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Tag Content
iUUCD ID IUUC-Ncr-068750
Ensembl Protein ID EAA28720
UniProt Accession Q7S083; ATG12_NEUCR
Genbank Protein ID EAA28720.3
Protein Name Ubiquitin-like protein atg12; Autophagy-related protein 12
Genbank Nucleotide ID CM002241
Gene Name atg12; NCU10049
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
NCU10049 EAA28720 EAA28720
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
ULD/UBL/ATG12 29.46 2.00e-10 62.40 IUUC-Hsa-046903
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Neurospora crassa
Functional Description
(View)

Functional Description


     Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. Conjugation with apg-4/atg5 through a ubiquitin-like conjugating system involving also apg-5/atg7 as an E1-like activating enzyme and atg10 as an E2-like conjugating enzyme, is essential for its function. The atg12-apg-4/atg5 conjugate functions as an E3-like enzyme which is required for lipidation of apg-6/atg8 and apg-6/atg8 association to the vesicle membranes (By similarity).
 Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. Conjugation with apg-4/atg5 through a ubiquitin-like conjugating system involving also apg-5/atg7 as an E1-like activating enzyme and atg10 as an E2-like conjugating enzyme, is essential for its function. The atg12-apg-4/atg5 conjugate functions as an E3-like enzyme which is required for lipidation of apg-6/atg8 and apg-6/atg8 association to the vesicle membranes (By similarity).
Protein Sequence
(Fasta)
MASSQPLHGT ASPSLVHDDN NPNSSTASPV LEGRDSPNLP LTMTASTVLM TLPRDATAAL 60
AEAGTFDQEK VVIRFKPVGS APALRREQVK VLSTHSFETV VAYLRKTLKV QETDSVFLYV 120
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Protein Fasta Sequence


>IUUC-Ncr-068750|ULD,ATG12|Neurospora crassa
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Nucleotide Sequence
(Fasta)
GTCGTCAACA TCATCAGCCT CACTCGATAG CCGACCGGTG CGGCCTACAA GCAGAGTCAC 60
CTGAATATAG CCGTTGGATC TCAGGCTGCT CAAGAAAGCT ACCAAAGGAA CACCACGATC 120
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Nucleotide Fasta Sequence


>IUUC-Ncr-068750|ULD,ATG12|Neurospora crassa
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Sequence Source Ensembl
Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0833--Ubl conjugation pathway
Interpro

IPR007242--Atg12
IPR029071--Ubiquitin-rel_dom
Pfam

PF04110--APG12
Gene Ontology

GO:0034274--C:Atg12-Atg5-Atg16 complex
GO:0034045--C:pre-autophagosomal structure membrane
GO:0019776--F:Atg8 ligase activity
GO:0000045--P:autophagosome assembly
GO:0006501--P:C-terminal protein lipidation
GO:0000422--P:mitophagy
GO:0044804--P:nucleophagy
GO:0015031--P:protein transport
KEGG ncr:NCU10049
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001177 Aegilops tauschii 32.22 8.00e-12 59.70
IUUC-Aml-002116 Ailuropoda melanoleuca 30.00 9.00e-12 60.80
IUUC-Atr-002615 Amborella trichopoda 33.71 9.00e-11 56.20
IUUC-Apl-003753 Anas platyrhynchos 43.90 2.00e-05 38.10
IUUC-Aca-005231 Anolis carolinensis 30.00 4.00e-08 48.50
IUUC-Aly-006172 Arabidopsis lyrata 35.96 1.00e-11 59.30
IUUC-Ath-006953 Arabidopsis thaliana 34.83 1.00e-11 58.90
IUUC-Ago-007970 Ashbya gossypii 37.50 3.00e-09 53.10
IUUC-Acl-008072 Aspergillus clavatus 60.00 2.00e-35 139.00
IUUC-Afl-008725 Aspergillus flavus 55.80 4.00e-40 155.00
IUUC-Afu-008967 Aspergillus fumigatus 55.73 9.00e-39 150.00
IUUC-Ani-009248 Aspergillus nidulans 52.90 6.00e-39 151.00
IUUC-Ang-009684 Aspergillus niger 50.34 2.00e-35 139.00
IUUC-Aor-009947 Aspergillus oryzae 55.80 4.00e-40 155.00
IUUC-Ame-011656 Astyanax mexicanus 27.47 8.00e-10 53.90
IUUC-Bgr-012174 Blumeria graminis 56.56 5.00e-33 131.00
IUUC-Bta-012483 Bos taurus 31.11 4.00e-12 61.60
IUUC-Bci-013755 Botrytis cinerea 60.66 6.00e-38 147.00
IUUC-Bdi-014156 Brachypodium distachyon 33.00 2.00e-11 58.20
IUUC-Bol-015683 Brassica oleracea 35.96 2.00e-12 61.60
IUUC-Bra-016802 Brassica rapa 33.71 1.00e-10 55.80
IUUC-Cel-018242 Caenorhabditis elegans 32.61 1.00e-12 63.20
IUUC-Cja-019514 Callithrix jacchus 31.11 1.00e-11 60.80
IUUC-Cfa-020748 Canis familiaris 30.00 1.00e-11 60.80
IUUC-Cpo-021965 Cavia porcellus 30.00 1.00e-11 61.20
IUUC-Cre-023009 Chlamydomonas reinhardtii 40.66 1.00e-14 68.60
IUUC-Csa-023494 Chlorocebus sabaeus 31.11 3.00e-12 62.00
IUUC-Cho-024631 Choloepus hoffmanni 31.11 8.00e-12 61.60
IUUC-Cin-025609 Ciona intestinalis 42.05 9.00e-18 79.70
IUUC-Cgl-026722 Colletotrichum gloeosporioides 53.57 8.00e-41 157.00
IUUC-Dre-027479 Danio rerio 27.47 1.00e-10 56.20
IUUC-Dno-029693 Dasypus novemcinctus 27.78 2.00e-05 39.70
IUUC-Dse-031440 Dothistroma septosporum 50.00 1.00e-31 126.00
IUUC-Dme-031892 Drosophila melanogaster 27.47 2.00e-10 55.50
IUUC-Ete-032550 Echinops telfairi 31.76 4.00e-11 58.20
IUUC-Eca-033553 Equus caballus 31.11 3.00e-12 62.00
IUUC-Fca-036524 Felis catus 30.00 4.00e-10 55.50
IUUC-Fal-036942 Ficedula albicollis 34.48 2.00e-12 61.20
IUUC-Fox-037753 Fusarium oxysporum 61.43 4.00e-46 175.00
IUUC-Gmo-039498 Gadus morhua 26.67 2.00e-09 52.00
IUUC-Ggr-039852 Gaeumannomyces graminis 67.77 6.00e-37 144.00
IUUC-Gga-041263 Gallus gallus 28.47 1.00e-12 63.90
IUUC-Gac-042346 Gasterosteus aculeatus 29.41 3.00e-09 51.60
IUUC-Gma-042896 Glycine max 33.71 1.00e-10 56.20
IUUC-Ggo-045601 Gorilla gorilla 31.11 8.00e-12 61.60
IUUC-Hsa-046903 Homo sapiens 31.11 4.00e-12 62.00
IUUC-Hvu-047239 Hordeum vulgare 33.68 2.00e-12 62.00
IUUC-Itr-048445 Ictidomys tridecemlineatus 31.11 5.00e-12 62.00
IUUC-Kpa-049355 Komagataella pastoris 30.71 3.00e-09 52.40
IUUC-Lch-050619 Latimeria chalumnae 31.11 5.00e-12 61.60
IUUC-Loc-052102 Lepisosteus oculatus 41.67 8.00e-05 36.20
IUUC-Lma-053299 Leptosphaeria maculans 52.53 4.00e-25 104.00
IUUC-Laf-054205 Loxodonta africana 30.17 2.00e-12 62.80
IUUC-Meu-056804 Macropus eugenii 30.00 8.00e-12 60.80
IUUC-Mor-057052 Magnaporthe oryzae 70.09 5.00e-43 164.00
IUUC-Mtr-057961 Medicago truncatula 34.83 3.00e-11 58.20
IUUC-Mla-059045 Melampsora laricipopulina 44.66 5.00e-22 94.00
IUUC-Mvi-060360 Microbotryum violaceum 43.96 8.00e-20 87.00
IUUC-Mmr-061654 Microcebus murinus 31.11 3.00e-12 62.00
IUUC-Mdo-062649 Monodelphis domestica 31.11 3.00e-12 62.40
IUUC-Mmu-064105 Mus musculus 31.11 4.00e-12 61.60
IUUC-Mac-065532 Musa acuminata 32.22 4.00e-11 57.40
IUUC-Mpu-066269 Mustela putorius furo 30.00 5.00e-12 61.60
IUUC-Mlu-067631 Myotis lucifugus 31.11 4.00e-12 62.40
IUUC-Nfi-068468 Neosartorya fischeri 60.00 8.00e-36 140.00
IUUC-Nle-069483 Nomascus leucogenys 31.11 3.00e-12 62.80
IUUC-Opr-070936 Ochotona princeps 31.11 4.00e-12 62.80
IUUC-Obr-076322 Oryza brachyantha 35.16 2.00e-13 64.70
IUUC-Ogl-077226 Oryza glaberrima 33.33 2.00e-10 55.50
IUUC-Oin-079220 Oryza indica 32.35 5.00e-06 40.80
IUUC-Olo-080688 Oryza longistaminata 33.33 2.00e-10 55.50
IUUC-Ome-081265 Oryza meridionalis 33.33 2.00e-10 55.50
IUUC-Oru-084342 Oryza rufipogon 35.16 1.00e-12 64.70
IUUC-Osa-086212 Oryza sativa 33.33 2.00e-10 55.50
IUUC-Ola-087277 Oryzias latipes 28.57 1.00e-10 56.20
IUUC-Olu-087780 Ostreococcus lucimarinus 38.04 3.00e-12 61.20
IUUC-Oga-088175 Otolemur garnettii 31.11 4.00e-12 61.60
IUUC-Oar-089477 Ovis aries 31.11 9.00e-12 60.80
IUUC-Ptr-091129 Pan troglodytes 31.11 8.00e-12 61.60
IUUC-Psi-093351 Pelodiscus sinensis 30.00 2.00e-11 60.10
IUUC-Pno-094948 Phaeosphaeria nodorum 53.33 1.00e-26 110.00
IUUC-Ppa-095788 Physcomitrella patens 32.97 2.00e-11 58.50
IUUC-Pfo-096993 Poecilia formosa 26.37 3.00e-09 51.60
IUUC-Pab-098502 Pongo abelii 31.11 8.00e-12 61.60
IUUC-Pop-098819 Populus trichocarpa 34.09 3.00e-11 57.80
IUUC-Ppe-101560 Prunus persica 34.88 3.00e-11 57.40
IUUC-Pva-102810 Pteropus vampyrus 31.88 3.00e-09 52.40
IUUC-Pgr-103531 Puccinia graminis 47.57 3.00e-23 98.60
IUUC-Ptt-103753 Puccinia triticina 47.57 7.00e-23 97.10
IUUC-Pyt-104733 Pyrenophora triticirepentis 46.58 6.00e-32 127.00
IUUC-Rno-106072 Rattus norvegicus 31.11 4.00e-12 62.00
IUUC-Sce-106275 Saccharomyces cerevisiae 35.96 2.00e-13 67.00
IUUC-Sha-107554 Sarcophilus harrisii 30.00 4.00e-12 62.00
IUUC-Sja-107682 Schizosaccharomyces japonicus 33.33 2.00e-18 82.80
IUUC-Spo-108275 Schizosaccharomyces pombe 37.36 4.00e-14 68.20
IUUC-Smo-109151 Selaginella moellendorffii 33.33 6.00e-10 53.10
IUUC-Sit-110270 Setaria italica 32.58 4.00e-11 57.40
IUUC-Sly-111862 Solanum lycopersicum 32.97 3.00e-11 57.80
IUUC-Sbi-114148 Sorghum bicolor 32.58 4.00e-11 57.40
IUUC-Sre-115216 Sporisorium reilianum 42.42 6.00e-21 90.90
IUUC-Ssc-116051 Sus scrofa 31.11 3.00e-12 62.00
IUUC-Tru-118466 Takifugu rubripes 28.74 8.00e-09 49.70
IUUC-Tni-119792 Tetraodon nigroviridis 28.74 3.00e-09 50.80
IUUC-Tca-121861 Theobroma cacao 33.33 4.00e-11 58.20
IUUC-Tvi-122499 Trichoderma virens 61.11 3.00e-41 158.00
IUUC-Tae-123431 Triticum aestivum 32.22 8.00e-12 59.70
IUUC-Tme-126934 Tuber melanosporum 48.08 2.00e-23 100.00
IUUC-Ttr-129001 Tursiops truncatus 28.89 4.00e-07 45.80
IUUC-Uma-129324 Ustilago maydis 41.41 1.00e-20 90.10
IUUC-Vda-129846 Verticillium dahliae 63.11 4.00e-43 164.00
IUUC-Vpa-130202 Vicugna pacos 41.46 5.00e-05 38.90
IUUC-Vvi-131474 Vitis vinifera 38.03 2.00e-10 55.80
IUUC-Xtr-132782 Xenopus tropicalis 30.00 5.00e-12 61.60
IUUC-Xma-134140 Xiphophorus maculatus 26.37 8.00e-09 50.80
IUUC-Yli-134517 Yarrowia lipolytica 39.09 3.00e-15 73.20
IUUC-Zma-134764 Zea mays 32.58 3.00e-11 57.40
Created Date 25-Jun-2017

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