-103813	Puccinia triticina	46.32	9.00e-111	396.00
IUUC-Pte-104018	Pyrenophora teres	52.83	4.00e-133	470.00
IUUC-Pyt-104713	Pyrenophora triticirepentis	52.36	3.00e-131	464.00
IUUC-Rno-105889	Rattus norvegicus	44.60	4.00e-107	384.00
IUUC-Sce-106449	Saccharomyces cerevisiae	50.59	3.00e-123	437.00
IUUC-Sha-106961	Sarcophilus harrisii	68.43	0.00e+00	788.00
IUUC-Sja-107814	Schizosaccharomyces japonicus	51.42	5.00e-125	442.00
IUUC-Spo-108024	Schizosaccharomyces pombe	50.81	9.00e-126	445.00
IUUC-Smo-109428	Selaginella moellendorffii	48.08	2.00e-124	441.00
IUUC-Sit-110598	Setaria italica	49.09	3.00e-122	434.00
IUUC-Sly-111285	Solanum lycopersicum	51.05	2.00e-123	438.00
IUUC-Stu-112582	Solanum tuberosum	32.92	6.00e-56	211.00
IUUC-Sar-113291	Sorex araneus	80.39	0.00e+00	723.00
IUUC-Sbi-114042	Sorghum bicolor	49.54	9.00e-123	436.00
IUUC-Sre-114958	Sporisorium reilianum	56.60	8.00e-140	489.00
IUUC-Ssc-115754	Sus scrofa	80.42	0.00e+00	748.00
IUUC-Tru-118570	Takifugu rubripes	68.83	0.00e+00	782.00
IUUC-Tsy-119159	Tarsius syrichta	75.69	5.00e-131	463.00
IUUC-Tni-120836	Tetraodon nigroviridis	65.95	0.00e+00	745.00
IUUC-Tca-121479	Theobroma cacao	47.70	1.00e-120	429.00
IUUC-Tre-121909	Trichoderma reesei	54.82	1.00e-134	475.00
IUUC-Tvi-122370	Trichoderma virens	54.59	4.00e-135	477.00
IUUC-Tae-125214	Triticum aestivum	48.71	2.00e-118	420.00
IUUC-Tme-127172	Tuber melanosporum	52.01	6.00e-131	462.00
IUUC-Tbe-127506	Tupaia belangeri	78.09	2.00e-86	315.00
IUUC-Ttr-129253	Tursiops truncatus	80.42	0.00e+00	746.00
IUUC-Uma-129355	Ustilago maydis	55.66	2.00e-138	485.00
IUUC-Vda-129886	Verticillium dahliae	54.61	1.00e-133	472.00
IUUC-Vpa-130708	Vicugna pacos	80.42	0.00e+00	745.00
IUUC-Vvi-131170	Vitis vinifera	50.93	7.00e-123	434.00
IUUC-Xtr-132123	Xenopus tropicalis	75.76	0.00e+00	682.00
IUUC-Xma-133869	Xiphophorus maculatus	68.83	0.00e+00	783.00
IUUC-Yli-134657	Yarrowia lipolytica	50.36	3.00e-125	443.00
IUUC-Zma-135570	Zea mays	48.16	7.00e-123	436.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence