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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Sce-106275
Ensembl Protein ID YBR217W
UniProt Accession P38316; D6VQL3; ATG12_YEAST
Genbank Protein ID BAA33473.1; CAA85181.1; AAS56032.1; DAA07333.1
Protein Name Ubiquitin-like protein ATG12; Autophagy-related protein 12
Genbank Nucleotide ID AB017924; Z36086; AY557706; BK006936
Gene Name ATG12; APG12; YBR217W; YBR1506
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YBR217W YBR217W YBR217W
Annotation
mRNA Expression
GEOFFGED
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
dbPAFdbPTM
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
ULD/UBL/ATG12 31.82 5.00e-09 58.50 IUUC-Hsa-046903
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes. ATG12-ATG5 rearranges the ATG3 catalytic center and enhances its E2 activity.
 Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes. ATG12-ATG5 rearranges the ATG3 catalytic center and enhances its E2 activity.
Protein Sequence
(Fasta)
MSRILESENE TESDESSIIS TNNGTAMERS RNNQELRSSP HTVQNRLELF SRRLSQLGLA 60
SDISVDQQVE DSSSGTYEQE ETIKTNAQTS KQKSHKDEKN IQKIQIKFQP IGSIGQLKPS 120
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Protein Fasta Sequence


>IUUC-Sce-106275|ULD,ATG12|Saccharomyces cerevisiae
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Nucleotide Sequence
(Fasta)
ATGAGTAGGA TCCTAGAGAG CGAAAATGAA ACAGAAAGTG ACGAAAGCTC CATCATATCC 60
ACAAATAATG GAACGGCAAT GGAAAGATCC AGAAATAATC AAGAATTAAG ATCATCTCCT 120
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Nucleotide Fasta Sequence


>IUUC-Sce-106275|ULD,ATG12|Saccharomyces cerevisiae
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Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0072--Autophagy
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0833--Ubl conjugation pathway
Interpro

IPR007242--Atg12
IPR029071--Ubiquitin-rel_dom
Pfam

PF04110--APG12
Gene Ontology

GO:0034274--C:Atg12-Atg5-Atg16 complex
GO:0000407--C:pre-autophagosomal structure
GO:0034045--C:pre-autophagosomal structure membrane
GO:0008047--F:enzyme activator activity
GO:0031386--F:protein tag
GO:0000045--P:autophagosome assembly
GO:0006501--P:C-terminal protein lipidation
GO:0032258--P:CVT pathway
GO:0044805--P:late nucleophagy
GO:0000422--P:mitophagy
GO:0034727--P:piecemeal microautophagy of nucleus
KEGG sce:YBR217W
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001177 Aegilops tauschii 37.65 5.00e-13 63.50
IUUC-Aml-002116 Ailuropoda melanoleuca 30.68 5.00e-11 58.20
IUUC-Atr-002615 Amborella trichopoda 31.76 9.00e-12 59.30
IUUC-Apl-003753 Anas platyrhynchos 42.50 6.00e-08 46.20
IUUC-Aca-005231 Anolis carolinensis 41.86 2.00e-08 49.30
IUUC-Aly-006172 Arabidopsis lyrata 33.72 2.00e-13 65.10
IUUC-Ath-006953 Arabidopsis thaliana 37.21 2.00e-14 68.20
IUUC-Ago-007970 Ashbya gossypii 43.65 2.00e-34 136.00
IUUC-Acl-008072 Aspergillus clavatus 45.98 5.00e-19 84.00
IUUC-Afl-008725 Aspergillus flavus 45.98 9.00e-20 87.40
IUUC-Afu-008967 Aspergillus fumigatus 45.56 5.00e-20 88.20
IUUC-Ani-009248 Aspergillus nidulans 45.98 7.00e-19 84.30
IUUC-Ang-009684 Aspergillus niger 43.33 2.00e-18 82.80
IUUC-Aor-009947 Aspergillus oryzae 45.98 9.00e-20 87.40
IUUC-Ame-011656 Astyanax mexicanus 29.55 8.00e-10 53.50
IUUC-Bgr-012174 Blumeria graminis 42.05 2.00e-15 72.40
IUUC-Bta-012483 Bos taurus 31.82 3.00e-11 58.50
IUUC-Bci-013755 Botrytis cinerea 41.05 2.00e-15 72.40
IUUC-Bdi-014156 Brachypodium distachyon 35.29 1.00e-12 62.40
IUUC-Bol-015683 Brassica oleracea 33.72 8.00e-14 66.20
IUUC-Bra-016802 Brassica rapa 34.88 3.00e-13 63.90
IUUC-Cel-018242 Caenorhabditis elegans 25.27 2.00e-03 32.30
IUUC-Cja-019514 Callithrix jacchus 31.82 1.00e-10 57.40
IUUC-Cfa-020748 Canis familiaris 30.68 3.00e-11 58.90
IUUC-Cpo-021965 Cavia porcellus 30.68 1.00e-10 57.00
IUUC-Cre-023009 Chlamydomonas reinhardtii 29.41 5.00e-09 50.10
IUUC-Csa-023494 Chlorocebus sabaeus 31.82 4.00e-11 58.50
IUUC-Cho-024631 Choloepus hoffmanni 31.82 6.00e-11 58.50
IUUC-Cin-025609 Ciona intestinalis 29.89 2.00e-11 58.50
IUUC-Cgl-026722 Colletotrichum gloeosporioides 40.45 2.00e-17 79.00
IUUC-Dre-027479 Danio rerio 31.18 2.00e-10 55.80
IUUC-Dno-029693 Dasypus novemcinctus 45.00 7.00e-08 47.40
IUUC-Dse-031440 Dothistroma septosporum 39.08 8.00e-17 77.40
IUUC-Dme-031892 Drosophila melanogaster 28.44 2.00e-10 55.10
IUUC-Ete-032550 Echinops telfairi 30.95 5.00e-10 54.30
IUUC-Eca-033553 Equus caballus 31.82 2.00e-11 59.30
IUUC-Fca-036524 Felis catus 28.74 1.00e-09 53.90
IUUC-Fal-036942 Ficedula albicollis 24.72 2.00e-09 51.20
IUUC-Fox-037753 Fusarium oxysporum 37.50 1.00e-14 70.10
IUUC-Gmo-039498 Gadus morhua 28.41 6.00e-09 50.80
IUUC-Ggr-039852 Gaeumannomyces graminis 40.45 6.00e-13 65.10
IUUC-Gga-041263 Gallus gallus 29.55 1.00e-10 56.60
IUUC-Gac-042346 Gasterosteus aculeatus 44.44 4.00e-10 54.30
IUUC-Gma-042896 Glycine max 32.56 3.00e-12 60.80
IUUC-Ggo-045601 Gorilla gorilla 31.82 6.00e-11 58.20
IUUC-Hsa-046903 Homo sapiens 31.82 2.00e-11 58.90
IUUC-Hvu-047239 Hordeum vulgare 36.47 7.00e-13 63.20
IUUC-Itr-048445 Ictidomys tridecemlineatus 31.82 5.00e-11 58.50
IUUC-Kpa-049355 Komagataella pastoris 40.82 3.00e-17 78.60
IUUC-Lch-050619 Latimeria chalumnae 32.95 1.00e-11 60.50
IUUC-Loc-052102 Lepisosteus oculatus 44.12 3.00e-05 37.40
IUUC-Lma-053299 Leptosphaeria maculans 29.31 4.00e-13 64.70
IUUC-Laf-054205 Loxodonta africana 31.82 3.00e-11 58.50
IUUC-Meu-056804 Macropus eugenii 30.68 7.00e-11 57.40
IUUC-Mor-057052 Magnaporthe oryzae 41.11 2.00e-14 70.10
IUUC-Mtr-057961 Medicago truncatula 32.56 2.00e-12 61.60
IUUC-Mla-059045 Melampsora laricipopulina 31.37 1.00e-13 66.20
IUUC-Mvi-060360 Microbotryum violaceum 35.16 1.00e-12 63.50
IUUC-Mmr-061654 Microcebus murinus 31.82 3.00e-11 58.50
IUUC-Mdo-062649 Monodelphis domestica 29.09 3.00e-11 58.50
IUUC-Mmu-064105 Mus musculus 31.82 4.00e-11 58.50
IUUC-Mac-065532 Musa acuminata 35.29 4.00e-13 63.90
IUUC-Mpu-066269 Mustela putorius furo 30.68 3.00e-11 58.50
IUUC-Mlu-067631 Myotis lucifugus 29.41 5.00e-12 61.60
IUUC-Nfi-068468 Neosartorya fischeri 47.13 1.00e-19 86.30
IUUC-Ncr-068750 Neurospora crassa 35.96 1.00e-13 67.40
IUUC-Nle-069483 Nomascus leucogenys 31.82 4.00e-11 58.90
IUUC-Opr-070936 Ochotona princeps 31.82 9.00e-11 57.80
IUUC-Obr-076322 Oryza brachyantha 35.29 4.00e-14 67.00
IUUC-Ogl-077226 Oryza glaberrima 36.71 6.00e-13 63.20
IUUC-Oin-079220 Oryza indica 33.82 1.00e-10 56.20
IUUC-Olo-080688 Oryza longistaminata 36.71 6.00e-13 63.20
IUUC-Ome-081265 Oryza meridionalis 36.71 6.00e-13 63.20
IUUC-Oru-084342 Oryza rufipogon 35.29 6.00e-13 65.50
IUUC-Osa-086212 Oryza sativa 36.71 6.00e-13 63.20
IUUC-Ola-087277 Oryzias latipes 30.68 8.00e-11 57.00
IUUC-Oga-088175 Otolemur garnettii 31.82 2.00e-11 59.30
IUUC-Oar-089477 Ovis aries 31.82 4.00e-11 58.50
IUUC-Ptr-091129 Pan troglodytes 31.82 7.00e-11 58.20
IUUC-Psi-093351 Pelodiscus sinensis 30.43 2.00e-11 59.30
IUUC-Pno-094948 Phaeosphaeria nodorum 38.57 3.00e-11 58.50
IUUC-Ppa-095788 Physcomitrella patens 36.47 7.00e-14 66.60
IUUC-Pfo-096993 Poecilia formosa 27.64 9.00e-11 56.60
IUUC-Pab-098502 Pongo abelii 31.82 6.00e-11 58.50
IUUC-Pop-098819 Populus trichocarpa 32.94 6.00e-11 56.60
IUUC-Ppe-101560 Prunus persica 33.33 5.00e-11 56.60
IUUC-Pva-102810 Pteropus vampyrus 28.28 1.00e-07 47.00
IUUC-Pgr-103531 Puccinia graminis 33.01 2.00e-14 68.90
IUUC-Ptt-103753 Puccinia triticina 34.78 1.00e-13 66.20
IUUC-Pyt-104733 Pyrenophora triticirepentis 37.76 4.00e-18 81.60
IUUC-Rno-106072 Rattus norvegicus 29.55 1.00e-10 56.60
IUUC-Sha-107554 Sarcophilus harrisii 30.68 4.00e-11 58.50
IUUC-Sja-107682 Schizosaccharomyces japonicus 42.71 1.00e-19 86.70
IUUC-Spo-108275 Schizosaccharomyces pombe 33.88 1.00e-15 73.20
IUUC-Smo-109151 Selaginella moellendorffii 33.73 3.00e-12 60.50
IUUC-Sit-110270 Setaria italica 36.47 1.00e-12 62.00
IUUC-Sly-111862 Solanum lycopersicum 30.59 5.00e-11 56.60
IUUC-Stu-112663 Solanum tuberosum 31.71 9.00e-05 36.60
IUUC-Sbi-114148 Sorghum bicolor 36.47 1.00e-12 62.00
IUUC-Sre-115216 Sporisorium reilianum 31.52 5.00e-12 61.20
IUUC-Ssc-116051 Sus scrofa 31.82 3.00e-11 58.90
IUUC-Tru-118466 Takifugu rubripes 42.59 5.00e-10 53.10
IUUC-Tsy-119334 Tarsius syrichta 28.41 3.00e-07 45.80
IUUC-Tni-119792 Tetraodon nigroviridis 42.59 3.00e-10 53.90
IUUC-Tca-121861 Theobroma cacao 32.18 4.00e-12 61.20
IUUC-Tvi-122499 Trichoderma virens 39.77 4.00e-15 71.60
IUUC-Tae-123431 Triticum aestivum 37.65 5.00e-13 63.50
IUUC-Tme-126934 Tuber melanosporum 41.38 2.00e-16 75.90
IUUC-Ttr-129001 Tursiops truncatus 31.03 3.00e-07 45.80
IUUC-Uma-129324 Ustilago maydis 31.52 7.00e-12 60.80
IUUC-Vda-129846 Verticillium dahliae 42.05 3.00e-15 72.40
IUUC-Vpa-130202 Vicugna pacos 45.00 5.00e-08 48.50
IUUC-Vvi-131474 Vitis vinifera 32.35 1.00e-07 47.00
IUUC-Xtr-132782 Xenopus tropicalis 32.00 1.00e-12 63.20
IUUC-Xma-134140 Xiphophorus maculatus 27.64 2.00e-10 55.80
IUUC-Yli-134517 Yarrowia lipolytica 41.11 2.00e-15 73.20
IUUC-Zma-134764 Zea mays 36.47 1.00e-12 62.00
Created Date 25-Jun-2017

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