iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046343

UUCD1 version

UUC-HoS-00178

Ensembl Protein ID

ENSP00000361990.1

UniProt Accession

Q8IWV8; O15057; Q4VXK2; Q5TFH6; Q6P2I2; Q6ZUD0; UBR2_HUMAN

Genbank Protein ID

AAL32101.1; BAC86295.1; CAI20399.1; CAI20399.1; CAI20399.1; CAI95685.1; CAI95685.1; CAI95685.1; CAI19919.1; CAI19919.1; CAI19920.1; CAI19920.1; CAI19920.1; CAI95666.1; CAI95666.1; CAI95666.1; CAI14737.1; CAI14737.1; CAI14738.1; CAI14738.1; CAI14738.1; CAI95298.1; CAI95298.1; CAI95298.1; AAH24217.1; AAH64512.1; BAA20806.1

Protein Name

E3 ubiquitin-protein ligase UBR2; N-recognin-2; RING-type E3 ubiquitin transferase UBR2; Ubiquitin-protein ligase E3-alpha-2; Ubiquitin-protein ligase E3-alpha-II

Genbank Nucleotide ID

AY061884; AK125795; AL049843; AL136223; AL391814; AL049843; AL136223; AL391814; AL136223; AL391814; AL136223; AL049843; AL391814; AL136223; AL049843; AL391814; AL391814; AL136223; AL391814; AL136223; AL049843; AL391814; AL049843; AL136223; BC024217; BC064512; AB002347

Gene Name

UBR2; C6orf133; KIAA0349

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000024048.10	ENST00000372903.6	ENSP00000361994.2
ENSG00000024048.10	ENST00000372899.5	ENSP00000361990.1
ENSG00000024048.10	ENST00000372901.1	ENSP00000361992.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	miRNAMap	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	20298436
E3 activity/N-recognin/UBR-box	UBR	20298436
E3 activity/N-recognin/N-domain	N-domain	20298436

Classification

Family	E-value	Score	Start	End
E3 activity/N-recognin/N-domain	3.50e-39	134.4	227	302
E3 activity/RING/RING	8.70e-09	37.4	1108	1213
E3 activity/N-recognin/UBR-box	2.70e-31	109.5	97	167

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/N-recognin/N-domain

   S: 1    YylvLfNDEkHsyeqviyslqkAleleqkeakkfatiidkeGRravkaGdyavceeakkeilknseklaqipLkVev 77
           Yy++LfNDE+H+yeqviy+lqkA++++qkea++fat++d++GRr+v++Gd+++ce+ak++i++n++++++ pLkV+v
   Q: 227  YYCMLFNDEVHTYEQVIYTLQKAVNCTQKEAIGFATTVDRDGRRSVRYGDFQYCEQAKSVIVRNTSRQTK-PLKVQV 302
           9*********************************************************************.****98 PP

E3 activity/RING/RING

   S: 1    CaiC......................................ledf........kdgplvlpCgHvfhadClqkw............... 29
           C++C                                      +           ++g+++ +CgH++ha+C+q++               
   Q: 1108 CILCqeeqevkvesramvlaafvqrstvlsknrskfiqdpekY--DplfmhpdlSCGTHTSSCGHIMHAHCWQRYfdsvqakeqrrqqrl 1195
           8888444444433333333333333333333333333333321..023444444558999****************************** PP
   S: 30   ..pglknssskefrCPlC 45
             + +++++++ef+CPlC
   Q: 1196 rlHTSYDVENGEFLCPLC 1213
           ****************** PP

E3 activity/N-recognin/UBR-box

   S: 1    slCgrvfkvgetiyeCrtCsvdetlvlCteCfakvvHkdHeyklkksggggfCdCGdteAwedgskCkkll 71
           +lCgrvfkvge +y+Cr+C+vd+t+vlC+eCf  ++H+dH+y++++sggggfCdCGdteAw++g++C+k++
   Q: 97   HLCGRVFKVGEPTYSCRDCAVDPTCVLCMECFLGSIHRDHRYRMTTSGGGGFCDCGDTEAWKEGPYCQKHE 167
           68******************************************************************996 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.

Protein Sequence
(Fasta)

MASELEPEVQ AIDRSLLECS AEEIAGKWLQ ATDLTREVYQ HLAHYVPKIY CRGPNPFPQK 60
EDMLAQHVLL GPMEWYLCGE DPAFGFPKLE QANKPSHLCG RVFKVGEPTY SCRDCAVDPT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTCTGTGTCC TTCCCTGGGT CAGGGACGAG CCAGTGACTT GACTCTTGGG CGCTAAGCTT 60
GGGAGGGAGC GCAGGAGGCC GCTGTCCTTC CTTTCCGGTT CACGTCACCC TTCTCTCCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003769--ClpS_core
IPR014719--Ribosomal_L7/12_C/ClpS-like
IPR011991--WHTH_DNA-bd_dom
IPR013083--Znf_RING/FYVE/PHD
IPR003126--Znf_UBR

PROSITE

PS51157--ZF_UBR

Pfam

PF02617--ClpS
PF02207--zf-UBR

SMART

SM00396--ZnF_UBR1

Gene Ontology

GO:0000785--C:chromatin
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0070728--F:leucine binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0071233--P:cellular response to leucine
GO:0006342--P:chromatin silencing
GO:0033522--P:histone H2A ubiquitination
GO:0007141--P:male meiosis I
GO:0032007--P:negative regulation of TOR signaling
GO:0000209--P:protein polyubiquitination
GO:0007283--P:spermatogenesis
GO:0071596--P:ubiquitin-dependent protein catabolic process via the N-end rule pathway

KEGG

hsa:23304

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000949	Aegilops tauschii	27.37	3.00e-21	99.00
IUUC-Aml-001876	Ailuropoda melanoleuca	84.91	0.00e+00	2745.00
IUUC-Atr-002501	Amborella trichopoda	28.67	1.00e-27	120.00
IUUC-Apl-003828	Anas platyrhynchos	87.56	0.00e+00	3073.00
IUUC-Aca-005189	Anolis carolinensis	84.91	0.00e+00	3019.00
IUUC-Aly-005901	Arabidopsis lyrata	32.39	6.00e-26	114.00
IUUC-Ath-007148	Arabidopsis thaliana	30.99	1.00e-24	110.00
IUUC-Ago-007946	Ashbya gossypii	22.74	9.00e-26	113.00
IUUC-Afl-008479	Aspergillus flavus	23.00	3.00e-46	182.00
IUUC-Afu-008929	Aspergillus fumigatus	24.06	4.00e-53	204.00
IUUC-Ang-009550	Aspergillus niger	23.49	1.00e-46	183.00
IUUC-Aor-010124	Aspergillus oryzae	23.00	2.00e-46	182.00
IUUC-Ame-011917	Astyanax mexicanus	73.12	0.00e+00	2477.00
IUUC-Bta-012768	Bos taurus	93.34	0.00e+00	3274.00
IUUC-Bci-013834	Botrytis cinerea	22.90	4.00e-32	134.00
IUUC-Bdi-014635	Brachypodium distachyon	25.87	3.00e-31	132.00
IUUC-Bol-015669	Brassica oleracea	31.45	2.00e-30	129.00
IUUC-Bra-017776	Brassica rapa	31.45	6.00e-31	130.00
IUUC-Cel-018476	Caenorhabditis elegans	32.26	5.00e-86	313.00
IUUC-Cja-019797	Callithrix jacchus	97.02	0.00e+00	2658.00
IUUC-Cfa-020950	Canis familiaris	95.33	0.00e+00	3326.00
IUUC-Cpo-022385	Cavia porcellus	93.50	0.00e+00	3298.00
IUUC-Csa-024082	Chlorocebus sabaeus	98.35	0.00e+00	3421.00
IUUC-Cho-025029	Choloepus hoffmanni	86.16	0.00e+00	2167.00
IUUC-Cin-025148	Ciona intestinalis	35.71	1.00e-137	484.00
IUUC-Csv-026296	Ciona savignyi	31.48	3.00e-21	96.30
IUUC-Cgl-026605	Colletotrichum gloeosporioides	23.22	2.00e-53	206.00
IUUC-Cne-026823	Cryptococcus neoformans	21.89	3.00e-39	158.00
IUUC-Dre-028343	Danio rerio	72.99	0.00e+00	2505.00
IUUC-Dno-030002	Dasypus novemcinctus	92.59	0.00e+00	1969.00
IUUC-Dor-030207	Dipodomys ordii	80.02	0.00e+00	1602.00
IUUC-Dse-031531	Dothistroma septosporum	24.06	2.00e-54	209.00
IUUC-Dme-031910	Drosophila melanogaster	34.23	0.00e+00	676.00
IUUC-Ete-033162	Echinops telfairi	84.79	0.00e+00	1385.00
IUUC-Eca-033454	Equus caballus	93.74	0.00e+00	3263.00
IUUC-Eeu-034783	Erinaceus europaeus	77.57	0.00e+00	1521.00
IUUC-Fca-036588	Felis catus	95.16	0.00e+00	3307.00
IUUC-Fal-036919	Ficedula albicollis	86.97	0.00e+00	2989.00
IUUC-Fso-038463	Fusarium solani	24.24	6.00e-42	167.00
IUUC-Gmo-039698	Gadus morhua	70.02	0.00e+00	1627.00
IUUC-Ggr-040070	Gaeumannomyces graminis	22.61	7.00e-42	167.00
IUUC-Gga-041123	Gallus gallus	89.18	0.00e+00	3136.00
IUUC-Gac-042622	Gasterosteus aculeatus	66.27	0.00e+00	2208.00
IUUC-Gma-043622	Glycine max	30.39	5.00e-26	114.00
IUUC-Ggo-045583	Gorilla gorilla	97.34	0.00e+00	3405.00
IUUC-Hvu-047626	Hordeum vulgare	29.33	8.00e-28	120.00
IUUC-Kpa-049088	Komagataella pastoris	23.54	8.00e-48	186.00
IUUC-Lch-049649	Latimeria chalumnae	75.33	0.00e+00	2613.00
IUUC-Lpe-051516	Leersia perrieri	26.30	3.00e-31	132.00
IUUC-Loc-052818	Lepisosteus oculatus	75.14	0.00e+00	2627.00
IUUC-Lma-053059	Leptosphaeria maculans	23.02	4.00e-47	184.00
IUUC-Laf-054142	Loxodonta africana	94.19	0.00e+00	3309.00
IUUC-Mcc-055677	Macaca mulatta	97.95	0.00e+00	3396.00
IUUC-Meu-056204	Macropus eugenii	68.35	0.00e+00	732.00
IUUC-Mor-057051	Magnaporthe oryzae	23.08	2.00e-48	189.00
IUUC-Mpo-057372	Magnaporthe poae	23.98	1.00e-43	172.00
IUUC-Mtr-058538	Medicago truncatula	30.39	1.00e-28	123.00
IUUC-Mla-058963	Melampsora laricipopulina	24.76	2.00e-55	212.00
IUUC-Mga-059698	Meleagris gallopavo	89.42	0.00e+00	3112.00
IUUC-Mvi-060535	Microbotryum violaceum	24.57	3.00e-49	192.00
IUUC-Mmr-060901	Microcebus murinus	92.19	0.00e+00	3206.00
IUUC-Mdo-062014	Monodelphis domestica	90.83	0.00e+00	3201.00
IUUC-Mmu-063699	Mus musculus	90.54	0.00e+00	3175.00
IUUC-Mac-064773	Musa acuminata	31.10	3.00e-27	119.00
IUUC-Mpu-066153	Mustela putorius furo	95.38	0.00e+00	3327.00
IUUC-Mlu-068151	Myotis lucifugus	94.02	0.00e+00	3264.00
IUUC-Nfi-068403	Neosartorya fischeri	23.55	2.00e-52	202.00
IUUC-Ncr-068864	Neurospora crassa	22.11	8.00e-48	187.00
IUUC-Nle-069529	Nomascus leucogenys	98.58	0.00e+00	3429.00
IUUC-Opr-071107	Ochotona princeps	87.78	0.00e+00	1351.00
IUUC-Ont-072189	Oreochromis niloticus	66.05	0.00e+00	2164.00
IUUC-Oan-072893	Ornithorhynchus anatinus	89.80	0.00e+00	3157.00
IUUC-Ocu-074082	Oryctolagus cuniculus	93.27	0.00e+00	3264.00
IUUC-Obr-076117	Oryza brachyantha	25.88	4.00e-27	118.00
IUUC-Ogl-077571	Oryza glaberrima	28.49	1.00e-20	96.70
IUUC-Olo-081056	Oryza longistaminata	25.34	4.00e-16	81.60
IUUC-Ome-081738	Oryza meridionalis	22.68	1.00e-14	77.00
IUUC-Opu-083202	Oryza punctata	26.82	2.00e-27	119.00
IUUC-Osa-085336	Oryza sativa	28.74	8.00e-21	96.30
IUUC-Ola-087460	Oryzias latipes	64.18	0.00e+00	2143.00
IUUC-Olu-087832	Ostreococcus lucimarinus	27.87	3.80e-02	33.90
IUUC-Oga-088432	Otolemur garnettii	94.76	0.00e+00	3335.00
IUUC-Oar-090206	Ovis aries	91.78	0.00e+00	3238.00
IUUC-Ptr-091180	Pan troglodytes	97.61	0.00e+00	3399.00
IUUC-Pan-092375	Papio anubis	98.12	0.00e+00	3416.00
IUUC-Psi-093049	Pelodiscus sinensis	88.56	0.00e+00	3088.00
IUUC-Pma-094152	Petromyzon marinus	47.64	0.00e+00	656.00
IUUC-Pno-094877	Phaeosphaeria nodorum	24.08	6.00e-31	130.00
IUUC-Ppa-095715	Physcomitrella patens	28.99	2.00e-23	106.00
IUUC-Pfo-096524	Poecilia formosa	64.05	0.00e+00	2070.00
IUUC-Pab-097989	Pongo abelii	96.75	0.00e+00	3341.00
IUUC-Pca-100207	Procavia capensis	80.53	0.00e+00	1263.00
IUUC-Ppe-101802	Prunus persica	28.90	3.00e-26	115.00
IUUC-Pva-102538	Pteropus vampyrus	93.08	0.00e+00	1219.00
IUUC-Pgr-103372	Puccinia graminis	24.11	2.00e-51	199.00
IUUC-Ptt-103878	Puccinia triticina	23.85	2.00e-48	189.00
IUUC-Rno-105567	Rattus norvegicus	89.01	0.00e+00	3071.00
IUUC-Sce-106272	Saccharomyces cerevisiae	21.24	9.00e-27	117.00
IUUC-Sha-106980	Sarcophilus harrisii	90.19	0.00e+00	3050.00
IUUC-Sja-107980	Schizosaccharomyces japonicus	23.87	7.00e-48	187.00
IUUC-Spo-108183	Schizosaccharomyces pombe	25.25	6.00e-50	194.00
IUUC-Smo-108719	Selaginella moellendorffii	31.54	2.00e-30	129.00
IUUC-Sit-110716	Setaria italica	26.48	3.00e-32	135.00
IUUC-Sly-111286	Solanum lycopersicum	31.67	1.00e-26	117.00
IUUC-Sar-113332	Sorex araneus	86.27	0.00e+00	2172.00
IUUC-Sbi-114577	Sorghum bicolor	28.73	2.00e-30	129.00
IUUC-Sre-115045	Sporisorium reilianum	26.31	2.00e-45	179.00
IUUC-Ssc-115525	Sus scrofa	94.15	0.00e+00	2550.00
IUUC-Tgu-116943	Taeniopygia guttata	88.96	0.00e+00	3123.00
IUUC-Tru-117673	Takifugu rubripes	65.15	0.00e+00	2175.00
IUUC-Tsy-119032	Tarsius syrichta	92.13	0.00e+00	1822.00
IUUC-Tni-119987	Tetraodon nigroviridis	65.72	0.00e+00	2155.00
IUUC-Tca-121077	Theobroma cacao	32.70	3.00e-26	115.00
IUUC-Tre-122137	Trichoderma reesei	24.52	7.00e-57	217.00
IUUC-Tvi-122272	Trichoderma virens	22.91	5.00e-53	204.00
IUUC-Tae-125501	Triticum aestivum	28.49	1.00e-28	122.00
IUUC-Tur-126562	Triticum urartu	28.68	6.00e-28	120.00
IUUC-Tme-127156	Tuber melanosporum	23.40	9.00e-50	193.00
IUUC-Tbe-128103	Tupaia belangeri	87.79	0.00e+00	1253.00
IUUC-Ttr-128253	Tursiops truncatus	88.26	0.00e+00	3041.00
IUUC-Uma-129344	Ustilago maydis	26.60	9.00e-50	193.00
IUUC-Vda-129778	Verticillium dahliae	23.46	5.00e-46	181.00
IUUC-Vpa-130540	Vicugna pacos	89.83	0.00e+00	2935.00
IUUC-Vvi-131290	Vitis vinifera	33.02	4.00e-28	121.00
IUUC-Xtr-132690	Xenopus tropicalis	80.71	0.00e+00	2857.00
IUUC-Xma-133748	Xiphophorus maculatus	64.31	0.00e+00	2011.00
IUUC-Yli-134662	Yarrowia lipolytica	24.21	2.00e-31	132.00
IUUC-Zma-135553	Zea mays	23.26	4.00e-16	81.60

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence