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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Sce-106198
UUCD1 version UUC-SaC-00023
Ensembl Protein ID YEL019C
UniProt Accession P38632; D3DLN0; NSE2_YEAST
Genbank Protein ID AAA20471.1; AAB64496.1; AAS56767.1; DAA07634.1
Protein Name E3 SUMO-protein ligase MMS21; Methyl methanesulfonate-sensitivity protein 21; Non-structural maintenance of chromosome element 2
Genbank Nucleotide ID U12311; U18530; AY558441; BK006939
Gene Name MMS21; NSE2; YEL019C
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YEL019C YEL019C YEL019C
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
dbPAFBioGRID
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 15781853
Classification
Family E-value Score Start End
E3 activity/RING/U-box 2.50e-06 25.9 181 251
E3 activity/RING/RING 7.10e-05 21.7 184 222
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/U-box
   S: 5    eflCpIslelMrdPvvlp.sGitydrssIekwlasggk.tcP..vtrqplteedl..vPnltlrrliqawc 69
           e+ CpI+ ++ + P ++  +++++dr  I+ +l+ + +  cP   ++q ++ +d+   P  +lr  i +  
   Q: 181  ELTCPITCKPYEAPLISRkCNHVFDRDGIQNYLQGYTTrDCPqaACSQVVSMRDFvrDPIMELRCKIAKMK 251
           789**************99**************99999867733678888888773347777777777655 PP
   

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCP 43
           C+i + +++ ++++  C+Hvf +d +q++     + +++  CP
   Q: 184  CPITCKPYEAPLISRKCNHVFDRDGIQNY----LQGYTTRDCP 222
           **********555555*************....7788999999 PP
   
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Acts as an E3 ligase mediating SUMO/Smt3 attachment to SMC5 and YKU70. Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.
 Acts as an E3 ligase mediating SUMO/Smt3 attachment to SMC5 and YKU70. Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.
Protein Sequence
(Fasta)
MALNDNPIPK SVPLHPKSGK YFHNLHARDL SNIYQQCYKQ IDETINQLVD STSPSTIGIE 60
EQVADITSTY KLLSTYESES NSFDEHIKDL KKNFKQSSDA CPQIDLSTWD KYRTGELTAP 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Sce-106198|E3,RING;E3,U-box|Saccharomyces cerevisiae
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGCCTTGA ACGATAATCC TATACCCAAG TCAGTTCCTC TACACCCAAA ATCAGGTAAG 60
TACTTCCATA ATTTACATGC CCGAGACTTA TCAAATATAT ATCAACAATG CTACAAACAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106198|E3,RING;E3,U-box|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0227--DNA damage
KW-0233--DNA recombination
KW-0234--DNA repair
KW-0436--Ligase
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR014893--Ku_PK_bind
IPR026846--Nse2(Mms21)
IPR004181--Znf_MIZ
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51044--ZF_SP_RING
Pfam

PF11789--zf-Nse
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005635--C:nuclear envelope
GO:0030915--C:Smc5-Smc6 complex
GO:0016874--F:ligase activity
GO:0030291--F:protein serine/threonine kinase inhibitor activity
GO:0019789--F:SUMO transferase activity
GO:0008270--F:zinc ion binding
GO:1990683--P:DNA double-strand break attachment to nuclear envelope
GO:0006281--P:DNA repair
GO:0000724--P:double-strand break repair via homologous recombination
KEGG sce:YEL019C
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000276 Aegilops tauschii 31.51 4.00e-06 42.70
IUUC-Aml-001627 Ailuropoda melanoleuca 25.84 3.00e-04 36.60
IUUC-Atr-002438 Amborella trichopoda 28.57 3.00e-07 46.60
IUUC-Aca-004433 Anolis carolinensis 22.87 2.00e-07 47.00
IUUC-Aly-006133 Arabidopsis lyrata 25.51 2.00e-05 40.40
IUUC-Ath-007424 Arabidopsis thaliana 26.19 2.00e-05 40.40
IUUC-Ago-007852 Ashbya gossypii 43.81 6.00e-45 171.00
IUUC-Acl-008011 Aspergillus clavatus 41.30 7.00e-07 46.60
IUUC-Afl-008461 Aspergillus flavus 35.85 9.00e-05 39.70
IUUC-Afu-008893 Aspergillus fumigatus 31.46 6.00e-07 47.00
IUUC-Ani-009414 Aspergillus nidulans 43.48 3.00e-07 47.80
IUUC-Ang-009587 Aspergillus niger 37.21 7.00e-05 40.00
IUUC-Aor-010063 Aspergillus oryzae 27.87 2.00e-04 37.70
IUUC-Ate-010326 Aspergillus terreus 32.22 5.00e-09 55.10
IUUC-Bgr-012088 Blumeria graminis 26.47 2.00e-05 41.60
IUUC-Bci-013738 Botrytis cinerea 28.12 2.00e-08 52.00
IUUC-Bdi-014403 Brachypodium distachyon 27.78 5.00e-06 42.70
IUUC-Bol-015454 Brassica oleracea 26.80 5.00e-06 42.70
IUUC-Cel-018588 Caenorhabditis elegans 28.12 6.00e-06 42.00
IUUC-Cja-019246 Callithrix jacchus 23.38 3.00e-04 36.60
IUUC-Cre-022738 Chlamydomonas reinhardtii 35.56 6.90e-02 26.60
IUUC-Cho-024905 Choloepus hoffmanni 25.53 2.40e-02 32.30
IUUC-Cin-025127 Ciona intestinalis 26.47 4.00e-04 36.20
IUUC-Cgl-026430 Colletotrichum gloeosporioides 27.63 2.00e-04 37.70
IUUC-Cne-026806 Cryptococcus neoformans 26.25 5.00e-05 39.70
IUUC-Cme-027175 Cyanidioschyzon merolae 23.81 1.10e-01 28.90
IUUC-Dre-028460 Danio rerio 26.67 8.00e-05 39.70
IUUC-Dno-029735 Dasypus novemcinctus 23.38 2.00e-04 37.40
IUUC-Dse-031273 Dothistroma septosporum 31.40 7.00e-06 43.10
IUUC-Eca-034371 Equus caballus 25.00 4.00e-06 42.70
IUUC-Fca-035576 Felis catus 23.38 2.00e-04 37.40
IUUC-Fal-037038 Ficedula albicollis 26.92 2.00e-05 40.80
IUUC-Fox-037843 Fusarium oxysporum 28.92 3.00e-08 50.80
IUUC-Fso-038272 Fusarium solani 32.91 1.00e-08 52.40
IUUC-Ggr-040059 Gaeumannomyces graminis 30.59 1.00e-07 49.30
IUUC-Gac-042591 Gasterosteus aculeatus 22.82 9.00e-08 48.10
IUUC-Gma-043177 Glycine max 27.16 3.00e-06 43.50
IUUC-Ggo-045206 Gorilla gorilla 24.68 2.00e-05 40.80
IUUC-Hsa-046704 Homo sapiens 24.68 2.00e-05 40.80
IUUC-Hvu-047252 Hordeum vulgare 34.25 2.00e-06 44.30
IUUC-Kpa-049181 Komagataella pastoris 24.86 5.00e-13 66.20
IUUC-Lpe-051150 Leersia perrieri 26.87 1.00e-05 41.20
IUUC-Loc-052687 Lepisosteus oculatus 29.23 4.00e-04 36.20
IUUC-Lma-053255 Leptosphaeria maculans 29.73 3.00e-07 47.80
IUUC-Mor-057028 Magnaporthe oryzae 35.21 1.00e-13 68.90
IUUC-Mpo-057462 Magnaporthe poae 29.41 3.00e-07 47.80
IUUC-Mtr-058011 Medicago truncatula 28.40 6.00e-06 42.40
IUUC-Mga-059215 Meleagris gallopavo 23.73 1.00e-03 32.70
IUUC-Mdo-061863 Monodelphis domestica 24.18 3.00e-05 40.00
IUUC-Mac-065639 Musa acuminata 26.47 6.00e-05 38.90
IUUC-Mpu-066092 Mustela putorius furo 23.38 3.00e-04 37.00
IUUC-Mlu-068198 Myotis lucifugus 23.38 9.00e-04 35.00
IUUC-Nfi-068508 Neosartorya fischeri 32.95 2.00e-07 48.50
IUUC-Ncr-068773 Neurospora crassa 33.33 3.00e-08 51.20
IUUC-Nle-070109 Nomascus leucogenys 24.68 2.00e-05 40.40
IUUC-Ocu-074730 Oryctolagus cuniculus 22.08 4.00e-04 36.60
IUUC-Oba-075725 Oryza barthii 24.62 2.00e-04 37.40
IUUC-Obr-076506 Oryza brachyantha 23.08 5.00e-05 39.30
IUUC-Ogu-079018 Oryza glumaepatula 24.62 1.00e-04 38.10
IUUC-Oin-079792 Oryza indica 24.62 9.00e-05 38.10
IUUC-Ome-081426 Oryza meridionalis 24.62 1.00e-04 37.70
IUUC-Oni-082286 Oryza nivara 24.62 9.00e-05 38.10
IUUC-Opu-083586 Oryza punctata 25.37 1.00e-04 37.40
IUUC-Oru-085158 Oryza rufipogon 24.62 9.00e-05 38.10
IUUC-Olu-087903 Ostreococcus lucimarinus 29.51 5.00e-04 35.80
IUUC-Ptr-091582 Pan troglodytes 24.68 2.00e-05 40.80
IUUC-Pma-094198 Petromyzon marinus 26.80 5.00e-05 38.10
IUUC-Pno-094931 Phaeosphaeria nodorum 28.74 1.00e-05 42.40
IUUC-Ppa-095570 Physcomitrella patens 25.97 2.00e-06 44.30
IUUC-Pab-098005 Pongo abelii 24.68 2.00e-05 40.80
IUUC-Pop-099559 Populus trichocarpa 24.69 4.00e-05 40.00
IUUC-Ppe-101873 Prunus persica 35.00 2.00e-08 50.10
IUUC-Pva-102951 Pteropus vampyrus 22.08 1.00e-03 34.70
IUUC-Pgr-103558 Puccinia graminis 29.00 2.00e-05 40.80
IUUC-Ptt-103843 Puccinia triticina 31.03 4.00e-05 40.40
IUUC-Pte-104390 Pyrenophora teres 31.40 5.00e-08 50.10
IUUC-Pyt-104633 Pyrenophora triticirepentis 31.40 1.00e-07 48.90
IUUC-Sja-107983 Schizosaccharomyces japonicus 29.17 6.00e-11 58.90
IUUC-Spo-108327 Schizosaccharomyces pombe 27.59 2.00e-06 43.50
IUUC-Ssl-108555 Sclerotinia sclerotiorum 25.32 4.00e-06 43.90
IUUC-Smo-109546 Selaginella moellendorffii 24.27 2.00e-06 43.90
IUUC-Sit-109919 Setaria italica 27.69 2.00e-05 40.80
IUUC-Sly-111667 Solanum lycopersicum 31.34 5.00e-06 42.70
IUUC-Stu-112211 Solanum tuberosum 30.30 4.00e-07 46.20
IUUC-Sar-113177 Sorex araneus 34.33 9.00e-03 34.30
IUUC-Sbi-113916 Sorghum bicolor 28.21 2.00e-06 43.90
IUUC-Sre-115187 Sporisorium reilianum 34.02 2.00e-10 57.80
IUUC-Tgu-116472 Taeniopygia guttata 28.21 3.00e-06 43.10
IUUC-Tni-119821 Tetraodon nigroviridis 28.74 7.00e-05 38.50
IUUC-Tca-121272 Theobroma cacao 28.12 4.00e-05 39.70
IUUC-Tre-122049 Trichoderma reesei 34.15 3.00e-11 60.50
IUUC-Tvi-122642 Trichoderma virens 35.37 4.00e-09 53.90
IUUC-Tae-122969 Triticum aestivum 31.51 4.00e-06 42.70
IUUC-Tur-126346 Triticum urartu 31.51 4.00e-06 42.70
IUUC-Tme-126988 Tuber melanosporum 28.92 9.00e-09 52.40
IUUC-Tbe-128134 Tupaia belangeri 25.70 1.20e-02 32.00
IUUC-Ttr-128602 Tursiops truncatus 23.33 5.00e-05 39.30
IUUC-Uma-129520 Ustilago maydis 32.56 3.00e-09 53.50
IUUC-Vpa-130510 Vicugna pacos 23.38 3.00e-04 36.60
IUUC-Vvi-131486 Vitis vinifera 27.06 2.00e-06 43.50
IUUC-Yli-134676 Yarrowia lipolytica 35.00 8.00e-05 39.30
IUUC-Zma-135045 Zea mays 28.12 4.00e-05 39.70
Created Date 25-Jun-2017

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