iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000021142.3	ENSXETT00000036079.2	ENSXETP00000036079.2
ENSXETG00000021142.3	ENSXETT00000045696.3	ENSXETP00000045696.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.20e-135	452.4	638	969

Active Site

Position(s)	Description	Evidence
939	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++ lk+rl++ef+ E+gld+gGv+re+++llske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld 
   Q: 638  PDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRIAGLAVFHGKLLDG 726
           57899************************************************************************************ PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
           ++ ++fyk++lgk+++l+d+e+vd+e+y+slk+i+en   d +e  ldl+f+++ee++g+t++++Lkp+G+++ Vtn+Nk+eY++lv++
   Q: 727  FFIRPFYKMMLGKQITLKDMESVDSEYYNSLKWILEN---DPTE--LDLRFCIDEENFGQTYQVDLKPNGSEMVVTNDNKREYIDLVIQ 810
           ***********************************99...6666..7****************************************** PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +++++q++af eGf+e+ip++l+++F+e+elell+cG  ++dv+d++++t yk+gy +++paiqwFw+++  +++e+r ++LqFv
   Q: 811  WRFVNRVQKQMNAFLEGFTELIPIDLIKIFDENELELLMCGLGDVDVNDWRQHTLYKNGYCPNHPAIQWFWKAVLLMDAEKRIRLLQFV 899
           ***************************************************************************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           Tg+sr+P++Gfael     p+lf+i++++s+d+lP+++TCfn+L+LP+Y+s e l+ekLl+A+e+++gFe
   Q: 900  TGTSRVPMNGFAELYgsngPQLFTIEQWGSPDKLPRAHTCFNRLDLPPYDSFEDLREKLLMAVENAQGFE 969
           *********************************************************************8 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

AVADIREGIQ EGIQEESRIL RVKIVSGTDL AKKDIFGASD PYVKLSLYVA DENRELALVQ 60
TKTIKKTLNP KWNEEFFFRV HPTNHRLLFE VFDENRLTRD DFLGQVDVPL NHLPTEDPTM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTCCTCTCT ACCCGCCGGC ACCGGCACGG ACCTTATACC CGGAATAGGC ACCTAGTGAG 60
CGGCAGCTGG CCAGCGCCCT CCTATTGTTT CCCATCTACT GTGCGCAAAG GATTAGGGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

PRINTS

PR00360--C2DOMAIN

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001314	Ailuropoda melanoleuca	87.59	0.00e+00	1556.00
IUUC-Apl-003893	Anas platyrhynchos	88.87	0.00e+00	1612.00
IUUC-Aca-004744	Anolis carolinensis	86.41	0.00e+00	1568.00
IUUC-Ago-007742	Ashbya gossypii	48.91	3.00e-161	562.00
IUUC-Acl-008273	Aspergillus clavatus	49.02	8.00e-165	574.00
IUUC-Afl-008713	Aspergillus flavus	48.68	2.00e-161	562.00
IUUC-Afu-009103	Aspergillus fumigatus	49.34	7.00e-165	574.00
IUUC-Ani-009259	Aspergillus nidulans	49.33	3.00e-162	565.00
IUUC-Ang-009738	Aspergillus niger	49.00	1.00e-161	563.00
IUUC-Aor-010053	Aspergillus oryzae	57.05	2.00e-100	358.00
IUUC-Ate-010529	Aspergillus terreus	49.26	3.00e-164	572.00
IUUC-Ame-010810	Astyanax mexicanus	73.02	0.00e+00	1268.00
IUUC-Bgr-012148	Blumeria graminis	47.83	1.00e-154	540.00
IUUC-Bta-012679	Bos taurus	89.08	0.00e+00	1470.00
IUUC-Bci-013785	Botrytis cinerea	47.49	2.00e-155	542.00
IUUC-Cel-018564	Caenorhabditis elegans	52.53	0.00e+00	632.00
IUUC-Cja-018732	Callithrix jacchus	90.01	0.00e+00	1659.00
IUUC-Cfa-021226	Canis familiaris	89.59	0.00e+00	1654.00
IUUC-Cpo-021671	Cavia porcellus	87.83	0.00e+00	1604.00
IUUC-Csa-023344	Chlorocebus sabaeus	88.02	0.00e+00	1643.00
IUUC-Cho-024832	Choloepus hoffmanni	96.88	0.00e+00	729.00
IUUC-Cin-025157	Ciona intestinalis	62.48	0.00e+00	783.00
IUUC-Csv-026098	Ciona savignyi	59.04	0.00e+00	653.00
IUUC-Cgl-026642	Colletotrichum gloeosporioides	48.17	9.00e-157	547.00
IUUC-Cne-026849	Cryptococcus neoformans	48.41	9.00e-162	563.00
IUUC-Dre-027770	Danio rerio	79.00	0.00e+00	1441.00
IUUC-Dno-029466	Dasypus novemcinctus	90.20	0.00e+00	1667.00
IUUC-Dor-030138	Dipodomys ordii	85.44	0.00e+00	1524.00
IUUC-Dse-031241	Dothistroma septosporum	47.86	2.00e-159	555.00
IUUC-Dme-032166	Drosophila melanogaster	67.22	0.00e+00	715.00
IUUC-Ete-033145	Echinops telfairi	82.51	0.00e+00	1194.00
IUUC-Eca-033445	Equus caballus	88.94	0.00e+00	1461.00
IUUC-Eeu-035247	Erinaceus europaeus	81.34	0.00e+00	1398.00
IUUC-Fca-035489	Felis catus	86.78	0.00e+00	1411.00
IUUC-Fal-037604	Ficedula albicollis	87.45	0.00e+00	1653.00
IUUC-Fox-037774	Fusarium oxysporum	48.02	3.00e-159	555.00
IUUC-Fso-038393	Fusarium solani	47.93	2.00e-154	539.00
IUUC-Gmo-039674	Gadus morhua	76.25	0.00e+00	1392.00
IUUC-Ggr-040107	Gaeumannomyces graminis	47.91	2.00e-156	546.00
IUUC-Gga-040703	Gallus gallus	89.39	0.00e+00	1644.00
IUUC-Gac-042020	Gasterosteus aculeatus	80.12	0.00e+00	1423.00
IUUC-Ggo-045332	Gorilla gorilla	88.27	0.00e+00	1587.00
IUUC-Hsa-045968	Homo sapiens	89.99	0.00e+00	1657.00
IUUC-Kpa-049273	Komagataella pastoris	48.66	2.00e-162	565.00
IUUC-Lch-050443	Latimeria chalumnae	86.46	0.00e+00	1439.00
IUUC-Loc-052662	Lepisosteus oculatus	80.71	0.00e+00	1440.00
IUUC-Laf-053850	Loxodonta africana	88.66	0.00e+00	1640.00
IUUC-Mcc-055821	Macaca mulatta	89.78	0.00e+00	1653.00
IUUC-Meu-056712	Macropus eugenii	73.73	0.00e+00	683.00
IUUC-Mor-057097	Magnaporthe oryzae	44.84	1.00e-156	546.00
IUUC-Mpo-057442	Magnaporthe poae	51.81	5.00e-146	511.00
IUUC-Mla-058996	Melampsora laricipopulina	53.94	1.00e-149	523.00
IUUC-Mvi-060395	Microbotryum violaceum	54.32	2.00e-151	529.00
IUUC-Mmr-060798	Microcebus murinus	86.49	0.00e+00	1565.00
IUUC-Mdo-062173	Monodelphis domestica	88.14	0.00e+00	1659.00
IUUC-Mmu-064136	Mus musculus	90.09	0.00e+00	1639.00
IUUC-Mpu-066765	Mustela putorius furo	89.89	0.00e+00	1639.00
IUUC-Mlu-067565	Myotis lucifugus	88.30	0.00e+00	1462.00
IUUC-Nfi-068427	Neosartorya fischeri	49.34	3.00e-165	575.00
IUUC-Ncr-068918	Neurospora crassa	47.24	4.00e-157	548.00
IUUC-Nle-069070	Nomascus leucogenys	86.98	0.00e+00	1592.00
IUUC-Opr-071044	Ochotona princeps	92.25	0.00e+00	1155.00
IUUC-Ont-072044	Oreochromis niloticus	77.27	0.00e+00	1461.00
IUUC-Oan-073032	Ornithorhynchus anatinus	85.77	0.00e+00	1348.00
IUUC-Ocu-074160	Oryctolagus cuniculus	87.63	0.00e+00	1587.00
IUUC-Ola-087467	Oryzias latipes	80.47	0.00e+00	1465.00
IUUC-Oga-088460	Otolemur garnettii	87.36	0.00e+00	1464.00
IUUC-Oar-090198	Ovis aries	89.19	0.00e+00	1626.00
IUUC-Ptr-090939	Pan troglodytes	89.99	0.00e+00	1657.00
IUUC-Pan-092284	Papio anubis	89.89	0.00e+00	1659.00
IUUC-Psi-093645	Pelodiscus sinensis	89.59	0.00e+00	1672.00
IUUC-Pma-094364	Petromyzon marinus	82.07	0.00e+00	864.00
IUUC-Pno-095118	Phaeosphaeria nodorum	49.01	5.00e-162	564.00
IUUC-Pfo-096768	Poecilia formosa	92.08	0.00e+00	974.00
IUUC-Pab-098088	Pongo abelii	90.11	0.00e+00	1659.00
IUUC-Pca-100714	Procavia capensis	78.77	0.00e+00	1089.00
IUUC-Pva-102354	Pteropus vampyrus	87.70	0.00e+00	1554.00
IUUC-Pgr-103620	Puccinia graminis	53.73	3.00e-148	518.00
IUUC-Ptt-103806	Puccinia triticina	53.86	9.00e-124	437.00
IUUC-Pte-104016	Pyrenophora teres	48.50	6.00e-162	564.00
IUUC-Pyt-104550	Pyrenophora triticirepentis	48.50	6.00e-162	564.00
IUUC-Rno-105318	Rattus norvegicus	89.07	0.00e+00	1617.00
IUUC-Sce-106289	Saccharomyces cerevisiae	49.25	5.00e-165	574.00
IUUC-Sha-107482	Sarcophilus harrisii	89.91	0.00e+00	1511.00
IUUC-Sja-107786	Schizosaccharomyces japonicus	48.24	3.00e-153	535.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	47.18	6.00e-157	547.00
IUUC-Stu-112582	Solanum tuberosum	36.36	1.00e-55	211.00
IUUC-Ssc-115950	Sus scrofa	68.73	0.00e+00	1139.00
IUUC-Tgu-117130	Taeniopygia guttata	89.39	0.00e+00	1655.00
IUUC-Tru-118610	Takifugu rubripes	79.90	0.00e+00	1471.00
IUUC-Tsy-119492	Tarsius syrichta	84.75	0.00e+00	1502.00
IUUC-Tni-120113	Tetraodon nigroviridis	75.31	0.00e+00	1365.00
IUUC-Tre-122203	Trichoderma reesei	44.23	2.00e-153	536.00
IUUC-Tvi-122595	Trichoderma virens	47.10	2.00e-154	539.00
IUUC-Tme-126897	Tuber melanosporum	53.40	4.00e-149	521.00
IUUC-Ttr-128235	Tursiops truncatus	94.95	0.00e+00	1049.00
IUUC-Uma-129332	Ustilago maydis	52.27	3.00e-141	495.00
IUUC-Vda-129753	Verticillium dahliae	47.51	3.00e-157	549.00
IUUC-Xma-133797	Xiphophorus maculatus	80.62	0.00e+00	1454.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence