iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Loc-052173

Ensembl Protein ID

ENSLOCP00000000051.1

UniProt Accession

W5LV94; W5LV94_LEPOC

Protein Name

Uncharacterized protein

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLOCG00000000043.1	ENSLOCT00000000051.1	ENSLOCP00000000051.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.10e-103	347.3	418	756

Active Site

Position(s)	Description	Evidence
724	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkk+l+v+fvgE+gld+gG+t+e++ ll+++++++d+g+f+y ++++++++ n +      ++ + F+++G+l+g+a++++  ld+
   Q: 418  RADLKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHTDYGMFTYLKDSHYHWFSNWKC-----DNYSEFRLVGTLMGLAVYNSITLDI 501
           589***************************************************88876.....789********************** PP
   S: 91   plsksfyklllgk..............klsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipV 165
           ++++++yk+ll+                l+l+dl++++pel++ l+e++++ e ++ee  +  tf+v +e+lg +k+++L pgG++ipV
   Q: 502  KFPPCCYKKLLSPpivpcdqntpvgiaALTLNDLQQIMPELAHGLEELLAY-EGNVEED-FYSTFQVYQEELGVIKSYNLRPGGDKIPV 588
           **********999555555555555555***********************.6788885.***************************** PP
   S: 166  tneNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevle 254
           tn+N++eYv+l++++ l+++i +q++af+ Gf++v+  + l l+++ee+e+l+cG++++d+++l+k t+y+ gy++++p+i++Fw+v+ 
   Q: 589  TNQNRKEYVQLYIDFLLNKSIYNQFAAFYYGFHSVCASNALMLLRPEEVEMLVCGSPDLDMSALQKVTQYE-GYSKSDPTIRFFWDVVL 676
           **********************************************************************5.5**************** PP
   S: 255  efsseerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +f  + +k++L+F+Tgs+r+P+gG+ +l+   f i k d s+d+lP s+TCfn+++LP+Y+sk++lk+kL++Ai++t+gF+l+
   Q: 677  GFPLDLQKKLLHFATGSDRVPVGGMVDLN---FKIAKnDVSTDWLPVSHTCFNQICLPPYKSKKELKQKLTIAISNTEGFGLE 756
           *****************************...8888879999**************************************985 PP

Organism

Lepisosteus oculatus

Protein Sequence
(Fasta)

MNEDTFYSVS QEGKGREMLP PILNASASGG FDRGTKQQFP NFSSFISTVN RRREVVSSRN 60
FSAQLVIPNG KPGVRELPPI RQKHRISIDT LPPEVKAPVP PEPIIPLRTK TVKEFQEDIE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGTGGGTCCC TTTTGCCAGG ACAATGACAT AAAAGCAATT AAAGCTACAA AAGCACAGCT 60
GCATATGTAA TGTATGACAT ACTCCAAAAG TCCCTTGCAT TCAGTTATAA ATTACGTTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001266	Ailuropoda melanoleuca	80.14	0.00e+00	1248.00
IUUC-Apl-003589	Anas platyrhynchos	80.16	0.00e+00	1223.00
IUUC-Aca-004350	Anolis carolinensis	75.37	0.00e+00	1154.00
IUUC-Ago-007908	Ashbya gossypii	36.20	2.00e-85	310.00
IUUC-Acl-008288	Aspergillus clavatus	35.20	4.00e-100	360.00
IUUC-Afl-008402	Aspergillus flavus	34.16	2.00e-93	336.00
IUUC-Afu-008762	Aspergillus fumigatus	34.48	4.00e-98	353.00
IUUC-Ani-009176	Aspergillus nidulans	35.38	4.00e-98	352.00
IUUC-Ang-009791	Aspergillus niger	34.91	3.00e-96	346.00
IUUC-Aor-009921	Aspergillus oryzae	34.00	6.00e-93	335.00
IUUC-Ate-010295	Aspergillus terreus	35.71	4.00e-104	372.00
IUUC-Ame-010660	Astyanax mexicanus	85.62	3.00e-160	557.00
IUUC-Bgr-011981	Blumeria graminis	31.14	7.00e-93	335.00
IUUC-Bta-012945	Bos taurus	79.65	0.00e+00	1220.00
IUUC-Bci-013697	Botrytis cinerea	32.72	9.00e-83	302.00
IUUC-Cja-019263	Callithrix jacchus	78.27	0.00e+00	1207.00
IUUC-Cfa-020486	Canis familiaris	83.57	0.00e+00	1164.00
IUUC-Cpo-021755	Cavia porcellus	78.17	0.00e+00	1228.00
IUUC-Csa-023814	Chlorocebus sabaeus	78.51	0.00e+00	1145.00
IUUC-Cho-024980	Choloepus hoffmanni	65.13	0.00e+00	952.00
IUUC-Cgl-026526	Colletotrichum gloeosporioides	40.66	6.00e-96	345.00
IUUC-Dre-028551	Danio rerio	80.51	0.00e+00	1225.00
IUUC-Dno-029497	Dasypus novemcinctus	79.42	0.00e+00	1118.00
IUUC-Dor-030867	Dipodomys ordii	68.90	0.00e+00	1008.00
IUUC-Dse-031239	Dothistroma septosporum	29.78	1.00e-92	335.00
IUUC-Ete-032902	Echinops telfairi	78.99	0.00e+00	982.00
IUUC-Eca-033678	Equus caballus	79.75	0.00e+00	1226.00
IUUC-Eeu-035262	Erinaceus europaeus	67.06	0.00e+00	930.00
IUUC-Fca-035590	Felis catus	80.16	0.00e+00	1250.00
IUUC-Fal-037123	Ficedula albicollis	75.30	0.00e+00	1163.00
IUUC-Fox-037941	Fusarium oxysporum	39.65	1.00e-102	367.00
IUUC-Fso-038388	Fusarium solani	40.48	2.00e-104	374.00
IUUC-Gmo-039553	Gadus morhua	68.95	0.00e+00	880.00
IUUC-Ggr-040110	Gaeumannomyces graminis	35.98	1.00e-98	354.00
IUUC-Gga-040406	Gallus gallus	80.22	0.00e+00	1264.00
IUUC-Gac-042141	Gasterosteus aculeatus	79.71	0.00e+00	1167.00
IUUC-Ggo-045504	Gorilla gorilla	78.07	0.00e+00	1212.00
IUUC-Hsa-045786	Homo sapiens	78.63	0.00e+00	1217.00
IUUC-Itr-048050	Ictidomys tridecemlineatus	76.74	0.00e+00	1088.00
IUUC-Kpa-049152	Komagataella pastoris	32.26	2.00e-77	284.00
IUUC-Lch-049824	Latimeria chalumnae	81.07	0.00e+00	1103.00
IUUC-Laf-054017	Loxodonta africana	81.95	0.00e+00	1193.00
IUUC-Mcc-055713	Macaca mulatta	78.27	0.00e+00	1192.00
IUUC-Meu-056212	Macropus eugenii	62.96	1.00e-102	367.00
IUUC-Mor-057045	Magnaporthe oryzae	36.85	7.00e-92	332.00
IUUC-Mla-059187	Melampsora laricipopulina	43.40	9.00e-90	323.00
IUUC-Mga-059884	Meleagris gallopavo	73.81	0.00e+00	1100.00
IUUC-Mmr-061344	Microcebus murinus	78.90	0.00e+00	1209.00
IUUC-Mdo-062653	Monodelphis domestica	78.13	0.00e+00	1203.00
IUUC-Mmu-063775	Mus musculus	76.89	0.00e+00	1130.00
IUUC-Mpu-066069	Mustela putorius furo	82.78	0.00e+00	1180.00
IUUC-Mlu-067925	Myotis lucifugus	79.34	0.00e+00	1208.00
IUUC-Nfi-068439	Neosartorya fischeri	34.32	7.00e-98	352.00
IUUC-Ncr-068903	Neurospora crassa	37.68	2.00e-94	341.00
IUUC-Nle-070046	Nomascus leucogenys	78.21	0.00e+00	1217.00
IUUC-Opr-071085	Ochotona princeps	69.46	4.00e-121	428.00
IUUC-Ont-072126	Oreochromis niloticus	78.04	0.00e+00	1247.00
IUUC-Oan-072933	Ornithorhynchus anatinus	82.38	0.00e+00	1121.00
IUUC-Ocu-073800	Oryctolagus cuniculus	82.78	0.00e+00	1167.00
IUUC-Ola-086988	Oryzias latipes	80.49	0.00e+00	1180.00
IUUC-Oga-088117	Otolemur garnettii	82.76	0.00e+00	1016.00
IUUC-Oar-089371	Ovis aries	80.03	0.00e+00	1199.00
IUUC-Ptr-090551	Pan troglodytes	78.67	0.00e+00	1176.00
IUUC-Pan-092067	Papio anubis	78.70	0.00e+00	1197.00
IUUC-Psi-092963	Pelodiscus sinensis	80.24	0.00e+00	1194.00
IUUC-Pfo-096562	Poecilia formosa	75.03	0.00e+00	1184.00
IUUC-Pab-098680	Pongo abelii	78.63	0.00e+00	1217.00
IUUC-Pca-100986	Procavia capensis	65.67	0.00e+00	805.00
IUUC-Pva-102219	Pteropus vampyrus	73.83	0.00e+00	923.00
IUUC-Pgr-103315	Puccinia graminis	35.36	3.00e-95	343.00
IUUC-Ptt-103736	Puccinia triticina	40.85	5.00e-93	335.00
IUUC-Rno-105270	Rattus norvegicus	77.84	0.00e+00	1130.00
IUUC-Sce-106306	Saccharomyces cerevisiae	35.63	3.00e-74	273.00
IUUC-Sha-106819	Sarcophilus harrisii	80.00	0.00e+00	1245.00
IUUC-Spo-108271	Schizosaccharomyces pombe	34.89	5.00e-92	332.00
IUUC-Ssl-108657	Sclerotinia sclerotiorum	33.06	5.00e-86	313.00
IUUC-Sar-113134	Sorex araneus	71.55	0.00e+00	1060.00
IUUC-Ssc-115441	Sus scrofa	79.89	0.00e+00	1209.00
IUUC-Tgu-117166	Taeniopygia guttata	78.09	0.00e+00	1179.00
IUUC-Tsy-118898	Tarsius syrichta	68.21	0.00e+00	964.00
IUUC-Tre-122108	Trichoderma reesei	37.74	4.00e-91	329.00
IUUC-Tvi-122644	Trichoderma virens	38.28	3.00e-96	346.00
IUUC-Tme-127004	Tuber melanosporum	34.72	9.00e-105	375.00
IUUC-Tbe-127292	Tupaia belangeri	65.39	0.00e+00	922.00
IUUC-Ttr-128352	Tursiops truncatus	76.47	0.00e+00	1156.00
IUUC-Vda-129969	Verticillium dahliae	39.34	4.00e-93	336.00
IUUC-Vpa-130218	Vicugna pacos	77.22	0.00e+00	859.00
IUUC-Xtr-132594	Xenopus tropicalis	74.14	0.00e+00	1126.00
IUUC-Xma-134157	Xiphophorus maculatus	78.86	0.00e+00	1089.00
IUUC-Yli-134470	Yarrowia lipolytica	36.69	8.00e-84	305.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence