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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Cel-018318
UUCD1 version UUC-CaE-00547
Ensembl Protein ID Y47D3B.11
UniProt Accession Q9U2B7; PLR1_CAEEL
Genbank Protein ID CAB54384.2
Protein Name Probable E3 ubiquitin-protein ligase plr-1
Genbank Nucleotide ID BX284603
Gene Name plr-1; Y47D3B.11
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00023404 Y47D3B.11 Y47D3B.11
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNAmiRNAMapRAID2
Protein Expression/Proteomics
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/RING 6.40e-08 33.3 317 358
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdg..plvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iCle++++g  ++vl CgH fh +C+  w         + rCPlC+
   Q: 317  CVICLEEYEEGteLRVLFCGHEFHPKCVDPW------LLSKRRCPLCQ 358
           ********7765588999*************......777788****7 PP
   
Organism Caenorhabditis elegans
Functional Description
(View)

Functional Description


     Probable E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled (By similarity). Acts on both canonical and non-canonical Wnt signaling pathway (By similarity). Plays a role in the migration and axon guidance of different neuronal cell types including CAN, HSN, AVK and AVG (PubMed:24401370, PubMed:25448694). Promotes the differentiation and regulates the anteroposterior polarity of AVG unpaired interneurons by sequestering the Wnt signaling proteins cfz-2, mig-1 and mom-5 to endosomes which thereby reduces their cell surface expression and negatively regulates Wnt signaling (PubMed:24401370). May also regulate AVG polarity and axon guidance through Wnt-independent mechanisms involving unc-53/Nav2, unc-73/Trio and cytosolic protein vab-8 (PubMed:25448694).
 Probable E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled (By similarity). Acts on both canonical and non-canonical Wnt signaling pathway (By similarity). Plays a role in the migration and axon guidance of different neuronal cell types including CAN, HSN, AVK and AVG (PubMed:24401370, PubMed:25448694). Promotes the differentiation and regulates the anteroposterior polarity of AVG unpaired interneurons by sequestering the Wnt signaling proteins cfz-2, mig-1 and mom-5 to endosomes which thereby reduces their cell surface expression and negatively regulates Wnt signaling (PubMed:24401370). May also regulate AVG polarity and axon guidance through Wnt-independent mechanisms involving unc-53/Nav2, unc-73/Trio and cytosolic protein vab-8 (PubMed:25448694).
Protein Sequence
(Fasta)
MRLLLFILLN TTLLSTNYVH ARPSVSHTTL ASQFKFAEKA DIFVTHTNIN EDRTQDEKTI 60
KLSGTFSPVG SNYETGGDIV QVSSFRACDA RRKGLDNTVF EHVPVVFYDD VEKFLTGCVA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Cel-018318|E3,RING|Caenorhabditis elegans
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATTTTGTATG AATTATTAAA ATTCTCTTCC TTCTCCAGTC AACAATAACA ATGCGGTTAC 60
TGTTATTCAT ATTACTTAAT ACAACCCTAT TATCAACCAA TTACGTACAT GCACGTCCAT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cel-018318|E3,RING|Caenorhabditis elegans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-1003--Cell membrane
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0967--Endosome
KW-0325--Glycoprotein
KW-0436--Ligase
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0879--Wnt signaling pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF13639--zf-RING_2
SMART

SM00184--RING
Gene Ontology

GO:0030424--C:axon
GO:0005769--C:early endosome
GO:0005794--C:Golgi apparatus
GO:0016021--C:integral component of membrane
GO:0005770--C:late endosome
GO:0043204--C:perikaryon
GO:0005886--C:plasma membrane
GO:0016874--F:ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0030178--P:negative regulation of Wnt signaling pathway
GO:0016055--P:Wnt signaling pathway
KEGG cel:CELE_Y47D3B.11
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001826 Ailuropoda melanoleuca 24.35 6.00e-17 81.60
IUUC-Atr-002551 Amborella trichopoda 46.43 6.00e-13 66.60
IUUC-Apl-003222 Anas platyrhynchos 52.63 3.00e-15 75.90
IUUC-Aca-004606 Anolis carolinensis 59.52 6.00e-12 63.90
IUUC-Aly-006551 Arabidopsis lyrata 50.98 3.00e-13 68.90
IUUC-Ath-007241 Arabidopsis thaliana 50.98 3.00e-13 68.90
IUUC-Acl-008221 Aspergillus clavatus 54.90 2.00e-13 69.70
IUUC-Afl-008383 Aspergillus flavus 54.90 3.00e-13 69.30
IUUC-Afu-008769 Aspergillus fumigatus 54.90 3.00e-13 69.30
IUUC-Ani-009201 Aspergillus nidulans 54.90 6.00e-13 68.20
IUUC-Ang-009856 Aspergillus niger 39.45 7.00e-15 74.70
IUUC-Aor-010134 Aspergillus oryzae 43.75 6.00e-13 67.40
IUUC-Ate-010334 Aspergillus terreus 54.90 3.00e-13 69.30
IUUC-Ame-011450 Astyanax mexicanus 56.52 3.00e-14 72.40
IUUC-Bgr-012131 Blumeria graminis 27.12 1.00e-10 60.50
IUUC-Bta-012714 Bos taurus 25.16 1.00e-19 90.10
IUUC-Bci-013829 Botrytis cinerea 54.90 2.00e-13 69.70
IUUC-Bdi-014406 Brachypodium distachyon 40.00 1.00e-13 69.30
IUUC-Bol-015185 Brassica oleracea 55.32 7.00e-13 67.00
IUUC-Bra-017355 Brassica rapa 55.32 4.00e-13 67.80
IUUC-Cja-018949 Callithrix jacchus 61.90 5.00e-13 66.20
IUUC-Cfa-021169 Canis familiaris 23.62 4.00e-16 78.60
IUUC-Cpo-022010 Cavia porcellus 26.11 2.00e-18 86.70
IUUC-Cre-022631 Chlamydomonas reinhardtii 60.00 3.00e-11 61.20
IUUC-Csa-023712 Chlorocebus sabaeus 32.62 2.00e-16 79.30
IUUC-Cin-025111 Ciona intestinalis 58.00 3.00e-15 74.30
IUUC-Csv-025869 Ciona savignyi 53.70 2.00e-14 72.80
IUUC-Cgl-026485 Colletotrichum gloeosporioides 54.90 5.00e-13 68.90
IUUC-Dre-027851 Danio rerio 56.52 4.00e-15 74.70
IUUC-Dno-029646 Dasypus novemcinctus 63.04 9.00e-15 74.30
IUUC-Dor-030676 Dipodomys ordii 46.15 7.00e-15 73.60
IUUC-Dse-031406 Dothistroma septosporum 54.90 6.00e-13 68.60
IUUC-Ete-033153 Echinops telfairi 25.73 5.00e-18 85.10
IUUC-Eca-034222 Equus caballus 25.00 2.00e-17 83.20
IUUC-Fca-036163 Felis catus 25.81 8.00e-18 84.30
IUUC-Fal-037463 Ficedula albicollis 54.55 5.00e-12 65.10
IUUC-Fox-037990 Fusarium oxysporum 39.76 2.00e-13 68.60
IUUC-Fso-038278 Fusarium solani 39.76 6.00e-12 63.90
IUUC-Gmo-039022 Gadus morhua 54.35 1.00e-14 72.00
IUUC-Ggr-039824 Gaeumannomyces graminis 54.90 4.00e-13 68.90
IUUC-Gga-040209 Gallus gallus 56.25 9.00e-15 74.30
IUUC-Gma-043490 Glycine max 54.55 6.00e-12 64.30
IUUC-Ggo-045644 Gorilla gorilla 25.32 2.00e-19 90.10
IUUC-Hsa-045983 Homo sapiens 25.41 2.00e-19 89.40
IUUC-Hvu-047367 Hordeum vulgare 49.09 2.00e-13 67.00
IUUC-Itr-049074 Ictidomys tridecemlineatus 24.84 3.00e-19 89.00
IUUC-Loc-052503 Lepisosteus oculatus 56.52 5.00e-14 71.60
IUUC-Lma-053120 Leptosphaeria maculans 56.86 3.00e-15 75.90
IUUC-Laf-054039 Loxodonta africana 25.65 8.00e-19 87.80
IUUC-Mcc-054760 Macaca mulatta 25.32 7.00e-20 91.30
IUUC-Mor-057005 Magnaporthe oryzae 40.43 2.00e-13 69.70
IUUC-Mpo-057321 Magnaporthe poae 39.47 1.00e-13 70.10
IUUC-Mtr-058719 Medicago truncatula 51.06 4.00e-12 64.70
IUUC-Mga-060022 Meleagris gallopavo 54.55 5.00e-12 64.70
IUUC-Mmr-061100 Microcebus murinus 25.65 2.00e-17 83.20
IUUC-Mdo-062909 Monodelphis domestica 52.73 7.00e-15 74.70
IUUC-Mmu-063835 Mus musculus 25.88 5.00e-19 88.60
IUUC-Mac-064494 Musa acuminata 54.35 3.00e-12 64.70
IUUC-Mpu-066916 Mustela putorius furo 23.87 1.00e-18 87.00
IUUC-Mlu-067234 Myotis lucifugus 25.48 2.00e-19 89.40
IUUC-Nfi-068444 Neosartorya fischeri 54.90 6.00e-13 68.60
IUUC-Ncr-068802 Neurospora crassa 42.50 2.00e-13 70.50
IUUC-Nle-069493 Nomascus leucogenys 25.32 5.00e-20 91.70
IUUC-Ont-072483 Oreochromis niloticus 24.43 4.00e-15 75.90
IUUC-Oan-073037 Ornithorhynchus anatinus 63.04 2.00e-14 72.80
IUUC-Ocu-074655 Oryctolagus cuniculus 26.30 5.00e-14 72.00
IUUC-Oba-075191 Oryza barthii 41.51 3.00e-09 53.10
IUUC-Obr-076860 Oryza brachyantha 53.85 4.00e-13 66.20
IUUC-Ogl-077584 Oryza glaberrima 41.51 3.00e-09 53.10
IUUC-Ogu-078773 Oryza glumaepatula 41.51 3.00e-09 53.10
IUUC-Oin-080112 Oryza indica 41.51 3.00e-09 53.10
IUUC-Olo-080611 Oryza longistaminata 31.74 9.00e-13 68.60
IUUC-Oni-082108 Oryza nivara 41.51 3.00e-09 53.10
IUUC-Oru-084593 Oryza rufipogon 41.51 3.00e-09 53.10
IUUC-Osa-086279 Oryza sativa 41.51 3.00e-09 53.10
IUUC-Ola-087097 Oryzias latipes 56.52 4.00e-15 74.70
IUUC-Oga-088134 Otolemur garnettii 25.97 7.00e-20 91.30
IUUC-Oar-089606 Ovis aries 25.16 4.00e-19 89.00
IUUC-Ptr-090726 Pan troglodytes 25.00 7.00e-19 88.20
IUUC-Pan-091958 Papio anubis 25.32 8.00e-20 91.30
IUUC-Psi-093208 Pelodiscus sinensis 22.98 3.00e-13 69.30
IUUC-Pno-094874 Phaeosphaeria nodorum 56.36 2.00e-15 75.90
IUUC-Pfo-096209 Poecilia formosa 56.52 9.00e-15 74.30
IUUC-Pab-097950 Pongo abelii 25.32 7.00e-20 90.50
IUUC-Pop-099020 Populus trichocarpa 55.32 2.00e-13 68.90
IUUC-Pca-100229 Procavia capensis 33.33 3.00e-16 79.30
IUUC-Ppe-101361 Prunus persica 52.46 3.00e-13 67.00
IUUC-Pgr-103263 Puccinia graminis 45.83 3.00e-10 59.30
IUUC-Pte-104044 Pyrenophora teres 58.70 3.00e-14 72.00
IUUC-Pyt-104819 Pyrenophora triticirepentis 58.70 5.00e-14 71.60
IUUC-Rno-104862 Rattus norvegicus 26.15 5.00e-18 85.10
IUUC-Sha-107577 Sarcophilus harrisii 25.97 2.00e-17 83.60
IUUC-Ssl-108465 Sclerotinia sclerotiorum 54.90 2.00e-13 69.70
IUUC-Smo-108790 Selaginella moellendorffii 52.54 3.00e-14 67.80
IUUC-Sly-111736 Solanum lycopersicum 45.45 4.00e-12 65.50
IUUC-Stu-112140 Solanum tuberosum 45.45 2.00e-12 66.20
IUUC-Sar-113693 Sorex araneus 35.46 4.00e-16 78.60
IUUC-Sbi-113868 Sorghum bicolor 45.90 2.00e-12 64.70
IUUC-Sre-114989 Sporisorium reilianum 45.10 9.00e-11 61.60
IUUC-Ssc-115909 Sus scrofa 45.90 2.00e-13 68.90
IUUC-Tgu-116568 Taeniopygia guttata 54.55 3.00e-12 65.10
IUUC-Tru-118126 Takifugu rubripes 56.52 1.00e-14 73.60
IUUC-Tni-120241 Tetraodon nigroviridis 49.15 8.00e-15 73.60
IUUC-Tre-121978 Trichoderma reesei 52.17 1.00e-13 69.70
IUUC-Tvi-122495 Trichoderma virens 52.17 2.00e-13 69.30
IUUC-Tae-125320 Triticum aestivum 48.21 7.00e-13 66.60
IUUC-Tur-126084 Triticum urartu 51.11 2.00e-11 63.90
IUUC-Tme-126970 Tuber melanosporum 55.10 3.00e-14 72.00
IUUC-Tbe-128106 Tupaia belangeri 26.94 1.00e-16 80.50
IUUC-Ttr-128832 Tursiops truncatus 60.00 1.00e-15 77.40
IUUC-Uma-129467 Ustilago maydis 49.02 1.00e-10 60.80
IUUC-Vda-129915 Verticillium dahliae 56.86 5.00e-14 71.60
IUUC-Vvi-131215 Vitis vinifera 48.39 3.00e-12 65.50
IUUC-Xtr-132280 Xenopus tropicalis 22.29 6.00e-13 68.20
IUUC-Xma-133252 Xiphophorus maculatus 52.17 3.00e-14 72.40
IUUC-Zma-135193 Zea mays 46.15 2.00e-12 65.50
Created Date 25-Jun-2017

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