iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
CPLM	dbPAF	dbPTM	UniProt
PHOSIDA	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	19033468; 20080635

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	3.40e-11	42.0	1220	1324

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf..........kd..................................................gplvlpCgHvfhadClqkwpglknssskef 40
           Ca+C+++            d                                                   ++ ++C+H++h++C+++++++k++ss++f
   Q: 1220 CALCQDSSstdffvipayHDhspifrpgnifnpnefmpmwdgfynddekqayidddvlealkengscgsrKVF-VSCNHHIHHNCFKRYVQKKRFSSNAF 1318
           9999666643333333330033444444444444444444444444444444444444444444433332466.99************************ PP
   S: 41   rCPlCr 46
           +CPlC+
   Q: 1319 ICPLCQ 1324
           *****7 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Interacts with UBC2. Interacts with RPN2, RPT1 and RPT6 from the 26S proteasome.

Protein Sequence
(Fasta)

MSVADDDLGS LQGHIRRTLR SIHNLPYFRY TRGPTERADM SRALKEFIYR YLYFVISNSG 60
ENLPTLFNAH PKQKLSNPEL TVFPDSLEDA VDIDKITSQQ TIPFYKIDES RIGDVHKHTG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCCGTTG CTGATGATGA TTTAGGATCT TTACAAGGTC ACATTAGGAG AACACTGAGG 60
TCTATTCATA ACCTCCCCTA TTTTAGGTAT ACGAGAGGTC CTACTGAAAG GGCTGACATG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR014719--Ribosomal_L7/12_C/ClpS-like
IPR013083--Znf_RING/FYVE/PHD
IPR003126--Znf_UBR

PROSITE

PS51157--ZF_UBR

Pfam

PF02207--zf-UBR

SMART

SM00396--ZnF_UBR1

Gene Ontology

GO:0005737--C:cytoplasm
GO:0000151--C:ubiquitin ligase complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0090089--P:regulation of dipeptide transport
GO:1990116--P:ribosome-associated ubiquitin-dependent protein catabolic process
GO:0071629--P:ubiquitin-dependent catabolism of misfolded proteins by cytoplasm-associated proteasome
GO:0030433--P:ubiquitin-dependent ERAD pathway
GO:0071596--P:ubiquitin-dependent protein catabolic process via the N-end rule pathway

KEGG

sce:YGR184C

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Atr-002501	Amborella trichopoda	35.11	1.00e-09	58.20
IUUC-Apl-003828	Anas platyrhynchos	23.94	8.00e-21	95.10
IUUC-Aca-004982	Anolis carolinensis	23.01	2.00e-20	94.00
IUUC-Aly-005901	Arabidopsis lyrata	26.18	6.00e-11	62.40
IUUC-Ath-007148	Arabidopsis thaliana	25.67	3.00e-11	63.20
IUUC-Ago-007946	Ashbya gossypii	53.22	0.00e+00	1958.00
IUUC-Acl-008055	Aspergillus clavatus	23.61	6.00e-44	172.00
IUUC-Afl-008479	Aspergillus flavus	23.57	1.00e-47	184.00
IUUC-Afu-008929	Aspergillus fumigatus	24.25	3.00e-49	189.00
IUUC-Ani-009334	Aspergillus nidulans	22.82	2.00e-45	176.00
IUUC-Ang-009550	Aspergillus niger	23.73	6.00e-46	178.00
IUUC-Aor-010124	Aspergillus oryzae	23.44	2.00e-47	183.00
IUUC-Ate-010550	Aspergillus terreus	23.15	2.00e-42	167.00
IUUC-Ame-011917	Astyanax mexicanus	20.60	5.00e-17	82.40
IUUC-Bgr-011999	Blumeria graminis	21.77	2.00e-39	157.00
IUUC-Bta-012768	Bos taurus	21.78	8.00e-24	104.00
IUUC-Bci-013834	Botrytis cinerea	21.99	1.00e-35	144.00
IUUC-Bol-015669	Brassica oleracea	24.91	3.00e-15	76.60
IUUC-Bra-017776	Brassica rapa	24.24	7.00e-15	75.10
IUUC-Cel-018476	Caenorhabditis elegans	22.50	9.00e-11	61.60
IUUC-Cja-019797	Callithrix jacchus	21.80	5.00e-17	81.60
IUUC-Cfa-020950	Canis familiaris	23.52	1.00e-19	90.90
IUUC-Cpo-022385	Cavia porcellus	23.63	2.00e-21	96.70
IUUC-Csa-024082	Chlorocebus sabaeus	21.54	9.00e-19	88.20
IUUC-Cho-025029	Choloepus hoffmanni	23.01	3.00e-19	89.70
IUUC-Cin-025148	Ciona intestinalis	21.10	3.00e-12	65.10
IUUC-Cgl-026605	Colletotrichum gloeosporioides	23.60	8.00e-41	161.00
IUUC-Dre-028343	Danio rerio	20.73	2.00e-23	103.00
IUUC-Dno-029427	Dasypus novemcinctus	21.08	2.00e-19	90.50
IUUC-Dor-030207	Dipodomys ordii	25.00	4.00e-16	79.30
IUUC-Dse-031531	Dothistroma septosporum	22.74	1.00e-49	191.00
IUUC-Dme-031910	Drosophila melanogaster	22.88	6.00e-20	92.00
IUUC-Ete-033162	Echinops telfairi	23.58	2.00e-14	73.60
IUUC-Eca-033454	Equus caballus	22.00	3.00e-19	89.70
IUUC-Eeu-034664	Erinaceus europaeus	38.54	4.00e-14	72.80
IUUC-Fca-036588	Felis catus	22.11	2.00e-19	90.50
IUUC-Fal-036919	Ficedula albicollis	23.42	2.00e-18	87.00
IUUC-Fox-037984	Fusarium oxysporum	23.57	1.00e-35	144.00
IUUC-Fso-038463	Fusarium solani	23.39	1.00e-36	147.00
IUUC-Gmo-039698	Gadus morhua	22.63	6.00e-19	88.60
IUUC-Ggr-040070	Gaeumannomyces graminis	23.16	5.00e-41	162.00
IUUC-Gga-041123	Gallus gallus	23.98	3.00e-22	99.40
IUUC-Gac-042622	Gasterosteus aculeatus	22.56	1.00e-20	94.40
IUUC-Ggo-045583	Gorilla gorilla	23.29	6.00e-19	88.60
IUUC-Hsa-046343	Homo sapiens	23.33	4.00e-20	92.40
IUUC-Itr-048410	Ictidomys tridecemlineatus	21.29	1.00e-19	90.90
IUUC-Kpa-049120	Komagataella pastoris	24.96	2.00e-120	425.00
IUUC-Lch-049649	Latimeria chalumnae	36.84	4.00e-17	82.80
IUUC-Lpe-051516	Leersia perrieri	22.68	2.00e-17	84.00
IUUC-Loc-052624	Lepisosteus oculatus	19.91	1.00e-20	94.40
IUUC-Lma-053059	Leptosphaeria maculans	21.56	4.00e-44	172.00
IUUC-Laf-054142	Loxodonta africana	21.77	3.00e-24	106.00
IUUC-Mcc-055677	Macaca mulatta	21.54	6.00e-19	88.60
IUUC-Meu-056204	Macropus eugenii	35.71	7.00e-17	82.00
IUUC-Mor-057051	Magnaporthe oryzae	22.75	3.00e-46	179.00
IUUC-Mpo-057372	Magnaporthe poae	24.43	3.00e-34	139.00
IUUC-Mga-059698	Meleagris gallopavo	23.98	4.00e-22	99.00
IUUC-Mvi-060535	Microbotryum violaceum	22.17	5.00e-28	119.00
IUUC-Mmr-060901	Microcebus murinus	23.43	8.00e-20	91.70
IUUC-Mdo-062014	Monodelphis domestica	23.01	4.00e-20	92.80
IUUC-Mmu-063699	Mus musculus	22.71	2.00e-21	96.70
IUUC-Mpu-066153	Mustela putorius furo	22.11	2.00e-19	90.50
IUUC-Mlu-068151	Myotis lucifugus	23.46	1.00e-19	90.90
IUUC-Nfi-068403	Neosartorya fischeri	23.85	3.00e-48	186.00
IUUC-Ncr-068864	Neurospora crassa	23.14	4.00e-42	166.00
IUUC-Nle-069529	Nomascus leucogenys	21.34	1.00e-18	87.80
IUUC-Opr-071107	Ochotona princeps	22.78	7.00e-11	61.60
IUUC-Ont-072189	Oreochromis niloticus	41.86	6.00e-16	79.00
IUUC-Oan-072893	Ornithorhynchus anatinus	23.42	1.00e-22	100.00
IUUC-Ocu-074082	Oryctolagus cuniculus	22.79	1.00e-19	90.90
IUUC-Ome-081738	Oryza meridionalis	32.14	2.00e-06	47.00
IUUC-Osa-086106	Oryza sativa	24.75	3.00e-05	42.00
IUUC-Ola-087460	Oryzias latipes	20.24	8.00e-24	104.00
IUUC-Oga-088432	Otolemur garnettii	22.71	1.00e-20	94.00
IUUC-Oar-090206	Ovis aries	21.53	5.00e-16	79.00
IUUC-Ptr-091180	Pan troglodytes	21.34	1.00e-18	87.80
IUUC-Pan-092375	Papio anubis	21.54	8.00e-19	88.20
IUUC-Psi-093049	Pelodiscus sinensis	23.17	2.00e-19	90.50
IUUC-Pma-094569	Petromyzon marinus	45.83	1.00e-15	75.50
IUUC-Pno-094877	Phaeosphaeria nodorum	22.26	4.00e-29	122.00
IUUC-Pfo-097124	Poecilia formosa	21.98	3.00e-20	92.80
IUUC-Pab-097989	Pongo abelii	22.72	8.00e-19	88.20
IUUC-Pop-099184	Populus trichocarpa	37.21	1.00e-04	38.90
IUUC-Pca-100673	Procavia capensis	21.46	2.00e-12	67.00
IUUC-Pva-102724	Pteropus vampyrus	21.49	2.00e-19	90.50
IUUC-Pte-104174	Pyrenophora teres	22.89	2.00e-39	157.00
IUUC-Pyt-104431	Pyrenophora triticirepentis	22.79	3.00e-40	159.00
IUUC-Rno-105567	Rattus norvegicus	20.85	5.00e-23	102.00
IUUC-Sha-106980	Sarcophilus harrisii	23.08	3.00e-20	92.80
IUUC-Sja-107980	Schizosaccharomyces japonicus	23.19	5.00e-51	195.00
IUUC-Spo-108183	Schizosaccharomyces pombe	21.29	7.00e-55	208.00
IUUC-Ssl-108651	Sclerotinia sclerotiorum	28.41	1.10e-02	33.90
IUUC-Sly-111286	Solanum lycopersicum	25.28	1.00e-15	77.80
IUUC-Ssc-115525	Sus scrofa	26.32	9.00e-18	84.30
IUUC-Tgu-116943	Taeniopygia guttata	23.98	4.00e-22	99.00
IUUC-Tru-117673	Takifugu rubripes	21.43	4.00e-19	89.40
IUUC-Tsy-119032	Tarsius syrichta	22.33	1.00e-19	90.90
IUUC-Tni-119987	Tetraodon nigroviridis	20.99	3.00e-18	86.30
IUUC-Tca-121077	Theobroma cacao	25.63	2.00e-12	67.00
IUUC-Tre-122137	Trichoderma reesei	22.90	4.00e-43	169.00
IUUC-Tvi-122272	Trichoderma virens	22.30	3.00e-42	166.00
IUUC-Tae-125616	Triticum aestivum	24.91	2.00e-12	67.00
IUUC-Tur-126562	Triticum urartu	23.55	3.00e-12	65.90
IUUC-Tme-127156	Tuber melanosporum	22.66	7.00e-47	181.00
IUUC-Tbe-128103	Tupaia belangeri	55.26	4.00e-09	56.20
IUUC-Ttr-128253	Tursiops truncatus	23.23	3.00e-19	89.70
IUUC-Uma-129344	Ustilago maydis	21.47	2.00e-24	107.00
IUUC-Vda-129778	Verticillium dahliae	22.66	2.00e-41	163.00
IUUC-Vpa-130540	Vicugna pacos	22.61	5.00e-21	95.50
IUUC-Vvi-130900	Vitis vinifera	29.81	7.00e-05	39.70
IUUC-Xtr-132690	Xenopus tropicalis	23.19	3.00e-20	92.80
IUUC-Xma-134112	Xiphophorus maculatus	22.55	6.00e-20	92.00
IUUC-Yli-134662	Yarrowia lipolytica	23.38	4.00e-72	265.00
IUUC-Zma-135553	Zea mays	19.61	8.00e-09	55.10

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence