iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000034584.2	ENSGALT00000077960.1	ENSGALP00000058428.1
ENSGALG00000034584.2	ENSGALT00000052116.1	ENSGALP00000055519.1
ENSGALG00000034584.2	ENSGALT00000056156.1	ENSGALP00000045309.1
ENSGALG00000034584.2	ENSGALT00000083547.1	ENSGALP00000063853.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.40e-135	452.4	641	972

Active Site

Position(s)	Description	Evidence
942	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++ lk+rl++ef+ E+gld+gGv+re+++llske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld 
   Q: 641  PDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVYHGKLLDG 729
           57899************************************************************************************ PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
           ++ ++fyk++lgk+++l+d+e+vd+e+y+slk+i+en   d +e  ldl+f+++ee++g+t++++Lkp+G++i+VtneNk+eY++lv++
   Q: 730  FFIRPFYKMMLGKPITLKDMESVDSEYYNSLKWILEN---DPTE--LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQ 813
           ***********************************99...6666..7****************************************** PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +++++q++af eGf+e++p++l+++F+e+elell+cG  ++dv+d++++t yk+gy +++p+iqwFw+++  +++e+r ++LqFv
   Q: 814  WRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHTIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFV 902
           ***************************************************************************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           Tg+sr+P++Gfael     p+lf+i++++++d+lP+++TCfn+L+LP Y+s + l+ekLl+A+e+++gFe
   Q: 903  TGTSRVPMNGFAELYgsngPQLFTIEQWGTPDKLPRAHTCFNRLDLPLYESFDDLREKLLMAVENAQGFE 972
           *********************************************************************8 PP

Organism

Gallus gallus

Protein Sequence
(Fasta)

MATAAVEPVY GLAEEEEESR ILRVKVVSGI DLAKKDIFGA SDPYVKLSLY VADENRELAL 60
VQTKTIKKTL NPKWNEEFYF RVNPTNHRLL FEVFDENRLT RDDFLGQVDV PLSHLPTEDP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGACCG CGGCGGTGGA GCCGGTGTAC GGGCTGGCGG AGGAGGAGGT GGGTCGGGTC 60
GGGTCGGGGG CATCGTCCCC ATCCCGGGGG GAGGGTGCGG GGATCTCCCC CCCACCCGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

PRINTS

PR00360--C2DOMAIN

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001314	Ailuropoda melanoleuca	91.61	0.00e+00	1631.00
IUUC-Apl-003893	Anas platyrhynchos	97.66	0.00e+00	1769.00
IUUC-Aca-004744	Anolis carolinensis	91.04	0.00e+00	1663.00
IUUC-Afu-009103	Aspergillus fumigatus	48.85	4.00e-162	565.00
IUUC-Ani-009259	Aspergillus nidulans	48.20	1.00e-159	556.00
IUUC-Ang-009738	Aspergillus niger	49.00	5.00e-160	558.00
IUUC-Ame-010810	Astyanax mexicanus	72.19	0.00e+00	1251.00
IUUC-Bta-012679	Bos taurus	92.94	0.00e+00	1534.00
IUUC-Cja-018732	Callithrix jacchus	93.45	0.00e+00	1759.00
IUUC-Cfa-021226	Canis familiaris	93.55	0.00e+00	1728.00
IUUC-Cpo-021671	Cavia porcellus	91.88	0.00e+00	1680.00
IUUC-Csa-023344	Chlorocebus sabaeus	91.74	0.00e+00	1746.00
IUUC-Cho-024832	Choloepus hoffmanni	98.30	0.00e+00	735.00
IUUC-Csv-026098	Ciona savignyi	58.70	0.00e+00	655.00
IUUC-Dre-027770	Danio rerio	78.62	0.00e+00	1443.00
IUUC-Dno-029466	Dasypus novemcinctus	93.54	0.00e+00	1761.00
IUUC-Dor-030138	Dipodomys ordii	88.12	0.00e+00	1565.00
IUUC-Dse-031241	Dothistroma septosporum	47.86	3.00e-158	551.00
IUUC-Dme-032166	Drosophila melanogaster	67.71	0.00e+00	717.00
IUUC-Ete-033145	Echinops telfairi	85.16	0.00e+00	1226.00
IUUC-Eca-033445	Equus caballus	93.72	0.00e+00	1537.00
IUUC-Eeu-035247	Erinaceus europaeus	85.27	0.00e+00	1445.00
IUUC-Fca-035489	Felis catus	90.50	0.00e+00	1475.00
IUUC-Fal-037604	Ficedula albicollis	93.61	0.00e+00	1767.00
IUUC-Gmo-039674	Gadus morhua	76.75	0.00e+00	1398.00
IUUC-Gac-042020	Gasterosteus aculeatus	80.04	0.00e+00	1439.00
IUUC-Ggo-045332	Gorilla gorilla	92.21	0.00e+00	1664.00
IUUC-Hsa-045968	Homo sapiens	93.54	0.00e+00	1757.00
IUUC-Lch-050443	Latimeria chalumnae	86.82	0.00e+00	1451.00
IUUC-Loc-052662	Lepisosteus oculatus	81.12	0.00e+00	1471.00
IUUC-Laf-053850	Loxodonta africana	92.80	0.00e+00	1723.00
IUUC-Mcc-055821	Macaca mulatta	93.84	0.00e+00	1734.00
IUUC-Meu-056712	Macropus eugenii	79.30	0.00e+00	756.00
IUUC-Mla-058996	Melampsora laricipopulina	47.14	6.00e-154	537.00
IUUC-Mmr-060798	Microcebus murinus	89.70	0.00e+00	1612.00
IUUC-Mdo-062173	Monodelphis domestica	91.75	0.00e+00	1764.00
IUUC-Mmu-064136	Mus musculus	92.83	0.00e+00	1724.00
IUUC-Mpu-066765	Mustela putorius furo	93.74	0.00e+00	1710.00
IUUC-Mlu-067565	Myotis lucifugus	91.13	0.00e+00	1519.00
IUUC-Nfi-068427	Neosartorya fischeri	48.85	4.00e-162	565.00
IUUC-Nle-069070	Nomascus leucogenys	89.86	0.00e+00	1665.00
IUUC-Opr-071044	Ochotona princeps	93.02	0.00e+00	1166.00
IUUC-Ont-072044	Oreochromis niloticus	77.98	0.00e+00	1479.00
IUUC-Oan-073032	Ornithorhynchus anatinus	90.50	0.00e+00	1413.00
IUUC-Ocu-074160	Oryctolagus cuniculus	91.24	0.00e+00	1654.00
IUUC-Ola-087467	Oryzias latipes	79.15	0.00e+00	1462.00
IUUC-Oga-088460	Otolemur garnettii	89.51	0.00e+00	1519.00
IUUC-Oar-090198	Ovis aries	93.32	0.00e+00	1699.00
IUUC-Ptr-090939	Pan troglodytes	93.54	0.00e+00	1757.00
IUUC-Pan-092284	Papio anubis	93.44	0.00e+00	1755.00
IUUC-Psi-093645	Pelodiscus sinensis	94.26	0.00e+00	1763.00
IUUC-Pfo-096768	Poecilia formosa	91.16	0.00e+00	962.00
IUUC-Pab-098088	Pongo abelii	93.67	0.00e+00	1739.00
IUUC-Pca-100714	Procavia capensis	74.28	0.00e+00	1270.00
IUUC-Pva-102354	Pteropus vampyrus	91.86	0.00e+00	1633.00
IUUC-Ptt-103806	Puccinia triticina	53.38	2.00e-122	433.00
IUUC-Rno-105318	Rattus norvegicus	92.18	0.00e+00	1680.00
IUUC-Sce-106289	Saccharomyces cerevisiae	49.58	7.00e-164	570.00
IUUC-Sha-107482	Sarcophilus harrisii	93.42	0.00e+00	1567.00
IUUC-Ssc-115950	Sus scrofa	68.28	0.00e+00	1142.00
IUUC-Tgu-117130	Taeniopygia guttata	96.98	0.00e+00	1798.00
IUUC-Tru-118610	Takifugu rubripes	79.98	0.00e+00	1491.00
IUUC-Tsy-119492	Tarsius syrichta	88.23	0.00e+00	1574.00
IUUC-Tni-120113	Tetraodon nigroviridis	75.52	0.00e+00	1361.00
IUUC-Tvi-122595	Trichoderma virens	46.52	1.00e-152	533.00
IUUC-Tbe-127441	Tupaia belangeri	84.45	0.00e+00	743.00
IUUC-Ttr-128235	Tursiops truncatus	84.93	0.00e+00	1468.00
IUUC-Vda-129753	Verticillium dahliae	46.83	1.00e-154	540.00
IUUC-Vpa-130544	Vicugna pacos	71.93	0.00e+00	828.00
IUUC-Xtr-132859	Xenopus tropicalis	89.42	0.00e+00	1645.00
IUUC-Xma-133797	Xiphophorus maculatus	80.36	0.00e+00	1466.00
IUUC-Yli-134668	Yarrowia lipolytica	47.33	1.00e-159	556.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence