iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000145782.12	ENST00000509910.1	ENSP00000425107.1
ENSG00000145782.12	ENST00000500945.2	ENSP00000425164.1
ENSG00000145782.12	ENST00000513322.5	ENSP00000424529.1
ENSG00000145782.12	ENST00000379594.7	ENSP00000368913.3
ENSG00000145782.12	ENST00000505993.5	ENSP00000425948.1
ENSG00000145782.12	ENST00000513167.1	ENSP00000425277.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	CircNet	miRTarBase
microRNA	TRANSFAC	miRWalk	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
ULD/UBL/ATG12	ATG12	16874032

Organism

Homo sapiens

Functional Description
(View)

Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Plays also a role in translation or delivery of incoming viral RNA to the translation apparatus.

Protein Sequence
(Fasta)

MAEEPQSVLQ LPTSIAAGGE GLTDVSPETT TPEPPSSAAV SPGTEEPAGD TKKKIDILLK 60
AVGDTPIMKT KKWAVERTRT IQGLIDFIKK FLKLVASEQL FIYVNQSFAP SPDQEVGTLY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAAAGCGGA AACATTTCTA GGTCCGAGCC AGCGGCCTAA CTGGAGTGTG CGCATTCGAC 60
CGAGCACAGA CACGTTGCCC ACCGCTCCTC TCCCGAGGTC TGTAGTCGCG GAGAAACACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0391--Immunity
KW-0399--Innate immunity
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR007242--Atg12
IPR029071--Ubiquitin-rel_dom

Pfam

PF04110--APG12

Gene Ontology

GO:0034274--C:Atg12-Atg5-Atg16 complex
GO:0005829--C:cytosol
GO:0030670--C:phagocytic vesicle membrane
GO:0034045--C:pre-autophagosomal structure membrane
GO:0019776--F:Atg8 ligase activity
GO:0000045--P:autophagosome assembly
GO:0006501--P:C-terminal protein lipidation
GO:0045087--P:innate immune response
GO:0016236--P:macroautophagy
GO:0000422--P:mitophagy
GO:0044804--P:nucleophagy

KEGG

hsa:9140

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001177	Aegilops tauschii	36.56	8.00e-16	74.70
IUUC-Aml-002116	Ailuropoda melanoleuca	94.29	2.00e-61	228.00
IUUC-Atr-002615	Amborella trichopoda	43.88	4.00e-19	85.50
IUUC-Apl-003753	Anas platyrhynchos	97.50	2.00e-20	90.10
IUUC-Aca-005231	Anolis carolinensis	94.85	1.00e-44	171.00
IUUC-Aly-006172	Arabidopsis lyrata	43.18	3.00e-18	82.80
IUUC-Ath-006953	Arabidopsis thaliana	42.86	7.00e-19	84.70
IUUC-Ago-007970	Ashbya gossypii	46.34	3.00e-06	45.10
IUUC-Acl-008072	Aspergillus clavatus	28.74	7.00e-11	58.90
IUUC-Afl-008725	Aspergillus flavus	30.34	6.00e-12	63.50
IUUC-Afu-008967	Aspergillus fumigatus	28.74	1.00e-11	62.80
IUUC-Ani-009248	Aspergillus nidulans	27.59	3.00e-11	61.60
IUUC-Ang-009684	Aspergillus niger	29.07	3.00e-11	61.60
IUUC-Aor-009947	Aspergillus oryzae	30.34	6.00e-12	63.50
IUUC-Ame-011656	Astyanax mexicanus	81.52	3.00e-42	163.00
IUUC-Bgr-012174	Blumeria graminis	30.77	3.00e-13	67.40
IUUC-Bta-012483	Bos taurus	98.98	2.00e-54	204.00
IUUC-Bci-013755	Botrytis cinerea	28.42	2.00e-09	54.30
IUUC-Bdi-014156	Brachypodium distachyon	35.23	8.00e-15	71.20
IUUC-Bol-015683	Brassica oleracea	42.27	5.00e-19	85.50
IUUC-Bra-016802	Brassica rapa	44.32	9.00e-18	81.30
IUUC-Cel-018242	Caenorhabditis elegans	34.07	8.00e-13	65.50
IUUC-Cja-019514	Callithrix jacchus	95.00	4.00e-67	247.00
IUUC-Cfa-020748	Canis familiaris	92.86	4.00e-60	223.00
IUUC-Cpo-021965	Cavia porcellus	84.29	5.00e-58	216.00
IUUC-Cre-023009	Chlamydomonas reinhardtii	32.26	1.00e-11	60.50
IUUC-Csa-023494	Chlorocebus sabaeus	97.14	2.00e-63	234.00
IUUC-Cho-024631	Choloepus hoffmanni	92.86	9.00e-61	226.00
IUUC-Cin-025609	Ciona intestinalis	57.14	7.00e-31	124.00
IUUC-Cgl-026722	Colletotrichum gloeosporioides	39.33	2.00e-14	71.60
IUUC-Dre-027479	Danio rerio	72.32	7.00e-45	172.00
IUUC-Dno-029693	Dasypus novemcinctus	80.71	6.00e-42	162.00
IUUC-Dse-031440	Dothistroma septosporum	31.25	4.00e-12	63.90
IUUC-Dme-031892	Drosophila melanogaster	55.14	5.00e-32	129.00
IUUC-Ete-032550	Echinops telfairi	97.70	2.00e-47	180.00
IUUC-Eca-033553	Equus caballus	93.57	5.00e-61	226.00
IUUC-Fca-036524	Felis catus	91.43	3.00e-58	217.00
IUUC-Fal-036942	Ficedula albicollis	93.02	6.00e-47	177.00
IUUC-Fox-037753	Fusarium oxysporum	32.95	2.00e-12	64.70
IUUC-Gmo-039498	Gadus morhua	72.57	4.00e-43	166.00
IUUC-Ggr-039852	Gaeumannomyces graminis	28.09	1.00e-09	55.80
IUUC-Gga-041263	Gallus gallus	74.83	3.00e-56	210.00
IUUC-Gac-042346	Gasterosteus aculeatus	80.95	4.00e-39	152.00
IUUC-Gma-042896	Glycine max	43.18	6.00e-18	81.60
IUUC-Ggo-045601	Gorilla gorilla	97.86	1.00e-64	238.00
IUUC-Hvu-047239	Hordeum vulgare	37.36	2.00e-15	73.20
IUUC-Itr-048445	Ictidomys tridecemlineatus	95.71	1.00e-64	238.00
IUUC-Kpa-049355	Komagataella pastoris	31.25	4.00e-09	53.90
IUUC-Lch-050619	Latimeria chalumnae	86.52	4.00e-44	170.00
IUUC-Loc-052102	Lepisosteus oculatus	78.18	7.00e-21	91.70
IUUC-Lma-053299	Leptosphaeria maculans	29.41	3.00e-06	43.90
IUUC-Laf-054205	Loxodonta africana	92.86	1.00e-72	264.00
IUUC-Meu-056804	Macropus eugenii	91.96	9.00e-58	215.00
IUUC-Mor-057052	Magnaporthe oryzae	28.97	5.00e-11	60.80
IUUC-Mtr-057961	Medicago truncatula	44.32	1.00e-18	84.00
IUUC-Mla-059045	Melampsora laricipopulina	39.08	7.00e-18	82.00
IUUC-Mvi-060360	Microbotryum violaceum	40.23	7.00e-19	85.90
IUUC-Mmr-061654	Microcebus murinus	85.29	5.00e-62	229.00
IUUC-Mdo-062649	Monodelphis domestica	89.43	1.00e-61	228.00
IUUC-Mmu-064105	Mus musculus	88.65	7.00e-60	222.00
IUUC-Mac-065532	Musa acuminata	38.83	1.00e-17	80.90
IUUC-Mpu-066269	Mustela putorius furo	92.14	2.00e-72	263.00
IUUC-Mlu-067631	Myotis lucifugus	96.06	6.00e-67	246.00
IUUC-Nfi-068468	Neosartorya fischeri	28.74	3.00e-11	60.10
IUUC-Ncr-068750	Neurospora crassa	29.46	1.00e-11	62.40
IUUC-Nle-069483	Nomascus leucogenys	97.14	2.00e-63	235.00
IUUC-Opr-070936	Ochotona princeps	96.94	7.00e-53	199.00
IUUC-Obr-076322	Oryza brachyantha	33.33	7.00e-15	71.60
IUUC-Ogl-077226	Oryza glaberrima	34.15	2.00e-13	67.00
IUUC-Oin-079220	Oryza indica	42.11	8.00e-11	58.50
IUUC-Olo-080688	Oryza longistaminata	34.15	2.00e-13	67.00
IUUC-Ome-081265	Oryza meridionalis	34.15	2.00e-13	67.00
IUUC-Oru-084342	Oryza rufipogon	33.71	2.00e-14	72.40
IUUC-Osa-086212	Oryza sativa	34.15	2.00e-13	67.00
IUUC-Ola-087277	Oryzias latipes	68.03	7.00e-44	168.00
IUUC-Olu-087780	Ostreococcus lucimarinus	33.67	9.00e-12	61.20
IUUC-Oga-088175	Otolemur garnettii	93.57	5.00e-64	236.00
IUUC-Oar-089477	Ovis aries	98.98	2.00e-54	204.00
IUUC-Ptr-091129	Pan troglodytes	98.57	3.00e-65	241.00
IUUC-Psi-093351	Pelodiscus sinensis	78.83	6.00e-52	196.00
IUUC-Pno-094948	Phaeosphaeria nodorum	28.12	6.00e-05	39.70
IUUC-Ppa-095788	Physcomitrella patens	40.59	4.00e-20	89.40
IUUC-Pfo-096993	Poecilia formosa	75.00	4.00e-43	166.00
IUUC-Pab-098502	Pongo abelii	97.86	6.00e-65	239.00
IUUC-Pop-098819	Populus trichocarpa	39.58	3.00e-17	79.30
IUUC-Pca-100144	Procavia capensis	78.57	9.00e-50	189.00
IUUC-Ppe-101560	Prunus persica	42.86	4.00e-16	75.90
IUUC-Pva-102810	Pteropus vampyrus	91.74	1.00e-59	221.00
IUUC-Pgr-103531	Puccinia graminis	34.95	1.00e-18	84.70
IUUC-Ptt-103753	Puccinia triticina	37.93	2.00e-18	84.30
IUUC-Pyt-104733	Pyrenophora triticirepentis	31.40	2.00e-10	58.20
IUUC-Rno-106072	Rattus norvegicus	91.96	4.00e-59	219.00
IUUC-Sce-106275	Saccharomyces cerevisiae	31.82	2.00e-10	58.50
IUUC-Sha-107554	Sarcophilus harrisii	94.44	1.00e-57	214.00
IUUC-Sja-107682	Schizosaccharomyces japonicus	29.21	3.00e-13	67.40
IUUC-Spo-108275	Schizosaccharomyces pombe	35.96	9.00e-17	79.00
IUUC-Smo-109151	Selaginella moellendorffii	29.07	5.00e-11	58.90
IUUC-Sit-110270	Setaria italica	36.56	4.00e-16	75.90
IUUC-Sly-111862	Solanum lycopersicum	45.16	3.00e-18	82.80
IUUC-Stu-112663	Solanum tuberosum	53.49	7.00e-10	55.50
IUUC-Sbi-114148	Sorghum bicolor	36.56	4.00e-16	75.90
IUUC-Sre-115216	Sporisorium reilianum	37.93	3.00e-19	87.00
IUUC-Ssc-116051	Sus scrofa	92.14	7.00e-61	225.00
IUUC-Tgu-117008	Taeniopygia guttata	86.27	7.00e-22	95.10
IUUC-Tru-118466	Takifugu rubripes	81.40	5.00e-40	154.00
IUUC-Tsy-119334	Tarsius syrichta	88.57	1.00e-67	249.00
IUUC-Tni-119792	Tetraodon nigroviridis	82.56	1.00e-40	157.00
IUUC-Tca-121861	Theobroma cacao	43.18	1.00e-17	81.60
IUUC-Tvi-122499	Trichoderma virens	29.09	9.00e-12	62.00
IUUC-Tae-123431	Triticum aestivum	36.56	8.00e-16	74.70
IUUC-Tme-126934	Tuber melanosporum	32.18	3.00e-13	67.40
IUUC-Ttr-129001	Tursiops truncatus	92.14	2.00e-56	211.00
IUUC-Uma-129324	Ustilago maydis	40.23	7.00e-20	89.40
IUUC-Vda-129846	Verticillium dahliae	29.55	4.00e-10	57.00
IUUC-Vpa-130202	Vicugna pacos	58.57	4.00e-26	110.00
IUUC-Vvi-131474	Vitis vinifera	34.57	6.00e-10	56.20
IUUC-Xtr-132782	Xenopus tropicalis	71.76	7.00e-52	195.00
IUUC-Xma-134140	Xiphophorus maculatus	76.00	9.00e-44	168.00
IUUC-Yli-134517	Yarrowia lipolytica	36.25	3.00e-10	58.50
IUUC-Zma-134764	Zea mays	36.56	4.00e-16	75.90

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence