iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
CPLM	dbPAF	dbPTM	UniProt
PHOSIDA	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Other/Other	UBD/Other/Other	12847084; 16004872

Reviewed

Classification

Family	Identity	E-value	Score	Source Orthology
DUB/Other	39.02	6.00e-53	206.00	IUUC-Hsa-046680
UBD/Other/Other	39.02	6.00e-53	206.00	IUUC-Hsa-046680

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Functions at a post-ubiquitation step in the ubiquitin fusion degradation (UFD) pathway. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway. Required for the proteasome-dependent processing/activation of MGA2 and SPT23 transcription factors leading to the subsequent expression of OLE1. Has an additional role in the turnover of OLE1 where it targets ubiquitinated OLE1 and other proteins to the ERAD.

Protein Sequence
(Fasta)

MFSGFSSFGG GNGFVNMPQT FEEFFRCYPI AMMNDRIRKD DANFGGKIFL PPSALSKLSM 60
LNIRYPMLFK LTANETGRVT HGGVLEFIAE EGRVYLPQWM METLGIQPGS LLQISSTDVP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTTTTCTG GCTTTAGTTC TTTTGGCGGC GGAAATGGTT TTGTAAATAT GCCTCAAACG 60
TTTGAGGAGT TCTTTAGATG CTACCCTATA GCTATGATGA ATGATAGAAT ACGGAAGGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR004854--UFD1

Pfam

PF03152--UFD1

Gene Ontology

GO:0000837--C:Doa10p ubiquitin ligase complex
GO:0000839--C:Hrd1p ubiquitin ligase ERAD-L complex
GO:0005634--C:nucleus
GO:1990112--C:RQC complex
GO:0034098--C:VCP-NPL4-UFD1 AAA ATPase complex
GO:0031593--F:polyubiquitin binding
GO:0043130--F:ubiquitin binding
GO:0071712--P:ER-associated misfolded protein catabolic process
GO:0051974--P:negative regulation of telomerase activity
GO:0070651--P:nonfunctional rRNA decay
GO:1900182--P:positive regulation of protein localization to nucleus
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0030970--P:retrograde protein transport, ER to cytosol
GO:1990116--P:ribosome-associated ubiquitin-dependent protein catabolic process
GO:0071629--P:ubiquitin-dependent catabolism of misfolded proteins by cytoplasm-associated proteasome
GO:0030433--P:ubiquitin-dependent ERAD pathway

KEGG

sce:YGR048W

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000441	Aegilops tauschii	46.40	2.00e-52	197.00
IUUC-Aml-001398	Ailuropoda melanoleuca	37.35	5.00e-53	199.00
IUUC-Atr-002449	Amborella trichopoda	52.94	6.00e-46	175.00
IUUC-Apl-004065	Anas platyrhynchos	39.32	9.00e-48	181.00
IUUC-Aca-004973	Anolis carolinensis	48.73	1.00e-54	204.00
IUUC-Aly-005501	Arabidopsis lyrata	40.62	2.00e-53	200.00
IUUC-Ath-007324	Arabidopsis thaliana	50.27	2.00e-51	194.00
IUUC-Ago-007918	Ashbya gossypii	68.88	1.00e-142	496.00
IUUC-Acl-008362	Aspergillus clavatus	41.79	5.00e-69	252.00
IUUC-Afl-008690	Aspergillus flavus	41.98	9.00e-71	258.00
IUUC-Afu-008787	Aspergillus fumigatus	41.83	5.00e-71	259.00
IUUC-Ani-009385	Aspergillus nidulans	42.14	3.00e-64	236.00
IUUC-Ang-009709	Aspergillus niger	42.00	3.00e-70	256.00
IUUC-Aor-010240	Aspergillus oryzae	41.98	9.00e-71	258.00
IUUC-Ate-010551	Aspergillus terreus	41.19	4.00e-69	253.00
IUUC-Ame-011417	Astyanax mexicanus	38.18	8.00e-53	198.00
IUUC-Bgr-011986	Blumeria graminis	56.22	1.00e-62	231.00
IUUC-Bta-012559	Bos taurus	48.73	2.00e-52	196.00
IUUC-Bci-013767	Botrytis cinerea	39.43	5.00e-64	236.00
IUUC-Bdi-014579	Brachypodium distachyon	49.73	8.00e-51	191.00
IUUC-Bol-015423	Brassica oleracea	50.27	1.00e-50	191.00
IUUC-Bra-017620	Brassica rapa	49.73	6.00e-50	188.00
IUUC-Cel-018590	Caenorhabditis elegans	50.00	1.00e-42	164.00
IUUC-Cja-019487	Callithrix jacchus	37.95	3.00e-53	199.00
IUUC-Cfa-020497	Canis familiaris	37.35	6.00e-53	198.00
IUUC-Cpo-022150	Cavia porcellus	37.35	3.00e-53	199.00
IUUC-Cre-023007	Chlamydomonas reinhardtii	47.85	5.00e-48	181.00
IUUC-Csa-023602	Chlorocebus sabaeus	37.35	6.00e-53	198.00
IUUC-Cin-025594	Ciona intestinalis	37.27	2.00e-53	200.00
IUUC-Csv-026040	Ciona savignyi	38.68	4.00e-53	199.00
IUUC-Cgl-026460	Colletotrichum gloeosporioides	41.04	5.00e-71	259.00
IUUC-Cne-026990	Cryptococcus neoformans	48.15	5.00e-47	179.00
IUUC-Cme-027323	Cyanidioschyzon merolae	42.95	4.00e-39	153.00
IUUC-Dre-027987	Danio rerio	47.24	8.00e-52	194.00
IUUC-Dor-030294	Dipodomys ordii	37.35	8.00e-53	198.00
IUUC-Dse-031411	Dothistroma septosporum	43.26	2.00e-71	260.00
IUUC-Dme-031798	Drosophila melanogaster	48.39	8.00e-51	191.00
IUUC-Ete-032432	Echinops telfairi	37.65	6.00e-53	198.00
IUUC-Eca-034427	Equus caballus	37.35	6.00e-53	198.00
IUUC-Eeu-034917	Erinaceus europaeus	51.32	5.00e-41	159.00
IUUC-Fca-035380	Felis catus	37.35	6.00e-53	198.00
IUUC-Fal-037659	Ficedula albicollis	38.79	4.00e-53	199.00
IUUC-Fox-038062	Fusarium oxysporum	55.42	6.00e-25	104.00
IUUC-Fso-038111	Fusarium solani	42.07	3.00e-75	273.00
IUUC-Gmo-039298	Gadus morhua	50.00	2.00e-50	190.00
IUUC-Ggr-039771	Gaeumannomyces graminis	41.91	3.00e-65	239.00
IUUC-Gga-040313	Gallus gallus	38.79	6.00e-53	198.00
IUUC-Gac-042009	Gasterosteus aculeatus	49.45	4.00e-50	189.00
IUUC-Gma-043844	Glycine max	41.41	2.00e-53	200.00
IUUC-Ggo-044639	Gorilla gorilla	33.70	8.00e-48	181.00
IUUC-Hsa-046680	Homo sapiens	37.35	6.00e-53	198.00
IUUC-Hvu-047614	Hordeum vulgare	46.40	4.00e-52	196.00
IUUC-Itr-047987	Ictidomys tridecemlineatus	37.35	5.00e-53	199.00
IUUC-Kpa-049136	Komagataella pastoris	58.60	8.00e-111	391.00
IUUC-Lch-050607	Latimeria chalumnae	38.27	7.00e-53	198.00
IUUC-Lpe-050726	Leersia perrieri	49.73	4.00e-51	193.00
IUUC-Loc-051848	Lepisosteus oculatus	37.80	7.00e-53	198.00
IUUC-Lma-053187	Leptosphaeria maculans	45.81	5.00e-76	275.00
IUUC-Laf-053569	Loxodonta africana	37.01	7.00e-51	192.00
IUUC-Mcc-055275	Macaca mulatta	38.25	1.00e-52	197.00
IUUC-Mor-056967	Magnaporthe oryzae	40.52	6.00e-65	238.00
IUUC-Mpo-057399	Magnaporthe poae	41.09	4.00e-65	239.00
IUUC-Mtr-058353	Medicago truncatula	49.73	2.00e-51	193.00
IUUC-Mla-058830	Melampsora laricipopulina	31.86	2.00e-41	160.00
IUUC-Mga-059803	Meleagris gallopavo	40.00	2.00e-48	183.00
IUUC-Mvi-060456	Microbotryum violaceum	37.65	9.00e-48	182.00
IUUC-Mmr-060573	Microcebus murinus	38.25	6.00e-53	198.00
IUUC-Mdo-062831	Monodelphis domestica	37.05	1.00e-52	197.00
IUUC-Mmu-064302	Mus musculus	37.65	6.00e-53	198.00
IUUC-Mac-065200	Musa acuminata	37.06	3.00e-54	203.00
IUUC-Mpu-065922	Mustela putorius furo	37.35	7.00e-53	198.00
IUUC-Mlu-068236	Myotis lucifugus	37.01	3.00e-51	192.00
IUUC-Nfi-068417	Neosartorya fischeri	41.83	4.00e-71	259.00
IUUC-Ncr-068747	Neurospora crassa	44.05	3.00e-62	229.00
IUUC-Nle-069948	Nomascus leucogenys	34.69	1.00e-47	181.00
IUUC-Opr-070919	Ochotona princeps	41.04	1.00e-38	151.00
IUUC-Ont-071467	Oreochromis niloticus	38.04	6.00e-53	198.00
IUUC-Oan-073436	Ornithorhynchus anatinus	39.10	6.00e-27	111.00
IUUC-Ocu-074427	Oryctolagus cuniculus	48.22	8.00e-52	194.00
IUUC-Oba-075440	Oryza barthii	47.85	6.00e-52	195.00
IUUC-Obr-076275	Oryza brachyantha	49.73	4.00e-50	189.00
IUUC-Ogl-077237	Oryza glaberrima	47.85	5.00e-52	195.00
IUUC-Ogu-078934	Oryza glumaepatula	47.85	3.00e-52	196.00
IUUC-Oin-079475	Oryza indica	47.85	6.00e-52	195.00
IUUC-Olo-080285	Oryza longistaminata	50.62	3.00e-48	182.00
IUUC-Ome-081887	Oryza meridionalis	47.85	5.00e-52	196.00
IUUC-Oni-082064	Oryza nivara	47.85	6.00e-52	195.00
IUUC-Opu-083610	Oryza punctata	41.83	4.00e-52	196.00
IUUC-Oru-084911	Oryza rufipogon	47.85	4.00e-52	196.00
IUUC-Osa-085366	Oryza sativa	47.85	6.00e-52	195.00
IUUC-Ola-086846	Oryzias latipes	40.69	5.00e-47	179.00
IUUC-Olu-087879	Ostreococcus lucimarinus	46.77	2.00e-46	177.00
IUUC-Oga-089017	Otolemur garnettii	37.01	1.00e-51	194.00
IUUC-Oar-089970	Ovis aries	38.91	3.00e-54	203.00
IUUC-Ptr-091147	Pan troglodytes	44.90	7.00e-48	181.00
IUUC-Pan-091757	Papio anubis	34.53	2.00e-42	164.00
IUUC-Psi-093931	Pelodiscus sinensis	38.79	7.00e-53	198.00
IUUC-Pno-094775	Phaeosphaeria nodorum	45.98	1.00e-69	254.00
IUUC-Ppa-095156	Physcomitrella patens	48.92	1.00e-49	187.00
IUUC-Pfo-097295	Poecilia formosa	41.47	3.00e-53	199.00
IUUC-Pab-098537	Pongo abelii	37.35	6.00e-53	198.00
IUUC-Pop-099436	Populus trichocarpa	50.80	2.00e-53	200.00
IUUC-Pca-100631	Procavia capensis	33.51	7.00e-43	165.00
IUUC-Ppe-101259	Prunus persica	50.27	5.00e-53	199.00
IUUC-Pva-102679	Pteropus vampyrus	42.79	5.00e-48	182.00
IUUC-Pgr-103475	Puccinia graminis	41.12	2.00e-38	150.00
IUUC-Ptt-104012	Puccinia triticina	32.99	8.00e-24	102.00
IUUC-Pte-104071	Pyrenophora teres	45.21	2.00e-73	267.00
IUUC-Pyt-104501	Pyrenophora triticirepentis	44.91	3.00e-73	266.00
IUUC-Rno-104858	Rattus norvegicus	37.95	2.00e-53	200.00
IUUC-Sha-107075	Sarcophilus harrisii	37.65	5.00e-53	199.00
IUUC-Sja-107663	Schizosaccharomyces japonicus	48.34	1.00e-80	291.00
IUUC-Spo-108259	Schizosaccharomyces pombe	44.22	3.00e-68	249.00
IUUC-Ssl-108473	Sclerotinia sclerotiorum	38.87	2.00e-57	214.00
IUUC-Smo-109290	Selaginella moellendorffii	40.94	4.00e-50	189.00
IUUC-Sit-109876	Setaria italica	50.27	3.00e-52	196.00
IUUC-Sly-110858	Solanum lycopersicum	50.79	5.00e-53	199.00
IUUC-Stu-112028	Solanum tuberosum	51.08	1.00e-51	194.00
IUUC-Sar-113061	Sorex araneus	37.35	9.00e-53	198.00
IUUC-Sbi-114882	Sorghum bicolor	47.06	2.00e-51	194.00
IUUC-Sre-115104	Sporisorium reilianum	37.33	2.00e-58	217.00
IUUC-Ssc-115403	Sus scrofa	37.35	9.00e-53	198.00
IUUC-Tgu-117013	Taeniopygia guttata	38.79	4.00e-53	199.00
IUUC-Tru-118307	Takifugu rubripes	50.00	2.00e-50	190.00
IUUC-Tsy-119309	Tarsius syrichta	48.91	4.00e-22	96.30
IUUC-Tni-120209	Tetraodon nigroviridis	50.00	1.00e-50	191.00
IUUC-Tca-121421	Theobroma cacao	48.22	4.00e-53	199.00
IUUC-Tre-122235	Trichoderma reesei	43.47	5.00e-72	262.00
IUUC-Tvi-122421	Trichoderma virens	42.99	1.00e-70	257.00
IUUC-Tae-124587	Triticum aestivum	46.40	1.00e-52	197.00
IUUC-Tur-126353	Triticum urartu	35.67	1.00e-21	95.90
IUUC-Tme-126918	Tuber melanosporum	56.84	7.00e-69	251.00
IUUC-Ttr-129286	Tursiops truncatus	41.36	5.00e-45	172.00
IUUC-Uma-129404	Ustilago maydis	37.08	2.00e-56	210.00
IUUC-Vda-129746	Verticillium dahliae	41.13	3.00e-69	253.00
IUUC-Vpa-130648	Vicugna pacos	22.58	1.00e-03	35.00
IUUC-Vvi-131301	Vitis vinifera	41.96	9.00e-53	198.00
IUUC-Xtr-132583	Xenopus tropicalis	49.48	1.00e-51	194.00
IUUC-Xma-133129	Xiphophorus maculatus	37.20	2.00e-53	200.00
IUUC-Yli-134515	Yarrowia lipolytica	57.09	1.00e-77	280.00
IUUC-Zma-135398	Zea mays	50.27	3.00e-52	196.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence