iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089556

Ensembl Protein ID

ENSOARP00000009666.1

UniProt Accession

W5PGU9; W5PGU9_SHEEP

Genbank Protein ID

ENSOARP00000009666

Protein Name

Phosphoinositide phospholipase C

Genbank Nucleotide ID

AMGL01027142

Gene Name

PLCG2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000008988.1	ENSOART00000009806.1	ENSOARP00000009666.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.90e-10	40.7	731	787

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 4    ekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           ++v++lydy a+++deL++ +G  ++ +   ++ +gW+kg    +  +  fP+n+ve ++
   Q: 731  RTVKALYDYRAKQSDELSFCRGALIHNV--SKEPGGWWKGD-YGTRIQQYFPSNYVEDIS 787
           789************************9..77889*****6.55556679******9885 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

MPLIPEFREG STETTGLPVD IMEIKEIRPG KNSKDFERAK AVRQKEECCF TILYGTQFIL 60
STLSLAADSK EDAAKWLSGL KILHQEVMSA STPTIIESWL RKQIYSVDQT RRNSISLREL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCCTCTGA TCCCCGAGTT CCGCGAGGGT AGCACAGAAA CTACGGGCTT GCCAGGTGAC 60
TCAGTGGTCA AGAATCTGCT TGCCACCGCA GGGGACTTAG AAGAGTCAGG GTCAGTCCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0442--Lipid degradation
KW-0443--Lipid metabolism
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0807--Transducer

Interpro

IPR000008--C2_dom
IPR011992--EF-hand-dom_pair
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR001192--PI-PLC_fam
IPR016279--PLC-gamma
IPR028381--PLC-gamma2
IPR017946--PLC-like_Pdiesterase_TIM-brl
IPR000909--PLipase_C_PInositol-sp_X_dom
IPR001711--PLipase_C_Pinositol-sp_Y
IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50004--C2
PS50003--PH_DOMAIN
PS50007--PIPLC_X_DOMAIN
PS50008--PIPLC_Y_DOMAIN
PS50001--SH2
PS50002--SH3

Pfam

PF00168--C2
PF00388--PI-PLC-X
PF00387--PI-PLC-Y
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00390--PHPHLIPASEC
PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00239--C2
SM00148--PLCXc
SM00149--PLCYc
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0004435--F:phosphatidylinositol phospholipase C activity
GO:0004871--F:signal transducer activity
GO:0032237--P:activation of store-operated calcium channel activity
GO:0050853--P:B cell receptor signaling pathway
GO:0002316--P:follicular B cell differentiation
GO:0032959--P:inositol trisphosphate biosynthetic process
GO:0035556--P:intracellular signal transduction
GO:0043069--P:negative regulation of programmed cell death
GO:0006661--P:phosphatidylinositol biosynthetic process
GO:0009395--P:phospholipid catabolic process
GO:0002092--P:positive regulation of receptor internalization
GO:0032481--P:positive regulation of type I interferon production
GO:0010468--P:regulation of gene expression
GO:0051209--P:release of sequestered calcium ion into cytosol
GO:0032496--P:response to lipopolysaccharide
GO:0050852--P:T cell receptor signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003345	Anas platyrhynchos	82.94	0.00e+00	1919.00
IUUC-Aca-004266	Anolis carolinensis	79.45	0.00e+00	1994.00
IUUC-Ame-011540	Astyanax mexicanus	58.39	0.00e+00	1377.00
IUUC-Bta-013196	Bos taurus	97.84	0.00e+00	2472.00
IUUC-Cpo-021890	Cavia porcellus	91.66	0.00e+00	2333.00
IUUC-Csa-024233	Chlorocebus sabaeus	93.37	0.00e+00	2355.00
IUUC-Dre-028650	Danio rerio	58.72	0.00e+00	1381.00
IUUC-Dno-028871	Dasypus novemcinctus	93.53	0.00e+00	2372.00
IUUC-Eca-033458	Equus caballus	95.02	0.00e+00	2381.00
IUUC-Eeu-035329	Erinaceus europaeus	89.32	0.00e+00	2244.00
IUUC-Fal-037390	Ficedula albicollis	82.10	0.00e+00	2061.00
IUUC-Gga-040918	Gallus gallus	82.68	0.00e+00	2054.00
IUUC-Ggo-045625	Gorilla gorilla	92.70	0.00e+00	2352.00
IUUC-Hsa-046129	Homo sapiens	93.95	0.00e+00	2394.00
IUUC-Loc-052025	Lepisosteus oculatus	62.12	0.00e+00	1524.00
IUUC-Mcc-054831	Macaca mulatta	93.36	0.00e+00	2288.00
IUUC-Mga-059368	Meleagris gallopavo	82.85	0.00e+00	2035.00
IUUC-Mmr-060898	Microcebus murinus	90.44	0.00e+00	2247.00
IUUC-Mmu-064334	Mus musculus	93.12	0.00e+00	2325.00
IUUC-Mlu-067230	Myotis lucifugus	94.53	0.00e+00	2393.00
IUUC-Nle-069318	Nomascus leucogenys	87.73	0.00e+00	2162.00
IUUC-Opr-070718	Ochotona princeps	79.20	0.00e+00	980.00
IUUC-Ocu-073814	Oryctolagus cuniculus	92.62	0.00e+00	2336.00
IUUC-Ola-086501	Oryzias latipes	56.59	0.00e+00	1387.00
IUUC-Oga-088036	Otolemur garnettii	93.15	0.00e+00	1790.00
IUUC-Ptr-091001	Pan troglodytes	94.11	0.00e+00	2398.00
IUUC-Pan-092744	Papio anubis	93.70	0.00e+00	2360.00
IUUC-Psi-093987	Pelodiscus sinensis	82.10	0.00e+00	2058.00
IUUC-Pfo-096249	Poecilia formosa	57.39	0.00e+00	1427.00
IUUC-Pab-098268	Pongo abelii	91.54	0.00e+00	2312.00
IUUC-Pva-102939	Pteropus vampyrus	91.95	0.00e+00	2294.00
IUUC-Sre-115229	Sporisorium reilianum	45.00	6.00e-10	60.80
IUUC-Ssc-115308	Sus scrofa	89.78	0.00e+00	2075.00
IUUC-Tgu-116811	Taeniopygia guttata	82.10	0.00e+00	2059.00
IUUC-Tru-117536	Takifugu rubripes	56.45	0.00e+00	1360.00
IUUC-Tsy-119139	Tarsius syrichta	83.40	0.00e+00	853.00
IUUC-Ttr-128392	Tursiops truncatus	92.12	0.00e+00	2289.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence