iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-028480

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 ubiquitin-protein ligase MARCH5; Membrane-associated RING finger protein 5; Membrane-associated RING-CH protein V; RING-type E3 ubiquitin transferase MARCH5

Genbank Nucleotide ID

BC066555

Gene Name

march5l; march5; zgc:56713

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000028559.8	ENSDART00000039187.7	ENSDARP00000037207.6
ENSDARG00000028559.8	ENSDART00000171404.1	ENSDARP00000135790.1
ENSDARG00000028559.8	ENSDART00000045757.6	ENSDARP00000045756.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	8.10e-09	36.5	10	67

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedek...slveCek..CrewfHpaClklsveeelpnsek..wiCpkCr 52
           k C+vC++++++++   ++  C++  C++w+H+ Cl+++ +e++++++   + Cp+C 
   Q: 10   KHCWVCFATEKEDRaaeWVSPCRCkgCTKWIHQSCLQRWLDEKQKGNSGgaVSCPQCG 67
           78**********97778999999999*************888888887789******5 PP

Organism

Danio rerio

Functional Description
(View)

Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control.

Protein Sequence
(Fasta)

MACVDEPPEK HCWVCFATEK EDRAAEWVSP CRCKGCTKWI HQSCLQRWLD EKQKGNSGGA 60
VSCPQCGTEY RIVFPKMGPV VYFLQQVDRA LSRASPFAAA GVVVGTVYWS AVTYGAVTVM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACATTTATT TTGACACGCG GAAGTTGCCC ATCCGGAAGT TGTCCTTCAT AAGGTTGTTG 60
TTCTGTCCTC GAAGAAATTG AAACTGTCAA ATCAGCCAGA TATCTGACAT AAACGCCCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0479--Metal-binding
KW-0496--Mitochondrion
KW-1000--Mitochondrion outer membrane
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR033275--MARCH-like
IPR011016--Znf_RING-CH
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51292--ZF_RING_CH

Pfam

PF12906--RINGv

SMART

SM00744--RINGv

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0005741--C:mitochondrial outer membrane
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0090344--P:negative regulation of cell aging
GO:0051865--P:protein autoubiquitination
GO:0090140--P:regulation of mitochondrial fission

KEGG

dre:326067

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Acl-008017	Aspergillus clavatus	27.08	3.00e-10	60.50
IUUC-Afu-008855	Aspergillus fumigatus	27.54	2.00e-10	60.80
IUUC-Ani-009440	Aspergillus nidulans	35.56	2.00e-06	46.20
IUUC-Ame-011303	Astyanax mexicanus	85.42	6.00e-150	523.00
IUUC-Cel-018634	Caenorhabditis elegans	41.79	1.00e-10	59.30
IUUC-Dse-031226	Dothistroma septosporum	30.60	4.00e-11	63.20
IUUC-Fox-037934	Fusarium oxysporum	29.27	2.00e-09	57.00
IUUC-Fso-038122	Fusarium solani	31.36	1.00e-10	61.60
IUUC-Loc-051822	Lepisosteus oculatus	86.72	2.00e-144	504.00
IUUC-Lma-053141	Leptosphaeria maculans	27.89	6.00e-10	59.30
IUUC-Nfi-068312	Neosartorya fischeri	27.54	2.00e-10	60.80
IUUC-Ncr-068837	Neurospora crassa	31.67	1.00e-13	72.00
IUUC-Ont-071896	Oreochromis niloticus	52.08	2.00e-78	285.00
IUUC-Ola-087234	Oryzias latipes	71.92	9.00e-110	389.00
IUUC-Pno-094820	Phaeosphaeria nodorum	27.51	2.00e-10	60.80
IUUC-Pfo-097400	Poecilia formosa	79.79	7.00e-131	460.00
IUUC-Pgr-103326	Puccinia graminis	26.85	6.00e-04	39.70
IUUC-Pte-104347	Pyrenophora teres	28.04	2.00e-10	60.80
IUUC-Pyt-104598	Pyrenophora triticirepentis	35.85	2.00e-07	49.70
IUUC-Spo-108227	Schizosaccharomyces pombe	24.68	2.00e-06	46.60
IUUC-Tru-118043	Takifugu rubripes	80.22	1.00e-127	448.00
IUUC-Tni-120674	Tetraodon nigroviridis	78.60	3.00e-122	431.00
IUUC-Tre-122138	Trichoderma reesei	25.00	9.00e-10	58.50
IUUC-Tvi-122629	Trichoderma virens	24.48	3.00e-10	60.10
IUUC-Vda-129998	Verticillium dahliae	31.58	2.00e-09	57.40

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence