iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPTM
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/Other	95.11	9.00e-151	530.00	IUUC-Hsa-046937

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Rattus norvegicus

Functional Description
(View)

GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly locomotor activity and motor coordination.

Protein Sequence
(Fasta)

MMKTLSSGNC TLNVPAKNSY RMVVLGASRV GKSSIVSRFL NGRFEDQYTP TIEDFHRKVY 60
NIHGDMYQLD ILDTSGNHPF PAMRRLSILT GDVFILVFSL DSRESFDEVK RLQKQILEVK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGTGCAGCA TCCGGAGCTC GAGCTTGGGC CATCCCGGGT GGACTCCACG TTCGCTGGCG 60
GGAGAGGACG AGGGAGGAGC CCACCCTAAG AAACTTCTCC CCCCTTTGGG GAGAGGAGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0342--GTP-binding
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0488--Methylation
KW-0547--Nucleotide-binding
KW-0636--Prenylation
KW-1185--Reference proteome

Interpro

IPR027417--P-loop_NTPase
IPR005225--Small_GTP-bd_dom
IPR001806--Small_GTPase
IPR020849--Small_GTPase_Ras

PROSITE

PS51421--RAS

Pfam

PF00071--Ras

Gene Ontology

GO:0005622--C:intracellular
GO:0005886--C:plasma membrane
GO:0005525--F:GTP binding
GO:0043548--F:phosphatidylinositol 3-kinase binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0007626--P:locomotory behavior
GO:0031397--P:negative regulation of protein ubiquitination
GO:0051897--P:positive regulation of protein kinase B signaling
GO:0033235--P:positive regulation of protein sumoylation
GO:0043949--P:regulation of cAMP-mediated signaling
GO:0007264--P:small GTPase mediated signal transduction
GO:0001963--P:synaptic transmission, dopaminergic

KEGG

rno:171099

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002300	Ailuropoda melanoleuca	95.11	7.00e-152	529.00
IUUC-Apl-003857	Anas platyrhynchos	87.59	1.00e-140	491.00
IUUC-Aca-004240	Anolis carolinensis	87.97	3.00e-140	490.00
IUUC-Bta-013228	Bos taurus	93.98	7.00e-150	522.00
IUUC-Cja-018957	Callithrix jacchus	94.74	2.00e-151	527.00
IUUC-Cfa-020131	Canis familiaris	95.11	3.00e-152	530.00
IUUC-Cpo-021614	Cavia porcellus	91.73	8.00e-147	512.00
IUUC-Csa-023844	Chlorocebus sabaeus	95.11	4.00e-152	530.00
IUUC-Dno-029174	Dasypus novemcinctus	96.24	3.00e-153	533.00
IUUC-Dor-031033	Dipodomys ordii	94.36	5.00e-151	526.00
IUUC-Dme-031780	Drosophila melanogaster	47.23	3.00e-62	232.00
IUUC-Ete-032309	Echinops telfairi	93.14	1.00e-95	341.00
IUUC-Eca-034018	Equus caballus	94.74	2.00e-151	527.00
IUUC-Fca-035875	Felis catus	94.74	2.00e-151	528.00
IUUC-Fal-037653	Ficedula albicollis	86.47	2.00e-138	484.00
IUUC-Gga-040943	Gallus gallus	87.97	1.00e-140	492.00
IUUC-Ggo-044688	Gorilla gorilla	95.11	5.00e-152	530.00
IUUC-Hsa-046937	Homo sapiens	95.11	4.00e-152	530.00
IUUC-Itr-048300	Ictidomys tridecemlineatus	95.86	2.00e-153	534.00
IUUC-Lch-050232	Latimeria chalumnae	79.28	2.00e-119	421.00
IUUC-Laf-053676	Loxodonta africana	94.74	2.00e-151	528.00
IUUC-Meu-056249	Macropus eugenii	91.35	4.00e-146	510.00
IUUC-Mga-059257	Meleagris gallopavo	87.97	6.00e-141	493.00
IUUC-Mdo-061991	Monodelphis domestica	91.35	9.00e-146	508.00
IUUC-Mmu-063268	Mus musculus	100.00	3.00e-160	556.00
IUUC-Mpu-066901	Mustela putorius furo	95.49	1.00e-152	531.00
IUUC-Mlu-067258	Myotis lucifugus	95.11	4.00e-152	530.00
IUUC-Nle-068973	Nomascus leucogenys	95.11	6.00e-152	530.00
IUUC-Opr-070743	Ochotona princeps	94.36	3.00e-150	524.00
IUUC-Oan-072868	Ornithorhynchus anatinus	89.89	1.00e-142	498.00
IUUC-Ocu-074790	Oryctolagus cuniculus	94.36	8.00e-151	525.00
IUUC-Oga-088431	Otolemur garnettii	95.49	9.00e-153	532.00
IUUC-Oar-089258	Ovis aries	95.17	4.00e-116	410.00
IUUC-Ptr-090978	Pan troglodytes	95.11	4.00e-152	530.00
IUUC-Pan-092088	Papio anubis	93.28	6.00e-132	462.00
IUUC-Psi-093630	Pelodiscus sinensis	87.97	7.00e-141	492.00
IUUC-Pma-094385	Petromyzon marinus	35.94	4.00e-26	111.00
IUUC-Pab-098310	Pongo abelii	95.11	4.00e-152	530.00
IUUC-Pca-100098	Procavia capensis	92.48	4.00e-145	506.00
IUUC-Pva-102212	Pteropus vampyrus	93.61	4.00e-150	523.00
IUUC-Sha-106504	Sarcophilus harrisii	91.35	3.00e-146	510.00
IUUC-Sar-113244	Sorex araneus	91.48	3.00e-93	333.00
IUUC-Tgu-116948	Taeniopygia guttata	86.09	5.00e-138	483.00
IUUC-Tur-126269	Triticum urartu	32.69	1.80e+00	26.20
IUUC-Tbe-127818	Tupaia belangeri	95.11	3.00e-152	530.00
IUUC-Ttr-128286	Tursiops truncatus	93.98	9.00e-150	522.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence