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Tag Content
iUUCD ID IUUC-Ago-007970
Ensembl Protein ID AAS50527
UniProt Accession Q75EB4; ATG12_ASHGO
Genbank Protein ID AAS50527.1
Protein Name Ubiquitin-like protein ATG12; Autophagy-related protein 12
Genbank Nucleotide ID AE016814
Gene Name ATG12; AAR160W
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
AGOS_AAR160W AAS50527 AAS50527
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
ULD/UBL/ATG12 46.34 5.00e-05 45.10 IUUC-Hsa-046903
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Ashbya gossypii
Functional Description
(View)

Functional Description


     Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate functions as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes (By similarity).
 Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate functions as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes (By similarity).
Protein Sequence
(Fasta)
MVPLLESETE NSISQSQFDS ESASAEPTPP QHTQESLQNR LEEYHERLSR LQLPSSSDSE 60
CSDIEQESLE LEQEVPLSTS VYLAGARSAG GLPSSSELSE TPEPPKVAIR FQPIGSVGQV 120
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Protein Fasta Sequence


>IUUC-Ago-007970|ULD,ATG12|Ashbya gossypii
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Nucleotide Sequence
(Fasta)
ATGGTACCGC TGCTCGAGAG CGAAACCGAG AATAGTATTA GCCAGTCACA GTTCGACAGC 60
GAGAGCGCGA GTGCAGAGCC CACGCCCCCG CAGCACACGC AGGAGTCGCT TCAGAACCGG 120
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Nucleotide Fasta Sequence


>IUUC-Ago-007970|ULD,ATG12|Ashbya gossypii
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Sequence Source Ensembl
Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0833--Ubl conjugation pathway
Interpro

IPR007242--Atg12
IPR029071--Ubiquitin-rel_dom
Pfam

PF04110--APG12
Gene Ontology

GO:0034274--C:Atg12-Atg5-Atg16 complex
GO:0034045--C:pre-autophagosomal structure membrane
GO:0019776--F:Atg8 ligase activity
GO:0008047--F:enzyme activator activity
GO:0031386--F:protein tag
GO:0000045--P:autophagosome assembly
GO:0006501--P:C-terminal protein lipidation
GO:0032258--P:CVT pathway
GO:0044805--P:late nucleophagy
GO:0000422--P:mitophagy
GO:0044804--P:nucleophagy
GO:0034727--P:piecemeal microautophagy of nucleus
KEGG ago:AGOS_AAR160W
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001177 Aegilops tauschii 33.33 7.00e-07 42.70
IUUC-Aml-002116 Ailuropoda melanoleuca 46.34 4.00e-07 45.10
IUUC-Atr-002615 Amborella trichopoda 31.52 4.00e-07 43.90
IUUC-Apl-003753 Anas platyrhynchos 52.63 2.00e-07 44.30
IUUC-Aca-005231 Anolis carolinensis 46.34 4.00e-07 44.70
IUUC-Aly-006172 Arabidopsis lyrata 32.14 3.00e-06 40.80
IUUC-Ath-006953 Arabidopsis thaliana 29.76 2.00e-06 41.60
IUUC-Acl-008072 Aspergillus clavatus 43.62 1.00e-14 69.30
IUUC-Afl-008725 Aspergillus flavus 43.62 5.00e-15 71.60
IUUC-Afu-008967 Aspergillus fumigatus 33.91 5.00e-14 68.60
IUUC-Ani-009248 Aspergillus nidulans 41.49 6.00e-14 67.80
IUUC-Ang-009684 Aspergillus niger 41.86 3.00e-12 62.40
IUUC-Aor-009947 Aspergillus oryzae 43.62 5.00e-15 71.60
IUUC-Ame-011656 Astyanax mexicanus 46.34 8.00e-07 43.50
IUUC-Bgr-012174 Blumeria graminis 44.57 5.00e-11 57.80
IUUC-Bta-012483 Bos taurus 46.34 5.00e-07 44.30
IUUC-Bci-013755 Botrytis cinerea 42.71 3.00e-10 55.10
IUUC-Bdi-014156 Brachypodium distachyon 32.14 2.00e-06 41.60
IUUC-Bol-015683 Brassica oleracea 30.53 4.00e-07 43.90
IUUC-Bra-016802 Brassica rapa 29.76 4.00e-07 43.50
IUUC-Cja-019514 Callithrix jacchus 44.19 1.00e-06 44.30
IUUC-Cfa-020748 Canis familiaris 46.34 4.00e-07 45.40
IUUC-Cpo-021965 Cavia porcellus 50.00 6.00e-07 44.70
IUUC-Cre-023009 Chlamydomonas reinhardtii 28.74 3.00e-03 30.80
IUUC-Csa-023494 Chlorocebus sabaeus 46.34 4.00e-07 45.10
IUUC-Cho-024631 Choloepus hoffmanni 46.34 6.00e-07 45.10
IUUC-Cin-025609 Ciona intestinalis 28.72 3.00e-08 47.80
IUUC-Cgl-026722 Colletotrichum gloeosporioides 35.23 7.00e-10 54.30
IUUC-Dre-027479 Danio rerio 28.89 5.00e-07 44.30
IUUC-Dno-029693 Dasypus novemcinctus 50.00 7.00e-07 44.30
IUUC-Dse-031440 Dothistroma septosporum 42.22 1.00e-11 60.10
IUUC-Dme-031892 Drosophila melanogaster 27.62 4.00e-06 40.80
IUUC-Ete-032550 Echinops telfairi 46.34 5.00e-07 44.30
IUUC-Eca-033553 Equus caballus 46.34 4.00e-07 45.10
IUUC-Fca-036524 Felis catus 46.34 4.00e-07 45.40
IUUC-Fal-036942 Ficedula albicollis 48.78 1.00e-07 45.10
IUUC-Fox-037753 Fusarium oxysporum 39.77 3.00e-10 55.50
IUUC-Gmo-039498 Gadus morhua 43.90 2.00e-06 42.00
IUUC-Ggr-039852 Gaeumannomyces graminis 39.33 4.00e-07 45.80
IUUC-Gga-041263 Gallus gallus 46.34 3.00e-07 45.40
IUUC-Gac-042346 Gasterosteus aculeatus 44.74 1.00e-06 42.70
IUUC-Gma-042896 Glycine max 30.95 6.00e-06 40.00
IUUC-Ggo-045601 Gorilla gorilla 50.00 6.00e-07 44.70
IUUC-Hsa-046903 Homo sapiens 46.34 4.00e-07 44.70
IUUC-Hvu-047239 Hordeum vulgare 34.52 5.00e-07 43.50
IUUC-Itr-048445 Ictidomys tridecemlineatus 50.00 5.00e-07 44.70
IUUC-Kpa-049355 Komagataella pastoris 42.71 9.00e-16 73.60
IUUC-Lch-050619 Latimeria chalumnae 43.90 1.00e-06 43.10
IUUC-Loc-052102 Lepisosteus oculatus 34.04 3.00e-03 30.80
IUUC-Lma-053299 Leptosphaeria maculans 31.94 8.00e-08 47.00
IUUC-Laf-054205 Loxodonta africana 46.34 3.00e-07 45.10
IUUC-Meu-056804 Macropus eugenii 46.34 6.00e-07 44.30
IUUC-Mor-057052 Magnaporthe oryzae 42.11 6.00e-10 54.70
IUUC-Mtr-057961 Medicago truncatula 29.76 1.00e-05 38.50
IUUC-Mla-059045 Melampsora laricipopulina 28.74 3.00e-07 45.10
IUUC-Mvi-060360 Microbotryum violaceum 27.96 2.00e-08 48.90
IUUC-Mmr-061654 Microcebus murinus 46.34 3.00e-07 44.70
IUUC-Mdo-062649 Monodelphis domestica 46.34 3.00e-07 45.10
IUUC-Mmu-064105 Mus musculus 46.34 4.00e-07 44.70
IUUC-Mac-065532 Musa acuminata 32.14 3.00e-07 44.30
IUUC-Mpu-066269 Mustela putorius furo 46.34 3.00e-07 45.40
IUUC-Mlu-067631 Myotis lucifugus 46.34 4.00e-07 45.10
IUUC-Nfi-068468 Neosartorya fischeri 42.55 4.00e-14 67.40
IUUC-Ncr-068750 Neurospora crassa 37.50 1.00e-09 53.50
IUUC-Nle-069483 Nomascus leucogenys 46.34 5.00e-07 45.40
IUUC-Opr-070936 Ochotona princeps 46.34 5.00e-07 45.10
IUUC-Obr-076322 Oryza brachyantha 32.18 5.00e-09 50.10
IUUC-Ogl-077226 Oryza glaberrima 31.25 3.00e-07 43.90
IUUC-Oin-079220 Oryza indica 33.82 2.00e-06 41.60
IUUC-Olo-080688 Oryza longistaminata 31.25 3.00e-07 43.90
IUUC-Ome-081265 Oryza meridionalis 31.25 3.00e-07 43.90
IUUC-Oru-084342 Oryza rufipogon 32.18 3.00e-08 49.70
IUUC-Osa-086212 Oryza sativa 31.25 3.00e-07 43.90
IUUC-Ola-087277 Oryzias latipes 43.90 2.00e-06 42.40
IUUC-Oga-088175 Otolemur garnettii 46.34 4.00e-07 44.70
IUUC-Oar-089477 Ovis aries 46.34 6.00e-07 44.70
IUUC-Ptr-091129 Pan troglodytes 50.00 6.00e-07 44.70
IUUC-Psi-093351 Pelodiscus sinensis 46.34 4.00e-07 44.70
IUUC-Pno-094948 Phaeosphaeria nodorum 32.81 1.00e-05 39.70
IUUC-Ppa-095788 Physcomitrella patens 29.59 6.00e-10 53.10
IUUC-Pfo-096993 Poecilia formosa 30.39 5.00e-07 44.30
IUUC-Pab-098502 Pongo abelii 46.34 7.00e-07 44.70
IUUC-Pop-098819 Populus trichocarpa 37.21 6.00e-06 39.70
IUUC-Ppe-101560 Prunus persica 37.50 8.00e-06 38.90
IUUC-Pva-102810 Pteropus vampyrus 54.55 6.00e-03 31.20
IUUC-Pgr-103531 Puccinia graminis 35.63 2.00e-08 48.90
IUUC-Ptt-103753 Puccinia triticina 34.29 2.00e-08 48.90
IUUC-Pyt-104733 Pyrenophora triticirepentis 37.36 8.00e-13 63.90
IUUC-Rno-106072 Rattus norvegicus 33.02 3.00e-07 45.10
IUUC-Sce-106275 Saccharomyces cerevisiae 47.47 3.00e-32 129.00
IUUC-Sha-107554 Sarcophilus harrisii 46.34 3.00e-07 45.40
IUUC-Sja-107682 Schizosaccharomyces japonicus 34.48 1.00e-11 60.10
IUUC-Spo-108275 Schizosaccharomyces pombe 34.62 3.00e-11 58.50
IUUC-Smo-109151 Selaginella moellendorffii 31.33 4.00e-06 40.40
IUUC-Sit-110270 Setaria italica 32.14 3.00e-06 40.80
IUUC-Sly-111862 Solanum lycopersicum 30.95 2.00e-05 37.70
IUUC-Stu-112663 Solanum tuberosum 36.84 5.00e-04 33.90
IUUC-Sbi-114148 Sorghum bicolor 32.14 3.00e-06 40.80
IUUC-Sre-115216 Sporisorium reilianum 36.78 4.00e-08 48.10
IUUC-Ssc-116051 Sus scrofa 46.34 4.00e-07 45.10
IUUC-Tru-118466 Takifugu rubripes 43.90 8.00e-07 42.40
IUUC-Tsy-119334 Tarsius syrichta 38.89 4.00e-03 32.30
IUUC-Tni-119792 Tetraodon nigroviridis 43.90 5.00e-07 43.10
IUUC-Tca-121861 Theobroma cacao 32.14 4.00e-06 41.20
IUUC-Tvi-122499 Trichoderma virens 40.00 6.00e-11 57.00
IUUC-Tae-123431 Triticum aestivum 33.33 7.00e-07 42.70
IUUC-Tme-126934 Tuber melanosporum 36.26 3.00e-13 65.50
IUUC-Ttr-129001 Tursiops truncatus 48.65 5.00e-06 42.00
IUUC-Uma-129324 Ustilago maydis 36.78 3.00e-08 48.50
IUUC-Vda-129846 Verticillium dahliae 38.64 1.00e-10 57.00
IUUC-Vpa-130202 Vicugna pacos 50.00 4.00e-07 45.40
IUUC-Vvi-131474 Vitis vinifera 31.34 3.00e-02 28.50
IUUC-Xtr-132782 Xenopus tropicalis 46.34 2.00e-07 45.80
IUUC-Xma-134140 Xiphophorus maculatus 30.39 9.00e-07 43.50
IUUC-Yli-134517 Yarrowia lipolytica 37.78 4.00e-09 52.40
IUUC-Zma-134764 Zea mays 32.14 3.00e-06 40.80
Created Date 25-Jun-2017

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