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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046686
UUCD1 version UUC-HoS-01198
Ensembl Protein ID ENSP00000251968.3
UniProt Accession Q99816; Q9BUM5; TS101_HUMAN
Genbank Protein ID AAC52083.1; AAH02487.1
Protein Name Tumor susceptibility gene 101 protein; ESCRT-I complex subunit TSG101
Genbank Nucleotide ID U82130; BC002487
Gene Name TSG101
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000074319.12 ENST00000536719.5 ENSP00000438471.1
ENSG00000074319.12 ENST00000584526.1 ENSP00000463213.1
ENSG00000074319.12 ENST00000251968.3 ENSP00000251968.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACmiRWalk
TargetScanmiRecordsRepTarmiRNAMap
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarGWASdbOMIM
Drug and target
TTD
Post-translational Modifications (PTMs)
CPLMdbPAFPhosSNPPhosphositePlus
dbPTMHPRDPhospho.ELMUniProt
PHOSIDABioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E2/UEV E2_UEV 15053872; 12006492
UBD/UBC-like/UBD_UEV UBD_UEV 11595185; 11916981; 11916981
Classification
Family E-value Score Start End
E2/UEV 6.80e-45 154.1 2 146
UBD/UBC-like/UBD_UEV 5.90e-68 228.8 2 145
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E2/UEV
   S: 1    avseselkvvvpr......nfrlleeleegekglgdgtvsygldDgddilllsltgtIigpertayegrIyqlklfvgkkYPekPPtv.... 82
           avses+lk++v++      ++r+++++++ +k+l+++++sy+++Dg++++l++ltgtI++p+r+++ ++I +++l++ ++YP++PP++    
   Q: 2    AVSESQLKKMVSKykyrdlTVRETVNVITLYKDLKPVLDSYVFNDGSSRELMNLTGTIPVPYRGNT-YNI-PICLWLLDTYPYNPPICfvkp 91
           799***************************************************************.***.********************* PP
   S: 83   rfsskinmaevndsnGvvdpralpvLanWkreysievvlvqlkkellskenrklqqPp 140
           ++s++i++ +++d+nG++   +lp+L++Wk+++s+++ l+q++++++++e++++++P 
   Q: 92   TSSMTIKTGKHVDANGKI---YLPYLHEWKHPQSDLLGLIQVMIVVFGDEPPVFSRPI 146
           ******************...************************************5 PP
   

   UBD/UBC-like/UBD_UEV
   S: 1    AvsesslkkvpskykdkrltvrellnliesykslkpktasfvlnDgesreLlrltGtipvpergitynipiilwlletYPekPPfvsvkeki 92
           Avses+lkk++skyk+++ltvre++n+i+ yk+lkp+++s+v+nDg+sreL++ltGtipvp+rg+tynipi+lwll+tYP++PP+++vk+++
   Q: 2    AVSESQLKKMVSKYKYRDLTVRETVNVITLYKDLKPVLDSYVFNDGSSRELMNLTGTIPVPYRGNTYNIPICLWLLDTYPYNPPICFVKPTS 93
           89****************************************************************************************** PP
   S: 93   dmntikssnehvdpnGkialpvLhkWknpasnlvelvqelivllskeppklsrp 146
           +m tik++ +hvd+nGki+lp+Lh+Wk+p+s+l+ l+q++iv++++epp++srp
   Q: 94   SM-TIKTG-KHVDANGKIYLPYLHEWKHPQSDLLGLIQVMIVVFGDEPPVFSRP 145
           **.*****.*******************************************98 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).
 Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).
Protein Sequence
(Fasta)
MAVSESQLKK MVSKYKYRDL TVRETVNVIT LYKDLKPVLD SYVFNDGSSR ELMNLTGTIP 60
VPYRGNTYNI PICLWLLDTY PYNPPICFVK PTSSMTIKTG KHVDANGKIY LPYLHEWKHP 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046686|E2,E2/UEV;UBD,UBD_UEV|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AATCAGTCAT TAAGGCTCAC TGGCAAGCCC TTCGTACTTC TTCCCTCTCC GGCACTAGCT 60
TCCTTAAGTC GACTCTGTGA AATACCTGCT AATCTTATCC TGAACCAGAG TTTCGACCCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046686|E2,E2/UEV;UBD,UBD_UEV|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0341--Growth regulation
KW-0945--Host-virus interaction
KW-0472--Membrane
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0832--Ubl conjugation
Interpro

IPR017916--SB_dom
IPR016135--UBQ-conjugating_enzyme/RWD
IPR008883--UEV_N
PROSITE

PS51312--SB
PS51322--UEV
Pfam

PF05743--UEV
PF09454--Vps23_core
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0005768--C:endosome
GO:0010008--C:endosome membrane
GO:0000813--C:ESCRT I complex
GO:0070062--C:extracellular exosome
GO:0005770--C:late endosome
GO:0031902--C:late endosome membrane
GO:0005771--C:multivesicular body
GO:0005730--C:nucleolus
GO:0005886--C:plasma membrane
GO:0048306--F:calcium-dependent protein binding
GO:0003677--F:DNA binding
GO:0030374--F:ligand-dependent nuclear receptor transcription coactivator activity
GO:0042803--F:protein homodimerization activity
GO:0003714--F:transcription corepressor activity
GO:0043130--F:ubiquitin binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0046790--F:virion binding
GO:0097352--P:autophagosome maturation
GO:0007050--P:cell cycle arrest
GO:0051301--P:cell division
GO:0016197--P:endosomal transport
GO:0008333--P:endosome to lysosome transport
GO:1990182--P:exosomal secretion
GO:0075733--P:intracellular transport of virus
GO:0030216--P:keratinocyte differentiation
GO:0016236--P:macroautophagy
GO:0036258--P:multivesicular body assembly
GO:0008285--P:negative regulation of cell proliferation
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:1903543--P:positive regulation of exosomal secretion
GO:2000397--P:positive regulation of ubiquitin-dependent endocytosis
GO:1903774--P:positive regulation of viral budding via host ESCRT complex
GO:0048524--P:positive regulation of viral process
GO:1902188--P:positive regulation of viral release from host cell
GO:0006513--P:protein monoubiquitination
GO:0015031--P:protein transport
GO:0001558--P:regulation of cell growth
GO:1903551--P:regulation of extracellular exosome assembly
GO:0043405--P:regulation of MAP kinase activity
GO:1903772--P:regulation of viral budding via host ESCRT complex
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0046755--P:viral budding
GO:0039702--P:viral budding via host ESCRT complex
GO:0019058--P:viral life cycle
KEGG hsa:7251
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001072 Aegilops tauschii 27.17 7.00e-27 114.00
IUUC-Aml-002415 Ailuropoda melanoleuca 97.70 0.00e+00 727.00
IUUC-Atr-002875 Amborella trichopoda 28.92 8.00e-35 141.00
IUUC-Apl-003473 Anas platyrhynchos 88.78 0.00e+00 681.00
IUUC-Aca-004573 Anolis carolinensis 90.82 0.00e+00 669.00
IUUC-Aly-006164 Arabidopsis lyrata 44.12 6.00e-22 98.60
IUUC-Ath-006575 Arabidopsis thaliana 44.12 6.00e-22 98.60
IUUC-Ago-007755 Ashbya gossypii 25.89 3.00e-05 43.50
IUUC-Acl-008218 Aspergillus clavatus 38.76 3.00e-25 110.00
IUUC-Afl-008597 Aspergillus flavus 39.10 3.00e-25 110.00
IUUC-Afu-009017 Aspergillus fumigatus 37.98 3.00e-23 103.00
IUUC-Ani-009468 Aspergillus nidulans 38.64 5.00e-21 96.30
IUUC-Ang-009755 Aspergillus niger 36.51 2.00e-22 100.00
IUUC-Aor-010072 Aspergillus oryzae 37.59 2.00e-25 110.00
IUUC-Ate-010400 Aspergillus terreus 37.98 1.00e-24 108.00
IUUC-Ame-011620 Astyanax mexicanus 80.00 0.00e+00 635.00
IUUC-Bgr-012136 Blumeria graminis 35.77 9.00e-24 105.00
IUUC-Bta-012557 Bos taurus 89.00 0.00e+00 719.00
IUUC-Bci-013881 Botrytis cinerea 38.35 4.00e-26 112.00
IUUC-Bdi-014325 Brachypodium distachyon 32.11 2.00e-14 73.20
IUUC-Bol-016308 Brassica oleracea 41.60 1.00e-26 115.00
IUUC-Bra-017605 Brassica rapa 41.13 1.00e-26 114.00
IUUC-Cel-018697 Caenorhabditis elegans 48.84 3.00e-37 149.00
IUUC-Cja-018963 Callithrix jacchus 92.58 0.00e+00 726.00
IUUC-Cfa-020472 Canis familiaris 97.70 0.00e+00 724.00
IUUC-Cpo-022001 Cavia porcellus 98.98 0.00e+00 732.00
IUUC-Cre-022918 Chlamydomonas reinhardtii 30.73 1.00e-33 137.00
IUUC-Csa-023959 Chlorocebus sabaeus 100.00 0.00e+00 711.00
IUUC-Cho-024389 Choloepus hoffmanni 56.36 3.00e-38 153.00
IUUC-Cin-025688 Ciona intestinalis 44.53 3.00e-99 355.00
IUUC-Cne-026904 Cryptococcus neoformans 30.56 2.00e-14 74.30
IUUC-Cme-027280 Cyanidioschyzon merolae 39.09 1.00e-17 84.00
IUUC-Dre-027913 Danio rerio 80.26 2.00e-174 605.00
IUUC-Dno-029672 Dasypus novemcinctus 97.95 0.00e+00 741.00
IUUC-Dor-030175 Dipodomys ordii 97.00 4.00e-93 334.00
IUUC-Dse-031375 Dothistroma septosporum 34.09 5.00e-23 102.00
IUUC-Dme-031736 Drosophila melanogaster 50.12 4.00e-99 355.00
IUUC-Ete-032343 Echinops telfairi 92.58 0.00e+00 694.00
IUUC-Eca-033926 Equus caballus 98.46 0.00e+00 733.00
IUUC-Eeu-034940 Erinaceus europaeus 90.28 0.00e+00 712.00
IUUC-Fca-035491 Felis catus 97.44 0.00e+00 709.00
IUUC-Fal-037508 Ficedula albicollis 91.58 0.00e+00 672.00
IUUC-Fox-037937 Fusarium oxysporum 32.31 3.00e-21 96.70
IUUC-Fso-038091 Fusarium solani 36.03 6.00e-25 108.00
IUUC-Gmo-039427 Gadus morhua 77.95 7.00e-170 589.00
IUUC-Ggr-039724 Gaeumannomyces graminis 37.31 6.00e-25 108.00
IUUC-Gga-040998 Gallus gallus 88.49 0.00e+00 696.00
IUUC-Gac-041356 Gasterosteus aculeatus 80.72 0.00e+00 636.00
IUUC-Gma-043566 Glycine max 39.68 4.00e-25 109.00
IUUC-Ggo-044967 Gorilla gorilla 100.00 0.00e+00 711.00
IUUC-Hvu-047430 Hordeum vulgare 27.17 9.00e-27 114.00
IUUC-Itr-047929 Ictidomys tridecemlineatus 98.21 9.00e-110 389.00
IUUC-Kpa-049287 Komagataella pastoris 30.41 9.00e-16 78.20
IUUC-Lch-050597 Latimeria chalumnae 86.73 0.00e+00 672.00
IUUC-Lpe-051090 Leersia perrieri 38.02 2.00e-20 93.20
IUUC-Loc-052399 Lepisosteus oculatus 78.77 1.00e-176 612.00
IUUC-Lma-053249 Leptosphaeria maculans 29.82 1.00e-13 71.60
IUUC-Laf-053766 Loxodonta africana 98.47 0.00e+00 731.00
IUUC-Mcc-055641 Macaca mulatta 100.00 0.00e+00 711.00
IUUC-Meu-055919 Macropus eugenii 89.88 3.00e-168 584.00
IUUC-Mor-056970 Magnaporthe oryzae 38.46 5.00e-24 105.00
IUUC-Mpo-057345 Magnaporthe poae 36.92 1.00e-22 101.00
IUUC-Mtr-058436 Medicago truncatula 38.10 9.00e-26 111.00
IUUC-Mla-059037 Melampsora laricipopulina 34.93 2.00e-25 110.00
IUUC-Mga-059263 Meleagris gallopavo 87.79 0.00e+00 669.00
IUUC-Mvi-060463 Microbotryum violaceum 30.20 2.00e-17 84.30
IUUC-Mmr-060915 Microcebus murinus 98.21 0.00e+00 724.00
IUUC-Mdo-062449 Monodelphis domestica 94.12 0.00e+00 686.00
IUUC-Mmu-063151 Mus musculus 94.63 0.00e+00 699.00
IUUC-Mac-065581 Musa acuminata 36.43 8.00e-22 97.80
IUUC-Mpu-066621 Mustela putorius furo 97.70 0.00e+00 727.00
IUUC-Mlu-067336 Myotis lucifugus 97.95 0.00e+00 709.00
IUUC-Nfi-068530 Neosartorya fischeri 38.76 3.00e-23 103.00
IUUC-Ncr-068785 Neurospora crassa 36.03 1.00e-24 107.00
IUUC-Nle-069972 Nomascus leucogenys 100.00 0.00e+00 711.00
IUUC-Opr-071150 Ochotona princeps 68.80 1.00e-122 432.00
IUUC-Ont-071366 Oreochromis niloticus 81.28 0.00e+00 632.00
IUUC-Oan-073290 Ornithorhynchus anatinus 93.91 5.00e-105 373.00
IUUC-Ocu-074351 Oryctolagus cuniculus 99.23 0.00e+00 733.00
IUUC-Oba-075338 Oryza barthii 37.14 2.00e-11 63.20
IUUC-Obr-076135 Oryza brachyantha 37.19 3.00e-20 92.80
IUUC-Ogl-077182 Oryza glaberrima 36.28 3.00e-17 82.80
IUUC-Ogu-078281 Oryza glumaepatula 37.19 3.00e-20 92.80
IUUC-Oin-079068 Oryza indica 36.28 8.00e-17 82.00
IUUC-Olo-080460 Oryza longistaminata 35.80 1.00e-08 52.80
IUUC-Ome-081781 Oryza meridionalis 25.61 6.00e-18 85.50
IUUC-Oni-082517 Oryza nivara 26.36 2.00e-20 94.00
IUUC-Opu-084101 Oryza punctata 36.28 3.00e-17 82.80
IUUC-Oru-084556 Oryza rufipogon 36.84 4.00e-17 82.80
IUUC-Osa-086264 Oryza sativa 36.28 3.00e-17 82.80
IUUC-Ola-087252 Oryzias latipes 93.29 4.00e-69 253.00
IUUC-Olu-087610 Ostreococcus lucimarinus 26.67 8.00e-15 74.70
IUUC-Oga-088304 Otolemur garnettii 97.95 0.00e+00 725.00
IUUC-Oar-089734 Ovis aries 89.00 0.00e+00 719.00
IUUC-Ptr-091476 Pan troglodytes 100.00 0.00e+00 711.00
IUUC-Pan-092341 Papio anubis 100.00 0.00e+00 711.00
IUUC-Psi-093470 Pelodiscus sinensis 92.99 0.00e+00 669.00
IUUC-Pma-094143 Petromyzon marinus 64.84 4.00e-135 474.00
IUUC-Pno-095069 Phaeosphaeria nodorum 31.93 2.00e-14 73.90
IUUC-Ppa-095933 Physcomitrella patens 29.09 6.00e-37 148.00
IUUC-Pfo-096321 Poecilia formosa 80.26 4.00e-173 600.00
IUUC-Pab-098527 Pongo abelii 99.43 0.00e+00 631.00
IUUC-Pop-099323 Populus trichocarpa 27.53 6.00e-37 148.00
IUUC-Pca-101044 Procavia capensis 79.54 2.00e-157 548.00
IUUC-Ppe-101458 Prunus persica 41.67 5.00e-27 115.00
IUUC-Pva-103014 Pteropus vampyrus 87.47 5.00e-172 597.00
IUUC-Pgr-103615 Puccinia graminis 36.09 2.00e-20 94.00
IUUC-Ptt-103826 Puccinia triticina 40.20 2.00e-16 80.50
IUUC-Pte-104171 Pyrenophora teres 35.29 2.00e-21 97.40
IUUC-Pyt-104433 Pyrenophora triticirepentis 33.01 2.00e-10 60.50
IUUC-Rno-105957 Rattus norvegicus 93.61 0.00e+00 693.00
IUUC-Sce-106262 Saccharomyces cerevisiae 27.34 2.00e-10 60.10
IUUC-Sha-107607 Sarcophilus harrisii 95.13 9.00e-174 602.00
IUUC-Spo-108175 Schizosaccharomyces pombe 30.56 1.40e-02 34.70
IUUC-Ssl-108672 Sclerotinia sclerotiorum 35.29 3.00e-25 110.00
IUUC-Smo-108973 Selaginella moellendorffii 39.47 7.00e-21 94.70
IUUC-Sly-111373 Solanum lycopersicum 36.51 1.00e-23 103.00
IUUC-Stu-112844 Solanum tuberosum 35.71 9.00e-23 101.00
IUUC-Sar-113653 Sorex araneus 85.82 1.00e-178 619.00
IUUC-Sbi-114390 Sorghum bicolor 35.54 3.00e-20 92.80
IUUC-Sre-115200 Sporisorium reilianum 38.36 5.00e-24 106.00
IUUC-Ssc-115888 Sus scrofa 98.24 3.00e-112 397.00
IUUC-Tgu-117506 Taeniopygia guttata 84.88 0.00e+00 686.00
IUUC-Tru-118063 Takifugu rubripes 79.03 7.00e-170 590.00
IUUC-Tsy-118851 Tarsius syrichta 74.71 1.00e-143 502.00
IUUC-Tni-120010 Tetraodon nigroviridis 78.83 1.00e-168 585.00
IUUC-Tca-121182 Theobroma cacao 38.89 4.00e-22 99.40
IUUC-Tre-122040 Trichoderma reesei 36.15 8.00e-22 98.60
IUUC-Tvi-122660 Trichoderma virens 39.71 9.00e-26 111.00
IUUC-Tae-124561 Triticum aestivum 27.17 7.00e-27 114.00
IUUC-Tur-126651 Triticum urartu 37.40 1.00e-20 94.40
IUUC-Tme-127184 Tuber melanosporum 47.32 1.00e-25 111.00
IUUC-Tbe-127894 Tupaia belangeri 82.00 6.00e-89 320.00
IUUC-Ttr-128264 Tursiops truncatus 89.00 0.00e+00 701.00
IUUC-Uma-129407 Ustilago maydis 36.99 2.00e-24 107.00
IUUC-Vda-130002 Verticillium dahliae 30.82 6.00e-16 79.00
IUUC-Vpa-130156 Vicugna pacos 96.50 5.00e-96 344.00
IUUC-Vvi-131479 Vitis vinifera 41.23 2.00e-23 103.00
IUUC-Xtr-132332 Xenopus tropicalis 81.68 7.00e-64 235.00
IUUC-Xma-133186 Xiphophorus maculatus 77.69 2.00e-173 601.00
IUUC-Yli-134500 Yarrowia lipolytica 33.55 1.00e-12 67.80
IUUC-Zma-135391 Zea mays 36.13 7.00e-20 91.70
Created Date 25-Jun-2017

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