iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-053487

UUCD1 version

UUC-LoA-00498

Ensembl Protein ID

ENSLAFP00000012018.3

UniProt Accession

G3TD27; G3TD27_LOXAF

Protein Name

Uncharacterized protein

Gene Name

KLHL22

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000014346.3	ENSLAFT00000014349.3	ENSLAFP00000012018.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	1.60e-19	70.3	50	114
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	5.30e-08	32.1	149	178

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 2    DvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklde 67
           Dv+lvv+g++++ah+i Laas+++F+ +f ++l+e++ +++v i++v++ ++ ++l+F+Yt++l++
   Q: 50   DVVLVVEGKHIEAHRILLAASCDYFRGMFAGGLKEME-QEEVLIHGVSYNAMCQILHFIYTSELEL 114
           9***********************************8.*************************986 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 2    eNclgilrfAdlydcpdLkdaaldfilkhF 31
           eN l+++r+A+l+d+++L ++ +++ilk+F
   Q: 149  ENILDVYRLAELFDLSRLTEQLDTYILKNF 178
           8***************************** PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

RRTRSSPQLC KLPPQASHPH CVSNNYRSAQ HSQALLRGLL ALRDSGILFD VVLVVEGKHI 60
EAHRILLAAS CDYFRGMFAG GLKEMEQEEV LIHGVSYNAM CQILHFIYTS ELELSLSNVQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGAGGACCA GGAGTTCCCC CCAGCTCTGC AAGTTGCCTC CACAGGCCTC ACACCCGCAC 60
TGCGTCAGCA ACAACTACCG GAGTGCGCAG CACTCCCAGG CCCTGCTGCG TGGGCTGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR030575--KLHL22
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0005813--C:centrosome
GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0072686--C:mitotic spindle
GO:0005827--C:polar microtubule
GO:0051301--P:cell division
GO:0000070--P:mitotic sister chromatid segregation
GO:0007094--P:mitotic spindle assembly checkpoint
GO:0006513--P:protein monoubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002097	Ailuropoda melanoleuca	95.40	0.00e+00	1194.00
IUUC-Apl-004081	Anas platyrhynchos	79.22	0.00e+00	1021.00
IUUC-Aca-005015	Anolis carolinensis	64.25	0.00e+00	828.00
IUUC-Ame-011712	Astyanax mexicanus	59.56	0.00e+00	716.00
IUUC-Bta-012594	Bos taurus	92.70	0.00e+00	1194.00
IUUC-Cja-019752	Callithrix jacchus	94.70	0.00e+00	1008.00
IUUC-Cfa-020884	Canis familiaris	95.87	0.00e+00	1236.00
IUUC-Cpo-021711	Cavia porcellus	93.81	0.00e+00	1213.00
IUUC-Csa-023211	Chlorocebus sabaeus	95.56	0.00e+00	1229.00
IUUC-Dre-028395	Danio rerio	60.03	0.00e+00	746.00
IUUC-Dno-030096	Dasypus novemcinctus	93.97	0.00e+00	1220.00
IUUC-Dor-030709	Dipodomys ordii	94.48	0.00e+00	679.00
IUUC-Eca-033388	Equus caballus	95.40	0.00e+00	1230.00
IUUC-Eeu-034616	Erinaceus europaeus	83.49	0.00e+00	1057.00
IUUC-Fca-035815	Felis catus	95.87	0.00e+00	1235.00
IUUC-Fal-037311	Ficedula albicollis	80.16	0.00e+00	1014.00
IUUC-Gmo-039571	Gadus morhua	52.99	2.00e-157	548.00
IUUC-Gga-040992	Gallus gallus	79.06	0.00e+00	1021.00
IUUC-Gac-042041	Gasterosteus aculeatus	59.75	0.00e+00	685.00
IUUC-Ggo-045141	Gorilla gorilla	89.84	0.00e+00	1152.00
IUUC-Hsa-045984	Homo sapiens	95.71	0.00e+00	1233.00
IUUC-Itr-048890	Ictidomys tridecemlineatus	94.92	0.00e+00	1226.00
IUUC-Lch-049700	Latimeria chalumnae	61.22	0.00e+00	726.00
IUUC-Loc-052141	Lepisosteus oculatus	61.19	0.00e+00	788.00
IUUC-Mcc-054682	Macaca mulatta	95.65	0.00e+00	984.00
IUUC-Meu-055937	Macropus eugenii	74.48	0.00e+00	964.00
IUUC-Mga-059953	Meleagris gallopavo	79.06	0.00e+00	1021.00
IUUC-Mmr-061743	Microcebus murinus	94.44	0.00e+00	1213.00
IUUC-Mdo-062328	Monodelphis domestica	83.04	0.00e+00	1089.00
IUUC-Mmu-063979	Mus musculus	91.97	0.00e+00	1172.00
IUUC-Mpu-066750	Mustela putorius furo	95.71	0.00e+00	1232.00
IUUC-Mlu-066960	Myotis lucifugus	93.81	0.00e+00	1206.00
IUUC-Nle-069690	Nomascus leucogenys	96.08	0.00e+00	1122.00
IUUC-Opr-071059	Ochotona princeps	88.59	0.00e+00	1120.00
IUUC-Ont-072004	Oreochromis niloticus	58.38	0.00e+00	680.00
IUUC-Oan-073172	Ornithorhynchus anatinus	63.38	0.00e+00	732.00
IUUC-Ocu-074310	Oryctolagus cuniculus	93.28	9.00e-152	528.00
IUUC-Ola-086599	Oryzias latipes	57.19	0.00e+00	694.00
IUUC-Oga-087980	Otolemur garnettii	94.29	0.00e+00	1214.00
IUUC-Oar-089956	Ovis aries	77.70	0.00e+00	887.00
IUUC-Ptr-090598	Pan troglodytes	95.91	0.00e+00	1125.00
IUUC-Pan-092387	Papio anubis	95.26	0.00e+00	983.00
IUUC-Psi-093484	Pelodiscus sinensis	79.05	0.00e+00	1045.00
IUUC-Pma-094224	Petromyzon marinus	49.75	3.00e-171	594.00
IUUC-Pfo-096149	Poecilia formosa	58.03	0.00e+00	705.00
IUUC-Pab-098097	Pongo abelii	95.56	0.00e+00	1233.00
IUUC-Pca-100118	Procavia capensis	96.13	0.00e+00	693.00
IUUC-Pva-103174	Pteropus vampyrus	93.26	4.00e-153	535.00
IUUC-Rno-105350	Rattus norvegicus	92.18	0.00e+00	1161.00
IUUC-Sha-106817	Sarcophilus harrisii	83.15	1.00e-137	483.00
IUUC-Sar-113490	Sorex araneus	94.46	0.00e+00	639.00
IUUC-Ssc-115827	Sus scrofa	93.97	0.00e+00	1212.00
IUUC-Tgu-116748	Taeniopygia guttata	82.13	0.00e+00	898.00
IUUC-Tru-118644	Takifugu rubripes	57.49	0.00e+00	687.00
IUUC-Tsy-118888	Tarsius syrichta	88.79	0.00e+00	1020.00
IUUC-Tni-120060	Tetraodon nigroviridis	52.60	2.00e-173	602.00
IUUC-Ttr-129183	Tursiops truncatus	93.95	0.00e+00	1103.00
IUUC-Uma-129534	Ustilago maydis	33.33	3.80e+00	28.10
IUUC-Xtr-132780	Xenopus tropicalis	69.89	0.00e+00	898.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence