iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Mmu-063263

UUCD1 version

UUC-MuM-01078

Ensembl Protein ID

ENSMUSP00000082754.5

UniProt Accession

Q9D9M2; Q790B0; Q7TNV4; Q80Y43; Q8CBN8; UBP12_MOUSE

Genbank Protein ID

BAB24720.2; BAC29129.1; BAE39295.1; AAH49274.1; AAH55398.1; AAH68136.1; AAL86740.1

Protein Name

Ubiquitin carboxyl-terminal hydrolase 12; Deubiquitinating enzyme 12; Ubiquitin thioesterase 12; Ubiquitin-hydrolyzing enzyme 1; Ubiquitin-specific-processing protease 12

Genbank Nucleotide ID

AK006739; AK035629; AK167153; BC049274; BC055398; BC068136; AF441835

Gene Name

Usp12; Ubh1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000029640.17	ENSMUST00000085614.5	ENSMUSP00000082754.5

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID	HINT	Mentha
Post-translational Modifications (PTMs)
PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	9615226

Classification

Family	E-value	Score	Start	End
DUB/USP	2.00e-98	330.8	39	368

Active Site

Position(s)	Description	Evidence
48	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
317	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw..kskkkavsprellkalkkeaeefsgy 87
           +Gl N+gNtCY+NSvLQ+L++++++re +l  +k++      + +k++ll++l++lf+++   k+k +++ p+++++ l+ke+e f++y
   Q: 39   FGLVNFGNTCYCNSVLQALYFCRPFREKVLA-YKSQ------PRKKENLLTCLADLFHSIAtqKKKVGVIPPKKFITRLRKENELFDNY 120
           6******************************.4444......456789************976777779******************** PP
   S: 88   eqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpv 176
           +qqDa+Efl++ll+++ + l   ++++k+e+++ + ++ + ++e+++ +  +++++++Fqg+l+++++cl+c+++ss++e+fldls++v
   Q: 121  MQQDAHEFLNYLLNTIADIL---QEERKQEKQNGRLRNGDVDNEDNNSTPDPTWVHEIFQGTLTNETRCLTCETISSKDEDFLDLSVDV 206
           ********************...456666666777788899999********************************************* PP
   S: 177  pgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfc 265
           ++++     s+++cL+ f+++e+l++e kyyce+c++kqea k++k+kklP +L lhLkRf++  + ++ +k++ +v fpleL l  f+
   Q: 207  EQNT-----SITHCLRGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPLILALHLKRFKYMDQLHRYTKLSYRVVFPLELRL--FN 288
           ****.....9**********************************************************************66665..77 PP
   S: 266  tspeekqkekkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetg.........staYvlfYkr 337
           ts +   + ++ Y+L+avvvH G +++ GHY+a+vk+ ++ WllfdD+ V++++ + ++e+ g         +++Y+lfY++
   Q: 289  TSGDA-TNPDRMYDLVAVVVHCGsGPNRGHYIAIVKS-HDFWLLFDDDIVEKIDAQAIEEFYGltsdisknsESGYILFYQS 368
           77444.4469***************************.555*******************999*****************97 PP

Organism

Mus musculus

Functional Description
(View)

Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2.

Protein Sequence
(Fasta)

MEILMTVSKF ASICTMGANA SALEKEIGPE QFPVNEHYFG LVNFGNTCYC NSVLQALYFC 60
RPFREKVLAY KSQPRKKENL LTCLADLFHS IATQKKKVGV IPPKKFITRL RKENELFDNY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGACGCTGC CCGGTCGTCG GGGCGGTAGG GCCTGCGCGG AGCTCTCTCC CCAGCGCGCT 60
GGGCGGGGTG TGCTGTGAGC GGCTTCCCGG GCAGGCGCGG GCCCTGAGGC GGCGGCTGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0004197--F:cysteine-type endopeptidase activity
GO:0046872--F:metal ion binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mmu:22217

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001964	Ailuropoda melanoleuca	95.95	0.00e+00	748.00
IUUC-Apl-003411	Anas platyrhynchos	97.22	0.00e+00	735.00
IUUC-Aca-005212	Anolis carolinensis	97.03	0.00e+00	753.00
IUUC-Acl-008239	Aspergillus clavatus	48.68	1.00e-77	284.00
IUUC-Afl-008602	Aspergillus flavus	49.50	2.00e-79	290.00
IUUC-Afu-008816	Aspergillus fumigatus	49.16	3.00e-77	283.00
IUUC-Ani-009137	Aspergillus nidulans	48.48	1.00e-75	277.00
IUUC-Ang-009703	Aspergillus niger	49.33	1.00e-78	288.00
IUUC-Aor-009901	Aspergillus oryzae	49.50	2.00e-79	290.00
IUUC-Ate-010431	Aspergillus terreus	49.16	3.00e-77	283.00
IUUC-Ame-011015	Astyanax mexicanus	92.72	0.00e+00	727.00
IUUC-Bgr-012071	Blumeria graminis	44.37	3.00e-75	276.00
IUUC-Bta-012981	Bos taurus	97.84	0.00e+00	757.00
IUUC-Bci-013837	Botrytis cinerea	40.74	1.00e-73	271.00
IUUC-Cja-018831	Callithrix jacchus	98.38	0.00e+00	765.00
IUUC-Cfa-020534	Canis familiaris	98.11	0.00e+00	765.00
IUUC-Cpo-021703	Cavia porcellus	98.31	0.00e+00	733.00
IUUC-Csa-023604	Chlorocebus sabaeus	98.22	0.00e+00	700.00
IUUC-Cho-024902	Choloepus hoffmanni	81.64	6.00e-170	589.00
IUUC-Cin-025659	Ciona intestinalis	56.84	1.00e-130	459.00
IUUC-Csv-025828	Ciona savignyi	54.00	2.00e-123	435.00
IUUC-Cgl-026611	Colletotrichum gloeosporioides	43.56	1.00e-75	278.00
IUUC-Dre-027845	Danio rerio	92.99	0.00e+00	731.00
IUUC-Dno-029460	Dasypus novemcinctus	98.02	0.00e+00	731.00
IUUC-Dor-030972	Dipodomys ordii	97.65	8.00e-151	526.00
IUUC-Dse-031470	Dothistroma septosporum	48.54	1.00e-76	281.00
IUUC-Ete-033125	Echinops telfairi	77.21	7.00e-131	459.00
IUUC-Eca-033439	Equus caballus	98.31	0.00e+00	733.00
IUUC-Fca-035524	Felis catus	97.75	0.00e+00	731.00
IUUC-Fal-036833	Ficedula albicollis	94.84	0.00e+00	728.00
IUUC-Fso-038299	Fusarium solani	38.08	1.00e-74	274.00
IUUC-Gmo-038763	Gadus morhua	92.47	0.00e+00	729.00
IUUC-Gga-041151	Gallus gallus	97.84	0.00e+00	756.00
IUUC-Gac-041967	Gasterosteus aculeatus	93.01	0.00e+00	732.00
IUUC-Hsa-045700	Homo sapiens	98.38	0.00e+00	765.00
IUUC-Hvu-047692	Hordeum vulgare	59.73	1.00e-123	436.00
IUUC-Itr-049082	Ictidomys tridecemlineatus	98.31	0.00e+00	736.00
IUUC-Lch-050237	Latimeria chalumnae	90.81	0.00e+00	671.00
IUUC-Loc-051968	Lepisosteus oculatus	95.14	0.00e+00	745.00
IUUC-Lma-053300	Leptosphaeria maculans	47.90	2.00e-79	290.00
IUUC-Laf-053887	Loxodonta africana	98.38	0.00e+00	765.00
IUUC-Mcc-055701	Macaca mulatta	98.11	0.00e+00	764.00
IUUC-Mor-057072	Magnaporthe oryzae	44.30	5.00e-76	279.00
IUUC-Mga-059195	Meleagris gallopavo	95.39	0.00e+00	738.00
IUUC-Mmr-060751	Microcebus murinus	98.38	0.00e+00	765.00
IUUC-Mdo-062735	Monodelphis domestica	96.24	0.00e+00	748.00
IUUC-Mlu-068128	Myotis lucifugus	98.31	0.00e+00	733.00
IUUC-Nfi-068611	Neosartorya fischeri	49.16	3.00e-77	283.00
IUUC-Ncr-068699	Neurospora crassa	44.63	5.00e-75	276.00
IUUC-Nle-069767	Nomascus leucogenys	98.31	0.00e+00	736.00
IUUC-Ont-072658	Oreochromis niloticus	93.28	0.00e+00	734.00
IUUC-Oan-073372	Ornithorhynchus anatinus	97.18	0.00e+00	725.00
IUUC-Ocu-074322	Oryctolagus cuniculus	95.14	0.00e+00	739.00
IUUC-Ola-087418	Oryzias latipes	93.28	0.00e+00	734.00
IUUC-Oga-088298	Otolemur garnettii	95.42	0.00e+00	739.00
IUUC-Oar-090269	Ovis aries	96.14	0.00e+00	732.00
IUUC-Ptr-090467	Pan troglodytes	98.38	0.00e+00	765.00
IUUC-Pan-092437	Papio anubis	95.38	0.00e+00	735.00
IUUC-Psi-092993	Pelodiscus sinensis	98.31	0.00e+00	733.00
IUUC-Pno-095044	Phaeosphaeria nodorum	48.51	1.00e-78	287.00
IUUC-Pfo-097052	Poecilia formosa	93.28	0.00e+00	734.00
IUUC-Pab-097797	Pongo abelii	98.38	0.00e+00	765.00
IUUC-Pca-100835	Procavia capensis	89.60	2.00e-172	597.00
IUUC-Pte-104356	Pyrenophora teres	46.91	1.00e-78	287.00
IUUC-Pyt-104709	Pyrenophora triticirepentis	48.34	3.00e-78	286.00
IUUC-Rno-104918	Rattus norvegicus	96.48	0.00e+00	740.00
IUUC-Sce-106196	Saccharomyces cerevisiae	38.80	2.00e-56	213.00
IUUC-Sha-107087	Sarcophilus harrisii	98.38	0.00e+00	765.00
IUUC-Sja-107684	Schizosaccharomyces japonicus	45.92	2.00e-67	250.00
IUUC-Spo-108095	Schizosaccharomyces pombe	47.08	7.00e-76	278.00
IUUC-Sar-113216	Sorex araneus	97.74	0.00e+00	724.00
IUUC-Sre-115197	Sporisorium reilianum	49.82	5.00e-80	293.00
IUUC-Ssc-116321	Sus scrofa	96.11	0.00e+00	730.00
IUUC-Tgu-117482	Taeniopygia guttata	93.75	0.00e+00	704.00
IUUC-Tru-118613	Takifugu rubripes	93.01	0.00e+00	732.00
IUUC-Tsy-119520	Tarsius syrichta	87.06	1.00e-129	455.00
IUUC-Tni-120293	Tetraodon nigroviridis	93.01	0.00e+00	732.00
IUUC-Tre-122226	Trichoderma reesei	45.70	8.00e-77	281.00
IUUC-Tvi-122330	Trichoderma virens	45.54	6.00e-76	278.00
IUUC-Tbe-127783	Tupaia belangeri	97.18	0.00e+00	713.00
IUUC-Ttr-129083	Tursiops truncatus	98.11	0.00e+00	764.00
IUUC-Uma-129409	Ustilago maydis	50.70	2.00e-81	297.00
IUUC-Vda-129736	Verticillium dahliae	38.76	3.00e-58	219.00
IUUC-Vpa-130391	Vicugna pacos	93.50	0.00e+00	685.00
IUUC-Xtr-132464	Xenopus tropicalis	98.03	0.00e+00	708.00
IUUC-Xma-133475	Xiphophorus maculatus	93.28	0.00e+00	734.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence