iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Spo-108275

Ensembl Protein ID

SPAC1783.06c.1:pep

UniProt Accession

Q9US24; ATG12_SCHPO

Genbank Protein ID

CAB66169.1

Protein Name

Ubiquitin-like protein ATG12; Autophagy-related protein 12

Genbank Nucleotide ID

CU329670

Gene Name

atg12; SPAC1783.06c

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPAC1783.06c	SPAC1783.06c.1	SPAC1783.06c.1:pep

Annotation

mRNA Expression
GEO
Protein-protein Interaction
Mentha
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
ULD/UBL/ATG12	35.96	1.00e-15	79.00	IUUC-Hsa-046903

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Schizosaccharomyces pombe

Functional Description
(View)

Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. Conjugation with atg5 through a ubiquitin-like conjugating system involving also atg7 as an E1-like activating enzyme and atg10 as an E2-like conjugating enzyme, is essential for its function. The atg12-atg5 conjugate functions as an E3-like enzyme which is required for lipidation of atg8 and atg8 association to the vesicle membranes (By similarity). Plays a role in meiosis and sporulation.

Protein Sequence
(Fasta)

MTGLVDQQEL EKRLATEEDS QNEDIENQLP SIETIINTYR EKENRRVNLR FKAIGRTPLL 60
RKTVFSINAS QRFEKVTRFL KKELGLPMNS SLVLYVNSSF APSPDEIVGN LYDNFAIDSH 120

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Nucleotide Sequence
(Fasta)

TGTATTTTAA CTCAGTATAA ATTAAGTGTA CAGTAGTAGT TACGAATCAA CACCAAACAG 60
ACATTGTGTG CTTAAACTTC AAGCTTACAA TTAGAAGCGT TTTTTATCAA TTGAAGTATT 120

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Sequence Source

Ensembl

Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-0539--Nucleus
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0833--Ubl conjugation pathway

Interpro

IPR007242--Atg12
IPR029071--Ubiquitin-rel_dom

Pfam

PF04110--APG12

Gene Ontology

GO:0034274--C:Atg12-Atg5-Atg16 complex
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0034045--C:pre-autophagosomal structure membrane
GO:0019776--F:Atg8 ligase activity
GO:0031386--F:protein tag
GO:0000045--P:autophagosome assembly
GO:0006914--P:autophagy
GO:0006501--P:C-terminal protein lipidation
GO:0016236--P:macroautophagy
GO:0000422--P:mitophagy
GO:0044804--P:nucleophagy
GO:0015031--P:protein transport

KEGG

spo:SPAC1783.06c

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001177	Aegilops tauschii	39.77	5.00e-18	80.10
IUUC-Aml-002116	Ailuropoda melanoleuca	35.96	9.00e-17	77.40
IUUC-Atr-002615	Amborella trichopoda	40.91	6.00e-19	83.20
IUUC-Apl-003753	Anas platyrhynchos	53.85	4.00e-09	50.40
IUUC-Aca-005231	Anolis carolinensis	36.36	3.00e-14	68.60
IUUC-Aly-006172	Arabidopsis lyrata	40.91	9.00e-18	79.30
IUUC-Ath-006953	Arabidopsis thaliana	37.50	5.00e-17	76.60
IUUC-Ago-007970	Ashbya gossypii	35.63	9.00e-11	57.80
IUUC-Acl-008072	Aspergillus clavatus	42.22	1.00e-18	83.20
IUUC-Afl-008725	Aspergillus flavus	43.68	5.00e-19	85.10
IUUC-Afu-008967	Aspergillus fumigatus	42.22	4.00e-18	82.00
IUUC-Ani-009248	Aspergillus nidulans	43.68	4.00e-18	81.60
IUUC-Ang-009684	Aspergillus niger	44.19	1.00e-17	80.90
IUUC-Aor-009947	Aspergillus oryzae	43.68	5.00e-19	85.10
IUUC-Ame-011656	Astyanax mexicanus	32.97	1.00e-16	76.60
IUUC-Bgr-012174	Blumeria graminis	41.00	5.00e-17	77.80
IUUC-Bta-012483	Bos taurus	35.96	3.00e-17	78.60
IUUC-Bci-013755	Botrytis cinerea	41.67	3.00e-15	71.60
IUUC-Bdi-014156	Brachypodium distachyon	39.13	1.00e-18	82.40
IUUC-Bol-015683	Brassica oleracea	40.91	3.00e-18	80.90
IUUC-Bra-016802	Brassica rapa	40.91	5.00e-18	80.10
IUUC-Cel-018242	Caenorhabditis elegans	30.77	8.00e-08	47.00
IUUC-Cja-019514	Callithrix jacchus	35.96	1.00e-16	77.40
IUUC-Cfa-020748	Canis familiaris	35.96	7.00e-17	77.80
IUUC-Cpo-021965	Cavia porcellus	35.96	9.00e-17	77.40
IUUC-Cre-023009	Chlamydomonas reinhardtii	28.89	2.00e-09	51.60
IUUC-Csa-023494	Chlorocebus sabaeus	35.96	2.00e-17	79.00
IUUC-Cho-024631	Choloepus hoffmanni	35.96	1.00e-16	77.40
IUUC-Cin-025609	Ciona intestinalis	36.78	1.00e-15	72.40
IUUC-Cgl-026722	Colletotrichum gloeosporioides	39.81	1.00e-15	73.60
IUUC-Dre-027479	Danio rerio	31.73	1.00e-16	76.30
IUUC-Dno-029693	Dasypus novemcinctus	31.46	1.00e-12	63.50
IUUC-Dse-031440	Dothistroma septosporum	40.37	3.00e-19	85.10
IUUC-Dme-031892	Drosophila melanogaster	29.41	3.00e-15	71.60
IUUC-Ete-032550	Echinops telfairi	37.93	2.00e-16	75.50
IUUC-Eca-033553	Equus caballus	35.96	2.00e-17	79.30
IUUC-Fca-036524	Felis catus	34.83	6.00e-15	71.20
IUUC-Fal-036942	Ficedula albicollis	39.53	3.00e-17	77.40
IUUC-Fox-037753	Fusarium oxysporum	45.45	2.00e-17	79.70
IUUC-Fso-038105	Fusarium solani	33.33	2.50e+00	25.00
IUUC-Gmo-039498	Gadus morhua	33.33	4.00e-16	74.70
IUUC-Ggr-039852	Gaeumannomyces graminis	42.70	2.00e-14	70.10
IUUC-Gga-041263	Gallus gallus	35.96	2.00e-17	79.00
IUUC-Gac-042346	Gasterosteus aculeatus	35.37	4.00e-15	71.20
IUUC-Gma-042896	Glycine max	38.64	2.00e-17	78.20
IUUC-Ggo-045601	Gorilla gorilla	35.96	8.00e-17	77.80
IUUC-Hsa-046903	Homo sapiens	35.96	2.00e-17	79.30
IUUC-Hvu-047239	Hordeum vulgare	40.91	3.00e-18	80.90
IUUC-Itr-048445	Ictidomys tridecemlineatus	35.96	6.00e-17	77.80
IUUC-Kpa-049355	Komagataella pastoris	31.36	1.00e-13	66.60
IUUC-Lch-050619	Latimeria chalumnae	37.50	4.00e-18	81.60
IUUC-Loc-052102	Lepisosteus oculatus	34.85	4.00e-07	43.50
IUUC-Lma-053299	Leptosphaeria maculans	45.83	2.00e-15	72.00
IUUC-Laf-054205	Loxodonta africana	35.96	3.00e-17	79.00
IUUC-Meu-056804	Macropus eugenii	35.96	4.00e-17	78.20
IUUC-Mor-057052	Magnaporthe oryzae	42.86	1.00e-15	73.90
IUUC-Mtr-057961	Medicago truncatula	40.91	3.00e-18	80.90
IUUC-Mla-059045	Melampsora laricipopulina	43.30	7.00e-24	100.00
IUUC-Mvi-060360	Microbotryum violaceum	47.42	3.00e-26	108.00
IUUC-Mmr-061654	Microcebus murinus	35.96	2.00e-17	78.60
IUUC-Mdo-062649	Monodelphis domestica	31.97	4.00e-17	78.20
IUUC-Mmu-064105	Mus musculus	35.96	3.00e-17	78.60
IUUC-Mac-065532	Musa acuminata	39.77	3.00e-18	80.90
IUUC-Mpu-066269	Mustela putorius furo	35.96	3.00e-17	78.60
IUUC-Mlu-067631	Myotis lucifugus	35.96	9.00e-17	77.40
IUUC-Nfi-068468	Neosartorya fischeri	42.22	2.00e-18	81.60
IUUC-Ncr-068750	Neurospora crassa	37.36	5.00e-14	68.20
IUUC-Nle-069483	Nomascus leucogenys	35.96	6.00e-17	78.60
IUUC-Opr-070936	Ochotona princeps	35.96	1.00e-16	77.00
IUUC-Obr-076322	Oryza brachyantha	36.67	4.00e-18	80.50
IUUC-Ogl-077226	Oryza glaberrima	37.35	1.00e-16	75.90
IUUC-Oin-079220	Oryza indica	39.39	1.00e-12	62.40
IUUC-Olo-080688	Oryza longistaminata	37.35	1.00e-16	75.90
IUUC-Ome-081265	Oryza meridionalis	37.35	1.00e-16	75.90
IUUC-Oru-084342	Oryza rufipogon	36.67	3.00e-17	79.70
IUUC-Osa-086212	Oryza sativa	37.35	1.00e-16	75.90
IUUC-Ola-087277	Oryzias latipes	30.17	9.00e-18	80.10
IUUC-Olu-087780	Ostreococcus lucimarinus	33.33	4.00e-08	47.40
IUUC-Oga-088175	Otolemur garnettii	35.96	2.00e-17	79.30
IUUC-Oar-089477	Ovis aries	35.96	6.00e-17	78.20
IUUC-Ptr-091129	Pan troglodytes	35.96	9.00e-17	77.80
IUUC-Psi-093351	Pelodiscus sinensis	35.87	7.00e-18	80.90
IUUC-Pno-094948	Phaeosphaeria nodorum	43.08	1.00e-12	62.80
IUUC-Ppa-095788	Physcomitrella patens	38.64	8.00e-19	82.80
IUUC-Pfo-096993	Poecilia formosa	33.33	5.00e-18	80.90
IUUC-Pab-098502	Pongo abelii	35.96	8.00e-17	77.80
IUUC-Pop-098819	Populus trichocarpa	36.36	8.00e-17	76.30
IUUC-Pca-100144	Procavia capensis	20.22	1.00e-04	37.70
IUUC-Ppe-101560	Prunus persica	39.29	1.00e-16	75.10
IUUC-Pva-102810	Pteropus vampyrus	35.71	4.00e-11	58.50
IUUC-Pgr-103531	Puccinia graminis	43.62	6.00e-24	100.00
IUUC-Ptt-103753	Puccinia triticina	40.38	4.00e-24	100.00
IUUC-Pyt-104733	Pyrenophora triticirepentis	38.37	5.00e-16	74.70
IUUC-Rno-106072	Rattus norvegicus	34.83	2.00e-16	76.30
IUUC-Sce-106275	Saccharomyces cerevisiae	33.88	2.00e-15	73.60
IUUC-Sha-107554	Sarcophilus harrisii	35.96	5.00e-17	77.80
IUUC-Sja-107682	Schizosaccharomyces japonicus	47.47	8.00e-28	113.00
IUUC-Smo-109151	Selaginella moellendorffii	34.88	1.00e-14	68.90
IUUC-Sit-110270	Setaria italica	37.08	1.00e-17	78.60
IUUC-Sly-111862	Solanum lycopersicum	38.89	1.00e-17	79.00
IUUC-Stu-112663	Solanum tuberosum	40.00	2.00e-10	55.10
IUUC-Sbi-114148	Sorghum bicolor	37.08	1.00e-17	78.60
IUUC-Sre-115216	Sporisorium reilianum	44.68	2.00e-23	99.00
IUUC-Ssc-116051	Sus scrofa	35.96	2.00e-17	79.30
IUUC-Tgu-117008	Taeniopygia guttata	24.49	6.00e-03	30.40
IUUC-Tru-118466	Takifugu rubripes	37.21	7.00e-17	75.90
IUUC-Tsy-119334	Tarsius syrichta	32.58	9.00e-12	61.20
IUUC-Tni-119792	Tetraodon nigroviridis	37.21	4.00e-17	77.00
IUUC-Tca-121861	Theobroma cacao	39.77	1.00e-17	79.30
IUUC-Tvi-122499	Trichoderma virens	44.94	8.00e-18	80.10
IUUC-Tae-123431	Triticum aestivum	39.77	5.00e-18	80.10
IUUC-Tme-126934	Tuber melanosporum	48.28	1.00e-21	93.20
IUUC-Ttr-129001	Tursiops truncatus	34.83	4.00e-13	65.50
IUUC-Uma-129324	Ustilago maydis	45.74	8.00e-24	100.00
IUUC-Vda-129846	Verticillium dahliae	44.44	7.00e-18	80.90
IUUC-Vpa-130202	Vicugna pacos	53.85	1.00e-09	54.30
IUUC-Vvi-131474	Vitis vinifera	40.85	1.00e-12	63.50
IUUC-Xtr-132782	Xenopus tropicalis	37.50	2.00e-17	79.30
IUUC-Xma-134140	Xiphophorus maculatus	33.33	5.00e-18	81.30
IUUC-Yli-134517	Yarrowia lipolytica	42.11	3.00e-17	79.70
IUUC-Zma-134764	Zea mays	37.08	1.00e-17	78.60

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence