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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046970
UUCD1 version UUC-HoS-00276
Ensembl Protein ID ENSP00000263754.4
UniProt Accession Q92831; Q6NSK1; KAT2B_HUMAN
Genbank Protein ID AAC50890.2; AAH60823.1; AAH70075.1
Protein Name Histone acetyltransferase KAT2B; Histone acetyltransferase PCAF; Lysine acetyltransferase 2B; P300/CBP-associated factor
Genbank Nucleotide ID U57317; BC060823; BC070075
Gene Name KAT2B; PCAF
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000114166.7 ENST00000263754.4 ENSP00000263754.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkTargetScanRepTarmiRNAMap
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Drug and target
TTDGRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMBioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/Other E3 activity/Other 17293853; 19176998; 21374733
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Also acetylates non-histone proteins, such as ACLY. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers.
 Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Also acetylates non-histone proteins, such as ACLY. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers.
Protein Sequence
(Fasta)
MSEAGGAGPG GCGAGAGAGA GPGALPPQPA ALPPAPPQGS PCAAAAGGSG ACGPATAVAA 60
AGTAEGPGGG GSARIAVKKA QLRSAPRAKK LEKLGVYSAC KAEESCKCNG WKNPNPSPTP 120
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Protein Fasta Sequence


>IUUC-Hsa-046970|E3,E3 activity/Other|Homo sapiens
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Nucleotide Sequence
(Fasta)
CCGCGGGCAG CGGAAAAGAG GCCGTGGGGG GCCTCCCAGC GCTGGCAGAC ACCGTGAGGC 60
TGGCAGCCGC CGGCACGCAC ACCTAGTCCG CAGTCCCGAG GAACATGTCC GCAGCCAGGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046970|E3,E3 activity/Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0010--Activator
KW-0012--Acyltransferase
KW-0090--Biological rhythms
KW-0103--Bromodomain
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0945--Host-virus interaction
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
Interpro

IPR016181--Acyl_CoA_acyltransferase
IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR016376--GCN5/PCAF
IPR000182--GNAT_dom
IPR009464--PCAF_N
PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS51186--GNAT
Pfam

PF00583--Acetyltransf_1
PF00439--Bromodomain
PF06466--PCAF_N
PRINTS

PR00503--BROMODOMAIN
SMART

SM00297--BROMO
Gene Ontology

GO:0031672--C:A band
GO:0042641--C:actomyosin
GO:0005671--C:Ada2/Gcn5/Ada3 transcription activator complex
GO:0031674--C:I band
GO:0000776--C:kinetochore
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0000125--C:PCAF complex
GO:0016407--F:acetyltransferase activity
GO:0003682--F:chromatin binding
GO:0004861--F:cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0004402--F:histone acetyltransferase activity
GO:0042826--F:histone deacetylase binding
GO:0004468--F:lysine N-acetyltransferase activity, acting on acetyl phosphate as donor
GO:0032403--F:protein complex binding
GO:0019901--F:protein kinase binding
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0003713--F:transcription coactivator activity
GO:0003712--F:transcription cofactor activity
GO:0008134--F:transcription factor binding
GO:0007050--P:cell cycle arrest
GO:0032869--P:cellular response to insulin stimulus
GO:0006338--P:chromatin remodeling
GO:0043966--P:histone H3 acetylation
GO:0043970--P:histone H3-K9 acetylation
GO:0018393--P:internal peptidyl-lysine acetylation
GO:0018076--P:N-terminal peptidyl-lysine acetylation
GO:0008285--P:negative regulation of cell proliferation
GO:0045736--P:negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0007219--P:Notch signaling pathway
GO:0018394--P:peptidyl-lysine acetylation
GO:0045815--P:positive regulation of gene expression, epigenetic
GO:0035948--P:positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0006473--P:protein acetylation
GO:0016579--P:protein deubiquitination
GO:0010835--P:regulation of protein ADP-ribosylation
GO:0048511--P:rhythmic process
GO:0006367--P:transcription initiation from RNA polymerase II promoter
GO:0016032--P:viral process
KEGG hsa:8850
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001599 Ailuropoda melanoleuca 96.35 0.00e+00 1383.00
IUUC-Atr-003130 Amborella trichopoda 41.80 9.00e-88 317.00
IUUC-Apl-004026 Anas platyrhynchos 91.80 0.00e+00 1304.00
IUUC-Aly-006486 Arabidopsis lyrata 43.36 4.00e-76 279.00
IUUC-Ath-006763 Arabidopsis thaliana 43.51 1.00e-76 280.00
IUUC-Ago-007819 Ashbya gossypii 48.31 3.00e-87 315.00
IUUC-Acl-008194 Aspergillus clavatus 44.89 5.00e-81 295.00
IUUC-Afl-008546 Aspergillus flavus 44.60 2.00e-81 296.00
IUUC-Afu-009124 Aspergillus fumigatus 45.45 2.00e-82 299.00
IUUC-Ani-009432 Aspergillus nidulans 43.81 1.00e-76 280.00
IUUC-Ang-009824 Aspergillus niger 45.45 2.00e-82 299.00
IUUC-Aor-010076 Aspergillus oryzae 43.73 4.00e-79 288.00
IUUC-Bgr-012003 Blumeria graminis 42.60 3.00e-76 278.00
IUUC-Bta-012381 Bos taurus 95.03 0.00e+00 1416.00
IUUC-Bci-013974 Botrytis cinerea 45.95 6.00e-83 301.00
IUUC-Bdi-015016 Brachypodium distachyon 44.51 4.00e-84 305.00
IUUC-Cel-018633 Caenorhabditis elegans 48.09 1.00e-85 311.00
IUUC-Cja-019375 Callithrix jacchus 98.62 0.00e+00 1377.00
IUUC-Cfa-020400 Canis familiaris 92.03 0.00e+00 1292.00
IUUC-Cpo-021686 Cavia porcellus 98.36 0.00e+00 1441.00
IUUC-Cre-023019 Chlamydomonas reinhardtii 55.98 3.00e-53 202.00
IUUC-Csa-024252 Chlorocebus sabaeus 99.56 0.00e+00 1333.00
IUUC-Cho-024635 Choloepus hoffmanni 94.61 0.00e+00 996.00
IUUC-Cgl-026660 Colletotrichum gloeosporioides 44.60 7.00e-77 281.00
IUUC-Cne-027050 Cryptococcus neoformans 44.83 5.00e-71 262.00
IUUC-Dre-027468 Danio rerio 82.14 0.00e+00 1218.00
IUUC-Dno-029306 Dasypus novemcinctus 88.25 0.00e+00 1242.00
IUUC-Dor-030465 Dipodomys ordii 85.14 0.00e+00 651.00
IUUC-Dse-031386 Dothistroma septosporum 41.11 3.00e-71 262.00
IUUC-Eca-034212 Equus caballus 98.77 0.00e+00 1410.00
IUUC-Eeu-034605 Erinaceus europaeus 70.20 0.00e+00 724.00
IUUC-Fca-035972 Felis catus 98.07 0.00e+00 1318.00
IUUC-Fal-037223 Ficedula albicollis 90.98 0.00e+00 1317.00
IUUC-Fox-037874 Fusarium oxysporum 44.99 2.00e-77 282.00
IUUC-Fso-038286 Fusarium solani 45.17 1.00e-77 283.00
IUUC-Gmo-039102 Gadus morhua 81.07 0.00e+00 1207.00
IUUC-Ggr-039925 Gaeumannomyces graminis 45.71 2.00e-80 293.00
IUUC-Gga-041181 Gallus gallus 91.72 0.00e+00 1376.00
IUUC-Gac-041887 Gasterosteus aculeatus 81.73 0.00e+00 1205.00
IUUC-Gma-043540 Glycine max 43.68 3.00e-87 315.00
IUUC-Ggo-044607 Gorilla gorilla 100.00 0.00e+00 1513.00
IUUC-Hvu-047105 Hordeum vulgare 49.73 5.00e-52 198.00
IUUC-Kpa-049146 Komagataella pastoris 44.41 2.00e-83 302.00
IUUC-Lch-049478 Latimeria chalumnae 87.62 0.00e+00 1338.00
IUUC-Lpe-051678 Leersia perrieri 44.59 6.00e-77 281.00
IUUC-Loc-052255 Lepisosteus oculatus 85.07 0.00e+00 1309.00
IUUC-Laf-054575 Loxodonta africana 97.47 0.00e+00 1423.00
IUUC-Mcc-055161 Macaca mulatta 99.05 0.00e+00 1456.00
IUUC-Mor-057026 Magnaporthe oryzae 44.94 1.00e-81 296.00
IUUC-Mpo-057590 Magnaporthe poae 45.27 6.00e-81 294.00
IUUC-Mtr-057835 Medicago truncatula 46.53 1.00e-80 293.00
IUUC-Mla-058950 Melampsora laricipopulina 44.99 2.00e-76 279.00
IUUC-Mvi-060295 Microbotryum violaceum 46.15 2.00e-77 283.00
IUUC-Mmr-060643 Microcebus murinus 94.62 0.00e+00 1406.00
IUUC-Mdo-062732 Monodelphis domestica 93.96 0.00e+00 1409.00
IUUC-Mmu-064125 Mus musculus 94.33 0.00e+00 1398.00
IUUC-Mpu-066371 Mustela putorius furo 98.37 0.00e+00 1320.00
IUUC-Mlu-067447 Myotis lucifugus 95.76 0.00e+00 1372.00
IUUC-Nfi-068373 Neosartorya fischeri 45.45 4.00e-83 301.00
IUUC-Ncr-068652 Neurospora crassa 44.32 1.00e-77 283.00
IUUC-Nle-069659 Nomascus leucogenys 99.87 0.00e+00 1511.00
IUUC-Ont-071244 Oreochromis niloticus 82.74 0.00e+00 1221.00
IUUC-Oan-072794 Ornithorhynchus anatinus 93.34 0.00e+00 1256.00
IUUC-Ocu-074701 Oryctolagus cuniculus 95.52 0.00e+00 1341.00
IUUC-Oba-075479 Oryza barthii 42.71 4.00e-58 219.00
IUUC-Ogl-076970 Oryza glaberrima 44.15 2.00e-80 293.00
IUUC-Oin-079610 Oryza indica 42.71 7.00e-58 218.00
IUUC-Oni-083016 Oryza nivara 43.83 4.00e-79 288.00
IUUC-Opu-083976 Oryza punctata 44.30 6.00e-79 288.00
IUUC-Osa-085814 Oryza sativa 44.15 2.00e-80 293.00
IUUC-Ola-087071 Oryzias latipes 81.55 0.00e+00 1212.00
IUUC-Olu-087711 Ostreococcus lucimarinus 41.76 2.00e-77 283.00
IUUC-Oga-089043 Otolemur garnettii 98.95 0.00e+00 1469.00
IUUC-Oar-089893 Ovis aries 91.13 0.00e+00 1315.00
IUUC-Ptr-090629 Pan troglodytes 99.87 0.00e+00 1511.00
IUUC-Pan-092305 Papio anubis 99.34 0.00e+00 1502.00
IUUC-Psi-093574 Pelodiscus sinensis 88.81 0.00e+00 1293.00
IUUC-Pma-094160 Petromyzon marinus 76.61 0.00e+00 1127.00
IUUC-Ppa-095410 Physcomitrella patens 43.48 4.00e-79 288.00
IUUC-Pfo-097043 Poecilia formosa 82.47 0.00e+00 1211.00
IUUC-Pab-098748 Pongo abelii 100.00 0.00e+00 782.00
IUUC-Pca-100223 Procavia capensis 96.58 0.00e+00 1407.00
IUUC-Ppe-101832 Prunus persica 45.50 1.00e-87 317.00
IUUC-Pva-102122 Pteropus vampyrus 98.42 0.00e+00 1461.00
IUUC-Pte-104228 Pyrenophora teres 44.48 3.00e-83 301.00
IUUC-Pyt-104702 Pyrenophora triticirepentis 40.91 4.00e-83 301.00
IUUC-Sce-106432 Saccharomyces cerevisiae 47.06 2.00e-84 306.00
IUUC-Sha-107338 Sarcophilus harrisii 93.47 0.00e+00 1249.00
IUUC-Spo-108273 Schizosaccharomyces pombe 48.17 2.00e-93 336.00
IUUC-Ssl-108545 Sclerotinia sclerotiorum 44.92 3.00e-79 288.00
IUUC-Smo-109385 Selaginella moellendorffii 43.69 5.00e-80 291.00
IUUC-Sit-110222 Setaria italica 44.15 5.00e-80 291.00
IUUC-Sly-111498 Solanum lycopersicum 49.30 2.00e-54 206.00
IUUC-Sar-113574 Sorex araneus 97.67 0.00e+00 1391.00
IUUC-Sbi-114471 Sorghum bicolor 44.68 9.00e-82 297.00
IUUC-Sre-114915 Sporisorium reilianum 43.05 1.00e-82 300.00
IUUC-Ssc-116097 Sus scrofa 97.11 0.00e+00 1297.00
IUUC-Tgu-116699 Taeniopygia guttata 91.53 0.00e+00 1305.00
IUUC-Tru-118001 Takifugu rubripes 81.52 0.00e+00 1211.00
IUUC-Tsy-118910 Tarsius syrichta 82.48 0.00e+00 850.00
IUUC-Tni-119684 Tetraodon nigroviridis 82.13 0.00e+00 1217.00
IUUC-Tca-121066 Theobroma cacao 43.63 2.00e-85 310.00
IUUC-Tre-122112 Trichoderma reesei 45.17 1.00e-79 290.00
IUUC-Tvi-122355 Trichoderma virens 45.17 2.00e-79 289.00
IUUC-Tae-123931 Triticum aestivum 44.23 1.00e-77 283.00
IUUC-Tur-126587 Triticum urartu 44.84 1.00e-77 283.00
IUUC-Tme-126963 Tuber melanosporum 45.69 5.00e-86 311.00
IUUC-Tbe-127304 Tupaia belangeri 83.58 0.00e+00 1182.00
IUUC-Ttr-128536 Tursiops truncatus 96.99 0.00e+00 1389.00
IUUC-Uma-129538 Ustilago maydis 42.78 1.00e-81 298.00
IUUC-Vda-129860 Verticillium dahliae 44.76 4.00e-82 298.00
IUUC-Vpa-130239 Vicugna pacos 77.59 4.00e-161 561.00
IUUC-Vvi-130897 Vitis vinifera 44.29 2.00e-87 316.00
IUUC-Xtr-132300 Xenopus tropicalis 86.97 0.00e+00 1273.00
IUUC-Xma-134105 Xiphophorus maculatus 79.87 0.00e+00 1202.00
IUUC-Yli-134345 Yarrowia lipolytica 49.00 1.00e-87 316.00
IUUC-Zma-135384 Zea mays 44.90 3.00e-79 289.00
Created Date 25-Jun-2017

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