iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cin-025212

UUCD1 version

UUC-CiI-00320

Ensembl Protein ID

ENSCINP00000026658.2

UniProt Accession

F7BGT4; F7BGT4_CIOIN

Protein Name

E3 ubiquitin-protein ligase

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCING00000014835.2	ENSCINT00000026904.2	ENSCINP00000026658.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.50e-132	440.0	578	909

Active Site

Position(s)	Description	Evidence
878	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlp 91
           +dl++rl++ f+gEegld+gGv+re+++l+s+e+ np+++lf+y  + ++tlq+np+s + np+h+ +F+f+Gr++++al++g+++d+ 
   Q: 578  YDLRRRLYIMFKGEEGLDYGGVAREWFFLVSHEVLNPMYCLFEYAGSTNYTLQINPASTI-NPDHMHYFRFVGRFIAMALYHGKFIDTG 665
           799*******************************************************98.89************************** PP
   S: 92   lsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvvey 180
           +s +fyk++l++kl+++d+e+vd+e+y+sl +i++n   +iee+gl+l f+++ e+lg++++ eLk gGe+ipVt+eNkeeY++l++++
   Q: 666  FSLPFYKRMLNRKLTIKDIESVDEEFYNSLVWIRDN---NIEECGLELDFTMDFEVLGKIDTIELKDGGEDIPVTEENKEEYIRLMIDW 751
           **********************************99...9************************************************* PP
   S: 181  rlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvT 269
           r+ +g+++q++ f +Gfnev+pl++l++F+e+elel++cG++e+dved++++  y++ yt++s+++ wFw+ ++e+++e+r+++LqFv+
   Q: 752  RFSRGVEKQTKGFLDGFNEVVPLQWLQYFDERELELMLCGMQEFDVEDWSRHSIYRN-YTKNSKQVLWFWQYIREIDNEKRARLLQFVS 839
           *******************************************************99.******************************* PP
   S: 270  gssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           g++r+P+gGfael     p++f+i+k +++++lP+s+TCfn+L+LP+Y+s+e+lkekL++Aieet+gF++
   Q: 840  GTCRIPVGGFAELLgsngPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSYEQLKEKLTMAIEETEGFGQ 909
           *************99*****************************************************96 PP

Organism

Ciona intestinalis

Protein Sequence
(Fasta)

MDQNGSNTYL SQLNITVLRG TIKPISGNWI FGSPRVPDSY VTITIDGQPP KKTGISNKTN 60
NPIWDEAFTL LVNVQSIIEF KVYNYFSMRA DTLIGAAKCD IQDILKKHNG KIESLDLALN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTGGTGAAA TAAAAAAATT GAGTGTTACT GGTTTGCACG TATTTTATTT TAAGTTCAGC 60
ATGAGACAAC ATGTGAGATA AGTGATGGAC CAAAACGGAT CGAATACTTA TCTTTCTCAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001213	Ailuropoda melanoleuca	55.14	0.00e+00	964.00
IUUC-Apl-003310	Anas platyrhynchos	74.44	0.00e+00	920.00
IUUC-Aca-005388	Anolis carolinensis	74.09	0.00e+00	912.00
IUUC-Ago-007742	Ashbya gossypii	47.52	2.00e-153	534.00
IUUC-Acl-008273	Aspergillus clavatus	46.30	1.00e-155	542.00
IUUC-Afl-008713	Aspergillus flavus	45.81	6.00e-154	536.00
IUUC-Afu-009103	Aspergillus fumigatus	46.63	7.00e-157	546.00
IUUC-Ani-009259	Aspergillus nidulans	46.49	9.00e-156	542.00
IUUC-Ang-009738	Aspergillus niger	45.48	3.00e-153	534.00
IUUC-Ate-010529	Aspergillus terreus	46.04	3.00e-155	540.00
IUUC-Ame-010601	Astyanax mexicanus	67.01	0.00e+00	845.00
IUUC-Bgr-012148	Blumeria graminis	45.92	3.00e-150	524.00
IUUC-Bta-012857	Bos taurus	56.85	0.00e+00	972.00
IUUC-Bci-013785	Botrytis cinerea	46.93	6.00e-153	533.00
IUUC-Cel-018299	Caenorhabditis elegans	64.20	0.00e+00	801.00
IUUC-Cja-019448	Callithrix jacchus	74.57	0.00e+00	917.00
IUUC-Cfa-020728	Canis familiaris	74.57	0.00e+00	918.00
IUUC-Cpo-021988	Cavia porcellus	72.32	0.00e+00	904.00
IUUC-Csa-023805	Chlorocebus sabaeus	74.31	0.00e+00	904.00
IUUC-Cho-024695	Choloepus hoffmanni	67.01	0.00e+00	852.00
IUUC-Csv-026256	Ciona savignyi	92.59	0.00e+00	1050.00
IUUC-Cgl-026642	Colletotrichum gloeosporioides	46.09	5.00e-152	530.00
IUUC-Cne-026849	Cryptococcus neoformans	45.03	2.00e-149	521.00
IUUC-Dre-028245	Danio rerio	73.23	0.00e+00	930.00
IUUC-Dno-029618	Dasypus novemcinctus	74.39	0.00e+00	916.00
IUUC-Dor-030176	Dipodomys ordii	72.17	0.00e+00	887.00
IUUC-Dme-032041	Drosophila melanogaster	69.88	0.00e+00	867.00
IUUC-Ete-032779	Echinops telfairi	70.21	0.00e+00	841.00
IUUC-Eca-033313	Equus caballus	69.57	0.00e+00	910.00
IUUC-Eeu-035259	Erinaceus europaeus	51.24	0.00e+00	839.00
IUUC-Fca-035420	Felis catus	55.29	0.00e+00	981.00
IUUC-Fal-037335	Ficedula albicollis	74.44	0.00e+00	924.00
IUUC-Fox-037774	Fusarium oxysporum	46.27	2.00e-151	528.00
IUUC-Fso-038393	Fusarium solani	46.27	2.00e-149	521.00
IUUC-Gmo-038842	Gadus morhua	70.26	0.00e+00	843.00
IUUC-Ggr-040107	Gaeumannomyces graminis	46.01	7.00e-151	526.00
IUUC-Gga-040246	Gallus gallus	74.44	0.00e+00	922.00
IUUC-Gac-042211	Gasterosteus aculeatus	73.06	0.00e+00	931.00
IUUC-Ggo-045001	Gorilla gorilla	74.39	0.00e+00	914.00
IUUC-Hsa-046544	Homo sapiens	74.39	0.00e+00	917.00
IUUC-Itr-048860	Ictidomys tridecemlineatus	57.14	0.00e+00	990.00
IUUC-Kpa-049273	Komagataella pastoris	47.95	1.00e-159	555.00
IUUC-Lch-050398	Latimeria chalumnae	74.09	0.00e+00	914.00
IUUC-Loc-052116	Lepisosteus oculatus	73.88	0.00e+00	937.00
IUUC-Laf-053551	Loxodonta africana	55.54	0.00e+00	972.00
IUUC-Mcc-055655	Macaca mulatta	72.17	0.00e+00	895.00
IUUC-Meu-055953	Macropus eugenii	62.98	0.00e+00	752.00
IUUC-Mor-057097	Magnaporthe oryzae	45.27	1.00e-149	522.00
IUUC-Mpo-057442	Magnaporthe poae	49.18	5.00e-141	494.00
IUUC-Mla-058996	Melampsora laricipopulina	49.90	2.00e-144	505.00
IUUC-Mga-059986	Meleagris gallopavo	74.61	0.00e+00	926.00
IUUC-Mmr-060896	Microcebus murinus	72.70	0.00e+00	901.00
IUUC-Mdo-062536	Monodelphis domestica	71.97	0.00e+00	898.00
IUUC-Mmu-063202	Mus musculus	56.44	0.00e+00	986.00
IUUC-Mpu-065773	Mustela putorius furo	74.48	0.00e+00	914.00
IUUC-Mlu-067623	Myotis lucifugus	70.26	0.00e+00	860.00
IUUC-Nfi-068427	Neosartorya fischeri	46.63	2.00e-156	545.00
IUUC-Ncr-068918	Neurospora crassa	45.81	2.00e-149	521.00
IUUC-Nle-069188	Nomascus leucogenys	74.57	0.00e+00	918.00
IUUC-Opr-070965	Ochotona princeps	72.07	0.00e+00	898.00
IUUC-Ont-072226	Oreochromis niloticus	73.92	0.00e+00	939.00
IUUC-Oan-073497	Ornithorhynchus anatinus	74.44	0.00e+00	922.00
IUUC-Ocu-074271	Oryctolagus cuniculus	71.83	0.00e+00	892.00
IUUC-Ola-087438	Oryzias latipes	73.92	0.00e+00	937.00
IUUC-Oga-087922	Otolemur garnettii	74.31	0.00e+00	914.00
IUUC-Oar-089317	Ovis aries	74.44	0.00e+00	910.00
IUUC-Ptr-090484	Pan troglodytes	74.39	0.00e+00	917.00
IUUC-Pan-092117	Papio anubis	74.57	0.00e+00	919.00
IUUC-Psi-093338	Pelodiscus sinensis	74.44	0.00e+00	923.00
IUUC-Pma-094279	Petromyzon marinus	64.78	0.00e+00	736.00
IUUC-Pno-095118	Phaeosphaeria nodorum	46.49	5.00e-151	526.00
IUUC-Pfo-096171	Poecilia formosa	73.92	0.00e+00	938.00
IUUC-Pab-098654	Pongo abelii	73.36	0.00e+00	900.00
IUUC-Pca-100596	Procavia capensis	76.23	0.00e+00	781.00
IUUC-Pva-102811	Pteropus vampyrus	74.57	0.00e+00	910.00
IUUC-Pte-104016	Pyrenophora teres	46.11	2.00e-150	524.00
IUUC-Pyt-104550	Pyrenophora triticirepentis	46.11	2.00e-150	524.00
IUUC-Rno-106125	Rattus norvegicus	56.99	0.00e+00	981.00
IUUC-Sce-106289	Saccharomyces cerevisiae	46.94	1.00e-151	529.00
IUUC-Sha-107243	Sarcophilus harrisii	73.41	0.00e+00	907.00
IUUC-Sja-107786	Schizosaccharomyces japonicus	48.50	4.00e-148	517.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	46.66	9.00e-154	536.00
IUUC-Sar-113761	Sorex araneus	66.96	0.00e+00	842.00
IUUC-Sre-114929	Sporisorium reilianum	45.73	1.00e-152	532.00
IUUC-Ssc-115368	Sus scrofa	74.48	0.00e+00	910.00
IUUC-Tgu-117079	Taeniopygia guttata	74.44	0.00e+00	922.00
IUUC-Tru-118062	Takifugu rubripes	73.58	0.00e+00	938.00
IUUC-Tsy-119507	Tarsius syrichta	68.69	0.00e+00	836.00
IUUC-Tni-120151	Tetraodon nigroviridis	73.28	0.00e+00	924.00
IUUC-Tre-122203	Trichoderma reesei	45.56	2.00e-149	521.00
IUUC-Tvi-122595	Trichoderma virens	45.33	9.00e-150	522.00
IUUC-Tbe-127793	Tupaia belangeri	73.66	0.00e+00	748.00
IUUC-Ttr-128275	Tursiops truncatus	71.65	0.00e+00	889.00
IUUC-Uma-129332	Ustilago maydis	50.10	2.00e-135	475.00
IUUC-Vda-129753	Verticillium dahliae	45.12	1.00e-148	518.00
IUUC-Vpa-130103	Vicugna pacos	58.86	0.00e+00	710.00
IUUC-Xtr-132866	Xenopus tropicalis	69.78	0.00e+00	864.00
IUUC-Xma-133778	Xiphophorus maculatus	73.92	0.00e+00	939.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence