iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Loc-052765

Ensembl Protein ID

ENSLOCP00000002304.1

UniProt Accession

W5M1P6; W5M1P6_LEPOC

Genbank Protein ID

ENSLOCP00000002304

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AHAT01031978

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLOCG00000001994.1	ENSLOCT00000002309.1	ENSLOCP00000002304.1
ENSLOCG00000001994.1	ENSLOCT00000002317.1	ENSLOCP00000002312.1
ENSLOCG00000001994.1	ENSLOCT00000002337.1	ENSLOCP00000002332.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	6.90e-76	255.8	177	524

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgyeq 89
           Gl NlgNtC+mN+++Q+L+++p lr+++l+ +++k++ +    ++ +l++++ +lf+e    ++++    + +l ++++++  + +y+q
   Q: 177  GLINLGNTCFMNCIVQALTHTPLLRDFFLS-DRHKCEMQ----SNSCLVCEMSQLFQEDFfFYSHHLCLHEYMLYTCWSCKAYILNYSQ 260
           9*****************************.99999865....689**********998777777777777888888888877666665 PP
   S: 90   ...qDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslp 175
                  E l++l  + ++ +         + +++     ++ ++ +++++ +++i+++F g l+s+++c+ c+ vs++ +pf+d+sl+
   Q: 261  llqCSYTEELTCLT-ASHRIC---------TVKGD-----DNGKKANNPNHCNCIIDQIFTGGLQSDVTCQVCHGVSTTIDPFWDISLD 334
           11155556555544.445556.........22222.....2345677899999************************************ PP
   S: 176  vpgkeetkke....................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqk 244
           +pg++    +                    +l+dcL+ ft++e+l ++ k++c+ c+++qe++k+l++kklP v ++hLkRf  +++ k
   Q: 335  LPGSSAPFWPlspgsdggvvngeshlsgatTLTDCLRRFTRPEHLGSSAKIKCSGCHSYQESTKQLTMKKLPIVACFHLKRF--EHSAK 421
           *****87777************************************************************************..56668 PP
   S: 245  srekinkkvefpleLdlspfctspeekqke............kkkYeLiavvvHsGslssGHYvayvknekgkWllfdDskVtevkeee 321
            r+ki+++v+fpleLd++pf++s++e+  +            ++kY+L+avv+H+G+l+sGHY+++++++k++W+++dD  +t+ + ++
   Q: 422  LRRKITTYVSFPLELDMTPFMASSKESRMNgqyqqpvdslnnDNKYSLFAVVNHQGTLESGHYTSFIRQHKDQWFKCDDAIITKASIKD 510
           99*********************6655555777777777777*********************************************** PP
   S: 322  vleetgstaYvlfYkrr 338
           vl    s++Y+lfY+++
   Q: 511  VLD---SEGYLLFYHKQ 524
           ***...********985 PP

Organism

Lepisosteus oculatus

Protein Sequence
(Fasta)

VMSPAGCSHV NSFKVENWKQ NLRLIYQCFV WSGTAETRKR KAKSCICHMC GAHLNRLHSC 60
LYCVFFGCFT KKHIHEHAKN KRHNLAIDLL YGGIYCFMCQ DYIYDKDMEQ IAKEEQRKAW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTGAATGTTG TTTCTGTCAT GAGTCCGGCC GGGTGCTCCC ATGTGAACAG TTTTAAGGTG 60
GAGAATTGGA AACAGAATCT ACGACTCATA TACCAGTGCT TTGTGTGGAG CGGGACTGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000393	Aegilops tauschii	33.06	1.00e-46	181.00
IUUC-Aml-001343	Ailuropoda melanoleuca	82.11	0.00e+00	895.00
IUUC-Atr-002653	Amborella trichopoda	33.15	8.00e-81	294.00
IUUC-Apl-003433	Anas platyrhynchos	85.92	0.00e+00	858.00
IUUC-Aca-005347	Anolis carolinensis	83.27	0.00e+00	914.00
IUUC-Aly-006565	Arabidopsis lyrata	32.49	1.00e-55	210.00
IUUC-Ath-007536	Arabidopsis thaliana	32.70	1.00e-55	211.00
IUUC-Ago-007811	Ashbya gossypii	27.40	4.00e-41	162.00
IUUC-Acl-008124	Aspergillus clavatus	27.53	1.00e-46	180.00
IUUC-Afl-008464	Aspergillus flavus	29.29	4.00e-44	171.00
IUUC-Afu-008912	Aspergillus fumigatus	28.00	4.00e-44	172.00
IUUC-Ani-009168	Aspergillus nidulans	28.22	3.00e-46	179.00
IUUC-Ang-009694	Aspergillus niger	28.29	2.00e-44	173.00
IUUC-Ate-010382	Aspergillus terreus	28.83	1.00e-42	167.00
IUUC-Ame-011253	Astyanax mexicanus	79.02	0.00e+00	759.00
IUUC-Bgr-012150	Blumeria graminis	28.87	6.00e-39	155.00
IUUC-Bta-013303	Bos taurus	82.52	0.00e+00	899.00
IUUC-Bci-013604	Botrytis cinerea	31.66	2.00e-50	192.00
IUUC-Bdi-014171	Brachypodium distachyon	31.90	3.00e-58	219.00
IUUC-Bol-016509	Brassica oleracea	34.36	3.00e-57	216.00
IUUC-Bra-016962	Brassica rapa	33.20	8.00e-56	211.00
IUUC-Cja-019283	Callithrix jacchus	83.00	0.00e+00	749.00
IUUC-Cfa-021239	Canis familiaris	83.00	0.00e+00	834.00
IUUC-Cpo-022354	Cavia porcellus	82.89	0.00e+00	898.00
IUUC-Csa-023145	Chlorocebus sabaeus	83.65	0.00e+00	909.00
IUUC-Cho-024938	Choloepus hoffmanni	80.30	1.00e-60	227.00
IUUC-Cin-025109	Ciona intestinalis	48.62	6.00e-96	344.00
IUUC-Csv-026214	Ciona savignyi	49.54	2.00e-149	522.00
IUUC-Cgl-026457	Colletotrichum gloeosporioides	30.72	4.00e-47	182.00
IUUC-Cne-027085	Cryptococcus neoformans	30.34	6.00e-49	188.00
IUUC-Dre-027433	Danio rerio	85.51	0.00e+00	848.00
IUUC-Dno-030095	Dasypus novemcinctus	83.74	0.00e+00	837.00
IUUC-Dor-030832	Dipodomys ordii	84.54	2.00e-96	345.00
IUUC-Dse-031415	Dothistroma septosporum	28.49	6.00e-52	198.00
IUUC-Dme-032074	Drosophila melanogaster	45.60	9.00e-120	423.00
IUUC-Ete-033175	Echinops telfairi	96.13	1.00e-103	370.00
IUUC-Eca-033736	Equus caballus	82.93	0.00e+00	830.00
IUUC-Eeu-034814	Erinaceus europaeus	96.19	2.00e-120	426.00
IUUC-Fca-035861	Felis catus	83.33	0.00e+00	833.00
IUUC-Fal-037645	Ficedula albicollis	85.89	0.00e+00	843.00
IUUC-Fox-038046	Fusarium oxysporum	30.54	1.00e-47	184.00
IUUC-Fso-038321	Fusarium solani	30.99	1.00e-47	183.00
IUUC-Gmo-038474	Gadus morhua	83.61	6.00e-145	507.00
IUUC-Ggr-040044	Gaeumannomyces graminis	29.75	6.00e-47	181.00
IUUC-Gga-040624	Gallus gallus	85.87	0.00e+00	927.00
IUUC-Gac-042197	Gasterosteus aculeatus	80.79	0.00e+00	862.00
IUUC-Gma-042897	Glycine max	30.55	5.00e-67	248.00
IUUC-Ggo-044409	Gorilla gorilla	83.83	0.00e+00	910.00
IUUC-Hsa-046521	Homo sapiens	83.83	0.00e+00	910.00
IUUC-Hvu-047739	Hordeum vulgare	33.24	3.00e-51	195.00
IUUC-Itr-048375	Ictidomys tridecemlineatus	83.05	0.00e+00	901.00
IUUC-Kpa-049135	Komagataella pastoris	31.96	5.00e-57	215.00
IUUC-Lch-050537	Latimeria chalumnae	86.44	0.00e+00	929.00
IUUC-Lpe-050969	Leersia perrieri	34.12	3.00e-56	212.00
IUUC-Lma-053105	Leptosphaeria maculans	29.59	6.00e-51	194.00
IUUC-Laf-053571	Loxodonta africana	84.15	0.00e+00	838.00
IUUC-Mcc-055166	Macaca mulatta	83.65	0.00e+00	909.00
IUUC-Mor-057103	Magnaporthe oryzae	30.41	2.00e-50	193.00
IUUC-Mpo-057621	Magnaporthe poae	29.96	6.00e-46	178.00
IUUC-Mtr-057894	Medicago truncatula	34.57	5.00e-70	258.00
IUUC-Mga-059709	Meleagris gallopavo	85.92	0.00e+00	858.00
IUUC-Mvi-060530	Microbotryum violaceum	30.20	1.00e-45	177.00
IUUC-Mmr-060988	Microcebus murinus	83.27	0.00e+00	907.00
IUUC-Mdo-063065	Monodelphis domestica	86.82	0.00e+00	933.00
IUUC-Mmu-063829	Mus musculus	83.27	0.00e+00	906.00
IUUC-Mac-065419	Musa acuminata	36.86	4.00e-57	215.00
IUUC-Mpu-066687	Mustela putorius furo	82.71	0.00e+00	901.00
IUUC-Mlu-067330	Myotis lucifugus	73.92	0.00e+00	789.00
IUUC-Nfi-068423	Neosartorya fischeri	28.22	5.00e-44	172.00
IUUC-Ncr-068809	Neurospora crassa	27.59	2.00e-48	186.00
IUUC-Nle-069261	Nomascus leucogenys	79.89	0.00e+00	856.00
IUUC-Opr-070469	Ochotona princeps	65.92	3.00e-160	557.00
IUUC-Ont-071961	Oreochromis niloticus	82.67	0.00e+00	895.00
IUUC-Oan-073565	Ornithorhynchus anatinus	79.96	0.00e+00	832.00
IUUC-Ocu-074435	Oryctolagus cuniculus	83.04	0.00e+00	879.00
IUUC-Oba-075688	Oryza barthii	32.56	4.00e-56	212.00
IUUC-Obr-076652	Oryza brachyantha	36.08	2.00e-55	209.00
IUUC-Ogl-077910	Oryza glaberrima	33.40	3.00e-60	226.00
IUUC-Ogu-078479	Oryza glumaepatula	33.40	2.00e-60	226.00
IUUC-Oin-079697	Oryza indica	34.44	5.00e-57	215.00
IUUC-Olo-080811	Oryza longistaminata	38.70	7.00e-41	160.00
IUUC-Ome-081706	Oryza meridionalis	33.40	8.00e-60	225.00
IUUC-Oni-083070	Oryza nivara	32.98	4.00e-60	225.00
IUUC-Opu-083605	Oryza punctata	34.77	2.00e-48	186.00
IUUC-Oru-084522	Oryza rufipogon	33.40	3.00e-60	226.00
IUUC-Osa-085351	Oryza sativa	34.78	2.00e-57	217.00
IUUC-Ola-086743	Oryzias latipes	76.42	0.00e+00	660.00
IUUC-Olu-087695	Ostreococcus lucimarinus	29.41	4.00e-42	165.00
IUUC-Oga-089131	Otolemur garnettii	83.65	0.00e+00	911.00
IUUC-Oar-089319	Ovis aries	83.10	0.00e+00	828.00
IUUC-Ptr-090783	Pan troglodytes	82.74	0.00e+00	841.00
IUUC-Pan-092927	Papio anubis	83.65	0.00e+00	909.00
IUUC-Psi-093670	Pelodiscus sinensis	85.12	0.00e+00	858.00
IUUC-Pma-094323	Petromyzon marinus	66.34	0.00e+00	691.00
IUUC-Pno-095141	Phaeosphaeria nodorum	28.29	5.00e-45	175.00
IUUC-Ppa-095413	Physcomitrella patens	33.06	4.00e-70	259.00
IUUC-Pfo-096462	Poecilia formosa	83.46	0.00e+00	915.00
IUUC-Pab-097612	Pongo abelii	83.83	0.00e+00	910.00
IUUC-Pop-099558	Populus trichocarpa	32.93	3.00e-73	269.00
IUUC-Pca-100329	Procavia capensis	74.30	0.00e+00	789.00
IUUC-Ppe-102020	Prunus persica	33.17	4.00e-76	278.00
IUUC-Pva-102721	Pteropus vampyrus	70.36	0.00e+00	731.00
IUUC-Pte-104340	Pyrenophora teres	29.17	4.00e-45	176.00
IUUC-Pyt-104782	Pyrenophora triticirepentis	32.72	2.00e-52	199.00
IUUC-Rno-105247	Rattus norvegicus	83.27	0.00e+00	907.00
IUUC-Sce-106247	Saccharomyces cerevisiae	27.62	4.00e-39	155.00
IUUC-Sha-107538	Sarcophilus harrisii	94.93	7.00e-124	435.00
IUUC-Sja-107656	Schizosaccharomyces japonicus	31.21	2.00e-53	202.00
IUUC-Spo-108226	Schizosaccharomyces pombe	29.40	1.00e-47	183.00
IUUC-Ssl-108531	Sclerotinia sclerotiorum	30.91	2.00e-47	183.00
IUUC-Smo-109310	Selaginella moellendorffii	32.68	5.00e-72	265.00
IUUC-Sit-109716	Setaria italica	31.94	3.00e-62	233.00
IUUC-Sly-111077	Solanum lycopersicum	34.43	5.00e-64	238.00
IUUC-Stu-112203	Solanum tuberosum	35.60	2.00e-55	210.00
IUUC-Sar-113174	Sorex araneus	70.77	0.00e+00	697.00
IUUC-Sbi-114205	Sorghum bicolor	31.68	5.00e-64	238.00
IUUC-Sre-115195	Sporisorium reilianum	33.58	3.00e-30	127.00
IUUC-Ssc-115315	Sus scrofa	74.44	0.00e+00	793.00
IUUC-Tgu-116938	Taeniopygia guttata	86.18	0.00e+00	853.00
IUUC-Tru-117622	Takifugu rubripes	85.88	0.00e+00	936.00
IUUC-Tsy-119431	Tarsius syrichta	71.89	0.00e+00	682.00
IUUC-Tni-120119	Tetraodon nigroviridis	85.31	0.00e+00	927.00
IUUC-Tca-121154	Theobroma cacao	33.58	3.00e-73	269.00
IUUC-Tre-122139	Trichoderma reesei	30.04	4.00e-46	178.00
IUUC-Tvi-122599	Trichoderma virens	29.55	6.00e-47	181.00
IUUC-Tae-125608	Triticum aestivum	32.34	8.00e-68	251.00
IUUC-Tme-127115	Tuber melanosporum	33.27	5.00e-70	258.00
IUUC-Ttr-129006	Tursiops truncatus	74.19	0.00e+00	777.00
IUUC-Uma-129455	Ustilago maydis	34.34	2.00e-32	134.00
IUUC-Vvi-131477	Vitis vinifera	32.97	2.00e-61	230.00
IUUC-Xtr-132444	Xenopus tropicalis	87.01	0.00e+00	940.00
IUUC-Xma-133514	Xiphophorus maculatus	85.88	0.00e+00	930.00
IUUC-Zma-134945	Zea mays	31.85	1.00e-59	224.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence