iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ocu-074097

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin-conjugating enzyme E2 Q2; E2 ubiquitin-conjugating enzyme Q2; Ubiquitin carrier protein Q2; Ubiquitin-conjugating enzyme UBCi; Ubiquitin-protein ligase Q2

Genbank Nucleotide ID

AY330351

Gene Name

UBE2Q2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000022720.2	ENSOCUT00000029964.2	ENSOCUP00000021489.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	6.30e-18	64.9	202	354

Active Site

Position(s)	Description	Evidence
298	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 1    Rlkkelkelekdpp..eg.isakpvdesdltewevlilG.pedtpYeg...........gvFkleiefpedYPfkPPkvkfltkifhPn 74
           Rl+kel ++ ++++  +g +s+++ ++  l++w+v++    +d+p +            ++  l+++f++++Pf+PP v+++ +++++ 
   Q: 202  RLMKELRDIYRSQSykTGiYSVELIND-SLYDWHVKLQKvDPDSPLHSdlqilkekegiEYILLNFSFKDNFPFDPPFVRVVLPVLSGG 289
           778888888665552233145666666.5888888876544555544312222222222346799***********************9 PP
   S: 75   vyen.GkvClsilkeeekWspalsvesvllsiqsll..aepnpesplneeaaellkknreeykkkvr 138
           +    G++C+++l +++ Ws+a+s+esv+++i+++l   +++++ ++n+++++l +++++ y+++v+
   Q: 290  YVLGgGALCMELL-TKQGWSSAYSIESVIMQINATLvkGKARVQFGANKNQYNLARAQQS-YNSIVQ 354
           99998********.59********************87789************9999998.999885 PP

Organism

Oryctolagus cuniculus

Functional Description
(View)

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination.

Protein Sequence
(Fasta)

MSVSGLKAEL KFLASIFDKN HERFRIVSWK LDELHCQFLV PPPAPPLLTL HCNITESYPS 60
SSPIWFVDSD DPNLTSVLER LEDSKNNNSL RQQLKWLICE LCRLYNLPKH LDVEMLDQPL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGGGGGGGG GGGGGCCCCT TTTTTCCAGG GGGGGGGGGG GGGGCGTCGC CCCTTGCCCT 60
TTTAAAAGCC GCGGGGGGCG CCCCCCTCCT GCCGGGTGGG GGGGTCGGTT TAAAAAAGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0070936--P:protein K48-linked ubiquitination

KEGG

ocu:100009425

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003420	Anas platyrhynchos	90.62	7.00e-160	556.00
IUUC-Afl-008523	Aspergillus flavus	31.69	7.00e-17	82.80
IUUC-Afu-009025	Aspergillus fumigatus	35.17	4.00e-15	77.40
IUUC-Ang-009729	Aspergillus niger	31.15	8.00e-21	96.30
IUUC-Aor-010200	Aspergillus oryzae	31.69	1.00e-16	82.80
IUUC-Ate-010283	Aspergillus terreus	35.47	3.00e-17	84.30
IUUC-Ame-011351	Astyanax mexicanus	80.16	7.00e-157	546.00
IUUC-Bta-012944	Bos taurus	87.00	3.00e-169	587.00
IUUC-Bci-013792	Botrytis cinerea	33.52	2.00e-16	81.30
IUUC-Cel-018705	Caenorhabditis elegans	45.34	3.00e-84	305.00
IUUC-Cfa-020582	Canis familiaris	93.09	0.00e+00	657.00
IUUC-Cpo-022469	Cavia porcellus	93.85	0.00e+00	668.00
IUUC-Csa-023724	Chlorocebus sabaeus	93.87	0.00e+00	671.00
IUUC-Cin-025383	Ciona intestinalis	51.61	8.00e-103	366.00
IUUC-Cgl-026471	Colletotrichum gloeosporioides	34.93	1.00e-18	89.00
IUUC-Dre-028429	Danio rerio	78.01	2.00e-160	558.00
IUUC-Dse-031418	Dothistroma septosporum	32.98	2.00e-18	88.20
IUUC-Dme-031720	Drosophila melanogaster	51.26	5.00e-110	390.00
IUUC-Ete-032744	Echinops telfairi	62.74	6.00e-87	313.00
IUUC-Eca-033376	Equus caballus	96.29	0.00e+00	679.00
IUUC-Fca-036101	Felis catus	93.65	0.00e+00	661.00
IUUC-Fal-036837	Ficedula albicollis	84.46	3.00e-174	604.00
IUUC-Fso-038245	Fusarium solani	29.19	2.00e-13	72.00
IUUC-Gmo-039573	Gadus morhua	83.38	2.00e-169	588.00
IUUC-Ggr-039776	Gaeumannomyces graminis	32.65	1.00e-15	79.30
IUUC-Gac-041518	Gasterosteus aculeatus	82.57	4.00e-170	590.00
IUUC-Hsa-046577	Homo sapiens	93.87	0.00e+00	664.00
IUUC-Lch-049959	Latimeria chalumnae	78.19	6.00e-154	536.00
IUUC-Loc-052754	Lepisosteus oculatus	81.82	7.00e-173	599.00
IUUC-Lma-052975	Leptosphaeria maculans	31.52	1.00e-21	99.40
IUUC-Mor-057265	Magnaporthe oryzae	30.20	7.00e-12	66.60
IUUC-Mpo-057298	Magnaporthe poae	31.97	2.00e-13	72.00
IUUC-Mga-059200	Meleagris gallopavo	91.11	2.00e-157	548.00
IUUC-Mvi-060299	Microbotryum violaceum	33.57	2.00e-14	75.10
IUUC-Mmr-061213	Microcebus murinus	96.02	0.00e+00	675.00
IUUC-Mdo-062562	Monodelphis domestica	79.52	2.00e-157	548.00
IUUC-Mmu-063747	Mus musculus	94.44	0.00e+00	671.00
IUUC-Mpu-066198	Mustela putorius furo	95.49	0.00e+00	677.00
IUUC-Nfi-068376	Neosartorya fischeri	34.48	3.00e-15	77.80
IUUC-Nle-069221	Nomascus leucogenys	93.87	0.00e+00	671.00
IUUC-Opr-070331	Ochotona princeps	78.08	2.00e-131	461.00
IUUC-Ont-071632	Oreochromis niloticus	82.06	3.00e-171	594.00
IUUC-Oan-072781	Ornithorhynchus anatinus	92.86	2.00e-141	494.00
IUUC-Ola-087271	Oryzias latipes	78.42	3.00e-170	590.00
IUUC-Olu-087612	Ostreococcus lucimarinus	29.41	7.00e-11	60.10
IUUC-Oga-089115	Otolemur garnettii	95.23	0.00e+00	664.00
IUUC-Oar-090270	Ovis aries	89.83	0.00e+00	656.00
IUUC-Ptr-090599	Pan troglodytes	93.33	0.00e+00	669.00
IUUC-Pan-092455	Papio anubis	94.13	0.00e+00	674.00
IUUC-Pma-094631	Petromyzon marinus	69.46	1.00e-131	462.00
IUUC-Pno-095082	Phaeosphaeria nodorum	34.22	4.00e-17	84.30
IUUC-Pfo-097215	Poecilia formosa	83.51	5.00e-172	596.00
IUUC-Pva-102975	Pteropus vampyrus	98.09	2.00e-171	594.00
IUUC-Pte-104028	Pyrenophora teres	35.20	5.00e-19	90.50
IUUC-Pyt-104588	Pyrenophora triticirepentis	35.20	4.00e-18	87.40
IUUC-Rno-105714	Rattus norvegicus	90.45	0.00e+00	630.00
IUUC-Sha-106904	Sarcophilus harrisii	90.22	3.00e-157	547.00
IUUC-Ssl-108486	Sclerotinia sclerotiorum	34.09	2.00e-17	81.60
IUUC-Sar-113657	Sorex araneus	96.18	3.00e-167	580.00
IUUC-Ssc-116046	Sus scrofa	94.96	0.00e+00	664.00
IUUC-Tgu-116888	Taeniopygia guttata	85.71	2.00e-156	544.00
IUUC-Tru-118721	Takifugu rubripes	81.91	3.00e-167	580.00
IUUC-Tsy-118894	Tarsius syrichta	89.64	2.00e-125	441.00
IUUC-Tni-120346	Tetraodon nigroviridis	80.43	8.00e-168	582.00
IUUC-Tre-122084	Trichoderma reesei	30.39	1.00e-16	82.40
IUUC-Tvi-122420	Trichoderma virens	32.97	4.00e-14	73.90
IUUC-Tme-127145	Tuber melanosporum	39.58	4.00e-18	87.40
IUUC-Ttr-128707	Tursiops truncatus	95.76	0.00e+00	677.00
IUUC-Vda-129662	Verticillium dahliae	30.00	1.00e-11	65.90
IUUC-Vpa-130455	Vicugna pacos	98.73	6.00e-173	599.00
IUUC-Xtr-132483	Xenopus tropicalis	87.03	2.00e-177	614.00
IUUC-Xma-134189	Xiphophorus maculatus	78.95	2.00e-161	561.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence